Synthesis and biological evaluation of 6,7-disubstituted 4-aminopyrido[2,3-d]pyrimidines as adenosine kinase inhibitors Fulltext Access 5 Pages 2005
Synthesis and phosphodiesterase 5 inhibitory activity of novel pyrido[1,2-e]purin-4(3H)-one derivatives Fulltext Access 5 Pages 2005
Decrease in the particle size of low-density lipoprotein (LDL) by oxidation Fulltext Access 5 Pages 2005
New cytotoxic bisindole alkaloids with protein tyrosine kinase inhibitory activity from a myxomycete Lycogala epidendrum Fulltext Access 5 Pages 2005
P2 pyridine N-oxide thrombin inhibitors: a novel peptidomimetic scaffold Fulltext Access 5 Pages 2005
Synthesis of all-trans arachidonic acid and its effect on rabbit platelet aggregation Fulltext Access 5 Pages 2005
Synthesis and in vitro pharmacological evaluation of salvinorin A analogues modified at C(2) Fulltext Access 5 Pages 2005
Synthesis of tricyclic analogs of stephaoxocanidine and their evaluation as acetylcholinesterase inhibitors Fulltext Access 5 Pages 2005
Carbonic anhydrase inhibitors. Synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, and IX with boron-containing sulfonamides, sulfamides, and sulfamates: Toward agents for boron neutron capture therapy of hypoxic tumo Fulltext Access 5 Pages 2005
Discovery of new diphenyloxazole derivatives containing a pyrrolidine ring: Orally active prostacyclin mimetics. Part 2 Fulltext Access 5 Pages 2005
Glutamic acid analogues as potent dipeptidyl peptidase IV and 8 inhibitors Fulltext Access 5 Pages 2005
A practical molecular clip for immobilization of receptors and biomolecules on devices’ surface: Synthesis, grafting protocol and analytical assay Fulltext Access 5 Pages 2005
Design, synthesis, and evaluation of proline based melanocortin receptor ligands Fulltext Access 5 Pages 2005
Sialyl Lewisx analogs based on a quinic acid scaffold as the fucose mimic Fulltext Access 5 Pages 2005
Design, synthesis, and evaluation of dioxane-based antiviral agents targeted against the Sindbis virus capsid protein Fulltext Access 5 Pages 2005
Estrogen receptor β selective ligands: Discovery and SAR of novel heterocyclic ligands Fulltext Access 5 Pages 2005
A novel one-pot three-component reaction: Synthesis of triheterocyclic 4H-pyrimido[2,1-b]benzazoles ring systems Fulltext Access 5 Pages 2005
Antioxidant and cytotoxic activities of xanthones from Cudrania tricuspidata Fulltext Access 5 Pages 2005
Cyclohexyl-linked tricyclic isoxazoles are potent and selective modulators of the multidrug resistance protein (MRP1) Fulltext Access 5 Pages 2005
Molecular docking and 3D-QSAR on 2-(oxalylamino) benzoic acid and its analogues as protein tyrosine phosphatase 1B inhibitors Fulltext Access 5 Pages 2005
Preparation of human Melanocortin-4 receptor agonist libraries: Linear peptides X-Y-DPhe7-Arg8-Trp(or 2-Nal)9-Z-NH2 Fulltext Access 5 Pages 2005
Synthesis and activity of N-acyl azacyclic urea HIV-1 protease inhibitors with high potency against multiple drug resistant viral strains Fulltext Access 5 Pages 2005
Toll-like receptor 2 antagonists. Part 1: Preliminary SAR investigation of novel synthetic phospholipids Fulltext Access 5 Pages 2005
Preparation of 3-spirocyclic indolin-2-ones as ligands for the ORL-1 receptor Fulltext Access 5 Pages 2005
High affinity iron(III) scavenging by a novel hexadentate 3-hydroxypyridin-4-one-based dendrimer: Synthesis and characterization Fulltext Access 5 Pages 2005
A series of bisaryl imidazolidin-2-ones has shown to be selective and orally active 5-HT2C receptor antagonists Fulltext Access 5 Pages 2005
Pentacyclic triterpenes. Part 1: The first examples of naturally occurring pentacyclic triterpenes as a new class of inhibitors of glycogen phosphorylases Fulltext Access 5 Pages 2005
Bis(indole) alkaloids as sortase A inhibitors from the sponge Spongosorites sp. Fulltext Access 5 Pages 2005
Discovery of 1-amino-4-phenylcyclohexane-1-carboxylic acid and its influence on agonist selectivity between human melanocortin-4 and -1 receptors in linear pentapeptides Fulltext Access 5 Pages 2005
Synthesis of benzoyl phenyl benzoates as effective inhibitors for phospholipase A2 and hyaluronidase enzymes Fulltext Access 5 Pages 2005
Benzazoles as allosteric potentiators of metabotropic glutamate receptor 2 (mGluR2): Efficacy in an animal model for schizophrenia Fulltext Access 5 Pages 2005
Synthesis and preliminary biological evaluation of new anti-tubulin agents containing different benzoheterocycles Fulltext Access 5 Pages 2005
Synthesis and antimicrobial activity of 5-hydroxymethyl- 8-methyl-2-(N-arylimino)-pyrano[2,3-c]pyridine-3-(N-aryl)-carboxamides Fulltext Access 5 Pages 2005
Discovery of a potent and selective 5-ht5A receptor antagonist by high-throughput chemistry Fulltext Access 5 Pages 2005
Discovery of potent and use-dependent sodium channel blockers for treatment of chronic pain Fulltext Access 5 Pages 2005
Discovery of selective aldo-keto reductase ligands—an on-bead assay strategy Fulltext Access 5 Pages 2005
Benzimidazolones and indoles as non-thiol farnesyltransferase inhibitors based on tipifarnib scaffold: synthesis and activity Fulltext Access 5 Pages 2005
A discriminant model constructed by the support vector machine method for HERG potassium channel inhibitors Fulltext Access 5 Pages 2005
Evaluation of 3-substituted arginine analogs as selective inhibitors of human nitric oxide synthase isozymes Fulltext Access 5 Pages 2005
Non-competitive inhibitors of metabotropic glutamate receptor 5 (mGluR5) Fulltext Access 5 Pages 2005
Synthesis and biological evaluation of sulfonamidooxazoles and β-keto sulfones: selective inhibitors of 11β-hydroxysteroid dehydrogenase type I Fulltext Access 5 Pages 2005
Discovery of AICAR Tfase inhibitors that disrupt requisite enzyme dimerization Fulltext Access 5 Pages 2005
Design, synthesis, and biological evaluation of novel human 5′-deoxy-5′-methylthioadenosine phosphorylase (MTAP) substrates Fulltext Access 5 Pages 2005
Discovery and development of dimeric podocarpic acid leads as potent agonists of liver X receptor with HDL cholesterol raising activity in mice and hamsters Fulltext Access 5 Pages 2005
Cyclohexenyl- and dehydropiperidinyl-alkynyl pyridines as potent metabotropic glutamate subtype 5 (mGlu5) receptor antagonists Fulltext Access 5 Pages 2005
Design, synthesis, and structure–activity relationship of podocarpic acid amides as liver X receptor agonists for potential treatment of atherosclerosis Fulltext Access 5 Pages 2005
A series of 5-(5,6)-dihydrouracil substituted 8-hydroxy-[1,6]naphthyridine-7-carboxylic acid 4-fluorobenzylamide inhibitors of HIV-1 integrase and viral replication in cells Fulltext Access 5 Pages 2005
Screening of active compounds as neuromedin U2 receptor agonist from natural products Fulltext Access 5 Pages 2005
An efficient synthesis of aryloxyphenyl cyclopropyl methanones: a new class of anti-mycobacterial agents Fulltext Access 5 Pages 2005
Hepatitis C virus NS3-4A serine protease inhibitors: Use of a P2–P1 cyclopropyl alanine combination for improved potency Fulltext Access 5 Pages 2005
Facile synthesis and PET imaging of a novel potential heart acetylcholinesterase tracer N-[11C]methyl-3-[[(dimethylamino)carbonyl]oxy]-2-(2â²,2â²-diphenylpropionoxymethyl)pyridinium Fulltext Access 5 Pages 2005
Synthesis and antibacterial activity of N-(5-benzylthio-1,3,4-thiadiazol-2-yl) and N-(5-benzylsulfonyl-1,3,4-thiadiazol-2-yl)piperazinyl quinolone derivatives Fulltext Access 5 Pages 2005
Synthesis and cytotoxic activity of platinum complex immobilized by branched polyethylene glycol Fulltext Access 5 Pages 2005
Synthesis, stability, and implications of phosphothioate agonists of sphingosine-1-phosphate receptors Fulltext Access 5 Pages 2005
Synthesis and evaluation of anti-HIV activity of isatin β-thiosemicarbazone derivatives Fulltext Access 5 Pages 2005
Minor structural modifications convert a selective PPARα agonist into a potent, highly selective PPARδ agonist Fulltext Access 5 Pages 2005
Novel 7-methoxy-6-oxazol-5-yl-2,3-dihydro-1H-quinazolin-4-ones as IMPDH inhibitors Fulltext Access 5 Pages 2005
Synthesis and biological evaluation of novel (l)-α-amino acid methyl ester, heteroalkyl, and aryl substituted 1,4-naphthoquinone derivatives as antifungal and antibacterial agents Fulltext Access 5 Pages 2005
Inhibitors of phenylethanolamine N-methyltransferase devoid of α2-adrenoceptor affinity Fulltext Access 5 Pages 2005
Binding of amine-substituted N1-benzenesulfonylindoles at human 5-HT6 serotonin receptors Fulltext Access 5 Pages 2005
Aminopiperidine indazoles as orally efficacious melanin concentrating hormone receptor-1 antagonists Fulltext Access 5 Pages 2005
Inhibition of Tpl2 kinase and TNF-α production with 1,7-naphthyridine-3-carbonitriles: Synthesis and structure–activity relationships Fulltext Access 5 Pages 2005
2-Cyano-4-fluoro-1-thiovalylpyrrolidine analogues as potent inhibitors of DPP-IV Fulltext Access 5 Pages 2005
Heteroaryl-O-glucosides as novel sodium glucose co-transporter 2 inhibitors. Part 1 Fulltext Access 5 Pages 2005
3-(5-chloro-2,4-dihydroxyphenyl)-Pyrazole-4-carboxamides as inhibitors of the Hsp90 molecular chaperone Fulltext Access 5 Pages 2005
Carbonic anhydrase inhibitors: Inhibition of the human isozymes I, II, VA, and IX with a library of substituted difluoromethanesulfonamides Fulltext Access 5 Pages 2005
N-[2-(Indan-1-yl)-3-mercapto-propionyl] amino acids as highly potent inhibitors of the three vasopeptidases (NEP, ACE, ECE): In vitro and In vivo activities Fulltext Access 5 Pages 2005
Discovery of novel 1-arylmethyl pyrrolidin-2-yl ethanol amines as calcium-sensing receptor antagonists Fulltext Access 5 Pages 2005
Synthesis and evaluation of novel 8,6-fused bicyclic peptidomimetic compounds as interleukin-1β converting enzyme inhibitors Fulltext Access 5 Pages 2005
Synthesis and structure–activity relationships of novel benzene sulfonamides with potent binding affinity for bovine carbonic anhydrase II Fulltext Access 5 Pages 2005
Synthesis, spectral studies and in vitro assessment for antiamoebic activity of new cyclooctadiene ruthenium(II) complexes with 5-nitrothiophene-2-carboxaldehyde thiosemicarbazones Fulltext Access 5 Pages 2005
N-8-Substituted benztropinamine analogs as selective dopamine transporter ligands Fulltext Access 5 Pages 2005
Selection of 5′-untranslated sequences that enhance initiation of translation in a cell-free protein synthesis system from wheat embryos Fulltext Access 5 Pages 2005
Synthesis and in vitro anti-hepatitis B and C virus activities of ring-expanded ('fat') nucleobase analogues containing the imidazo[4,5-e][1,3]diazepine-4,8-dione ring system Fulltext Access 5 Pages 2005
Photoisomerization as a trigger for Bergman cyclization: Synthesis and reactivity of azoenediynes Fulltext Access 5 Pages 2005
Factors affecting the protease activity of venom from jellyfish Rhopilema esculentum Kishinouye Fulltext Access 5 Pages 2005
Screening of electrophilic compounds yields an aziridinyl peptide as new active-site directed SARS-CoV main protease inhibitor Fulltext Access 5 Pages 2005
Virtual screening to identify lead inhibitors for bacterial NAD synthetase (NADs) Fulltext Access 5 Pages 2005
Synthesis and biological evaluation of methoxylated analogs of the newer generation taxoids IDN5109 and IDN5390 Fulltext Access 5 Pages 2005
Structure–activity relationships within a series of caspase inhibitors. Part 2: Heterocyclic warheads Fulltext Access 5 Pages 2005
Hydantoin derivative formation from oxidation of 7,8-dihydro-8-oxo-2′-deoxyguanosine (8-oxodG) and incorporation of 14C-labeled 8-oxodG into the DNA of human breast cancer cells Fulltext Access 5 Pages 2005
Identification of 4-methyl-1,2,3,4,10,10a-hexahydropyrazino[1,2-a]indoles as 5-HT2C receptor agonists Fulltext Access 5 Pages 2005
Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: Discovery of potent S1P1 receptor agonists Fulltext Access 5 Pages 2005
Synthesis and antiviral activities of novel N-alkoxy-arylsulfonamide-based HIV protease inhibitors Fulltext Access 5 Pages 2005
Discovery of a novel and potent series of dianilinopyrimidineurea and urea isostere inhibitors of VEGFR2 tyrosine kinase Fulltext Access 5 Pages 2005
Synthesis and SAR of 2-carboxylic acid indoles as inhibitors of plasminogen activator inhibitor-1 Fulltext Access 5 Pages 2005
Discovery and activity of (1R,4S,6R)-N-[(1R)-2-[4-cyclohexyl-4-[[(1,1-dimethylethyl)amino]carbonyl]-1-piperidinyl]-1-[(4-fluorophenyl)methyl]-2-oxoethyl]-2-methyl-2-azabicyclo[2.2.2]octane-6-carboxamide (3, RY764), a potent and selective melanocortin subt Fulltext Access 5 Pages 2005
Novel P1 chain-extended HIV protease inhibitors possessing potent anti-HIV activity and remarkable inverse antiviral resistance profiles Fulltext Access 5 Pages 2005