The structural basis for mTOR function
Keywords: راپامایسین; mTOR; PI3K; Rapamycin; 4E-BP1; S6K1; PIKK;
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Oxidative damage to osteoblasts can be alleviated by early autophagy through the endoplasmic reticulum stress pathway-Implications for the treatment of osteoporosis
Keywords: راپامایسین; 7-AAD; 7-aminoactinomycin D; Baf-A1; bafilomycin-A1; CAT; catalase; DCFH-DA; 2â²-,7â²-dichlorofluorescein diacetate; E64d; (2S,3S)-trans-epoxysuccinyl-L-leucylamido-3-methylbutane ethyl ester; ER; endoplasmic reticulum; JC-1; 5,5â²,6,6â²-tetrachloro-1
Benzofuran derivatives as anticancer inhibitors of mTOR signaling
Keywords: راپامایسین; Benzofuran; Cytotoxicity; mTOR; Cancer; Rapamycin;
Combined mTOR inhibitor rapamycin and doxorubicin-loaded cyclic octapeptide modified liposomes for targeting integrin α3 in triple-negative breast cancer
Keywords: راپامایسین; Triple-negative breast cancer; Liposomal doxorubicin; Targeting delivery; Rapamycin; Combined therapy
Early molecular and behavioral response to lipopolysaccharide in the WAG/Rij rat model of absence epilepsy and depressive-like behavior, involves interplay between AMPK, AKT/mTOR pathways and neuroinflammatory cytokine release
Keywords: راپامایسین; Lipopolysaccharide (LPS); Neuroinflammation; Epileptogenesis; Absence epilepsy; WAG/Rij rats; mTOR; AKT; AMPK; Cytokines; NF-κB; Rapamycin;
Identification and pharmacological induction of autophagy in the larval stages of Echinococcus granulosus: an active catabolic process in calcareous corpuscles
Keywords: راپامایسین; Echinococcus; Autophagy; Rapamycin; Arsenic trioxide; Calcareous corpuscles; Eg-Atg8 expression;
The effects of rapamycin on regulatory T cells: Its potential time-dependent role in inducing transplant tolerance
Keywords: راپامایسین; Rapamycin; Regulatory T cells; Transplantation; Tolerance induction; Time-dependent effects; Systematic review;
mTOR/p70S6K signaling distinguishes routine, maintenance-level autophagy from autophagic cell death during influenza A infection
Keywords: راپامایسین; Influenza; Cell death; Autophagy; Apoptosis; mTORC1/2; p70S6K; Rapamycin; Torin1;
Systematic combination screening reveals synergism between rapamycin and sunitinib against human lung cancer
Keywords: راپامایسین; Combination; Rapamycin; Sunitinib; Non-small cell lung cancer;
Rapamycin prevents strong phosphorylation of p53 on serine 46 and attenuates activation of the p53 pathway in A549 lung cancer cells exposed to actinomycin D
Keywords: راپامایسین; p53; Phosphorylation; Actinomycin D; Rapamycin; Survivin;
Expression of budding yeast FKBP12 confers rapamycin susceptibility to the unicellular red alga Cyanidioschyzon merolae
Keywords: راپامایسین; Cyanidioschyzon merolae; FKBP12; Rapamycin; Red alga; TOR kinase; DMSO; dimethyl sulfoxide; His-tag; histidine-tag; kDa; kilodalton;
Pharmacological inhibition of the mTOR pathway impairs hippocampal development in mice
Keywords: راپامایسین; BrdU; 5-bromo-2-deoxyuridine; DCX; doublecortin; DG; dentate gyrus; GFP; green fluorescent protein; GS; glutamine synthetase; Iba1; ionized calcium binding adaptor molecule 1; mTOR; mammalian target of rapamycin; Neu N; neuronal nuclei; Dentate gyrus; Neu
Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression
Keywords: راپامایسین; P70S6K; ribosomal protein S6 kinase; mTOR; the mammalian target of rapamycin; SIRT; silent information regulator; Tsc; tuberous sclerosis complex; mTORC1; the mammalian target of rapamycin complex 1; POF; premature ovarian failure; PTEN; phosphatase and t
Gamma interferon-inducible lysosomal thioreductase (GILT) ablation renders mouse fibroblasts sensitive to dengue virus replication
Keywords: راپامایسین; GILT knockout mice; Dengue virus type 2 reporter replicon; Renilla luciferase; Rapamycin; Autophagy; Viral replication; Translation;
Rapamycin enhances eIF4E phosphorylation by activating MAP kinase-interacting kinase 2a (Mnk2a)
Keywords: راپامایسین; Mnk; mTORC1; Rapamycin; eIF4E;
Carrier free rapamycin loaded drug eluting stent: In vitro and in vivo evaluation
Keywords: راپامایسین; Drug eluting stents; Rapamycin; Biocompatibility; Controlled release;
Behavioural and EEG effects of chronic rapamycin treatment in a mouse model of Tuberous Sclerosis Complex
Keywords: راپامایسین; Tuberous Sclerosis Complex; Rapamycin; Behaviour; EEG; Spectral analysis; DSA; density spectral array; EEG; electroencephalography; EPM; elevated-plus maze; FFT; Fast Fourier Transform; FST; forced-swim test; MDF; mean dominant frequency; mTOR; mammalian
Rapamycin-induced modulation of HIV gene transcription attenuates progression of HIVAN
Keywords: راپامایسین; HIV-associated nephropathy; Rapamycin; HIV genes;
Activation of mTOR in the spinal cord is required for pain hypersensitivity induced by chronic constriction injury in mice
Keywords: راپامایسین; mTOR; Rapamycin; Neuropathic pain;
Research reportInhibition of mTOR kinase via rapamycin blocks persistent predator stress-induced hyperarousal
Keywords: راپامایسین; Rapamycin; mTOR; Predator stress; Anxiety; Startle; Acquisition;
MicroRNA-21 mediates the rapamycin-induced suppression of endothelial proliferation and migration
Keywords: راپامایسین; Rapamycin; MicroRNA; RhoB; Raptor;
Elastin-based protein polymer nanoparticles carrying drug at both corona and core suppress tumor growth in vivo
Keywords: راپامایسین; Rapa; rapamycin; ELPs; elastin-like polypeptides; FKBP; FK506 binding protein 12; mTOR; mammalian target of rapamycin; ITC; inverse transition cycling; CMT; critical micelle temperature; CMC; critical micelle concentration; DLS; dynamic light scattering;
mTOR complex 2 mediates Akt phosphorylation that requires PKCε in adult cardiac muscle cells
Keywords: راپامایسین; Cardiomyocytes; PKCε; mTOR; Akt; Rapamycin; Torin1;
The immunosuppressive agents rapamycin, cyclosporin A and tacrolimus increase lipolysis, inhibit lipid storage and alter expression of genes involved in lipid metabolism in human adipose tissue
Keywords: راپامایسین; aP2; fatty acid binding protein 4; ATGL; adipose triacylglycerol lipase; BMI; body mass index; CGI-58; α/β-hydrolase domain containing 5; CNI; calcineurin inhibitor; CsA; cyclosporin A; DGAT1; diglyceride acyltransferase 1; FAS; fatty acid synthase; FFA
Potential autophagy enhancers protect against fipronil-induced apoptosis in SH-SY5Y cells
Keywords: راپامایسین; Fipronil; Autophagy; Apoptosis; Neuroprotection; Rapamycin; Reactive oxygen species;
Distinct sensitivity of CD8+CD4â and CD8+CD4+ leukemic cell subpopulations to cyclophosphamide and rapamycin in Notch1-induced T-ALL mouse model
Keywords: راپامایسین; T-ALL; Rapamycin; CTX; Cell cycle; Apoptosis;
Selective aminopeptidase-N (CD13) inhibitors with relevance to cancer chemotherapy
Keywords: راپامایسین; Metalloenzyme; Aminopeptidase; HIF-1α; Antitumor; Rapamycin;
eIF4E-Overexpression imparts perillyl alcohol and rapamycin-mediated regulation of telomerase reverse transcriptase
Keywords: راپامایسین; TERT; telomerase reverse transcriptase; mTOR; mechanistic target of rapamycin; S6K; p70 S6 kinase; 4E-BP1; 4E-binding protein 1; eIF4; eukaryotic initiation factor 4; PI3K; phosphoinositide 3-kinase; CHAPS; 3-[(3-Cholamidopropyl)dimethylammonio]-l-propane
A rapamycin-binding protein polymer nanoparticle shows potent therapeutic activity in suppressing autoimmune dacryoadenitis in a mouse model of Sjögren's syndrome
Keywords: راپامایسین; Rapa; rapamycin; SjS; Sjögren's syndrome; ELP; Elastin like-Polypeptide; FSI; FKBP-S48I48; CATS; cathepsin S; NOD; Non obese diabetic mouse; LG; lacrimal gland; mTOR; mammalian target of Rapamycin; SG; salivary gland; CMT; critical micelle temperature; T
Trilayer micelles for combination delivery of rapamycin and siRNA targeting Y-box binding protein-1 (siYB-1)
Keywords: راپامایسین; Micelles; Combination therapy; Animals; siRNA; YB-1; Rapamycin;
Wnt signaling inhibits CTL memory programming
Keywords: راپامایسین; T cells; Cytotoxicity; Wnt; GSK3; Cytokines; Memory; mTOR; Rapamycin;
FKBP52 is involved in the regulation of SOCE channels in the human platelets and MEG 01 cells
Keywords: راپامایسین; Cyps; cyclophilins; FKBPs; immunophilin; FKBP52; FK506 binding protein (52); ER; rough endoplasmic reticulum; SERCA2b; sarco-endoplasmic Ca2Â +-ATPase isotype 2b; IP3R II; inositol 1,4,5-trisphosphate receptor; TRPC; transient receptor potential channel;
Role of the mTOR signaling pathway in epilepsy
Keywords: راپامایسین; Epilepsy; mTOR; Epileptogenesis; Rapamycin; Therapy; Seizure; Tuberous sclerosis complex; Focal cortical dysplasias;
mTOR inhibition modulates epileptogenesis, seizures and depressive behavior in a genetic rat model of absence epilepsy
Keywords: راپامایسین; Rapamycin; LPS; WAG/Rij rats; SWDs; Depressive behavior; Neuroinflammation;
mTORC1 inhibition induces pain via IRS-1-dependent feedback activation of ERK
Keywords: راپامایسین; Rapamycin; Sensory neurons; mTOR; ERK; Nav1.7; AMPK;
Research reportRTP801 immunoreactivity in retinal ganglion cells and its down-regulation in cultured cells protect them from light and cobalt chloride
Keywords: راپامایسین; RTP801; Ganglion cells; Chemical hypoxia; Blue light; Neuroprotection; Rapamycin;
Growth differentiation factor 15 stimulates rapamycin-sensitive ovarian cancer cell growth and invasion
Keywords: راپامایسین; GDF15; mTOR; PI3K; Ovarian cancer; Invasion; Rapamycin;
Research ReportRapamycin inhibits the growth of glioblastoma
Keywords: راپامایسین; Glioblastoma; mTOR; Rapamycin; GBM brain xenografts; Human GBM primary cultures;
Unusual radiological presentation of sirolimus-associated pneumonitis
Keywords: راپامایسین; lung toxicity; pneumonitis; rapamycin; sirolimus; solid organ transplantation
The enhancement of rapamycin production using Streptomyces hygroscopicus through a simple pH-shifted control
Keywords: راپامایسین; pH; Rapamycin; Two-stage; Pellet; Morphology
Effects of dissolved oxygen level on rapamycin production by pellet-form of Streptomyces hygroscopicus
Keywords: راپامایسین; Dissolved oxygen; Rapamycin; Shear force; Pellet; Morphology
Cytopenia and autoimmune diseases: A vicious cycle fueled by mTOR dysregulation in hematopoietic stem cells
Keywords: راپامایسین; Cytopenia; Homeostatic proliferation; CD24; mTOR; Hematopoietic stem cells; Autoimmune diseases; Inflammatory cytokines; Rapamycin
A phase I study of decitabine and rapamycin in relapsed/refractory AML
Keywords: راپامایسین; AML; Decitabine; Rapamycin; Phase I; Relapsed; Refractory
Central Leucine Sensing in the Control of Energy Homeostasis
Keywords: راپامایسین; Food intake; Leucine; Nutrient sensing; Rapamycin; Diabetes; Obesity; Hypothalamus; Brainstem;
Haloperidol promotes mTORC1-dependent phosphorylation of ribosomal protein S6 via dopamine- and cAMP-regulated phosphoprotein of 32 kDa and inhibition of protein phosphatase-1
Keywords: راپامایسین; Striatum; Medium spiny neurons; Dopamine D2 receptor; Rapamycin; Mouse
Recombinant strains for the enhanced production of bioengineered rapalogs
Keywords: راپامایسین; Rapamycin; Polyketide; Bioengineering
mTOR activation is required for the anti-alcohol effect of ketamine, but not memantine, in alcohol-preferring rats
Keywords: راپامایسین; Animal model; Ethanol; NMDA; Drinking; Rapamycin; Glutamate; Addiction; Rat; Reinforcement; Reward
Multifaceted effects of rapamycin on functional recovery after spinal cord injury in rats through autophagy promotion, anti-inflammation, and neuroprotection
Keywords: راپامایسین; Autophagy; Inflammation; Neuroprotection; Rapamycin; Spinal cord injury
From genes to cognition in tuberous sclerosis: Implications for mTOR inhibitor-based treatment approaches
Keywords: راپامایسین; Tuberous sclerosis; TSC; mTOR; Rapamycin; Autism; Cognition; Epilepsy
mTOR activation in immature cells of primary nasopharyngeal carcinoma and anti-tumor effect of rapamycin in vitro and in vivo
Keywords: راپامایسین; Cancer stem cells; Nasopharyngeal carcinoma; mTOR signaling; Rapamycin