Synthesis and in vitro pharmacological studies of new C(2) modified salvinorin A analogues Fulltext Access 4 Pages 2005
Substituted tetraazaacenaphthylenes as potent CRF1 receptor antagonists for the treatment of depression and anxiety Fulltext Access 4 Pages 2005
2-(2-Furanyl)-7-phenyl[1,2,4]triazolo[1,5-c]pyrimidin-5-amine analogs as adenosine A2A antagonists: The successful reduction of hERG activity. Part 2 Fulltext Access 4 Pages 2005
QSAR for phospholipase A2 inhibitions by 1-acyloxy-3-N-n-octylcarbamyl-benzenes Fulltext Access 4 Pages 2005
Quorum sensing in Vibrio harveyi: probing the specificity of the LuxP binding site Fulltext Access 4 Pages 2005
2,3-Diaminopyridine as a platform for designing structurally unique nonpeptide bradykinin B1 receptor antagonists Fulltext Access 4 Pages 2005
New pyrazolo[1′,5′:1,6]pyrimido[4,5-d]pyridazin-4(3H)-ones as potent and selective PDE5 inhibitors Fulltext Access 4 Pages 2005
Equipotent activity in both enantiomers of a series of ketopiperazine-based renin inhibitors Fulltext Access 4 Pages 2005
Stereospecific deuteration of 2-deoxyerythrose 4-phosphate using 3-deoxy-D-arabino-heptulosonate 7-phosphate synthase Fulltext Access 4 Pages 2005
N-DEVD-N′-morpholinecarbonyl-rhodamine 110: novel caspase-3 fluorogenic substrates for cell-based apoptosis assay Fulltext Access 4 Pages 2005
Inhibition of tumor cell proliferation by thieno[2,3-d]pyrimidin-4(1H)-one-based analogs Fulltext Access 4 Pages 2005
Hypoxia-selective activation of 5-fluorodeoxyuridine prodrug possessing indolequinone structure: radiolytic reduction and cytotoxicity characteristics Fulltext Access 4 Pages 2005
A new development of matrix metalloproteinase inhibitors: twin hydroxamic acids as potent inhibitors of MMPs Fulltext Access 4 Pages 2005
Synthesis and photochemotherapeutic activity of thiopyrano[2,3-e]indol-2-ones Fulltext Access 4 Pages 2005
Reduction of a 4-pyrrole phenylacyl-containing peptide with trifluoroacetic acid–triisopropylsilane–phenol–H2O during solid-phase peptide synthesis and its protein kinase C α inhibitory activity Fulltext Access 4 Pages 2005
Solid-phase synthesis of naphthylamidines as factor VIIa/tissue factor inhibitors Fulltext Access 4 Pages 2005
Observations on the reactivity of thiyl radicals derived from 3,6-epidithiodiketopiperazine-2,5-diones and related congeners Fulltext Access 4 Pages 2005
Phthalazinones. Part 1: The design and synthesis of a novel series of potent inhibitors of poly(ADP-ribose)polymerase Fulltext Access 4 Pages 2005
NMDA-NR2B subtype selectivity of stereoisomeric 2-(1,2,3,4-tetrahydro-1-isoquinolyl)ethanol derivatives Fulltext Access 4 Pages 2005
3-Acyl-2,6-diaminopyridines as cyclin-dependent kinase inhibitors: synthesis and biological evaluation Fulltext Access 4 Pages 2005
Synthesis and assay of isoquinoline derivatives as HIV-1 Tat–TAR interaction inhibitors Fulltext Access 4 Pages 2005
Design, synthesis and activity of novel derivatives of Oxybutynin and Tolterodine Fulltext Access 4 Pages 2005
Discovery of 3-OH-3-methylpipecolic hydroxamates: Potent orally active inhibitors of aggrecanase and MMP-13 Fulltext Access 4 Pages 2005
Inhibitors of the inducible microsomal prostaglandin E2 synthase (mPGES-1) derived from MK-886 Fulltext Access 4 Pages 2005
Synthesis and evaluation of potential inhibitors of eIF4E cap binding to 7-methyl GTP Fulltext Access 4 Pages 2005
Fluorescence resonance energy transfer studies of aminoglycoside binding to a T box antiterminator RNA Fulltext Access 4 Pages 2005
A proof of the specificity of kanamycin-ribosomal RNA interaction with designed synthetic analogs and the antibacterial activity Fulltext Access 4 Pages 2005
Quinazolines revisited: search for novel anxiolytic and GABAergic agents Fulltext Access 4 Pages 2005
Synthesis of sphingomyelin sulfur analogue and its behavior toward sphingomyelinase Fulltext Access 4 Pages 2005
Synthesis and opioid receptor binding properties of a highly potent 4-hydroxy analogue of naltrexone Fulltext Access 4 Pages 2005
Discovery, synthesis and biological evaluation of novel glucokinase activators Fulltext Access 4 Pages 2005
A colorimetric titration method for quantification of millimolar glucose in a pH 7.4 aqueous phosphate buffer Fulltext Access 4 Pages 2005
Synthesis, in vitro, and in vivo antibacterial activity of nocathiacin I thiol-Michael adducts Fulltext Access 4 Pages 2005
Inhibitory activities against topoisomerase I and II by isoaurostatin derivatives and their structure–activity relationships Fulltext Access 4 Pages 2005
Dependence of reactivity of a novel 2,6-diamino pyridine-based enediyne on the extent of salt formation with external acids: a possible implication in pH based drug design Fulltext Access 4 Pages 2005
A general carbometalation, three component coupling strategy for the synthesis of α,β-unsaturated γ-sultines including thio-rofecoxib, a selective COX-2 inhibitor Fulltext Access 4 Pages 2005
Inosine substitutions demonstrate that intramolecular DNA quadruplexes adopt different conformations in the presence of sodium and potassium Fulltext Access 4 Pages 2005
Effects of B group vitamins on reactions of various α-hydroxyl-containing organic radicals Fulltext Access 4 Pages 2005
Structure-based design and synthesis of novel non-zinc chelating MMP-12 inhibitors Fulltext Access 4 Pages 2005
Discovery and in vitro evaluation of potent kinase inhibitors: Pyrido[1â²,2â²:1,5]pyrazolo[3,4-d]pyrimidines Fulltext Access 4 Pages 2005
Synthesis and structural modeling of the amphiphilic siderophore rhizobactin-1021 and its analogs Fulltext Access 4 Pages 2005
Hydrophobicity in the design of P2/P2â² tetrahydropyrimidinone HIV protease inhibitors Fulltext Access 4 Pages 2005
Synthesis and structure–activity relationship of imidazo[1,2-a]benzimidazoles as corticotropin-releasing factor 1 receptor antagonists Fulltext Access 4 Pages 2005
Design, synthesis, and bioavailability evaluation of coumarin-based prodrug of meptazinol Fulltext Access 4 Pages 2005
Insecticidal activity of proteinous venom from tentacle of jellyfish Rhopilema esculentum Kishinouye Fulltext Access 4 Pages 2005
Design, synthesis, and enzymatic property of a sulfur-substituted analogue of trigalacturonic acid Fulltext Access 4 Pages 2005
Solid support synthesis of 6-aryl-2-substituted pyrimidin-4-yl phenols as anti-infective agents Fulltext Access 4 Pages 2005
The synthesis and 16S A-site rRNA recognition of carbohydrate-free aminoglycosides Fulltext Access 4 Pages 2005
The synthesis and biological evaluation of dopamine transporter inhibiting activity of substituted diphenylmethoxypiperidines Fulltext Access 4 Pages 2005
Solid-phase synthesis and anti-infective activity of a combinatorial library based on the natural product anisomycin Fulltext Access 4 Pages 2005
Contribution of site-specific PEGylation to the dipeptidyl peptidase IV stability of glucose-dependent insulinotropic polypeptide Fulltext Access 4 Pages 2005
Controllable selective synthesis of a polymerizable prodrug of cytarabine by enzymatic and chemical methods Fulltext Access 4 Pages 2005
Utilizing the intramolecular Fukuyama–Mitsunobu reaction for a flexible synthesis of novel heterocyclic scaffolds for peptidomimetic drug design Fulltext Access 4 Pages 2005
Synthesis of 2-[3,5-substituted pyrazol-1-yl]-4,6-trisubstituted triazine derivatives as antimalarial agents Fulltext Access 4 Pages 2005
New HIV-1 replication inhibitors of the styryquinoline class bearing aroyl/acyl groups at the C-7 position: Synthesis and biological activity Fulltext Access 4 Pages 2005
SAR studies of 2-arylthiazolidine-4-carboxylic acid amides: A novel class of cytotoxic agents for prostate cancer Fulltext Access 4 Pages 2005
O-Methylglucogalloyl esters: Synthesis and evaluation of their antimycotic activity Fulltext Access 4 Pages 2005
Novel peptide derivatives of bleomycin A5: Synthesis, antitumor activity and interaction with DNA Fulltext Access 4 Pages 2005
Design and synthesis of new bis-pyridinium oxime reactivators for acetylcholinesterase inhibited by organophosphorous nerve agents Fulltext Access 4 Pages 2005
Synthesis and structure–activity relationship of 3-phenyl-3H-quinazolin-4-one derivatives as CXCR3 chemokine receptor antagonists Fulltext Access 4 Pages 2005
Novel 2-N,N-dimethylaminomethyl-2,3,3a,12b-tetrahydrodibenzo[b,f]furo[2,3-d]oxepin derivatives displaying combined norepinephrine reuptake inhibition and 5-HT2A/2C receptor antagonism Fulltext Access 4 Pages 2005
Synthesis of desthio prenylcysteine analogs: Sulfur is important for biological activity Fulltext Access 4 Pages 2005
Design, synthesis, and evaluation of novelly substituted benzimidazole compounds as angiotensin II receptor antagonists Fulltext Access 4 Pages 2005
Synthesis and in vitro study of novel 7-O-acyl derivatives of Oroxylin A as antibacterial agents Fulltext Access 4 Pages 2005
In vitro antiproliferative activity against human colon cancer cell lines of representative 4-thiazolidinones. Part I Fulltext Access 4 Pages 2005
Self-assembly of bivalent protein-binding agents based on oligonucleotide-linked organic fragments Fulltext Access 4 Pages 2005
Synthesis, structure–activity relationships, and anxiolytic activity of 7-aryl-6,7-dihydroimidazoimidazole corticotropin-releasing factor 1 receptor antagonists Fulltext Access 4 Pages 2005
Lead optimization of 4-(dimethylamino)quinazolines, potent and selective antagonists for the melanin-concentrating hormone receptor 1 Fulltext Access 4 Pages 2005
Structure–activity relationship studies of salubrinal lead to its active biotinylated derivative Fulltext Access 4 Pages 2005
Design, synthesis, and evaluation of 2-phenoxy-indan-1-one derivatives as acetylcholinesterase inhibitors Fulltext Access 4 Pages 2005
Toward high yield synthesis of peptide–oligonucleotide chimera through a disulfide bridge: A simplified method for oligonucleotide activation Fulltext Access 4 Pages 2005
Synthesis, in vivo and in vitro biological activity of novel azaline B analogs Fulltext Access 4 Pages 2005
Synthesis of (2R,3S) 3-amino-4-mercapto-2-butanol, a threonine analogue for covalent inhibition of sortases Fulltext Access 4 Pages 2005
3-[Substituted]-5-(5-pyridin-2-yl-2H-tetrazol-2-yl)benzonitriles: Identification of highly potent and selective metabotropic glutamate subtype 5 receptor antagonists Fulltext Access 4 Pages 2005
Design, synthesis, and antiproliferative activity of some novel aminosubstituted xanthenones, able to overcome multidrug resistance toward MES-SA/Dx5 cells Fulltext Access 4 Pages 2005
Synthesis and HIV-1 integrase inhibitory activities of caffeic acid dimers derived from Salvia officinalis Fulltext Access 4 Pages 2005
Synthesis of a novel prodrug of 3-(4′-geranyloxy-3′-methoxyphenyl)-2-trans-propenoic acid for colon delivery Fulltext Access 4 Pages 2005
Polymer supported carbodiimide strategy for the synthesis of N-acylated derivatives of deoxy- and ribo purinenucleosides using active esters Fulltext Access 4 Pages 2005
Synthesis and biological activities of novel aryl indole-2-carboxylic acid analogs as PPARγ partial agonists Fulltext Access 4 Pages 2005
Modulators of the human CCR5 receptor. Part 2: SAR of substituted 1-(3,3-diphenylpropyl)-piperidinyl phenylacetamides Fulltext Access 4 Pages 2005
(4-Substituted-phenyl)-(5H-10,11-dihydro-pyrrolo [2,1-c][1,4] benzodiazepin-10-yl)-methanone derivatives as vasopressin receptor modulators Fulltext Access 4 Pages 2005
Solid-phase binding assays of peptides using EGFP-Src SH2 domain fusion protein and biotinylated Src SH2 domain Fulltext Access 4 Pages 2005
Synthesis and biological activities of aryl-ether-, biaryl-, and fluorene-aspartic acid and diaminopropionic acid analogs as potent inhibitors of the high-affinity glutamate transporter EAAT-2 Fulltext Access 4 Pages 2005