Constraining the amide bond in N-Sulfonylated dipeptide VLA-4 antagonists Fulltext Access 4 Pages 2008
Synthesis and biological evaluation of novel 8-aminomethylated oroxylin A analogues as α-glucosidase inhibitors Fulltext Access 4 Pages 2008
Isoindol-1,3-dione and isoindol-1-one derivatives with high binding affinity to β-amyloid fibrils Fulltext Access 4 Pages 2008
Biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s Fulltext Access 4 Pages 2008
Conformational significance of EH21A1–A4, phenolic derivatives of geldanamycin, for Hsp90 inhibitory activity Fulltext Access 4 Pages 2008
Discovery of small molecule benzimidazole antagonists of the chemokine receptor CXCR3 Fulltext Access 4 Pages 2008
6-Acetyl-7,7-dimethyl-5,6,7,8-tetrahydropterin is an activator of nitric oxide synthases Fulltext Access 4 Pages 2008
New cytotoxic saturated and unsaturated cyclohexanones from Anthemis maritima Fulltext Access 4 Pages 2008
Characterization of the two major CYP450 metabolites of ozonide (1,2,4-trioxolane) OZ277 Fulltext Access 4 Pages 2008
Synthesis, characterization and evaluation of benzimidazole derivative and its precursors as inhibitors of MDA-MB-231 human breast cancer cell proliferation Fulltext Access 4 Pages 2008
Multi-target-directed coumarin derivatives: hAChE and BACE1 inhibitors as potential anti-Alzheimer compounds Fulltext Access 4 Pages 2008
Syntheses and in vitro evaluation of arylsulfone-based MMP inhibitors with heterocycle-derived zinc-binding groups (ZBGs) Fulltext Access 4 Pages 2008
Antiviral activities against herpes simplex virus type 1 by HPH derivatives and their structure–activity relationships Fulltext Access 4 Pages 2008
4-Aminopyridine derivatives with anticholinesterase and antiamnesic activity Fulltext Access 4 Pages 2008
Discovery of indenopyrazoles as EGFR and VEGFR-2 tyrosine kinase inhibitors by in silico high-throughput screening Fulltext Access 4 Pages 2008
Phosphoramidate derivatives of hydroxysteroids as inhibitors of prostate-specific membrane antigen Fulltext Access 4 Pages 2008
Synthesis and properties of oligodeoxynucleotides containing 5-carboxy-2′-deoxycytidines Fulltext Access 4 Pages 2008
Parasiticidal 2-alkoxy- and 2-aryloxyiminoalkyl trifluoromethanesulfonanilides Fulltext Access 4 Pages 2008
Sterol C24-methyltransferase: Mechanistic studies of the C-methylation reaction with 24-fluorocycloartenol Fulltext Access 4 Pages 2008
Leishmanicidal and trypanocidal activities of 2-aminocyclohexanol and 1,2-cyclohexanediamine derivatives Fulltext Access 4 Pages 2008
Selenosartans: Novel selenophene analogues of milfasartan and eprosartan Fulltext Access 4 Pages 2008
The synthesis and biological evaluation of a range of novel functionalised benzopyrans as potential potassium channel activators Fulltext Access 4 Pages 2008
Synthesis and antibiotic activity of a small molecules library of 1,2,3-triazole derivatives Fulltext Access 4 Pages 2008
Three-component, one-pot synthesis of novel 2,4-substituted 5-azolylthiopyrimidine library for screening against anti-influenza virus A Fulltext Access 4 Pages 2008
Triazole derivatives as non-nucleoside inhibitors of HIV-1 reverse transcriptase—Structure–activity relationships and crystallographic analysis Fulltext Access 4 Pages 2008
Synthesis and anti-HIV activity of GS-9148 (2′-Fd4AP), a novel nucleoside phosphonate HIV reverse transcriptase inhibitor Fulltext Access 4 Pages 2008
Synthesis and anti-HIV activity of 2′-fluorine modified nucleoside phosphonates: Analogs of GS-9148 Fulltext Access 4 Pages 2008
Cy3-3-acylcholine: A fluorescent analogue of acetylcholine for single molecule detection Fulltext Access 4 Pages 2008
Synthesis and protective effects of coumarin derivatives against oxidative stress induced by doxorubicin Fulltext Access 4 Pages 2008
Acylguanidine inhibitors of β-secretase: Optimization of the pyrrole ring substituents extending into the S1 and S3 substrate binding pockets Fulltext Access 4 Pages 2008
Comparative structure-activity relationship studies of 1-(5-methylsulfonylpyrid-2-yl)-5-alkyl and (hetero)aryl triazoles and pyrazoles in canine COX inhibition Fulltext Access 4 Pages 2008
Ergoline derivatives as highly potent and selective antagonists at the somatostatin sst1 receptor Fulltext Access 4 Pages 2008
Energetic effects for observed and unobserved HIV-1 reverse transcriptase mutations of residues L100, V106, and Y181 in the presence of nevirapine and efavirenz Fulltext Access 4 Pages 2008
Novel 3-alkoxy-1H-pyrazolo[3,4-d]pyrimidines as EGFR and erbB2 receptor tyrosine kinase inhibitors Fulltext Access 4 Pages 2008
Synthesis and in vitro anti-leukemic activity of structural analogues of JS-K, an anti-cancer lead compound Fulltext Access 4 Pages 2008
Indole-2-amide based biochemical antagonist of Dishevelled PDZ domain interaction down-regulates Dishevelled-driven Tcf transcriptional activity Fulltext Access 4 Pages 2008
Rational design of the first small-molecule antagonists of NHERF1/EBP50 PDZ domains Fulltext Access 4 Pages 2008
Photoactivated enediynes as targeted antitumoral agents: Efficient routes to antibody and gold nanoparticle conjugates Fulltext Access 4 Pages 2008
Entry into a new class of protein kinase inhibitors by pseudo ring design Fulltext Access 4 Pages 2008
A potential new prodrug for the treatment of cystinosis: Design, synthesis and in-vitro evaluation Fulltext Access 4 Pages 2008
Transkarbams with terminal branching as transdermal permeation enhancers Fulltext Access 4 Pages 2008
Synthesis of celecoxib analogs that possess a N-hydroxypyrid-2(1H)one 5-lipoxygenase pharmacophore: Biological evaluation as dual inhibitors of cyclooxygenases and 5-lipoxygenase with anti-inflammatory activity Fulltext Access 4 Pages 2008
Synthesis of new sulfonate and phosphonate derivatives for cation-independent mannose 6-phosphate receptor targeting Fulltext Access 4 Pages 2008
Modifications of the isonipecotic acid fragment of SNS-032: Analogs with improved permeability and lower efflux ratio Fulltext Access 4 Pages 2008
Synthetic chalcones as efficient inhibitors of Mycobacterium tuberculosis protein tyrosine phosphatase PtpA Fulltext Access 4 Pages 2008
2-Aminobenzimidazoles as potent ITK antagonists: trans-stilbene-like moieties targeting the kinase specificity pocket Fulltext Access 4 Pages 2008
Imidazo[5,1-f][1,2,4]triazin-2-amines as novel inhibitors of polo-like kinase 1 Fulltext Access 4 Pages 2008
Naphthalimide intercalators with chiral amino side chains: Effects of chirality on DNA binding, photodamage and antitumor cytotoxicity Fulltext Access 4 Pages 2008
The design, synthesis and biological evaluation of 7-alkoxy-4-heteroarylamino-3-cyanoquinolines as dual inhibitors of c-Src and iNOS Fulltext Access 4 Pages 2008
Possible involvement of radical intermediates in the inhibition of cysteine proteases by allenyl esters and amides Fulltext Access 4 Pages 2008
Design at the atomic level: Design of biaryloxazolidinones as potent orally active antibiotics Fulltext Access 4 Pages 2008
2-Alkylamino- and alkoxy-substituted 2-amino-1,3,4-oxadiazoles—O-Alkyl benzohydroxamate esters replacements retain the desired inhibition and selectivity against MEK (MAP ERK kinase) Fulltext Access 4 Pages 2008
Peptides based on CcdB protein as novel inhibitors of bacterial topoisomerases Fulltext Access 4 Pages 2008
Synthesis of 3,6-diazabicyclo[3.1.1]heptanes as novel ligands for neuronal nicotinic acetylcholine receptors Fulltext Access 4 Pages 2008
Clubbed [1,2,3] triazoles by fluorine benzimidazole: A novel approach to H37Rv inhibitors as a potential treatment for tuberculosis Fulltext Access 4 Pages 2008
Radiolytic one-electron reduction characteristics of tyrosine derivative caged by 2-oxopropyl group Fulltext Access 4 Pages 2008
Interaction of ladder-shaped polyethers with transmembrane α-helix of glycophorin A as evidenced by saturation transfer difference NMR and surface plasmon resonance Fulltext Access 4 Pages 2008
Exploring 8-benzyl pteridine-6,7-diones as inhibitors of glutamate racemase (MurI) in Gram-positive bacteria Fulltext Access 4 Pages 2008
Identification of KD5170: A novel mercaptoketone-based histone deacetylase inhibitor Fulltext Access 4 Pages 2008
Synthesis and activity of novel 1- or 3-(3-amino-1-phenyl propyl)-1,3-dihydro-2H-benzimidazol-2-ones as selective norepinephrine reuptake inhibitors Fulltext Access 4 Pages 2008
Synthesis and characterization of novel natural product-Gd(III) MRI contrast agent conjugates Fulltext Access 4 Pages 2008
Synthesis and preliminary pharmacological evaluation of N-2-(4-(4-(2-substitutedthiazol-4-yl) piperazin-1-yl)-2-oxoethyl)acetamides as novel atypical antipsychotic agents Fulltext Access 4 Pages 2008
Pyrrospirones A and B, apoptosis inducers in HL-60 cells, from an endophytic fungus, Neonectria ramulariae Wollenw KS-246 Fulltext Access 4 Pages 2008
Pterocarpans and flavanones from Sophora flavescens displaying potent neuraminidase inhibition Fulltext Access 4 Pages 2008
Rotational deviation of 3-acetyl group from cyclic tetrapyrrole π-plane in synthetic bacteriochlorophyll-a analogs by 20-substitution Fulltext Access 4 Pages 2008
Triphenylmethylamides (TPMAs): Structure–activity relationship of compounds that induce apoptosis in melanoma cells Fulltext Access 4 Pages 2008
Determination of absolute stereochemistry, total synthesis, and evaluation of peptides from the myxomycete Physarum melleum Fulltext Access 4 Pages 2008
Optimization of 2,3,5-trisubstituted pyridine derivatives as potent allosteric Akt1 and Akt2 inhibitors Fulltext Access 4 Pages 2008
Inhibition of lipopolysaccharide-induced inducible nitric oxide synthase and cyclooxygenase-2 expression by xanthanolides isolated from Xanthium strumarium Fulltext Access 4 Pages 2008
Photochemical DNA cleavage by novel water-soluble sulfonated dihydroxy phosphorus(V) tetrabenzotriazacorrole Fulltext Access 4 Pages 2008
Synthesis and in vitro activity of N′-cyano-4-(2-phenylacetyl)-N-o-tolylpiperazine-1-carboximidamide P2X7 antagonists Fulltext Access 4 Pages 2008
Highly potent and selective chiral inhibitors of PDE5: An illustration of Pfeiffer’s rule Fulltext Access 4 Pages 2008
Conformational analysis of a covalently cross-linked Watson–Crick base pair model Fulltext Access 4 Pages 2008
Monoacylglycerol lipase regulates 2-arachidonoylglycerol action and arachidonic acid levels Fulltext Access 4 Pages 2008
Sensitive and selective viral DNA detection assay via microbead-based rolling circle amplification Fulltext Access 4 Pages 2008
Oxidative inactivation of protein tyrosine phosphatase 1B by organic hydroperoxides Fulltext Access 4 Pages 2008
Correlation of inhibitor effects on enzyme activity and thermal stability for the integral membrane protein fatty acid amide hydrolase Fulltext Access 4 Pages 2008
Selectivity of inhibitors of endocannabinoid biosynthesis evaluated by activity-based protein profiling Fulltext Access 4 Pages 2008
Quinazolines as potent and highly selective PDE5 inhibitors as potential therapeutics for male erectile dysfunction Fulltext Access 4 Pages 2008