DNA methylation and microRNA dysregulation in cancer
Keywords: سرکوبگر تومور; MicroRNA; DNA methylation; Epigenetic silencing; Tumor suppressor
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Sorafenib Down-regulates Expression of HTATIP2 to Promote Invasiveness and Metastasis of Orthotopic Hepatocellular Carcinoma Tumors in Mice
Keywords: سرکوبگر تومور; Tumor Suppressor; Gene Regulation; Tumor Progression; Mouse Model of Liver Cancer; EMT; epithelial-mesenchymal transition; IHM; intrahepatic metastasis; LV; lentiviral vector; PCR; polymerase chain reaction; RFP; red fluorescent protein;
Cdx2 Controls Expression of the Protocadherin Mucdhl, an Inhibitor of Growth and β-Catenin Activity in Colon Cancer Cells
Keywords: سرکوبگر تومور; Tumor Suppressor; cdhr5; Colorectal Cancer; CRC; ChIP; chromatin immunoprecipitation; PLA; proximal ligation assay; qPCR; quantitative polymerase chain reaction; RT; reverse transcription;
Disruption of Trp53 in Livers of Mice Induces Formation of Carcinomas With Bilineal Differentiation
Keywords: سرکوبگر تومور; Liver Cancer; Cancer Stem Cell; Tumor Suppressor; aCGH; array-comparative genomic hybridization; DEN; diethylnitrosamine; LPC; liver progenitor cell;
NIRF/UHRF2 occupies a central position in the cell cycle network and allows coupling with the epigenetic landscape
Keywords: سرکوبگر تومور; CAN gene; candidate cancer gene; CD; cluster of differentiation; CDK; cyclin-dependent kinase; COPA; cancer outlier profile analysis; DNMT; DNA methyltransferase; GRN; gene regulatory network; HDAC; histone deacetylase; H3K9; Histone H3 lysine 9; ICBP90;
Aspirin Inhibits mTOR Signaling, Activates AMP-Activated Protein Kinase, and Induces Autophagy in Colorectal Cancer Cells
Keywords: سرکوبگر تومور; Chemoprevention; Colon Cancer; Oncogene; Tumor Suppressor; ACC; acetyl-CoA carboxylase; ADP; adenosine diphosphate; AMPK; adenosine monophosphate-activated protein kinase; ATP; adenosine triphosphate; CRC; colorectal cancer; eIF4E; eukaryotic translatio
RACK1 Suppresses Gastric Tumorigenesis by Stabilizing the β-Catenin Destruction Complex
Keywords: سرکوبگر تومور; Dvl2; Tumor Suppressor; GNB2L1; Stomach Cancer; Dvl; Dishevelled; LRP; low-density lipoprotein receptor-related protein; MO; morpholino nucleotides; PKC; protein kinase C; RACK1; receptor for activated protein kinase C;
Endoplasmic reticulum protein 29 (ERp29): An emerging role in cancer
Keywords: سرکوبگر تومور; Endoplasmic reticulum protein 29 (ERp29); ER stress; Mesenchymal–epithelial transition; Tumor suppressor; Protein folding; Chaperone
Expression of the Active Notch1 Decreases MTC Tumor Growth In Vivo
Keywords: سرکوبگر تومور; Notch1 pathway; tumor suppressor; medullary thyroid cancer (MTC); chromogranin A; achaete-scute complex-like 1; xenograft model
Knockdown of TFPI-2 promotes migration and invasion of glioma cells
Keywords: سرکوبگر تومور; TFPI-2; tissue factor pathway inhibitor-2; MMP; matrix metallo proteinase; Brain tumor; Tumor suppressor; Tumor microenvironment; ECM degradation; Cell proliferation; MMPs;
Ubiquitin proteasomal pathway mediated degradation of p53 in melanoma
Keywords: سرکوبگر تومور; Skin Cancer; p53; Tumor suppressor; Proteasomal degradation; Ubiquitination; Proteasomal inhibitor MG132
The hallmarks of CDKN1C (p57, KIP2) in cancer
Keywords: سرکوبگر تومور; AML; acute myeloid leukemia; Bcl-2; B-cell lymphoma 2; Bcl-xL; B-cell lymphoma-x long; BCR-ABL; breakpoint cluster region-V-abl Abelson murine leukemia viral oncogene homolog 1; bHLH; basic helix-loop-helix; BWS; Beckwith-Wiedemann Syndrome; CDK; cy
miR-181a shows tumor suppressive effect against oral squamous cell carcinoma cells by downregulating K-ras
Keywords: سرکوبگر تومور; miR-181a; K-ras; Tumor suppressor; Oral cancer
NF-Y transcriptionally regulates the Drosophila p53 gene
Keywords: سرکوبگر تومور; NF-Y, nuclear factor Y; UAS, upstream activating sequence; pnr, pannier; RT-PCR, real-time polymerase chain reaction; EGFP, enhanced green fluorescence proteinCCAAT box; NF-YA; Tumor suppressor; Transcriptional regulation; EGFP
SIRT3 and cancer: Tumor promoter or suppressor?
Keywords: سرکوبگر تومور; NAD+; Nicotinamide adenine dinucleotide; NAM; Nicotinamide; CR; Calorie Restriction; OSCC; Oral Squamous Cell Carcinoma; Sirtuin-3; SIRT3; Cancer; Tumor promoter; Tumor suppressor;
Research ArticleSOCS1 controls liver regeneration by regulating HGF signaling in hepatocytes
Keywords: سرکوبگر تومور; SOCS1; suppressor of cytokine signaling 1; HCC; hepatocellular carcinoma; HGF; hepatocyte growth factor; BrdU; bromodeoxyuridine; PH; partial hepatectomy; Hepatocellular carcinoma; SOCS1; Tumor suppressor; Liver regeneration; HGF; c-Met;
15-Hydroxyprostaglandin dehydrogenase as a novel molecular target for cancer chemoprevention and therapy
Keywords: سرکوبگر تومور; 15-Hydroxyprostaglandin dehydrogenase (15-PGDH); Tumor suppressor; Chemoprevention; Cyclooxygenase-2 (COX-2); Prostaglandin E2 (PGE2)
Liver Kinase B1 (LKB1) in the pathogenesis of epithelial cancers
Keywords: سرکوبگر تومور; LKB1; STK11; Epithelial cancer; Tumor suppressor
MicroRNA-143 functions as a tumor suppressor in human bladder cancer T24 cells
Keywords: سرکوبگر تومور; Bladder cancer; MicroRNA-143; Tumor suppressor; ERK5; AktmRNA, messenger RNA; cDNA, complementary DNA; PCR, polymerase chain reaction; siRNA, small interfering RNA; UTR, untranslated region; RISC, RNA-induced silencing complex; Ago2, Argonaute 2
The Novel Protein Suppressed in Lung Cancer Down-Regulated in Lung Cancer Tissues Retards Cell Proliferation and Inhibits the Oncokinase Aurora-A
Keywords: سرکوبگر تومور; SLAN; KIAA0256; Mitosis; Tumor suppressor; Aurora-A
Transforming growth factor-β and the hallmarks of cancer
Keywords: سرکوبگر تومور; Angiogenesis; Apoptosis; Epithelial–mesenchymal transition; Immunosurveillance; Invasion; Metastasis; Signaling transduction; Tumor suppressor
Ligand stimulation of ErbB4 and a constitutively-active ErbB4 mutant result in different biological responses in human pancreatic tumor cell lines
Keywords: سرکوبگر تومور; ErbB4/HER4; ErbB2/HER2/Neu; Pancreatic cancer; Signal transduction; Tumor suppressor; Oncogene
Original ResearchBasic and Translational-Alimentary TractNeurotensin Signaling Activates MicroRNAs-21 and -155 and Akt, Promotes Tumor Growth in Mice, and Is Increased in Human Colon Tumors
Keywords: سرکوبگر تومور; Neuropeptide; Colorectal Cancer; Signal Transduction; Tumor Suppressor; miRNA; microRNA; mRNA; messenger RNA; NF-κB; Nuclear factor-κB; NT; neurotensin; PCR; polymerase chain reaction; siRNA; small interfering RNA; UTR; untranslated region;
Characterization of DOK1, a candidate tumor suppressor gene, in epithelial ovarian cancer
Keywords: سرکوبگر تومور; Epithelial ovarian cancer; DNA methylation; DOK1; Tumor suppressor; Progression-free survival; DNA microarraysEOC, epithelial ovarian cancer; PFS, progression-free survival; IHC, immunohistochemistry; CT, chemotherapy; IPA, Ingenuity Pathway Analysis; TMA
Mutant Kras Promotes Hyperplasia and Alters Differentiation in the Colon Epithelium but Does Not Expand the Presumptive Stem Cell Pool
Keywords: سرکوبگر تومور; Colon Cancer; Oncogene; Tumor Suppressor; Transgenic Mice; Cdk; cyclin-dependent kinase; CRC; colorectal cancer; EGFP; enhanced green fluorescent protein; ERK; extracellular signal-regulated kinase; EYFP; enhanced yellow fluorescent protein; HPP; hyperpla
Genetic inactivation of Ikaros is a rare event in human T-ALL
Keywords: سرکوبگر تومور; T cell acute lymphoblastic leukemia; Ikaros; Tumor suppressor; Cytoplasmic retention;
RBM5 as a Putative Tumor Suppressor Gene for Lung Cancer
Keywords: سرکوبگر تومور; RBM5; LUCA-15; Apoptosis; Tumor suppressor; Gene expression; Lung cancer
Menin dynamics and functional insight: Take your partners
Keywords: سرکوبگر تومور; Menin; Multiple endocrine neoplasia type 1; Cell cycle; Tumor suppressor
Tumor suppressor, AT motif binding factor 1 (ATBF1), translocates to the nucleus with runt domain transcription factor 3 (RUNX3) in response to TGF-β signal transduction
Keywords: سرکوبگر تومور; AT motif binding factor 1 (ATBF1); Runt domain transcription factor 3 (RUNX3); TGF-β; Tumor suppressor; Transcription factor; Gastric cancer;
The forkhead factor FOXL2: A novel tumor suppressor?
Keywords: سرکوبگر تومور; FOXL2; Cancer; Ovary; Granulosa cell; Tumor suppressor
Scintillation proximity assay for total p53 protein as an alternative to ELISA
Keywords: سرکوبگر تومور; DNA binding; ELISA; p53; SPA; Streptavidin; Tumor suppressor
Solution structure of the N-terminal catalytic domain of human H-REV107 – A novel circular permutated NlpC/P60 domain
Keywords: سرکوبگر تومور; H-REV107; Tumor suppressor; Phospholipase; Lecithin retinol acyltransferase; NMR
p53 codon 72 polymorphism association with head and neck squamous cell carcinoma
Keywords: سرکوبگر تومور; genes; head and neck neoplasms; prognosis; tumor suppressor
The p53 tumor suppressor: A master regulator of diverse cellular processes and therapeutic target in cancer
Keywords: سرکوبگر تومور; p53; Tumor suppressor; Apoptosis; Wrap53; Antisense RNA; PRIMA-1; APR-246; Cancer therapy
Copy number alterations and expression profiles of candidate genes in a pulmonary inflammatory myofibroblastic tumor
Keywords: سرکوبگر تومور; Inflammatory myofibroblastic tumor; Lung neoplasm; Oligoarray-CGH; Copy number alteration; Tumor suppressor; Oncogene;
LMO3 interacts with p53 and inhibits its transcriptional activity
Keywords: سرکوبگر تومور; LMO3; p53; LIM-only protein; Tumor suppressor; Oncogene; Neuroblastoma
CTCF is a DNA methylation-sensitive positive regulator of the INK/ARF locus
Keywords: سرکوبگر تومور; DNA methylation; CTCF; Tumor suppressor; ANRIL; ARF
TAp63 plays compensatory roles in p53-deficient cancer cells under genotoxic stress
Keywords: سرکوبگر تومور; TAp63; Tumor suppressor; Doxorubicin; p53
Tumor suppressor QM-like gene from disk abalone (Haliotis discus discus): Molecular characterization and transcriptional analysis upon immune challenge
Keywords: سرکوبگر تومور; Abalone Haliotis discus discus; Hemocytes; Invertebrate; QM gene; Tumor suppressor
Vers un inventaire des mutations oncogéniques dans les cancers humains
Keywords: سرکوبگر تومور; mutation; oncogène; suppresseur de tumeur; génome; cascades oncogéniques; mutation; oncogene; tumor suppressor; genome; oncogenic cascades;
Identification of LATS transcriptional targets in HeLa cells using whole human genome oligonucleotide microarray
Keywords: سرکوبگر تومور; CTP, cytidine triphospate; LATS, Large Tumor Suppressor; MEFs, mouse embryonic fibroblasts; siRNA, small-interfering RNA; qRT-PCR, quantitative reverse transcriptase polymerase chain reactionLATS1; LATS2; Microarray; Tumor suppressor; Cell proliferation;
Prep1 (pKnox1)-deficiency leads to spontaneous tumor development in mice and accelerates EμMyc lymphomagenesis: A tumor suppressor role for Prep1
Keywords: سرکوبگر تومور; Prep1; Pbx1; Meis1; Tumor suppressor; EmuMyc;
Restoration of leukotriene B4-12-hydroxydehydrogenase/15- oxo-prostaglandin 13-reductase (LTBDH/PGR) expression inhibits lung cancer growth in vitro and in vivo
Keywords: سرکوبگر تومور; Leukotriene B4; Prostaglandin E2; Dehydrogenase; Reductase; Tumor suppressor; Lung cancer; Dithiolethiones
The mitochondrial transcription factor A functions in mitochondrial base excision repair
Keywords: سرکوبگر تومور; TFAM; BER; Tumor suppressor; ROS (reactive oxygen species); 8oxoG; OGG1;
Hippo signaling regulates Yorkie nuclear localization and activity through 14-3-3 dependent and independent mechanisms
Keywords: سرکوبگر تومور; Cell growth; Organ size; Tumor suppressor; Hpo; Yki; Yap; 14-3-3; Nuclear export; Phosphorylation; Kinase;
MicroRNAs: Oncogenes, tumor suppressors or master regulators of cancer heterogeneity?
Keywords: سرکوبگر تومور; microRNA; Cancer; Oncogene; Tumor suppressor; Robustness; Heterogeneity;
Protein lysine acetylation in cellular function and its role in cancer manifestation
Keywords: سرکوبگر تومور; Acetylation; Cancer; Acetyltransferases; Tumor suppressor
Sqd interacts with the Drosophila retinoblastoma tumor suppressor Rbf
Keywords: سرکوبگر تومور; RB; Rbf; Rbf1; Retinoblastoma; Tumor suppressor; Sqd; hnRNP; RNA binding; RNA processing
MicroRNA 125a and its regulation of the p53 tumor suppressor gene
Keywords: سرکوبگر تومور; MicroRNA; p53; RNA interference; Tumor suppressor; Apoptosis; DNA damage;
Epigenetic therapy upregulates the tumor suppressor microRNA-126 and its host gene EGFL7 in human cancer cells
Keywords: سرکوبگر تومور; Epigenetic therapy; DNA methylation; MicroRNA; Cancer; Tumor suppressor