Design, synthesis and structure-activity relationship of a series of fragment analogues of antistasin (ATS) and ghilantens (GLS) Fulltext Access 4 Pages 2005
A new synthesis of isoaurones: Cytotoxic activity of compounds related to the alleged structure of isoaurostatin Fulltext Access 4 Pages 2005
Squaric monoamide monoester as a new class of reactive immunization hapten for catalytic antibodies Fulltext Access 4 Pages 2005
Aqua mediated synthesis of substituted 2-amino-4H-chromenes and in vitro study as antibacterial agents Fulltext Access 4 Pages 2005
Discovery of novel conformationally restricted diazocan peptidomimetics as inhibitors of interleukin-1β synthesis Fulltext Access 4 Pages 2005
A general method for the synthesis of aryl [11C]methylsulfones: Potential PET probes for imaging cyclooxygenase-2 expression Fulltext Access 4 Pages 2005
Reactions of α-hydroxyethyl radicals with flavonoids of various structures Fulltext Access 4 Pages 2005
Design and synthesis of a novel peptidomimetic inhibitor of HIV-1 Tat–TAR interactions: Squaryldiamide as a new potential bioisostere of unsubstituted guanidine Fulltext Access 4 Pages 2005
Synthesis and structure–activity relationship of N-alkyl Gly-boro-Pro inhibitors of DPP4, FAP, and DPP7 Fulltext Access 4 Pages 2005
Structure–activity relationships of Erwinia carotovora quorum sensing signaling molecules Fulltext Access 4 Pages 2005
5-Substituted 4-anilinoquinazolines as potent, selective and orally active inhibitors of erbB2 receptor tyrosine kinase Fulltext Access 4 Pages 2005
Molecular design, chemical synthesis, and evaluation of cytosine–carbohydrate hybrids for selective recognition of a single guanine bulged duplex DNA Fulltext Access 4 Pages 2005
Characterisation and biodistribution of two neutral 99mTc(CO)3 complexes with a tridentate ligand Fulltext Access 4 Pages 2005
Isolation, structure elucidation, preparation, and biological properties of neolambertellin Fulltext Access 4 Pages 2005
SAR, species specificity, and cellular activity of cyclopentene dicarboxylic acid amides as DHODH inhibitors Fulltext Access 4 Pages 2005
Camptothecin binds to a synthetic peptide identified by a T7 phage display screen Fulltext Access 4 Pages 2005
Synthesis of a biotinylated camptothecin derivative and determination of the binding sequence by T7 phage display technology Fulltext Access 4 Pages 2005
Synthesis and biological evaluation of 1,3-diphenylprop-2-yn-1-ones as dual inhibitors of cyclooxygenases and lipoxygenases Fulltext Access 4 Pages 2005
Investigation of factor Xa inhibitors containing non-amidine S1 elements Fulltext Access 4 Pages 2005
A fluorogenic and chromogenic probe that detects the esterase activity of trace copper(II) Fulltext Access 4 Pages 2005
Novel indole α-methylene-γ-lactones as potent inhibitors for AKT-mTOR signaling pathway kinases Fulltext Access 4 Pages 2005
Synthesis and evaluation of 3-anilino-quinoxalinones as glycogen phosphorylase inhibitors Fulltext Access 4 Pages 2005
Synthesis and antibacterial activity of novel (un)substituted benzotriazolyl oxazolidinone derivatives Fulltext Access 4 Pages 2005
Synthesis and biological evaluation of chalcones and their derived pyrazoles as potential cytotoxic agents Fulltext Access 4 Pages 2005
Synthesis, antitumor evaluation and DNA photocleaving activity of novel methylthiazonaphthalimides with aminoalkyl side chains Fulltext Access 4 Pages 2005
Synthesis of substituted indole derivatives as a new class of antimalarial agents Fulltext Access 4 Pages 2005
Design and synthesis of new 2-substituted-5-(2-benzylthiophenyl)-1,3,4-oxadiazoles as benzodiazepine receptor agonists Fulltext Access 4 Pages 2005
Synthesis and characterization of the monomer ruthenium complex of hypocrellin B Fulltext Access 4 Pages 2005
Synthesis and binding affinity of novel 3-aminoethyl-1-tetralones, potential atypical antipsychotics Fulltext Access 4 Pages 2005
The synthesis of substituted bipiperidine amide compounds as CCR3 ligands: Antagonists versus agonists Fulltext Access 4 Pages 2005
Total synthesis and bioactivity of unique flavone desmosdumotin B and its analogs Fulltext Access 4 Pages 2005
4-Substituted (benzo[b]thiophene-2-carbonyl)guanidines as novel Na+/H+ exchanger isoform-1 (NHE-1) inhibitors Fulltext Access 4 Pages 2005
Three-dimensional structure of Plasmodium falciparum Ca2+-ATPase(PfATP6) and docking of artemisinin derivatives to PfATP6 Fulltext Access 4 Pages 2005
New piperidinyl- and 1,2,3,6-tetrahydropyridinyl-pyrimidine derivatives as selective 5-HT1A receptor agonists with highly potent anti-ischemic effects Fulltext Access 4 Pages 2005
Structure-activity relationships of novel endomorphin-2 analogues with N-O turns induced by α-aminoxy acids Fulltext Access 4 Pages 2005
Non-hydroxamate 5-phenylpyrimidine-2,4,6-trione derivatives as selective inhibitors of tumor necrosis factor-α converting enzyme Fulltext Access 4 Pages 2005
Synthetic lanostane-type triterpenoids as inhibitors of DNA topoisomerase II Fulltext Access 4 Pages 2005
DNA binding specificity and cytotoxicity of novel antitumor agent Ge132 derivatives Fulltext Access 4 Pages 2005
Epibatidine analogues as selective ligands for the αxβ2-containing subtypes of nicotinic acetylcholine receptors Fulltext Access 4 Pages 2005
Synthesis of aryl-1,2,4-triazine-3,5-diones as antagonists of the gonadotropin-releasing hormone receptor Fulltext Access 4 Pages 2005
Adamantyl triazoles as selective inhibitors of 11β-hydroxysteroid dehydrogenase type 1 Fulltext Access 4 Pages 2005
Dipyridyl amines: Potent metabotropic glutamate subtype 5 receptor antagonists Fulltext Access 4 Pages 2005
Synthesis of functionalized acetophenones as protein tyrosine phosphatase 1B inhibitors Fulltext Access 4 Pages 2005
EB1627: a soluble prodrug of the potent anticancer cyanoguanidine CHS828 Fulltext Access 4 Pages 2005
Antiproliferative activity in HL60 cells by tetrasubstituted pyrroles: a structure–activity relationship study Fulltext Access 4 Pages 2005
Synthesis of dehydroalanine fragments as thiostrepton side chain mimetics Fulltext Access 4 Pages 2005
Synthesis and biological evaluation of novel 1,4-naphthoquinone derivatives as antibacterial and antiviral agents Fulltext Access 4 Pages 2005
Structure-driven HtL: Design and synthesis of novel aminoindazole inhibitors of c-Jun N-terminal kinase activity Fulltext Access 4 Pages 2005
Isomeric thiazole derivatives as ligands for the neuropeptide Y5 receptor Fulltext Access 4 Pages 2005
1-Amino-1,2,3,4-tetrahydronaphthalene-2-carboxylic acid as a Tic mimetic: Application in the synthesis of potent human melanocortin-4 receptor selective agonists Fulltext Access 4 Pages 2005
4,4′-Dimethoxytrityl group derived from secondary alcohols: Are they removed slowly under acidic conditions? Fulltext Access 4 Pages 2005
A novel [99mTcN]2+ complex of metronidazole xanthate as a potential agent for targeting hypoxia Fulltext Access 4 Pages 2005
Uracils as potent antagonists of the human gonadotropin-releasing hormone receptor without atropisomers Fulltext Access 4 Pages 2005
SAR studies of 6-aryl-1,3-dihydrobenzimidazol-2-ones as progesterone receptor antagonists Fulltext Access 4 Pages 2005
Synthesis of some diguanidino 1-methyl-2,5-diaryl-1H-pyrroles as antifungal agents Fulltext Access 4 Pages 2005
Synthesis and biological evaluation of novel angularly fused polycyclic coumarins Fulltext Access 4 Pages 2005
Total synthesis and antiangiogenic activity of cyclopentane analogues of fumagillol Fulltext Access 4 Pages 2005
A macromolecular prodrug of doxorubicin conjugated to a biodegradable cyclotriphosphazene bearing a tetrapeptide Fulltext Access 4 Pages 2005
Synthesis and biological activity of mustard derivatives of combretastatins Fulltext Access 4 Pages 2005
Gastric cytoprotective activity of ilicic aldehyde: Structure–activity relationships Fulltext Access 4 Pages 2005
Indole alkaloids from Tabernaemontana australis (Müell. Arg) Miers that inhibit acetylcholinesterase enzyme Fulltext Access 4 Pages 2005
Design and synthesis of novel diphenacoum-derived, conformation-restricted vitamin K 2,3-epoxide reductase inhibitors Fulltext Access 4 Pages 2005
New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors Fulltext Access 4 Pages 2005
Potential antitumor agents: Flavones and their derivatives from Linaria reflexa Desf. Fulltext Access 4 Pages 2005
High affinity ligands for the α7 nicotinic receptor that show no cross-reactivity with the 5-HT3 receptor Fulltext Access 4 Pages 2005
Benzyl ether structure–activity relationships in a series of ketopiperazine-based renin inhibitors Fulltext Access 4 Pages 2005
Synthesis of 4-(5-[18F]fluoromethyl-3-phenylisoxazol-4-yl)benzenesulfonamide, a new [18F]fluorinated analogue of valdecoxib, as a potential radiotracer for imaging cyclooxygenase-2 with positron emission tomography Fulltext Access 4 Pages 2005
Inhibition of Src kinase activity by 7-[(2,4-dichloro-5-methoxyphenyl)amino]-2-heteroaryl-thieno[3,2-b]pyridine-6-carbonitriles Fulltext Access 4 Pages 2005
Synthesis of linked berberine dimers and their remarkably enhanced DNA-binding affinities Fulltext Access 4 Pages 2005
Human serum transferrin cobalt complex: Stability and cellular uptake of cobalt Fulltext Access 4 Pages 2005
Isolation, characterization and antiplasmodial activity of steroidal alkaloids from Funtumia elastica (Preuss) Stapf Fulltext Access 4 Pages 2005
A divergent chemoenzymatic route to an intermediate for nucleoside analogues Fulltext Access 4 Pages 2005
Synthesis and antifungal activity of 5-arylamino-4,7-dioxobenzo[b]thiophenes Fulltext Access 4 Pages 2005
Optimization of isotope-labeling conditions for lambertellin based on isotope patterns observed by mass spectrometry Fulltext Access 4 Pages 2005
Lambertellol C, a labile and novel biosynthetic congener of lambertellols A and B Fulltext Access 4 Pages 2005
2,5-Diketopiperazines as potent and selective oxytocin antagonists 1: identification, stereochemistry and initial SAR Fulltext Access 4 Pages 2005
Synthesis of thiosemicarbazone and 4-thiazolidinone derivatives and their in vitro anti-Toxoplasma gondii activity Fulltext Access 4 Pages 2005
Synthesis and biological evaluation of gemcitabine–lipid conjugate (NEO6002) Fulltext Access 4 Pages 2005
Design, new synthesis, and calcilytic activity of substituted 3H-pyrimidin-4-ones Fulltext Access 4 Pages 2005
Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors Fulltext Access 4 Pages 2005
Lactams as prostanoid receptor ligands. Part 4: 2-Piperidones as selective EP4 receptor agonists Fulltext Access 4 Pages 2005