دانلود مقالات ISI درباره آژانس دارویی اروپا + ترجمه فارسی

Bioanalytical assay for the quantification of the ALK inhibitor lorlatinib in mouse plasma using liquid chromatography-tandem mass spectrometry

Keywords: آژانس دارویی اروپا; ALK; anaplastic lymphoma kinase; EMA; European Medicines Agency; EML4; echinoderm microtubule-associated protein-like 4; ESI; electro spray ionization; FDA; Food and Drug Administration; IS; internal standard; LC-MS/MS; liquid chromatography-tandem mass s

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2018 سفارش ترجمه

In vitro assessment of the interactions of dopamine β-hydroxylase inhibitors with human P-glycoprotein and Breast Cancer Resistance Protein

Keywords: آژانس دارویی اروپا; BBB; blood-brain barrier; BCRP; Breast Cancer Resistance Protein; BSA; bovine serum albumin; DAD; diode-array detection; DBH; dopamine β-hydroxylase; DDIs; drug-drug interactions; DMSO; dimethyl sulfoxide; EMA; European Medicines Agency; HBSS; Hanks bala

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2018 سفارش ترجمه

A phase III, open-label, randomised multicentre study to evaluate the immunogenicity and safety of a booster dose of two different reduced antigen diphtheria-tetanus-acellular pertussis-polio vaccines, when co-administered with measles-mumps-rubella vacci

Keywords: آژانس دارویی اروپا; AE; adverse event; ap; acellular pertussis; ATP; according to protocol; CI; confidence interval; d; diphtheria (low dose); D; diphtheria, (high dose); dTap-IPV; reduced antigen diphtheria-tetanus-acellular pertussis-inactivated poliovirus vaccine; ELISA;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

Report on eighth WHO meeting on development of influenza vaccines that induce broadly protective and long-lasting immune responses: Chicago, USA, 23-24 August 2016

Keywords: آژانس دارویی اروپا; Influenza; Pandemic influenza vaccine; Seasonal influenza vaccine; Universal influenza vaccine; Vaccine development; Nextgeneration influenza vaccine; ADCC; Antibody-dependent cell-mediated cytotoxicity; AE; Adverse event; CMI; cell-mediated immunity; CON

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2018 سفارش ترجمه

A fully validated liquid chromatography-mass spectrometry method for the quantification of the soluble receptor of advanced glycation end-products (sRAGE) in serum using immunopurification in a 96-well plate format

Keywords: آژانس دارویی اروپا; BSA; bovine serum albumin; CML-BSA; Nε-(carboxymethyl)lysine-modified bovine serum albumin; COPD; chronic obstructive pulmonary disease; CV; coefficient of variation; EMA; European Medicines Agency; ELISA; enzyme-linked immunosorbent assay; FDA; Food and

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Antiangiogenic therapy for patients with aggressive or refractory advanced non-small cell lung cancer in the second-line setting

Keywords: آژانس دارویی اروپا; CI; confidence interval; DCR; disease control rate; DOC; docetaxel; EMA; European Medicines Agency; FDA; US Food and Drug Administration; HR; hazard ratio; ITT; intent to treat; NSCLC; non-small cell lung cancer; OR; odds ratio; ORR; objective response ra

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2018 سفارش ترجمه

Extractability-mediated stability bias and hematocrit impact: High extraction recovery is critical to feasibility of volumetric adsorptive microsampling (VAMS) in regulated bioanalysis

Keywords: آژانس دارویی اروپا; VAMS; volumetric absorptive microsampling; Ht; hematocrit; LLE; liquid-liquid extraction; GLP; good laboratory practice; LC-MS/MS; liquid chromatography coupled with triple quadrupole mass spectrometry; LLOQ; lower limit of quantification; ULOQ; upper

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Transitioning from first- to second-generation biosimilars: An appraisal of regulatory and post-marketing challenges

Keywords: آژانس دارویی اروپا; ACR; American College of Rheumatology; ADAb; anti-drug antibody; ADCC; antibody-dependent cell-mediated cytotoxicity; AIFA; Italian Medicines Agency; CDC; complement-dependent cytotoxicity; CHMP; Committee for Medicinal Products for Human Use; DAS28; 28-j

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2018 سفارش ترجمه

Effective phospholipids removing microelution-solid phase extraction LC-MS/MS method for simultaneous plasma quantification of aripiprazole and dehydro-aripiprazole: Application to human pharmacokinetic studies

Keywords: آژانس دارویی اروپا; ARI; aripiprazole; AUC; area under curve; CAL; calibration standard; CID; collision-induced dissociation; Cmax; maximum plasma concentration; CV; coefficient of variation; CYP; cytochrome P450; DAD; diode array detection; DARI; dehydro-aripiprazole; EDTA;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Polymorphism in the co-crystallization of the anticonvulsant drug carbamazepine and saccharin using supercritical CO2 as an anti-solvent

Keywords: آژانس دارویی اروپا; API; active pharmaceutical ingredient; BCS; Biopharmaceutics Classification System; BPR; back pressure regulator; CBZ; carbamazepine; CSS; co-crystallization with supercritical solvent; DCM; dichloromethane; DSC; differential scanning calorimetry; DMSO; d

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Clinical data supporting a 2-dose schedule of MenB-FHbp, a bivalent meningococcal serogroup B vaccine, in adolescents and young adults

Keywords: آژانس دارویی اروپا; ACIP; Advisory Committee on Immunization Practices; EMA; European Medicines Agency; FDA; US Food and Drug Administration; FHbp; factor H binding protein; GMT; geometric mean titer; HPV; human papillomavirus; hSBA; serum bactericidal assay using human comp

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2018 سفارش ترجمه

Resistance to EGFR inhibitors in non-small cell lung cancer: Clinical management and future perspectives

Keywords: آژانس دارویی اروپا; NNSCLC; non-small cell lung cancer; OS; overall survival; EGFR; epidermal growth factor receptor; TKI; tyrosine kinase inhibitor; ALK; Anaplastic lymphoma kinase; MET; mesenchymal epithelial transition factor; PFS; progression free survival; HER2; human e

دانلود رایگان متن کامل مقاله ISI 13 صفحه سال انتشار : 2018 سفارش ترجمه

A new cause of false positive voriconazole levels: Watch your collection tubes!

Keywords: آژانس دارویی اروپا; TDM; Therapeutic drug monitoring; VOR; Voriconazole; HPLC-UV; High-performance liquid chromatography with ultraviolet detector; FDA; Food and drug administration; EMEA; European Medicines Agency; PRE; Percentage relative error; LLOQ; Lower limit of quanti

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2018 سفارش ترجمه

Quantitative evaluation of the matrix effect in bioanalytical methods based on LC-MS: A comparison of two approaches

Keywords: آژانس دارویی اروپا; AAPS; American Association of Pharmaceutical Scientists; CV(%); coefficient of variation; EMA; European Medicines Agency; FDA; U.S. Food and Drug Administration; GLP; good laboratory practice; IS; internal standard; IS-norm; internal standard normalized;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2018 سفارش ترجمه

High throughput routine determination of 17 tyrosine kinase inhibitors by LC-MS/MS

Keywords: آژانس دارویی اروپا; ALL; Acute Lymphoid Leukemia; CML; Chronic Myeloid Leukaemia; CV; Coefficient of Variation; EGFR; Endothelial derived growth factor Receptor; EMA; European Medicines Agency; ER; Extraction Recovery; FDA; Food and Drug Administration; GIST; Gastro Intestin

دانلود رایگان متن کامل مقاله ISI 21 صفحه سال انتشار : 2018 سفارش ترجمه

Phytosome complex of curcumin as complementary therapy of advanced pancreatic cancer improves safety and efficacy of gemcitabine: Results of a prospective phase II trial

Keywords: آژانس دارویی اروپا; CM; complementary medicine; CT; computerized tomography; DCR; disease control rate; ECOG PS; Eastern Cooperative Oncology Group performance status; EMA; European Medicines Agency; EORTC QLQ-C30; European Organization for Research and Treatment of Cancer Q

دانلود رایگان متن کامل مقاله ISI 29 صفحه سال انتشار : 2018 سفارش ترجمه

Signal management in pharmacovigilance and human risk assessment of CpG 7909, integrating embryo-fetal and post-natal developmental toxicity studies in rats and rabbits

Keywords: آژانس دارویی اروپا; BW; body weight; CpG; unmethylated 2′ deoxyribo (cytidine-phosphate-guanosine); EFD; embryo-fetal development; EMA; European Medicines Agency; FDA; Food and Drug Administration; G0; day 0 of gestation; GSK; GlaxoSmithKline; HLS; Huntington Life Sciences

دانلود رایگان متن کامل مقاله ISI 31 صفحه سال انتشار : 2018 سفارش ترجمه

Ribociclib shows potential for pharmacokinetic drug-drug interactions being a substrate of ABCB1 and potent inhibitor of ABCB1, ABCG2 and CYP450 isoforms in vitro

Keywords: آژانس دارویی اروپا; 95%CI; 95% confidential interval; AB; apical-to-basolateral; ABC; ATP-binding cassette; Abcb1; canine P-glycoprotein; ABCB1; human P-glycoprotein; ABCC1; multidrug resistance-associated protein 1; ABCG2; breast cancer resistance protein; BA; basolateral-t

دانلود رایگان متن کامل مقاله ISI 32 صفحه سال انتشار : 2018 سفارش ترجمه

Development and validation of a sensitive and rapid UHPLC-MS/MS method for the simultaneous quantification of the common active and inactive metabolites of vicagrel and clopidogrel in human plasma

Keywords: آژانس دارویی اروپا; AUC; area under the concentration-time curve; Cmax; maximum plasma concentration; EDTA; ethylenediaminetetraacetic acid; EMA; European Medicines Agency; ESI; electrospray ionization; H1, H2, H3, H4; the thiol metabolite isomers of clopidogrel; HPLC; hig

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2018 سفارش ترجمه

In vitro models for immunogenicity prediction of therapeutic proteins

Keywords: آژانس دارویی اروپا; Therapeutic protein; Immunogenicity assessment; In vitro model; Subcutaneous injection; Injection site reactions; ADAs; antidrug antibodies; ALN; artificial lymph node; APCs; antigen presenting cells; ASCs; adipose-derived stem/stromal cells; DCs; dendrit

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2018 سفارش ترجمه

Cell cultures in drug discovery and development: The need of reliable in vitro-in vivo extrapolation for pharmacodynamics and pharmacokinetics assessment

Keywords: آژانس دارویی اروپا; 3Rs; Reduction, Replacement, Refinement; PBPK; physiologically based pharmacokinetic; 2D; two-dimensional; 3D; three-dimensional; HTS; high-throughput screening; IVIVE; in vitro-in vivo extrapolation; ADME; absorption, distribution, metabolism and excreti

دانلود رایگان متن کامل مقاله ISI 43 صفحه سال انتشار : 2018 سفارش ترجمه

The Mexican consensus on the treatment of hepatitis C

Keywords: آژانس دارویی اروپا; Consensus; Direct-acting antiviral agents; Interferon-free regimens; Ribavirin; Consenso; Agentes antivirales de acción directa; Regímenes libres de interferón; Ribavirina; AASLD; American Association for the Study of Liver Diseases; AFP; alpha-fetopro

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2018 سفارش ترجمه

Safety evaluation of a mixture of the human-identical milk oligosaccharides 2′-fucosyllactose and difucosyllactose

Keywords: آژانس دارویی اروپا; 2′-fucosyllactose; Difucosyllactose; Lactodifucotetraose; Human-identical milk oligosaccharide; Infant formula; Safety; 2-AA; 2-aminoanthracene; 2′-FL; 2′-fucosyllactose; 2′-FL/DFL; 2′-fucosyllactose/difucosyllactose mixture; 2-NF; 2-nitroflouri

دانلود رایگان متن کامل مقاله ISI 53 صفحه سال انتشار : 2018 سفارش ترجمه

Bispecific antibodies for cancer therapy: A review

Keywords: آژانس دارویی اروپا; ADCC; antibody-dependent cell-mediated cytotoxicity; AE; adverse events; ALL; acute lymphoblastic leukemia; ALP; alkaline phosphatase; ALT; alanine aminotransferase; AST; aspartate aminotransferase; B-ALL; B-cell acute lymphoblastic leukemia; BiTES; Bi-sp

دانلود رایگان متن کامل مقاله ISI 59 صفحه سال انتشار : 2018 سفارش ترجمه

Regulatory-accepted drug development tools are needed to accelerate innovative CNS disease treatments

Keywords: آژانس دارویی اروپا; ACR; American College of Radiology; AD; Alzheimer disease; ADNI; Alzheimer's Disease Neuroimaging Initiative; ALS; Amyotrophic Lateral Sclerosis; ASD; Autism Spectrum Disorder; BBB; Blood-Brain-Barrier; BEST; Biomarkers, Endpoints and other Tools; BLA; Bi

دانلود رایگان متن کامل مقاله ISI 65 صفحه سال انتشار : 2018 سفارش ترجمه

Finding synergies for 3Rs - Toxicokinetics and read-across: Report from an EPAA partners' Forum

Keywords: آژانس دارویی اروپا; Physiologically-based kinetic (PBK) modelling; Hazard and risk assessment; Weight-of-evidence (WoE); Threshold of toxicological concern (TTC); In vitro to in vivo extrapolation (IVIVE); Integrated approach for testing and assessment (IATA); Absorption; Di

دانلود رایگان متن کامل مقاله ISI 68 صفحه سال انتشار : 2018 سفارش ترجمه

Is a deuterated internal standard appropriate for the reliable determination of olmesartan in human plasma?

Keywords: آژانس دارویی اروپا; CI; confidence interval; EMA; European Medicines Agency; FDA; US Food and Drug Administration; IS; internal standard; LLOQ; lower limit of quantification; OLM; olmesartan; SIL; stable isotopically labelled; Olmesartan; Liquid chromatography/mass spectrome

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Development and validation of an ELISA method for the quantification of nivolumab in plasma from non-small-cell lung cancer patients

Keywords: آژانس دارویی اروپا; ALP; Alkaline Phosphatase; ALT; alanine transaminase; AST; aspartate aminotransferase; BSA; Bovine Serum Albumin; CRP; C-Reactive Protein; CV; Coefficient of Variation; ECOG; Eastern Cooperative Oncology Group; EMA; European Medicines Agency; FDA; Food an

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Evaluation of the virus clearance capacity and robustness of the manufacturing process for the recombinant factor VIII protein, turoctocog alfa

Keywords: آژانس دارویی اروپا; Turoctocog alfa; Manufacture; Virus clearance; rFVIII; Virus safety; Virus clearance evaluation; BEV; Bovine enterovirus; CHO; Chinese hamster ovary; EMA; European Medicines Agency; eMuLV; Ecotropic murine leukaemia virus; FDA; US Food and Drug Administra

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2017 سفارش ترجمه

Evaluation of a primary course of H9N2 vaccine with or without AS03 adjuvant in adults: A phase I/II randomized trial

Keywords: آژانس دارویی اروپا; AE; adverse event; AESI; adverse event of specific interest; AS; adjuvant system; CBER; Center for Biologics Evaluation and Research; CHMP; Committee for Medicinal Products for Human Use; CI; confidence interval; EMA; European Medicines Agency; GMT; geome

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Determination of prodrug treosulfan and its biologically active monoepoxide in rat plasma, liver, lungs, kidneys, muscle, and brain by HPLC-ESI-MS/MS method

Keywords: آژانس دارویی اروپا; CV; coefficient of variation; EMA; European Medicines Agency; ESI; electrospray ionization; HSCT; hematopoietic stem cell transplantation; IS; internal standard; LLOQ; lower limit of quantitation; MF; matrix effect; RID; refractive index detector; r.t.; r

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Detailed analysis of cortisol, cortisone and their tetrahydro- and allo-tetrahydrometabolites in human urine by LC-MS/MS

Keywords: آژانس دارویی اروپا; ACN; acetonitrile; allo-THE; 5α-tetrahydrocortisone, allo-tetrahydrocortisone; alloTHF; 5α-tetrahydrocortisol, allo-tetrahydrocortisol; AME; apparent mineralocorticoid excess; DCM; dichloromethane; E; cortisone; EMA; European Medicines Agency; F; cortis

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Research paperIn-line monitoring of multi-layered film-coating on pellets using Raman spectroscopy by MCR and PLS analyses

Keywords: آژانس دارویی اروپا; PAT; process analytical technology; EMA; European medicines agency; FDA; food and drug administration; ICH; international conference for harmonization of technical requirements for registration of pharmaceuticals for human use; PLS; partial least squares;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Prediction of human percutaneous absorption from in vitro and in vivo animal experiments

Keywords: آژانس دارویی اروپا; PK; pharmacokinetic; Vd; steady-state volume of distribution; CL; total body clearance; OECD; the Organization for Economic Co-operation and Development; FDA; U.S. Food and Drug Administration; EMA; European Medicines Agency; IV; intravenous; LC-MS/MS;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

Genotoxic evaluation of poly(anhydride) nanoparticles in the gastrointestinal tract of mice

Keywords: آژانس دارویی اروپا; ALS; alkali-labile sites; DAPI; 4,6-diamidino-2-phenylindole; DMSO; dimethyl sulfoxide; ECVAM; european centre for the validation of alternative methods; EMA; european medicines agency; EMS; ethyl methanesulfonate; Fpg; formamidopyridine DNA glycosilase;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2017 سفارش ترجمه

In vitro studies to evaluate the wound healing properties of Calendula officinalis extracts

Keywords: آژانس دارویی اروپا; HE; n-hexanic extract; EE; ethanolic extract; AE; aqueous extract; EMSA; electrophoretic mobility shift assay; qRT-PCR; quantitative real-time polymerase chain reaction; EMA; European Medicines Agency; HMPC; Committee on Herbal Medicinal Products; THF; te

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2017 سفارش ترجمه

Hypericum perforatum (St John's wort) beyond depression: A therapeutic perspective for pain conditions

Keywords: آژانس دارویی اروپا; CREB; cyclic AMP response element binding protein; CYP; cytochrome P450; EMA; European Medicines Agency; HMPC; Herbal Medicinal Product Committee; iNOS; inducible nitric-oxide synthase; NO; nitric oxide; NF-kB; nuclear factor-kB; P-gp; P-glycoprotein; PKC

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

Herbal medicinal products in pregnancy − which data are available?

Keywords: آژانس دارویی اروپا; EMA; European Medicines Agency; HMP; herbal medicinal product; HMPC; Committee of Herbal Medicinal Products; HP; herbal preparation; HS; herbal substance; SmPC; summary of product characteristics; THMP; traditional herbal medicinal product; TRAD; traditio

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2017 سفارش ترجمه

In Vitro-In Vivo Extrapolation of Metabolism- and Transporter-Mediated Drug-Drug Interactions-Overview of Basic Prediction Methods

Keywords: آژانس دارویی اروپا; drug interaction; cytochrome P450s; membrane transport/transporters; regulatory; guidance/guideline; ADME; absorption, distribution, metabolism and excretion; BCRP; breast cancer resistance protein; CYP; cytochrome P-450; d; induction calibration factor;

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Intestinal Drug Interactions Mediated by OATPs: A Systematic Review of Preclinical and Clinical Findings

Keywords: آژانس دارویی اروپا; drug interaction; inhibition; transporter; organic anion-transporting polypeptide transporters; intestinal absorption; polymorphism; AUC; area under the plasma concentration-time curve; DDIs; drug-drug interactions; EMA; European Medicines Agency; FDA

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2017 سفارش ترجمه

Inclusion complex of ITH12674 with 2-hydroxypropyl-β-cyclodextrin: Preparation, physical characterization and pharmacological effect

Keywords: آژانس دارویی اروپا; ARE; antioxidant response elements; CD; cyclodextrin; DMSO-d6; deuterated dimethyl sulfoxide; DSC; differential scanning calorimetry; EMA; European Medicines Agency; FBS; fetal bovine serum; FDA; Food and Drug Administration; FT-IR; Fourier transform infr

دانلود رایگان متن کامل مقاله ISI 34 صفحه سال انتشار : 2017 سفارش ترجمه

Perspectives on using a multiplex human kidney safety biomarker panel to detect cisplatin-induced tubular toxicity in male and female Cynomolgus monkeys

Keywords: آژانس دارویی اروپا; AKI; acute kidney injury; ALB; albumin; α1M; alpha 1 microglobulin; αGST; alpha glutathione S-transferase; β2M; beta 2 microglobulin; BUN; blood urea nitrogen; CALB; calbindin D28k; CLU; clusterin; Cr; creatinine; CYS C; cystatin C; DIKI; drug-induced

دانلود رایگان متن کامل مقاله ISI 37 صفحه سال انتشار : 2017 سفارش ترجمه

Antifungal photosensitive activity of Porophyllum obscurum (Spreng.) DC.: Correlation of the chemical composition of the hexane extract with the bioactivity

Keywords: آژانس دارویی اروپا; ACN; acetonitrile; AHP; American Herbal Pharmacopoeia; AMB; Amphotericin B; ANOVA; analysis of Variance; ATCC; American Type Culture Collection; CCC; CEREMIC culture collection; CEREMIC; Centro de Referencia de Micología; CFU; colony-forming units; CLSI;

دانلود رایگان متن کامل مقاله ISI 38 صفحه سال انتشار : 2017 سفارش ترجمه

Andrographolide-loaded nanoparticles for brain delivery: Formulation, characterisation and in vitro permeability using hCMEC/D3 cell line

Keywords: آژانس دارویی اروپا; AG; andrographolide; ATM; adsorptive-mediated transcytosis; BBB; blood-brain barrier; BSA; bovine serum albumin; CNS; central nervous system; DLS; Dynamic Light Scattering; DMSO; dimethyl sulfoxide; ECA; ethylcyanoacrylate; EE; encapsulation efficiency; E

دانلود رایگان متن کامل مقاله ISI 40 صفحه سال انتشار : 2017 سفارش ترجمه

Design, synthesis and biological evaluation of 4-anilinoquinoline derivatives as novel potent tubulin depolymerization agents

Keywords: آژانس دارویی اروپا; Quinoline; Antiproliferative; Microtubules; Depolymerization; Antimitotic; EBI; N, N′-ethylenebis (iodoacetamide); CA-4; combretastatin A-4; FDA; Food and Drug Administration; EMA; European Medicines Agency; DMF; N, N-Dimethylformamide; MTT; 3-(4,5-dime

دانلود رایگان متن کامل مقاله ISI 48 صفحه سال انتشار : 2017 سفارش ترجمه

Targeted pharmacotherapies for defective ABC transporters

Keywords: آژانس دارویی اروپا; 4-PBA; 4-phenylbutyrate; ABC; ATP-Binding Cassette; BRIC2; Benign Recurrent Intrahepatic Cholestasis type 2; BSEP; Bile Salt Export Pump; CF; Cystic Fibrosis; CFTR; Cystic Fibrosis Transmembrane conductance Regulator; CsA; Cyclosporin A; DMSO; DiMethylSul

دانلود رایگان متن کامل مقاله ISI 50 صفحه سال انتشار : 2017 سفارش ترجمه

Patterns of spontaneous reports on narcolepsy following administration of pandemic influenza vaccine; a case series of individual case safety reports in Eudravigilance

Keywords: آژانس دارویی اروپا; ADR; Adverse Drug Reaction; AESI; Adverse Events of Special Interest; BC; Brighton Collaboration; ABC-tool; Automated Brighton Collaboration Case definition tool; EMA; European Medicines Agency; EU/EEA; European Union/European Economic Area; HCP; Health C

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2016 سفارش ترجمه

Physicians prefer greater detail in the biosimilar label (SmPC) - Results of a survey across seven European countries

Keywords: آژانس دارویی اروپا; Regulatory requirements; Biosimilars; Labelling survey; Physician preference; ASBM; Alliance for Safe Biologic Medicines; CHMP; Committee for Medicinal Products for Human Use; EMA; European Medicines Agency; EPAR; European Public Assessment Report; GaBI;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

Simultaneous quantification of PGI2 and TXA2 metabolites in plasma and urine in NO-deficient mice by a novel UHPLC/MS/MS method

Keywords: آژانس دارویی اروپا; PGI2; prostacyclin; TXA2; thromboxane A2; IP; PGI receptor; TP; TX receptor; PLA2; phospholipase A2; PGIS; prostacyclin synthase; TXS; thromboxane A synthase; UHPLC/MS/MS; ultra high-performance liquid chromatography coupled to mass spectrometry; TXB2; th

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2016 سفارش ترجمه

An FDA oncology analysis of immune activating products and first-in-human dose selection

Keywords: آژانس دارویی اروپا; MABEL; Immune oncology; First-in-human dose; ADCC; antibody-dependent cellular cytotoxicity; CRA; cytokine release assay; CRS; cytokine release syndrome; DLT; dose limiting toxicity; EMA; European Medicines Agency; FIH; first-in-human; HHD; highest human

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2016 سفارش ترجمه