دانلود مقالات ISI درباره راپامایسین + ترجمه فارسی

Neuroprotective effect of paeoniflorin on okadaic acid-induced tau hyperphosphorylation via calpain/Akt/GSK-3β pathway in SH-SY5Y cells

Keywords: راپامایسین; PF; paeoniflorin; OA; okadaic acid; 3-MA; 3-methyladenine; Rapa; rapamycin; LiCl; lithium chloride; AD; Alzhiemer's disease; CAST; Ac-calpastain; CQ; chloroquine; NFTs; neurofibrillary tangles; CaMKII; calcium/calmodulin protein kinase II; MAP2; microtu

دانلود رایگان متن کامل مقاله ISI 33 صفحه سال انتشار : 2018 سفارش ترجمه

Cardiac natriuretic peptides promote adipose 'browning' through mTOR complex-1

Keywords: راپامایسین; Thermogenesis; UCP1; Kinases; βAR; β-adrenergic receptor; 8-Br-cAMP; 8-Bromoadenosine 3′,5′-cyclic monophosphate; 8-Br-cGMP; 8-Bromoguanosine 3′,5′-cyclic monophosphate; Akt; protein kinase B; ANP; Atrial natriuretic peptide; BNP; B-type natriur

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2018 سفارش ترجمه

Long-term follow-up of IPEX syndrome patients after different therapeutic strategies: An international multicenter retrospective study

Keywords: راپامایسین; IPEX; primary immune deficiency; FOXP3; Treg cells; hematopoietic stem cell transplantation; immunosuppression; rapamycin; enteropathy; neonatal diabetes; genetic autoimmunity; DFS; Disease-free survival; FKH; Forkhead domain; GvHD; Graft-versus-host dise

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

Monitoring autophagic flux using p62/SQSTM1 based luciferase reporters in glioma cells

Keywords: راپامایسین; 3-MA; 3-methyladenine; CQ; Chloroquine; Rapa; Rapamycin; EBSS; Dulbecco's Phosphate-Buffered Saline; ATG5; Autophagy-related 5; MAP1LC3/LC3; Microtubule-associated protein 1 light chain 3; mTOR; Mammalian (or mechanistic) Target of Rapamycin; SQSTM1; sequ

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

Rapamycin attenuates Th2-driven experimental allergic conjunctivitis

Keywords: راپامایسین; Allergic conjunctivitis; Dendritic cells; Eosinophil; Rapamycin; Th2 type immune response;

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2018 سفارش ترجمه

Astragaloside exerts anti-photoaging effects in UVB-induced premature senescence of rat dermal fibroblasts through enhanced autophagy

Keywords: راپامایسین; Astragaloside; Autophagy; Collagen; MAPK; Photoaging; AM; Astragalus Membranaceus; APS; astragalus polysaccharides; ASF; astragalus flavonoids; ASI; astragaloside IV; AST; astragaloside; Col1; collagen-I; CQ; chloroquine; 3-MA; 3-methyladenine; MAPK; mito

دانلود رایگان متن کامل مقاله ISI 36 صفحه سال انتشار : 2018 سفارش ترجمه

E-selectin targeted immunoliposomes for rapamycin delivery to activated endothelial cells

Keywords: راپامایسین; Immunoliposomes; Rapamycin; Targeted delivery; Endothelial cells;

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

Acrolein induces NLRP3 inflammasome-mediated pyroptosis and suppresses migration via ROS-dependent autophagy in vascular endothelial cells

Keywords: راپامایسین; AS; atherosclerosis; CVD; cardiovascular diseases; ROS; reactive oxygen species; HUVECs; human umbilical vein endothelial cells; LPS; lipopolysaccharide; MTT; 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyltetrazo- lium bromide; DMSO; dimethyl sulfoxide; NAC;

دانلود رایگان متن کامل مقاله ISI 45 صفحه سال انتشار : 2018 سفارش ترجمه

ERK1/2/mTOR/Stat3 pathway-mediated autophagy alleviates traumatic brain injury-induced acute lung injury

Keywords: راپامایسین; ERK1/2; extracellular signal-regulated kinase 1/2; mTOR; mechanistic target of rapamycin; Stat3; signal transducer and activator of transcription 3; TBI; traumatic brain injury; ALI; acute lung injury; HMGB1; high-mobility group box protein 1; 3-MA; 3‑m

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2018 سفارش ترجمه

Rapamycin mediates mTOR signaling in reactive astrocytes and reduces retinal ganglion cell loss

Keywords: راپامایسین; Astrocyte activation; Retinal ganglion cell; Rapamycin; mTOR pathway; Neuroprotective strategies; Retina injury;

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2018 سفارش ترجمه

The novel, catalytic mTORC1/2 inhibitor PQR620 and the PI3K/mTORC1/2 inhibitor PQR530 effectively cross the blood-brain barrier and increase seizure threshold in a mouse model of chronic epilepsy

Keywords: راپامایسین; Epilepsy; Rapamycin; Everolimus; Pharmacokinetics; Tolerability; Levetiracetam; AKT; protein kinase B; ASD; anti-seizure drug; 4E-BP1; initiation factor 4E binding protein; HPβCD; hydroxypropyl-ß-cyclodextrin; MTD; maximal tolerated dose; MES-T; maximal

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2018 سفارش ترجمه

Cellular stress and AMPK activation as a common mechanism of action linking the effects of metformin and diverse compounds that alleviate accelerated aging defects in Hutchinson-Gilford progeria syndrome

Keywords: راپامایسین; AMP-activated protein kinase (AMPK); Hutchinson-Gilford progeria syndrome (HGPS); Oocyte; HIV-1 latency; Rapamycin; Metformin; Retinoic acid; Methylene blue; Sulforaphane; Oltipraz; Vitamin D; MG132; Acrosome; Alternative splicing; ULK1; Autophagy; PGC-1Î

دانلود رایگان متن کامل مقاله ISI 62 صفحه سال انتشار : 2018 سفارش ترجمه

Expression of miRNA-155 in carotid atherosclerotic plaques of apolipoprotein E knockout (ApoE−/−) mice and the interventional effect of rapamycin

Keywords: راپامایسین; Atherosclerosis; Autophagy; Rapamycin; miRNA-155;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Selected life-extending interventions reduce arterial CXCL10 and macrophage colony-stimulating factor in aged mouse arteries

Keywords: راپامایسین; CVD; cardiovascular disease; EDD; endothelium dependent dilation; CL; crowded litter; CR; caloric restriction; Rap; rapamycin; IL; interleukin; VAMC-SLC; Veteran's Affairs Medical Center-Salt Lake City; CCL; CC ligand; CXC; CXC-ligand; GCSF; Granulocyte

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2017 سفارش ترجمه

Efficacy of an autophagy-targeted DNA vaccine against avian leukosis virus subgroup J

Keywords: راپامایسین; DNA vaccine; Avian leucosis virus; Autophagy; Rapamycin;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Kaempferol alleviates ox-LDL-induced apoptosis by up-regulation of autophagy via inhibiting PI3K/Akt/mTOR pathway in human endothelial cells

Keywords: راپامایسین; ox-LDL; oxidized low-density lipoprotein; ECs; endothelial cells; HUVECs; human umbilical vein endothelial cells; FCM; flow cytometry method; RAP; rapamycin; Atherosclerosis; Apoptosis; Autophagy; Kaempferol; PI3K/Akt/mTOR pathway;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2017 سفارش ترجمه

Inhibition of Cyclosporine A or rapamycin on T lymphocyte counts and the influence on the immune responses of B lymphocytes in flounder (Paralichthys olivaceus)

Keywords: راپامایسین; T lymphocytes counts; B lymphocytes counts; Antibodies level; Cyclosporine A; Rapamycin; Paralichthys olivaceus;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Research paperAnti-HER2 immunoliposomes for co-delivery of paclitaxel and rapamycin for breast cancer therapy

Keywords: راپامایسین; Paclitaxel; Rapamycin; Trastuzumab; Immunoliposome; Targeting; Breast cancer;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Sirtuin 1 independent effects of resveratrol in INS-1E β-cells

Keywords: راپامایسین; Sirt1; Resveratrol; mTOR; Rapamycin; Cell size; Hypertrophy;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Lhermitte-Duclos Disease (Dysplastic Gangliocytoma of the Cerebellum) and Cowden Syndrome: Clinical Experience From a Single Institution with Long-Term Follow-Up

Keywords: راپامایسین; Cowden syndrome; Dysplastic gangliocytoma of the cerebellum; Lhermitte-Duclos disease; PTEN Hamartoma Tumor Syndrome; Rapamycin; CS; Cowden syndrome; CT; Computed tomography; LDD; Lhermitte-Duclos disease; MRI; Magnetic resonance imaging; PHTS; PTEN hamar

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2017 سفارش ترجمه

Dysregulation of autophagy in melanocytes contributes to hypopigmented macules in tuberous sclerosis complex

Keywords: راپامایسین; Autophagy; TSC; mTOR; Rapamycin; Pigmentation;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Rapamycin-induced autophagy restricts porcine epidemic diarrhea virus infectivity in porcine intestinal epithelial cells

Keywords: راپامایسین; Porcine epidemic diarrhea virus; Rapamycin; Antiviral effect; Autophagy; IPEC-J2;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Autophagy contributes to 4-Amino-2-Trifluoromethyl-Phenyl Retinate-induced differentiation in human acute promyelocytic leukemia NB4 cells

Keywords: راپامایسین; AML; acute myeloid leukemia; APL; acute promyelocytic leukemia; ATRA; all-trans retinoic acid; ATPR; 4-Amino-2-Trifluoromethyl-Phenyl Retinate; 3-MA; 3-methyladenine; RAPA; rapamycin; ATO; arsenic trioxide; siRNA; small interfering RNA; MDC; monodansylcad

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Kinetic modelling of in vitro data of PI3K, mTOR1, PTEN enzymes and on-target inhibitors Rapamycin, BEZ235, and LY294002

Keywords: راپامایسین; Kinetic modelling; PI3K; mTOR1; PTEN; Rapamycin; BEZ235;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

OP16, a novel ent-kaurene diterpenoid, potentiates the antitumor effect of rapamycin by inhibiting rapamycin-induced feedback activation of Akt signaling in esophageal squamous cell carcinoma

Keywords: راپامایسین; Akt; protein kinase B; DMSO; dimethyl sulfoxide; ESCC; esophageal squamous cell carcinoma; FBS; fetal bovine serum; IC50; half maximal inhibitory concentration; mTOR; mammalian target of rapamycin; PI3K; phosphatidylinositol 3 kinase; Rapa; rapamycin; Rap

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

ReviewReappraisal to the study of 4E-BP1 as an mTOR substrate - A normative critique

Keywords: راپامایسین; mTOR; 4E-BP; eIF4E; Rapamycin; Post-translational modification;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2017 سفارش ترجمه

Cell cycle and growth stimuli regulate different steps of RNA polymerase I transcription

Keywords: راپامایسین;  + S; With serum;  − S; Without serum; CHX; Cycloheximide; DMEM; Dulbecco's modified Eagle's medium; ECL; Enhanced chemiluminescence; ETS; Externally transcribed spacer; Exp; Exponentially growing cells; FBS; Fetal bovine serum; h; Hour; LY; LY29400

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Differential roles of the infralimbic and prelimbic areas of the prefrontal cortex in reconsolidation of a traumatic memory

Keywords: راپامایسین; Extinction; Inhibitory avoidance; Post-traumatic stress disorder (PTSD); Rapamycin;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

T-cadherin promotes autophagy and survival in vascular smooth muscle cells through MEK1/2/Erk1/2 axis activation

Keywords: راپامایسین; AMPK; 5′ adenosine monophosphate-activated protein kinase; BSA; bovine serum albumin; CQ; chloroquine; EC; endothelial cell; eIF2α; eukaryotic translation initiation factor 2α; ER; endoplasmic reticulum; Erk1/2; extracellular signal-regulated kinase;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2017 سفارش ترجمه

Arsenic sulfide induces apoptosis and autophagy through the activation of ROS/JNK and suppression of Akt/mTOR signaling pathways in osteosarcoma

Keywords: راپامایسین; OS; osteosarcoma; ROS; reactive oxygen species; 3-MA; 3-methyladenine; RA; rapamycin; NAC; NAcetyl-L-cysteine; CCK8; Cell Counting Kit-8; PARP; poly (ADPribose) polymerase; MMP; mitochondrial membrane potential; MAPK; mitogen-activated protein kinase; ERK

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

The involvement of cannabinoids and mTOR in the reconsolidation of an emotional memory in the hippocampal-amygdala-insular circuit

Keywords: راپامایسین; Reconsolidation; Extinction; Cannabinoids; Rapamycin; Fear memory; mTOR;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Original ArticleRole of nutrients and mTOR signaling in the regulation of pancreatic progenitors development

Keywords: راپامایسین; Nutrients; mTOR; Rapamycin; Pancreas; Development; Islets; β-cells; T2D; type 2 diabetes; mTOR; mammalian target of Rapamycin; TORC1, TORC2; target of Rapamycin complex 1, 2; AA; amino acids;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Elimination of cancer stem cells and reactivation of latent HIV-1 via AMPK activation: Common mechanism of action linking inhibition of tumorigenesis and the potential eradication of HIV-1

Keywords: راپامایسین; AMP-activated protein kinase (AMPK); HIV-1 latency; Cancer stem cell; Tumor initiating cell; LKB1; CaMKK2; Bryostatin-1; Resveratrol; Metformin; Retinoic acid; Methylene blue; JQ1; Sulforaphane; Rapamycin; Oocyte; Hutchinson-Gilford progeria syndrome (HGP

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Rapamycin additively extends lifespan in short- and long-lived lines of the nematode Caenorhabditis remanei

Keywords: راپامایسین; Experimental evolution; Lifespan; Rapamycin; TOR;

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2017 سفارش ترجمه

Rapamycin protects against paraquat-induced pulmonary fibrosis: Activation of Nrf2 signaling pathway

Keywords: راپامایسین; Rapamycin; Paraquat; Epithelial mesenchymal transition; Nrf2; Pulmonary fibrosis;

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2017 سفارش ترجمه

Modulating angiogenesis with integrin-targeted nanomedicines

Keywords: راپامایسین; (RGD)m; RGD mimetics; 4-NQO; 4-nitroquinoline 1-oxide; AAA; Abdominal Aortic Aneurysms; ADA; 8-Amino-3,6-Dioxaoctonoic Acid; AH-GDM; Aminohexyl-Geldanamycin; ami; Amide; AP-2α; Activating Protein 2α; ARMS; Alveolar Rhabdomyosarcoma; ATO; Arsenic Trioxid

دانلود رایگان متن کامل مقاله ISI 19 صفحه سال انتشار : 2017 سفارش ترجمه

Triggering autophagic cell death with a di-manganese(II) developmental therapeutic

Keywords: راپامایسین; γH2AX; phosphorylated H2AX histone; caspase; cysteine-dependent asparate-specific proteases CAT, catalase; CCCP; carbonyl cyanide m-chlorophenyl hydrazine; Dox; doxorubicin; DSB; double strand breaks; LC-3; microtubule associated protein 1 light weight c

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

Regulation of skeletal muscle insulin-stimulated signaling through the MEK-REDD1-mTOR axis

Keywords: راپامایسین; Insulin signaling; REDD1; PD184352; Rapamycin; Skeletal muscle;

دانلود رایگان متن کامل مقاله ISI 27 صفحه سال انتشار : 2017 سفارش ترجمه

The role of the TOR pathway in mediating the link between nutrition and longevity

Keywords: راپامایسین; TOR; target of rapamycin; TSC; tuberous sclerosis complex; Rheb; Ras homologue enriched in brain; 4EBP; 4E binding protein; S6K; S6 kinase; PI3K; phosphatidylinositol-3-kinase; Raptor; regulatory-associated protein of mTOR; Deptor; DEP domain-containing m

دانلود رایگان متن کامل مقاله ISI 35 صفحه سال انتشار : 2017 سفارش ترجمه

A progressive reduction in autophagic capacity contributes to induction of replicative senescence in Hs68 cells

Keywords: راپامایسین; Autophagy; Replicative senescence; Aging; Hs68; Rapamycin;

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

Both cytopathic and non-cytopathic bovine viral diarrhea virus (BVDV) induced autophagy at a similar rate

Keywords: راپامایسین; Autophagy; Cytopathic bovine viral diarrhea virus; Non-cytopathic bovine viral 35 diarrhea virus; Rapamycin; 3-Methyladenine;

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2017 سفارش ترجمه

Molecular neurobiology of mTOR

Keywords: راپامایسین; 4E-BPs; 4E-binding proteins; Atg13; autophagy-related protein 13; BDNF; brain-derived neurotrophic factor; CGG; trinucleotide; EGF; epidermal growth factor; FXS; Fragile X syndrome; Hif1α; hypoxia-inducible factor 1-α; LTD; long-term depression; LTP; lo

دانلود رایگان متن کامل مقاله ISI 42 صفحه سال انتشار : 2017 سفارش ترجمه

Formulation and characterization of a 0.1% rapamycin cream for the treatment of Tuberous Sclerosis Complex-related angiofibromas

Keywords: راپامایسین; Rapamycin; Sirolimus; Tuberous Sclerosis; m-Tor inhibitor; Topic formulation; Stability study

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Data of intracellular insulin protein reduced by autophagy in INS-1E cells

Keywords: راپامایسین; Insulin; Autophagy; 2-Deoxy-D-glucose; Rapamycin; INS-1E Insulinoma cells;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Rapamycin increases RSV RNA levels and survival of RSV-infected dendritic cell depending on T cell contact

Keywords: راپامایسین; RSV; respiratory syncytial virus; BMDC; bone marrow derived dendritic cells; DC; dendritic cells; mTOR; mechanist target of rapamycin; Respiratory syncytial virus; Rapamycin; Dendritic cells; CD8 T cells;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Rapamycin regulates the proliferation of Huh7, a hepatocellular carcinoma cell line, by up-regulating p53 expression

Keywords: راپامایسین; Rapamycin; mTOR; p53; Hepatocellular carcinoma cells; ERK signal;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Autophagy in osteoarthritis

Keywords: راپامایسین; Autophagy; Chondrocyte; Osteoarthritis; Rapamycin

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Inhibition of the Let-7 Family MicroRNAs Induces Cardioprotection Against Ischemia-Reperfusion Injury in Diabetic Rats

Keywords: راپامایسین; AAR; area at risk; antimiR; antimicroRNA; C; control; DR; diabetic rat; GLUT4; glucose transporter type 4; IGF-1R; insulinlike growth factor-1 receptor; InsR; insulin receptor; IS; infarct size; L; lentivirus vectors with let-7 antimiR; LY; LY294002; miRN

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Rapamycin-induced oligomer formation system of FRB–FKBP fusion proteins

Keywords: راپامایسین; FRB; FKBP; Rapamycin; Oligomer; Chemically-induced oligomerization; Protein engineering

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

The dynamics of histone H2A ubiquitination in HeLa cells exposed to rapamycin, ethanol, hydroxyurea, ER stress, heat shock and DNA damage

Keywords: راپامایسین; DNA damage; ER stress; Heat shock; Histone H2A; Stress response; Ubiquitin; ER; endoplasmic reticulum; hH2A; histone H2A; HU; hydroxyurea; MMS; methyl methanesulfonate; Tg; thapsigargin; Tm; tunicamycin; Rap; rapamycin; Ub; ubiquitin;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه