دانلود مقالات ISI درباره راپامایسین + ترجمه فارسی

Inhibition of mTOR improves the impairment of acidification in autophagic vesicles caused by hepatic steatosis

Keywords: راپامایسین; Autophagy; Lysosome; Vacuolar-ATPase; Rapamycin; Analysis of variance; ANOVA; mammalian target of rapamycin; mTOR; nonalcoholic fatty liver disease; NAFLD; nonalcoholic steatohepatitis; NASH; endoplasmic reticulum; ER; green fluorescent protein; GFP; micr

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Rapamycin reduces motivated responding for cocaine and alters GluA1 expression in the ventral but not dorsal striatum

Keywords: راپامایسین; Cocaine; Striatum; mTOR; Nucleus accumbens; Rapamycin; Progressive ratio

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Rapamycin/GABA combination treatment ameliorates diabetes in NOD mice

Keywords: راپامایسین; Rapamycin; GABA; Autoimmune diabetes;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

mTOR, metabolism, and the immune response in HPV-positive head and neck squamous cell cancer

Keywords: راپامایسین; Head and neck oropharyngeal carcinoma; Human papillomavirus; Metabolism; mTOR; Rapamycin

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Huaier aqueous extract sensitizes cells to rapamycin and cisplatin through activating mTOR signaling

Keywords: راپامایسین; Huaier; Rapamycin; Cisplatin; mTOR; Cancer

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Are invertebrates relevant models in ageing research? Focus on the effects of rapamycin on TOR

Keywords: راپامایسین; AMPK; AMP-activated protein kinase; IGF; insulin-like growth factor; PI3K; phosphoinositide 3-kinase; RHEB; RAS homolog enriched in brain; TOR; target of rapamycin; TORC; TOR complex; TSC1/2; tuberous sclerosis 1 and 2; Invertebrate; TOR; Longevity; Rapam

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

Tolerogenic nanoparticles to induce immunologic tolerance: Prevention and reversal of FVIII inhibitor formation

Keywords: راپامایسین; FVIII protein; Human; Hemophilia A; Immune tolerance; PLGA; Rapamycin; Nanoparticles;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2016 سفارش ترجمه

mTOR inhibition attenuates glucose deprivation-induced death in photoreceptors via suppressing a mitochondria-dependent apoptotic pathway

Keywords: راپامایسین; mTOR; Mitochondrial membrane potential; Rapamycin; Photoreceptor cells; Oxidative stress; DRP1

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Histone deacetylase inhibitors reduce WB-F344 oval cell viability and migration capability by suppressing AKT/mTOR signaling in vitro

Keywords: راپامایسین; Oval cells; AKT/mTOR signaling pathway; Histone deacetylase inhibitor; Rapamycin; Cell proliferation; ApoptosisHDAC, Histone deacetylase; SAHA, suberoylanilidehydroxamic acid; TSA, trichostatin-A; HCC, hepatocellular carcinoma; AKT, Protein Kinase B; mTOR

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه

Multidrug PLA-PEG filomicelles for concurrent delivery of anticancer drugs—The influence of drug-drug and drug-polymer interactions on drug loading and release properties

Keywords: راپامایسین; Combination therapy; Multidrug micelles; PLA-PEG; Paclitaxel; 17-AAG; Rapamycin

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Depdc5 knockout rat: A novel model of mTORopathy

Keywords: راپامایسین; DEPDC5; Familial focal epilepsy; Focal cortical dysplasia; mTOR; Rapamycin; Knockout;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2016 سفارش ترجمه

Improvement of mTORC1-driven overproduction of apoB-containing triacylglyceride-rich lipoproteins by short-chain fatty acids, 4-phenylbutyric acid and (R)-α-lipoic acid, in human hepatocellular carcinoma cells

Keywords: راپامایسین; ACC; acetyl-CoA carboxylase; Akt; protein kinase B; AMPK; AMP-activated protein kinase; apoB; apolipoprotein B; apoE; apolipoprotein E; CPT1α; carnitine palmitoyltransferase 1α; DGAT1; diacylglycerol O-acyltransferase 1; DGAT2; diacylglycerol O-acyltran

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Autophagy activation attenuates angiotensin II-induced cardiac fibrosis

Keywords: راپامایسین; Autophagy; Angiotensin II; Cardiac fibrosis; Rapamycin; ChloroquineAng II, angiotensin II; ECM, extracellular matrix; CFs, cardiac fibroblasts; Rapa, rapamycin; CQ, chloroquine; Col-I, type I collagen; FN, fibronectin; LAMP1, lysosomal associated membrane

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Lymphangioleiomyomatosis: Current understanding and potential treatments

Keywords: راپامایسین; Tuberous sclerosis; Rapamycin; Simvastatin; Hydroxychloroquine; Tyrosine kinase inhibitors; LymphangiogenesisAtg13, autophagy related protein 13; AML, angiomyolipoma; COX, cyclooxygenase; Deptor, DEP domain-containing mTOR interacting protein; DLCO, diffu

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Functional regulation of PI3K-associated signaling in the accumbens by binge alcohol drinking in male but not female mice

Keywords: راپامایسین; Group 1 metabotropic glutamate receptor; Homer2; Rapamycin; SHAC procedure; Sex differences; Nucleus accumbens;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2016 سفارش ترجمه

Synergistic antitumor activity of rapamycin and EF24 via increasing ROS for the treatment of gastric cancer

Keywords: راپامایسین; 4E-BP-1; eukaryotic initiation factor 4E binding protein-1; ATF4; activating transcription factor 4; Bcl2; B-cell lymphoma 2; C/EBP; CAAT/enhancer binding protein; cdc-2; cyclin-dependent kinase 1 (cell division cycle protein 2); CHOP; CAAT/enhancer bindi

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

CNS remyelination as a novel reparative approach to neurodegenerative diseases: The roles of purinergic signaling and the P2Y-like receptor GPR17

Keywords: راپامایسین; Purinergic receptors; Oligodendrocytes; Remyelination; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ATX; autotaxin; CNS; central nervous system; DRG; dorsal root ganglion; EAE; experimental autoimmune encephalomyelitis; GDNF; glial cell de

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Rapamycin/DiR loaded lipid-polyaniline nanoparticles for dual-modal imaging guided enhanced photothermal and antiangiogenic combination therapy

Keywords: راپامایسین; Rapamycin; Lipid-polyaniline nanoparticles; Enhanced photothermal therapy; Antiangiogenesis; Imaging-guided therapy;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

mTORC1 alters the expression of glycolytic genes by regulating KPNA2 abundances

Keywords: راپامایسین; mTORC1; Rapamycin; Proteomics; KPNA2; HIF1α; Glycolysis;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Mammalian target of rapamycin controls glucose consumption and redox balance in human Sertoli cells

Keywords: راپامایسین; mTOR; Sertoli cells; spermatogenesis; testis; rapamycin;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Astemizole-Histamine induces Beclin-1-independent autophagy by targeting p53-dependent crosstalk between autophagy and apoptosis

Keywords: راپامایسین; AST; Astemizole; HIS; Histamine; H1R; Histamine H1 receptor; ROS; Reactive oxygen species; ER; Endoplasmic reticulum; PERK; Protein kinase R-like endoplasmic reticulum kinase; IRE1α; Inositol-requiring enzyme 1; ATF; Activating transcription factor; JNK;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Modulation of mTOR Signalling Triggers the Formation of Stem Cell-like Memory T Cells

Keywords: راپامایسین; Human T cells; T cell differentiation; Adoptive cell transfer therapy; Rapamycin

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Stress granules at the intersection of autophagy and ALS

Keywords: راپامایسین; Amyotrophic lateral sclerosis; Autophagy; Motor neuron diseases; Neurodegeneration; Neuromuscular diseases; P-bodies; Protein degradation pathways; Rapamycin; Stress granules

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

CWF-145, a novel synthetic quinolone derivative exerts potent antimitotic activity against human prostate cancer: Rapamycin enhances antimitotic drug-induced apoptosis through the inhibition of Akt/mTOR pathway

Keywords: راپامایسین; CWF-145; Prostate cancer; G2/M arrest; Akt/mTOR; Rapamycin;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2016 سفارش ترجمه

Cell ManufactureA robust, good manufacturing practice-compliant, clinical-scale procedure to generate regulatory T cells from patients with amyotrophic lateral sclerosis for adoptive cell therapy

Keywords: راپامایسین; amyotrophic lateral sclerosis; good manufacturing practice; rapamycin; regulatory T cells;

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Momordin Ic couples apoptosis with autophagy in human hepatoblastoma cancer cells by reactive oxygen species (ROS)-mediated PI3K/Akt and MAPK signaling pathways

Keywords: راپامایسین; HepG2; human hepatoblastoma; ROS; reactive oxygen species; 3-MA; 3-methyladenine; RAP; rapamycin; NAC; NAcetyl-l-cysteine; PARP; poly (ADP-ribose) polymerase; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; MDC; Monodansylcadaverine; MM

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2016 سفارش ترجمه

Topical Use of Mammalian Target of Rapamycin (mTOR) Inhibitors in Tuberous Sclerosis Complex-A Comprehensive Review of the Literature

Keywords: راپامایسین; tuberous sclerosis; rapamycin; mTOR inhibitors; angiofibroma;

دانلود رایگان متن کامل مقاله ISI 20 صفحه سال انتشار : 2016 سفارش ترجمه

Intrathecal administration of rapamycin inhibits the phosphorylation of DRG Nav1.8 and attenuates STZ-induced painful diabetic neuropathy in rats

Keywords: راپامایسین; STZ; streptozotocin; PDN; painful diabetic neuropathy; DRG; dorsal root ganglion; mTOR; mammalian target of rapamycin; S6K; ribosomal protein S6 kinase; 4E-BP; eukaryotic initiation factor 4E (eIF4E) binding protein; IR; insulin receptor; IRS-1; insulin r

دانلود رایگان متن کامل مقاله ISI 23 صفحه سال انتشار : 2016 سفارش ترجمه

Endothelial AMPK activation induces mitochondrial biogenesis and stress adaptation via eNOS-dependent mTORC1 signaling

Keywords: راپامایسین; Endothelial dysfunction; AICAR; Mitochondrial biogenesis; eNOS; Nitric oxide; mTORC1; AMPK; Rapamycin;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2016 سفارش ترجمه

Rapamycin prevents, but does not reverse, aberrant migration in Pten knockout neurons

Keywords: راپامایسین; Pten; Rapamycin; Migration; Autism; Focal cortical dysplasia;

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2016 سفارش ترجمه

A SIRT3/AMPK/autophagy network orchestrates the protective effects of trans-resveratrol in stressed peritoneal macrophages and RAW 264.7 macrophages

Keywords: راپامایسین; AAPH; 2,2′-azobis (2-amidinopropane) dihydrochloride; AMPK; AMP-activated protein kinase; ComC; compound C; Edar; edaravone; 3-MA; 3-methyladenine; MMP; mitochondrial membrane potential; Rapa; rapamycin; Resv; trans-resveratrol; VitC; vitamin C; Autopha

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2016 سفارش ترجمه

Sustained delivery by a cyclodextrin material-based nanocarrier potentiates antiatherosclerotic activity of rapamycin via selectively inhibiting mTORC1 in mice

Keywords: راپامایسین; Atherosclerosis; Rapamycin; Nanomedicine; Sustained delivery; Cyclodextrin; mTOR;

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2016 سفارش ترجمه

Co-loaded paclitaxel/rapamycin liposomes: Development, characterization and in vitro and in vivo evaluation for breast cancer therapy

Keywords: راپامایسین; Liposomes; Co-loading; Paclitaxel; Rapamycin; Breast cancer;

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2016 سفارش ترجمه

The Akt/mTOR/p70S6K pathway is activated in IgA nephropathy and rapamycin may represent a viable treatment option

Keywords: راپامایسین; Akt/mTOR/p70S6K pathway; Rapamycin; IgA nephropathy

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Artificial regulation of p53 function by modulating its assembly

Keywords: راپامایسین; p53; Rapamycin; FRB; FKBP; Chemically induced oligomerization; Protein engineering;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

The Immunosuppressive drug – Rapamycin – Electroanalytical Sensing Using Boron- Doped Diamond electrode

Keywords: راپامایسین; rapamycin; differential pulse voltammetry; boron-doped diamond electrode; electrochemical oxidation

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Rapamycin suppresses PTZ-induced seizures at different developmental stages of zebrafish

Keywords: راپامایسین; AED, antiepileptic drug; CNS, central nervous system; mTOR, mechanist target of rapamycin; PTZ, pentylenetetrazole; VPA, valproatemTOR; Pentylenetetrazole; Rapamycin; Seizures; Zebrafish

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2015 سفارش ترجمه

Effects of topically applied rapamycin and mycophenolic acid on TNCB-induced atopic dermatitis-like skin lesions in NC/Nga mice

Keywords: راپامایسین; Atopic dermatitis; Mycophenolic acid; Rapamycin; Topical administration

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

A phase I-II study on the combination of rapamycin and short course radiotherapy in rectal cancer

Keywords: راپامایسین; Rapamycin; mTOR; Rectal cancer; Radiotherapy; Phase I/II;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Rapamycin-induced G1 cell cycle arrest employs both TGF-β and Rb pathways

Keywords: راپامایسین; mTOR; Rapamycin; Rb; TGF-β; eIF4E; 4E-BP1; eIF4E-binding protein-1; CDK; cyclin-dependent kinase; eIF4E; eukaryotic initiation factor 4E; mTOR; mammalian target of rapamycin; mTORC1; mTOR complex 1; S6K; S6 kinase; TGF-β; transforming growth factor-β;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2015 سفارش ترجمه

Sirolimus and tacrolimus rather than cyclosporine A cause bone loss in healthy adult male rats

Keywords: راپامایسین; Immunosuppressants; Cyclosporine; Tacrolimus; Rapamycin; Osteopenia; Bone quality

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Regulation of T cells by mTOR: the known knowns and the known unknowns

Keywords: راپامایسین; mTOR; T cells; rapamycin

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Autophagic flux determination in vivo and ex vivo

Keywords: راپامایسین; ATP; adenosine triphosphate; BBB; blood brain barrier; BRB; blood retinal barrier; BGT; BSA/glycine/Triton X-100; BSA; bovine serum albumin; CNS; central nervous system; DABCO; 1,4-diazabicyclo[2.2.2]octane; DAPI; 4,6-diamidino-2-phenylindole dihydrochlor

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Chronic stress enhanced fear memories are associated with increased amygdala zif268 mRNA expression and are resistant to reconsolidation

Keywords: راپامایسین; Amygdala; Chronic stress; Fear conditioning; Hippocampus; PTSD; Rapamycin; Reconsolidation; mTOR

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Interplay between mTOR and STAT5 signaling modulates the balance between regulatory and effective T cells

Keywords: راپامایسین; Tregs; regulatory T cells; Teffs; effective T cells; Rapa; Rapamycin; miR-155; micro-RNA 155; Regulatory T cell; mTOR signaling; STAT5 signaling; MicroRNA-155; Immune balance; Rapamycin;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2015 سفارش ترجمه

Clinically-relevant cyclosporin and rapamycin concentrations enhance regulatory T cell function to a similar extent but with different mechanisms: An in-vitro study in healthy humans

Keywords: راپامایسین; Tregs; regulatory T cells; CsA; cyclosporin A; RAPA; rapamycin; MPA; mycophenolic acid; PBMCs; peripheral blood mononuclear cells; FoxP3; forkhead box protein 3; MLR; mixed lymphocyte reaction; MFI; mean fluorescence intensity.; Cyclosporine; FoxP3; Immun

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Dermatologic surgeryTopical rapamycin combined with pulsed dye laser in the treatment of capillary vascular malformations in Sturge-Weber syndrome: Phase II, randomized, double-blind, intraindividual placebo-controlled clinical trial

Keywords: راپامایسین; capillary vascular malformation; pulsed dye laser; rapamycin; Sturge-Weber syndrome; HIF; hypoxia-inducible factor; OV; office visit; PDL; pulsed dye laser; PWS; port-wine stain; SWS; Sturge-Weber syndrome;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

Rapamycin protects against apoptotic neuronal death and improves neurologic function after traumatic brain injury in mice via modulation of the mTOR-p53-Bax axis

Keywords: راپامایسین; Rapamycin; Traumatic brain injury; Apoptosis; Mammalian target of rapamycin; p53; Bax

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2015 سفارش ترجمه

IL-35 inhibits acute graft-versus-host disease in a mouse model

Keywords: راپامایسین; Bone marrow transplantation; Acute graft-versus-host disease; IL-35; Rapamycin;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه

Importance of EEG in validating the chronic effects of drugs: Suggestions from animal models of epilepsy treated with rapamycin

Keywords: راپامایسین; Video-EEG monitoring; Behavior; Rapamycin

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2015 سفارش ترجمه