Pyrazole inhibitors of coactivator associated arginine methyltransferase 1 (CARM1) Fulltext Access 4 Pages 2008
Tubulysin analogs incorporating desmethyl and dimethyl tubuphenylalanine derivatives Fulltext Access 4 Pages 2008
Design, synthesis and evaluation of 2-phenyl-1H-benzo[d]imidazole-4,7-diones as vascular smooth muscle cell proliferation inhibitors Fulltext Access 4 Pages 2008
N-Acetylhexosaminidase inhibitory properties of C-1 homologated GlcNAc- and GalNAc-thiazolines Fulltext Access 4 Pages 2008
Discovery of amino-acetonitrile derivatives, a new class of synthetic anthelmintic compounds Fulltext Access 4 Pages 2008
Antagonists of the human adenosine A2A receptor. Part 2: Design and synthesis of 4-arylthieno[3,2-d]pyrimidine derivatives Fulltext Access 4 Pages 2008
Antagonists of the human adenosine A2A receptor. Part 1: Discovery and synthesis of thieno[3,2-d]pyrimidine-4-methanone derivatives Fulltext Access 4 Pages 2008
Pyridyl-phenyl ether monoamine reuptake inhibitors: Impact of lipophilicity on dual SNRI pharmacology and off-target promiscuity Fulltext Access 4 Pages 2008
Synthesis and PKCθ inhibitory activity of a series of 4-(indol-5-ylamino)thieno[2,3-b]pyridine-5-carbonitriles Fulltext Access 4 Pages 2008
The isolation, structure determination and cytotoxicity of the new fungal metabolite, trichodermamide C Fulltext Access 4 Pages 2008
Development of a fluorescence polarization based assay for histone deacetylase ligand discovery Fulltext Access 4 Pages 2008
Synthesis and evaluation of sulfamide-type indolizidines as glycosidase inhibitors Fulltext Access 4 Pages 2008
Design and synthesis of 6-amino-1,4-oxazepane-3,5-dione derivatives as novel broad spectrum anticonvulsants Fulltext Access 4 Pages 2008
Synthesis and evaluation of α,α′-disubstituted phenylacetate derivatives for T-type calcium channel blockers Fulltext Access 4 Pages 2008
2-Alkenylthieno[2,3-b]pyridine-5-carbonitriles: Potent and selective inhibitors of PKCθ Fulltext Access 4 Pages 2008
Synthesis of some novel imidazole-based dicationic carbazolophanes as potential antibacterials Fulltext Access 4 Pages 2008
Synthesis and anti-inflammatory activity of 2-(2-aroylaroxy)-4,6-dimethoxy pyrimidines Fulltext Access 4 Pages 2008
Sialyl α(2 → 3) lactose clusters using carbosilane dendrimer core scaffolds as influenza hemagglutinin blockers Fulltext Access 4 Pages 2008
Benzodiazepine ligands can act as allosteric modulators of the Type 1 cholecystokinin receptor Fulltext Access 4 Pages 2008
Synthesis and biological evaluation of a focused library of beauveriolides Fulltext Access 4 Pages 2008
Discovery of imidazole carboxamides as potent and selective CCK1R agonists Fulltext Access 4 Pages 2008
The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase Fulltext Access 4 Pages 2008
Pyrrolidinyl pyridone and pyrazinone analogues as potent inhibitors of prolyl oligopeptidase (POP) Fulltext Access 4 Pages 2008
Synthesis and in vitro activity of 1-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-1H-1,2,4-triazol-5-amine and 4-(2,3-dichlorophenyl)-N-(pyridin-3-ylmethyl)-4H-1,2,4-triazol-3-amine P2X7 antagonists Fulltext Access 4 Pages 2008
N-Alkyl-4-piperidinyl-2,3-diarylpyrrole derivatives with heterocyclic substitutions as potent and broad spectrum anticoccidial agents Fulltext Access 4 Pages 2008
Glycosidase profiling with immobilised glycosidase-inhibiting iminoalditols—A proof-of-concept study Fulltext Access 4 Pages 2008
Synthesis and evaluation of 3- and 7-substituted geranylgeranyl pyrophosphate analogs Fulltext Access 4 Pages 2008
Induction of apoptosis of human tumor cells by hybrid liposomes including docosahexaenoic acid Fulltext Access 4 Pages 2008
Synthesis and pharmacological evaluation of a new targeted drug carrier system: β-Cyclodextrin coupled to oxytocin Fulltext Access 4 Pages 2008
Synthesis of all stereoisomers of 3-hydroxypipecolic acid and 3-hydroxy-4,5-dehydropipecolic acid and their evaluation as glycosidase inhibitors Fulltext Access 4 Pages 2008
[4-(Phenoxy)pyridin-3-yl]methylamines: A new class of selective noradrenaline reuptake inhibitors Fulltext Access 4 Pages 2008
Indole- and indolizine-glyoxylamides displaying cytotoxicity against multidrug resistant cancer cell lines Fulltext Access 4 Pages 2008
Electrophilic α-thiocyanation of chiral and achiral N-acyl imides. A convenient route to 5-substituted and 5,5-disubstituted 2,4-thiazolidinediones Fulltext Access 4 Pages 2008
Discovery of triazolinone non-nucleoside inhibitors of HIV reverse transcriptase Fulltext Access 4 Pages 2008
Design and synthesis of hydroxy-alkynoic acids and their methyl esters as novel activators of BK channels Fulltext Access 4 Pages 2008
New anti-inflammatory ergostane-type ecdysteroids from the sclerotium of Polyporus umbellatus Fulltext Access 4 Pages 2008
Design and synthesis of N-alkyl oxindolylidene acetic acids as a new class of potent Cdc25A inhibitors Fulltext Access 4 Pages 2008
Synthesis of 2-[3-(7-Chloro-quinolin-4-ylamino)-alkyl]-1-(substituted phenyl)-2,3,4,9-tetrahydro-1H-β-carbolines as a new class of antimalarial agents Fulltext Access 4 Pages 2008
Novel ORL1-selective antagonists with oral bioavailability and brain penetrability Fulltext Access 4 Pages 2008
Identification of novel benzimidazole series of potent and selective ORL1 antagonists Fulltext Access 4 Pages 2008
Design and synthesis of releasable folate–drug conjugates using a novel heterobifunctional disulfide-containing linker Fulltext Access 4 Pages 2008
New PPARγ ligands based on 2-hydroxy-1,4-naphthoquinone: Computer-aided design, synthesis, and receptor-binding studies Fulltext Access 4 Pages 2008
Discovery of novel series of benzoic acid derivatives containing biphenyl ether moiety as potent and selective human β3-adrenergic receptor agonists: Part IV Fulltext Access 4 Pages 2008
Design, synthesis, biochemical, and biological evaluation of nitrogen-containing trifluoro structural modifications of combretastatin A-4 Fulltext Access 4 Pages 2008
7-[1H-Indol-2-yl]-2,3-dihydro-isoindol-1-ones as dual Aurora-A/VEGF-R2 kinase inhibitors: Design, synthesis, and biological activity Fulltext Access 4 Pages 2008
Identification of ring-fused pyrazolo pyridin-2-ones as novel poly(ADP-ribose)polymerase-1 inhibitors Fulltext Access 4 Pages 2008
Novel hypoglycemic dihydropyridones serendipitously discovered from O- versus C-alkylation in the synthesis of VMAT2 antagonists Fulltext Access 4 Pages 2008
Bradykinin B1 receptor antagonists: An α-hydroxy amide with an improved metabolism profile Fulltext Access 4 Pages 2008
Design, synthesis, and bioactivity of putative tubulin ligands with adamantane core Fulltext Access 4 Pages 2008
Synthesis and antibacterial activity of the C-7 side chain of 3-aminoquinazolinediones Fulltext Access 4 Pages 2008
Discovery and optimization of (R)-prolinol-derived agonists of the Growth Hormone Secretagogue receptor (GHSR) Fulltext Access 4 Pages 2008
Design, synthesis and preliminary biological evaluation of new hydroxamate histone deacetylase inhibitors as potential antileukemic agents Fulltext Access 4 Pages 2008
PNA/DNA interstrand cross-links from a modified PNA base upon photolysis or oxidative conditions Fulltext Access 4 Pages 2008
Promising core structure for nuclear receptor ligands: Design and synthesis of novel estrogen receptor ligands based on diphenylamine skeleton Fulltext Access 4 Pages 2008
Impacts of baicalein analogs with modification of the 6th position of A ring on the activity toward NF-κB-, AP-1-, or CREB-mediated transcription Fulltext Access 4 Pages 2008
1-[4-(2-Aminoethoxy)phenylcarbonyl]-3,5-bis-(benzylidene)-4-oxopiperidines: A novel series of highly potent revertants of P-glycoprotein associated multidrug resistance Fulltext Access 4 Pages 2008
Structure-guided design of substituted aza-benzimidazoles as potent hypoxia inducible factor-1α prolyl hydroxylase-2 inhibitors Fulltext Access 4 Pages 2008
ortho-Dihydroxyisoflavone derivatives from aged Doenjang (Korean fermented soypaste) and its radical scavenging activity Fulltext Access 4 Pages 2008
Hexahydro-pyrrolo- and hexahydro-1H-pyrido[1,2-b]pyridazin-2-ones as potent inhibitors of HCV NS5B polymerase Fulltext Access 4 Pages 2008
Design, synthesis, and evaluation of novel aryl-tetrahydropyridine PPARα/γ dual agonists Fulltext Access 4 Pages 2008
Synthesis of N-isobutylnoroxymorphone from naltrexone by a selective cyclopropane ring opening reaction Fulltext Access 4 Pages 2008
Synthesis of a 200-member library of squaric acid N-hydroxylamide amides Fulltext Access 4 Pages 2008
New PPARγ ligands based on barbituric acid: Virtual screening, synthesis and receptor binding studies Fulltext Access 4 Pages 2008
Discovery of pyrazolopyrimidines as the first class of allosteric agonists for the high affinity nicotinic acid receptor GPR109A Fulltext Access 4 Pages 2008
New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter Fulltext Access 4 Pages 2008
Design and synthesis of novel furoquinoline based inhibitors of multiple targets in the PI3K/Akt-mTOR pathway Fulltext Access 4 Pages 2008
Synthesis and evaluation of heteroaryl-ketone derivatives as a novel class of VEGFR-2 inhibitors Fulltext Access 4 Pages 2008
Synthesis of hydantoin analogues of (2S,3R,4S)-4-hydroxyisoleucine with insulinotropic properties Fulltext Access 4 Pages 2008
N-(thiazol-2-yl)-2-thiophene carboxamide derivatives as Abl inhibitors identified by a pharmacophore-based database screening of commercially available compounds Fulltext Access 4 Pages 2008
N-Acyl-3-amino-5H-furanone derivatives as new inhibitors of LuxR-dependent quorum sensing: Synthesis, biological evaluation and binding mode study Fulltext Access 4 Pages 2008
Molecular modeling of a PAMAM-CGS21680 dendrimer bound to an A2A adenosine receptor homodimer Fulltext Access 4 Pages 2008
N-Benzyl-N-(pyrrolidin-3-yl)carboxamides as a new class of selective dual serotonin/noradrenaline reuptake inhibitors Fulltext Access 4 Pages 2008
Structure–activity relationships of 2-aryl-1H-indole inhibitors of the NorA efflux pump in Staphylococcus aureus Fulltext Access 4 Pages 2008
Structure–activity relationship studies on vitamin D lactam derivatives as vitamin D receptor antagonist Fulltext Access 4 Pages 2008
Design and synthesis of tetrahydroisoquinoline derivatives as potential multidrug resistance reversal agents in cancer Fulltext Access 4 Pages 2008
Design, synthesis and evaluation of potent thymidylate synthase X inhibitors Fulltext Access 4 Pages 2008
Analogues of N-hydroxy-N′-phenylthiourea and N-hydroxy-N′-phenylurea as inhibitors of tyrosinase and melanin formation Fulltext Access 4 Pages 2008
N-Alkyl-5H-pyrido[4,3-b]indol-1-amines and derivatives as novel urotensin-II receptor antagonists Fulltext Access 4 Pages 2008
Carbonic anhydrase inhibitors: Inhibition of the new membrane-associated isoform XV with phenols Fulltext Access 4 Pages 2008
Monoglycerides from the brown alga Sargassum sagamianum: Isolation, synthesis, and biological activity Fulltext Access 4 Pages 2008
Oligonucleotide microarrays with stem–loop probes: Enhancing the hybridization of nucleic acids for sensitive analysis Fulltext Access 4 Pages 2008
2,5-Diaminopyrimidines and 3,5-disubstituted azapurines as inhibitors of glycogen synthase kinase-3 (GSK-3) Fulltext Access 4 Pages 2008
4,5-Disubstituted oxazolidinones: High affinity molecular effectors of RNA function Fulltext Access 4 Pages 2008
Synthesis of BC-ring model of globostellatic acid X methyl ester, an anti-angiogenic substance from marine sponge Fulltext Access 4 Pages 2008
Synthesis of diketopiperazine-based carboline homodimers and in vitro growth inhibition of human carcinomas Fulltext Access 4 Pages 2008
Discovery and Initial SAR of Arylsulfonylpiperazine Inhibitors of 11β-Hydroxysteroid Dehydrogenase Type 1 (11β-HSD1) Fulltext Access 4 Pages 2008
The effect of different electrostatic potentials on docking accuracy: A case study using DOCK5.4 Fulltext Access 4 Pages 2008
Development of potent and selective small-molecule human Urotensin-II antagonists Fulltext Access 4 Pages 2008
Binding properties of positively charged deoxynucleic guanidine (DNG), AgTgAgTgAgT and DNG/DNA chimeras to DNA Fulltext Access 4 Pages 2008