Discovery of a tetrahydroisoquinoline-based HDAC inhibitor with improved plasma stability
Keywords: اپی ژنتیک; Pharmacokinetics; Epigenetics; Antitumor; Plasma stability;
مقالات ISI اپی ژنتیک (ترجمه نشده)
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Research paperEffect of BIX-01294 on proliferation, apoptosis and histone methylation of acute T lymphoblastic leukemia cells
Keywords: اپی ژنتیک; G9a; BIX-01294; Histone acetylation; Histone methylation; Epigenetics; Acute T lymphocytic leukemia;
Regulation of BAZ1A and nucleosome positioning in the nucleus accumbens in response to cocaine
Keywords: اپی ژنتیک; BDNF; brain-derived neurotrophic factors; ChIP; chromatin immunoprecipitation; CPP; conditioned place preference; NAc; nucleus accumbens; PMI; postmortem intervals; cocaine; addiction; epigenetics; chromatin; chromatin remodeling;
Technical noteUse of human methylation arrays for epigenome research in the common marmoset (Callithrix jacchus)
Keywords: اپی ژنتیک; NGS; next generation sequencing; WGBS; whole-genome bisulfite sequencing; MeDIP-Seq; methylated DNA immunoprecipitation sequencing; Epigenetics; DNA methylation; Cytosine modification; Beadarray; Nonhuman primate;
Genes, epigenetics and miRNA regulation in the placenta
Keywords: اپی ژنتیک; Placenta; Epigenetics; Preeclampsia; Micro-RNA; DNA methylation;
Epigenetics: The third pillar of nitric oxide signaling
Keywords: اپی ژنتیک; Nitric oxide; Epigenetics; Histones; Posttranslational modifications; Methylation; Cancer;
CirugÃa Cardiovascular del adulto - Revisión de temasPerspectivas moleculares en cardiopatÃa hipertrófica: abordaje epigenético desde la modificación de la cromatinaMolecular perspectives in hypertrophic cardiomyopathy: epigenetic approach from chro
Keywords: اپی ژنتیک; Hipertrofia cardiaca; Epigenética; Demetilación de histonas; Hypertrophic cardiomyopathy; Epigenetics; Histone methylation;
Epigenetics of human diseases and scope in future therapeutics
Keywords: اپی ژنتیک; Alzheimer's disease; Cancer; Diabetes; Epigenetics; Imprinting disorders;
A phase II study of panobinostat in patients with primary myelofibrosis (PMF) and post-polycythemia vera/essential thrombocythemia myelofibrosis (post-PV/ET MF)
Keywords: اپی ژنتیک; Myelofibrosis; Histone deacetylase inhibitor; Panobinostat; Epigenetics; Phase II;
Research paperEpigenetic drug combination induces remission in mouse xenograft models of pediatric acute myeloid leukemia
Keywords: اپی ژنتیک; Acute myeloid leukemia; Azacitidine; Panobinostat; Epigenetics; Xenograft; Pediatric;
Mini-reviewReview: Regulation of the cancer epigenome by long non-coding RNAs
Keywords: اپی ژنتیک; Cancer; Long non-coding RNAs; Epigenetics; DNA Methylation; Histone modifications; Metabolism;
Research articleQuantification of various APP-mRNA isoforms and epistasis in Lesch-Nyhan disease
Keywords: اپی ژنتیک; Kinetic method; Amyloid precursor protein; Lesch-Nyhan disease; Epigenetics; Epistasis; Neurodevelopmental and neurodegenerative disorders;
Long-term effects of maternal separation coupled with social isolation on reward seeking and changes in dopamine D1 receptor expression in the nucleus accumbens via DNA methylation in mice
Keywords: اپی ژنتیک; CpG; cytosine-phospho-guanine dinucleotide; CPP; conditioned place preference; DNMT; DNA methyltransferase; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; MS; maternal separation; MSÂ +Â SI; maternal separation coupled with social isolation; NAc; nucleu
The Feulgen reaction: A brief review and new perspectives
Keywords: اپی ژنتیک; Feulgen reaction; DNA; Cytochemistry; Image analysis; Epigenetics;
Oxidized C5-methyl cytosine bases in DNA: 5-Hydroxymethylcytosine; 5-formylcytosine; and 5-carboxycytosine
Keywords: اپی ژنتیک; 5-hydroxymethylcytosine; 5-methylcytosine; 5-formylcytosine; 5-carboxycytosine; DNA demethylation; Epigenetics;
Virtual screen to NMR (VS2NMR): Discovery of fragment hits for the CBP bromodomain
Keywords: اپی ژنتیک; Alpha; amplified luminescent proximity homogeneous assay; ATAD2; ATAD2 ATPase family, AAA domain containing 2; BAZ2A; bromodomain adjacent to zinc finger domain protein 2A; BAZ2B; bromodomain adjacent to zinc finger domain protein 2B; BRPF1; bromodomain a
BET-bromodomain inhibitors modulate epigenetic patterns at the diacylglycerol kinase alpha enhancer associated with radiation-induced fibrosis
Keywords: اپی ژنتیک; Epigenetics; Radiation-induced fibrosis; Bromodomain inhibitor JQ1; DGKA; Enhancer;
Cocaine alters Homer1 natural antisense transcript in the nucleus accumbens
Keywords: اپی ژنتیک; Long noncoding RNA; Natural antisense transcripts; Cocaine; Nucleus accumbens; Epigenetics;
Ancestral benzo[a]pyrene exposure affects bone integrity in F3 adult fish (Oryzias latipes)
Keywords: اپی ژنتیک; AcvR1b; activating receptor type 1b; ALP; alkaline phosphatase; APC; adenomatous polyposis coli; ATF4; activating transcription factor 4; BaP; benzo[a]pyrene; BMD; bone mineral density; BMP2; bone morphogenetic protein 2; Col2a1b; collagen 2a1b; Col10; co
Epigenetics in chemical-induced genotoxic carcinogenesis
Keywords: اپی ژنتیک; Epigenetics; Epigenomics; Genotoxicity; Cancer; microRNAs; DNA methylation; Histone modifications; DNA damage;
Development and crystallographic evaluation of histone H3 peptide with N-terminal serine substitution as a potent inhibitor of lysine-specific demethylase 1
Keywords: اپی ژنتیک; Crystal structure; Enzyme inhibitors; Epigenetics; Peptides; Protein structure;
DNA methylation analysis of cancer-related genes from cell-free DNA of patients with cancer
Keywords: اپی ژنتیک; DNA methylation; Tumor suppressor genes; Oncogenes; Epigenetics; Cell-free DNA;
DNA methylation contributes to deregulation of 12 cancer-associated microRNAs and breast cancer progression
Keywords: اپی ژنتیک; miRNA; microRNA; mRNA; messenger RNA; cDNA; coding DNA; BC; breast cancer; NSCLC; non-small cell lung cancer; ld; low-differentiated; md; moderate-differentiated; hd; high-differentiated; qPCR; quantitative PCR; MSP; methylation-specific PCR; rs; Spearman
Differential DNA Methylation in Monozygotic Twins Discordant for Female Sexual Functioning
Keywords: اپی ژنتیک; Epigenetics; Female Sexual Functioning; Female Sexual Dysfunction; FSD; Twins; Methylation; Epidemiology; Risk Factors;
Biofluids, cell mechanics and epigenetics: Flow-induced epigenetic mechanisms of endothelial gene expression
Keywords: اپی ژنتیک; Hemodynamics; Epigenetics; Endothelial phenotype; Gene transcription; Disturbed blood flow; Mechanotransduction;
Searching for new biomarkers in ovarian cancer patients: Rationale and design of a retrospective study under the Mermaid III project
Keywords: اپی ژنتیک; Ovarian cancer; Diagnostic/prognostic biomarkers; MicroRNA; Epigenetics; Next Generation Sequencing; OC; Ovarian cancer; FIGO; International Federation of Gynecology and Obstetrics; CA125; Cancer Antigen 125; RMI; Risk of Malignancy Index; DGCD; Danish Gy
Evaluating the methylation status of CXCR4 promoter: A cost-effective and sensitive two-step PCR method
Keywords: اپی ژنتیک; CXCR4; Promoter; Epigenetics; DNA methylation; qPCR; SYBR green;
Differential peripheral blood methylation by α-lipoic acid and EPA supplementation in overweight or obese women during a weight loss program
Keywords: اپی ژنتیک; ANOVA; analysis of variance; BMI; body mass index; CREBBP; CREB binding protein; DHA; docosahexaenoic acid; EPA; eicosapentaenoic acid; FDR; false discovery rate; FFA; free fatty acids; HAT; histone acyltransferases; FITM2; fat storage inducing transmembr
From a novel HTS hit to potent, selective, and orally bioavailable KDM5 inhibitors
Keywords: اپی ژنتیک; KDM5; KDM5 inhibitors; Epigenetics; Structure-based drug discovery; Overcome cancer resistance;
MicroRNA-149 is associated with clinical outcome in human neuroblastoma and modulates cancer cell proliferation through Rap1 independent of MYCN amplification
Keywords: اپی ژنتیک; Neuroblastoma; miR-149; Overall survival; Rap1; Proliferation; Epigenetics;
Chronic MeHg exposure modifies the histone H3K4me3 epigenetic landscape in Caenorhabditis elegans
Keywords: اپی ژنتیک; Chromatin immunoprecipitation sequencing (ChIP-seq); RNA sequencing (RNA-seq); Heavy metal; Epigenetics; Mercury;
Research ArticleTomato (Lycopersicon esculentum) or lycopene supplementation attenuates ventricular remodeling after myocardial infarction through different mechanistic pathways
Keywords: اپی ژنتیک; Myocardial infarction; Remodeling; microRNA; Epigenetics; Nutrition;
Effect of drought stress on male fertility restoration in A3 CMS-inducing cytoplasm of sorghum
Keywords: اپی ژنتیک; Sorghum bicolor (L.) Moench; Cytoplasmic male sterility; A3 cytoplasm; Fertility-restoring genes; Epigenetics; Vapor pressure deficit;
Regulation of stem cell aging by SIRT1 - Linking metabolic signaling to epigenetic modifications
Keywords: اپی ژنتیک; Sirtuin; SIRT1; Aging; Stem cells; Metabolism; Epigenetics;
Regulation of drug metabolism and toxicity by multiple factors of genetics, epigenetics, lncRNAs, gut microbiota, and diseases: a meeting report of the 21st International Symposium on Microsomes and Drug Oxidations (MDO)
Keywords: اپی ژنتیک; Drug metabolism and toxicity; Genetics; Epigenetics; Gut microbiota; Long non-coding RNAs; Disease; Personalized medication;
Sirtuins, epigenetics and longevity
Keywords: اپی ژنتیک; Sirtuins; Epigenetics; Longevity; Aging; DNA;
Progress in identifying epigenetic mechanisms of xenobiotic-induced non-genotoxic carcinogenesis
Keywords: اپی ژنتیک; Non-genotoxic carcinogenesis; Cancer risk assessment; Epigenetics; Genetics; Epigenome;
PRC2 during vertebrate organogenesis: A complex in transition
Keywords: اپی ژنتیک; Polycomb; Cell fate; Histone methyltransferase; Differentiation; PRC2; Epigenetics;
The roles of class I histone deacetylases (HDACs) in memory, learning, and executive cognitive functions: A review
Keywords: اپی ژنتیک; Epigenetics; Cognition; Histones; HDACs; Learning; Memory; Attention; Working memory; Animal models;
Paternal preconception alcohol exposure imparts intergenerational alcohol-related behaviors to male offspring on a pure C57BL/6J background
Keywords: اپی ژنتیک; Epigenetics; Chronic intermittent vapor ethanol; Alcohol drinking; Alcohol sensitivity; BDNF; Stress;
World Trade Center (WTC) dust exposure in mice is associated with inflammation, oxidative stress and epigenetic changes in the lung
Keywords: اپی ژنتیک; WTC; World Trade Center; i.t.; intratracheal; i.p.; intraperitoneal; HO-1; heme oxygenase-1; COX-2; cyclooxygenase-2; MMP-12; matrix metalloproteinase-12; BAL; bronchoalveolar lavage; PEEP; positive end expiratory pressure; COPD; chronic obstructive pulmo
CPT1A methylation is associated with plasma adiponectin
Keywords: اپی ژنتیک; Epigenetics; Methylation; Adiponectin; Epidemiology;
Beyond the survival and death of the deltamethrin-threatened pollen beetle Meligethes aeneus: An in-depth proteomic study employing a transcriptome database
Keywords: اپی ژنتیک; Pesticide resistance; Cytochrome b5; Anoxia up-regulated protein; Ribosomal proteins; Pathogenesis-related protein 5; Epigenetics;
Effects of high progesterone level on the day of human chorionic gonadotrophin administration in in vitro fertilization cycles on epigenetic modification of endometrium in the peri-implantation period
Keywords: اپی ژنتیک; Endometrium; progesterone; epigenetics;
Epigenome-wide analysis links SMAD3 methylation at birth to asthma in children of asthmatic mothers
Keywords: اپی ژنتیک; Epigenetics; DNA methylation; childhood asthma; SMAD3; CBMC; Cord blood mononuclear cell; COAST; Childhood Origins of Asthma; DMR; Differentially methylated region; GWAS; Genome-wide association study; IIS; Infant Immune Study; MAAS; Manchester Asthma and
Methylation of the circadian Clock gene in the offspring of a free-living passerine bird increases with maternal and individual exposure to PM10
Keywords: اپی ژنتیک; Air pollution; Barn swallow; DNA methylation; Epigenetics; Clock gene;
Selective inhibition of BET proteins reduces pancreatic damage and systemic inflammation in bile acid- and fatty acid ethyl ester- but not caerulein-induced acute pancreatitis
Keywords: اپی ژنتیک; Acute pancreatitis; Epigenetics; BET inhibition; Drug discovery; AP; acute pancreatitis; AUC; area under the curve; BET proteins; bromodomain and extra-terminal proteins; CCL2; chemokine (C-C motif) ligand 2; CER-AP; caerulein-induced AP; Cmax; peak serum
Induction and maintenance of regulatory T cells by transcription factors and epigenetic modifications
Keywords: اپی ژنتیک; Foxp3; Transcription factors; Regulatory T cell; Nr4a; TGF-β; Smad; DNA methylation; Epigenetics;
Essential roles of G9a in cell proliferation and differentiation during tooth development
Keywords: اپی ژنتیک; Tooth development; Epigenetics; Differentiation;
Deficient expression of JMJD1A histone demethylase in patients with round spermatid maturation arrest
Keywords: اپی ژنتیک; epigenetics; JMJD1A histone demethylase; PRM; spermatogenesis; TNP;