Synthesis and antimicrobial activity of 7α-amino-23,24-bisnor-5α-cholan-22-ol derivatives Fulltext Access 4 Pages 2008
Metal-free artificial nucleases based on simple oxime and hydroxylamine scaffolds Fulltext Access 4 Pages 2008
Synthesis and structure–activity relationships of selective norepinephrine reuptake inhibitors (sNRI) with a heterocyclic ring constraint Fulltext Access 4 Pages 2008
Structure–activity relationships of chiral selective norepinephrine reuptake inhibitors (sNRI) with increased oxidative stability Fulltext Access 4 Pages 2008
4-(1H-Indazol-5-yl)-6-phenylpyrimidin-2(1H)-one analogs as potent CDC7 inhibitors Fulltext Access 4 Pages 2008
Des-A-ring benzothiadiazines: Inhibitors of HCV genotype 1 NS5B RNA-dependent RNA polymerase Fulltext Access 4 Pages 2008
Alkyne–quinuclidine derivatives as potent and selective muscarinic antagonists for the treatment of COPD Fulltext Access 4 Pages 2008
Selective vasodilatation effect of sargahydroquinoic acid, an active constituent of Sargassum micracanthum, on the basilar arteries of rabbits Fulltext Access 4 Pages 2008
Synthesis of 4′-modified noraristeromycins to clarify the effect of the 4′-hydroxyl groups for inhibitory activity against S-adenosyl-l-homocysteine hydrolase Fulltext Access 4 Pages 2008
Microarray-based label-free detection of RNA using bispyrene-modified 2′-O-methyl oligoribonucleotide as capture and detection probe Fulltext Access 4 Pages 2008
Interaction of human serum albumin and its clinically relevant modification with oligoribonucleotides Fulltext Access 4 Pages 2008
Use of γ-aminopropyl-coated glass surface for the patterning of oligonucleotides through oxime bond formation Fulltext Access 4 Pages 2008
Synthesis and evaluation of novel aromatic substrates and competitive inhibitors of GABA aminotransferase Fulltext Access 4 Pages 2008
Design and characterization of mechanism-based inhibitors for the tyrosine aminomutase SgTAM Fulltext Access 4 Pages 2008
Substrate specificity and diastereoselectivity of strictosidine glucosidase, a key enzyme in monoterpene indole alkaloid biosynthesis Fulltext Access 4 Pages 2008
New insights into the first oxidative phenol coupling reaction during vancomycin biosynthesis Fulltext Access 4 Pages 2008
Synthetic ligands that activate and inhibit a quorum-sensing regulator in Pseudomonas aeruginosa Fulltext Access 4 Pages 2008
Identification of ACE pharmacophore in the phosphonopeptide metabolite K-26 Fulltext Access 4 Pages 2008
Design and synthesis of macrocyclic peptidyl hydroxamates as peptide deformylase inhibitors Fulltext Access 4 Pages 2008
Stereoselectivity of binding of α-(N-benzylamino)benzylphosphonic acids to prostatic acid phosphatase Fulltext Access 4 Pages 2008
Structure–activity relationship study of a novel necroptosis inhibitor, necrostatin-7 Fulltext Access 4 Pages 2008
Synthesis and biological evaluation of novel 1-O- and 14-O-derivatives of oridonin as potential anticancer drug candidates Fulltext Access 4 Pages 2008
3-(4-(6-Fluoroalkoxy-3,4-dihydroisoquinoline-2(1H)-yl)cyclohexyl)-1H-indole-5-carbonitriles for SERT imaging: Chemical synthesis, evaluation in vitro and radiofluorination Fulltext Access 4 Pages 2008
Discovery of imidazole vinyl pyrimidines as a novel class of kinase inhibitors which inhibit Tie-2 and are orally bioavailable Fulltext Access 4 Pages 2008
Substituted 3-((Z)-2-(4-nitrophenyl)-2-(1H-tetrazol-5-yl) vinyl)-4H-chromen-4-ones as novel anti-MRSA agents: Synthesis, SAR, and in-vitro assessment Fulltext Access 4 Pages 2008
Design, synthesis, and biological activities of conformationally restricted analogs of primaquine with a 1,10-phenanthroline framework Fulltext Access 4 Pages 2008
Epiboxidine and novel-related analogues: A convenient synthetic approach and estimation of their affinity at neuronal nicotinic acetylcholine receptor subtypes Fulltext Access 4 Pages 2008
Anti-HBV agents. Part 1: Synthesis of alisol A derivatives: A new class of hepatitis B virus inhibitors Fulltext Access 4 Pages 2008
Synthesis and evaluation of 5′-modified 2′-deoxyadenosine analogues as anti-hepatitis C virus agents Fulltext Access 4 Pages 2008
Inhibition of human mitochondrial carbonic anhydrases VA and VB with para-(4-phenyltriazole-1-yl)-benzenesulfonamide derivatives Fulltext Access 4 Pages 2008
On the conversion of structural analogues of (S)-2-hydroxypropylphosphonic acid to epoxides by the final enzyme of fosfomycin biosynthesis in S. fradiae Fulltext Access 4 Pages 2008
Synthesis and positive inotropic activity of N-(4,5-dihydro-[1,2,4]triazolo[4,3-a]quinolin-7-yl)-2-(piperazin-1-yl)acetamide derivatives Fulltext Access 4 Pages 2008
Synthesis and biological evaluation of C-12′ substituted vinflunine derivatives Fulltext Access 4 Pages 2008
A synthetic method for peptide-PEG-lipid conjugates: Application of Octreotide-PEG-DSPE synthesis Fulltext Access 4 Pages 2008
Fluorescence generation from tandem repeats of a malachite green RNA aptamer using rolling circle transcription Fulltext Access 4 Pages 2008
Design and regioselective synthesis of a new generation of targeted chemotherapeutics. Part II: Folic acid conjugates of tubulysins and their hydrazides Fulltext Access 4 Pages 2008
Crystal structure of chemically synthesized HIV-1 protease and a ketomethylene isostere inhibitor based on the p2/NC cleavage site Fulltext Access 4 Pages 2008
Synthesis and biological evaluation of N-mercaptoacylproline and N-mercaptoacylthiazolidine-4-carboxylic acid derivatives as leukotriene A4 hydrolase inhibitors Fulltext Access 4 Pages 2008
Improvement of the transactivation activity of phenylpropanoic acid-type peroxisome proliferator-activated receptor pan agonists: Effect of introduction of fluorine at the linker part Fulltext Access 4 Pages 2008
Efficient synthesis and utilization of phenyl-substituted heteroaromatic carboxylic acids as aryl diketo acid isosteres in the design of novel HIV-1 integrase inhibitors Fulltext Access 4 Pages 2008
Novel anthraquinone derivatives: Synthesis via click chemistry approach and their induction of apoptosis in BGC gastric cancer cells via reactive oxygen species(ROS)-dependent mitochondrial pathway Fulltext Access 4 Pages 2008
Open-chain half-bastadins mimic the effects of cyclic bastadins on calcium homeostasis in cultured neurons Fulltext Access 4 Pages 2008
Discovery of (naphthalen-4-yl)(phenyl)methanones and N-methyl-N-phenylnaphthalen-1-amines as new apoptosis inducers using a cell- and caspase-based HTS assay Fulltext Access 4 Pages 2008
Azaflavones compared to flavones as ligands to the benzodiazepine binding site of brain GABAA receptors Fulltext Access 4 Pages 2008
Synthesis and cytotoxic activities of 1-benzylidine substituted β-carboline derivatives Fulltext Access 4 Pages 2008
Activation and inhibition of leukotriene A4 hydrolase aminopeptidase activity by diphenyl ether and derivatives Fulltext Access 4 Pages 2008
Carbon analogs of antifungal dioxane-triazole derivatives: Synthesis and in vitro activities Fulltext Access 4 Pages 2008
Coagulanolide, a withanolide from Withania coagulans fruits and antihyperglycemic activity Fulltext Access 4 Pages 2008
Synthesis and bioevaluation of hybrid 4-aminoquinoline triazines as a new class of antimalarial agents Fulltext Access 4 Pages 2008
Synthesis of spiro-1,2-dioxolanes and their activity against Plasmodium falciparum Fulltext Access 4 Pages 2008
Simple and rapid colorimetric detection of cofactors of aptazymes using noncrosslinking gold nanoparticle aggregation Fulltext Access 4 Pages 2008
cis-Nitromethylene neonicotinoids as new nicotinic family: Synthesis, structural diversity, and insecticidal evaluation of hexahydroimidazo[1,2-α]pyridine Fulltext Access 4 Pages 2008
Synthesis and evaluation of a series of homologues of lobelane at the vesicular monoamine transporter-2 Fulltext Access 4 Pages 2008
Highly cytotoxic and neurotoxic acetogenins of the Annonaceae: New putative biological targets of squamocin detected by activity-based protein profiling Fulltext Access 4 Pages 2008
The discovery of the benzhydroxamate MEK inhibitors CI-1040 and PD 0325901 Fulltext Access 4 Pages 2008
Synthesis and biological evaluation of helicid analogues as mushroom tyrosinase inhibitors Fulltext Access 4 Pages 2008
Imidazole pyrimidine amides as potent, orally bioavailable cyclin-dependent kinase inhibitors Fulltext Access 4 Pages 2008
Design and synthesis of a bis(cycloisodityrosine) analogue of RA-VII, an antitumor bicyclic hexapeptide Fulltext Access 4 Pages 2008
N-((8-Hydroxy-5-substituted-quinolin-7-yl)(phenyl)methyl)-2-phenyloxy/amino-acetamide inhibitors of ADAMTS-5 (Aggrecanase-2) Fulltext Access 4 Pages 2008
2-Arylimino-5,6-dihydro-4H-1,3-thiazines as a new class of cannabinoid receptor agonists. Part 3: Synthesis and activity of isosteric analogs Fulltext Access 4 Pages 2008
Novel 2-imidazoles as potent, selective and CNS penetrant α1A adrenoceptor partial agonists Fulltext Access 4 Pages 2008
Design, synthesis, and evaluation of orally active inhibitors of plasminogen activator inhibitor-1 (PAI-1) production Fulltext Access 4 Pages 2008
Design, synthesis, and evaluation of bisubstrate analog inhibitors of cholera toxin Fulltext Access 4 Pages 2008
Synthesis of diglycosylceramides and evaluation of their iNKT cell stimulatory properties Fulltext Access 4 Pages 2008
Synthesis and stereochemistry of the terminal spiroketal domain of the phosphatase inhibitor dinophysistoxin-2 Fulltext Access 4 Pages 2008
An orthogonal purification strategy for isolating crosslinked domains of modular synthases Fulltext Access 4 Pages 2008
Use of lantibiotic synthetases for the preparation of bioactive constrained peptides Fulltext Access 4 Pages 2008
Design, synthesis and evaluation of isaindigotone derivatives as acetylcholinesterase and butyrylcholinesterase inhibitors Fulltext Access 4 Pages 2008
Solid-phase synthesis of backbone-modified DNA analogs by the boranophosphotriester method using new protecting groups for nucleobases Fulltext Access 4 Pages 2008
Sucutiniranes A and B, new cassane-type diterpenes from Bowdichia nitida Fulltext Access 4 Pages 2008
Development of a novel fluorescent probe for fluorescence correlation spectroscopic detection of kinase inhibitors Fulltext Access 4 Pages 2008
Microwave-assisted synthesis of 5-aminopyrazol-4-yl ketones and the p38MAPK inhibitor RO3201195 for study in Werner syndrome cells Fulltext Access 4 Pages 2008
Effect of some P-glycoprotein modulators on Rhodamine-123 absorption in guinea-pig ileum Fulltext Access 4 Pages 2008
Antimalarial activity of novel pyrrolizidinyl derivatives of 4-aminoquinoline Fulltext Access 4 Pages 2008
Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors Fulltext Access 4 Pages 2008
Potent and selective small-molecule human urotensin-II antagonists with improved pharmacokinetic profiles Fulltext Access 4 Pages 2008
Protein subtype-targeting through ligand epimerization: Talose-selectivity of galectin-4 and galectin-8 Fulltext Access 4 Pages 2008
Insight from molecular modeling into different conformation and SAR of natural steroids and unnatural 7-oxa-steroids Fulltext Access 4 Pages 2008
Synthesis and antibacterial activities of novel oxazolidinones having cyclic sulfonamide moieties Fulltext Access 4 Pages 2008
One-pot synthesis and antibacterial activities of pyrazolo[4′,3′:5,6]pyrido[2,3-d]pyrimidine-dione derivatives Fulltext Access 4 Pages 2008
Application of a trifunctional reactive linker for the construction of antibody–drug hybrid conjugates Fulltext Access 4 Pages 2008
Synthesis and free radical scavenging activity of some new spiropyranocoumarins Fulltext Access 4 Pages 2008
Towards novel S-DABOC inhibitors: Synthesis, biological investigation, and molecular modeling studies Fulltext Access 4 Pages 2008