Keywords: توسعه دارویی; drug development; integrative; reductionism; systems biology; target-based approach
مقالات ISI توسعه دارویی (ترجمه نشده)
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در صورتی که به ترجمه آماده هر یک از مقالات زیر نیاز داشته باشید، می توانید سفارش دهید تا مترجمان با تجربه این مجموعه در اسرع وقت آن را برای شما ترجمه نمایند.
STOP the TRAFfic and Reduce the Plaqueâ
Keywords: توسعه دارویی; atherosclerosis; drug development; immunology; inflammation; nanotechnology;
Pharmacoepidemiology in pediatrics: Needs, challenges and future directions for research
Keywords: توسعه دارویی; Pediatrics; Pharmacoepidemiology; Drug development; Challenges;
Are phase I trials safe for older patients?
Keywords: توسعه دارویی; Phase I trial; Cancer; Drug development; Older patients; Toxicity;
Clinical Outcome of Patients with Advanced Biliary Tract Cancer in a Dedicated Phase I Unit
Keywords: توسعه دارویی; Biliary tract cancer; developmental therapeutics; drug development; phase I clinical trial;
Synthetic analogues of the parasitic worm product ES-62 reduce disease development in in vivo models of lung fibrosis
Keywords: توسعه دارویی; ECM; extracellular matrix; PC; phosphorylcholine; SMA; small molecule analogue; Drug development; Fibrosis; ES-62; Immunomodulation; Parasitic worm;
Effect of the bradykinin 1 receptor antagonist SSR240612 after oral administration in Mycobacterium tuberculosis-infected mice
Keywords: توسعه دارویی; Tuberculosis; Drug development; Kinin receptors; SSR240612;
Clinical outcomes of adolescents and young adults with advanced solid tumours participating in phase I trials
Keywords: توسعه دارویی; Adolescents and young adults (AYAs); Advanced solid tumours; Phase I clinical trials; Drug development; Cancer syndromes;
Exploring the prediction of emotional valence and pharmacologic effect across fMRI studies of antidepressants
Keywords: توسعه دارویی; Antidepressant; Emotional valence; Machine learning; Drug development; Predictive analysis; Task-based fMRI;
Building Synergy between Regulatory and HTA Agencies beyond Processes and Procedures-Can We Effectively Align the Evidentiary Requirements? A Survey of Stakeholder Perceptions
Keywords: توسعه دارویی; drug development; early scientific advice; evidence generation; health technology assessment (HTA); HTA-regulatory synergy; review and reimbursement;
Differentiated HASTR/ci35 cells: A promising in vitro human astrocyte model for facilitating CNS drug development studies
Keywords: توسعه دارویی; Astrocytes; Drug development; Immortalized cells; In vitro model; Central nervous system;
Are Pax proteins potential therapeutic targets in kidney disease and cancer?
Keywords: توسعه دارویی; drug development; Pax2; Pax8; polycystic kidney disease; renal cancer; renal epithelia;
Pharmacological inhibition of ALDH1A enzymes suppresses weight gain in a mouse model of diet-induced obesity
Keywords: توسعه دارویی; Retinoids; Enzymes; Energy expenditure; Animal model; Drug development;
Can NO-indomethacin counteract the topical gastric toxicity induced by indomethacin interactions with phospholipid bilayers?
Keywords: توسعه دارویی; Nitric oxide; Nonsteroidal anti-inflammatory drugs; Phospholipids; Liposomes; Drug development;
Challenges in drug discovery targeting TriTryp diseases with an emphasis on leishmaniasis
Keywords: توسعه دارویی; Chemotherapy; Drug development; Leishmania; Public-private partnership; Trypanosomatids;
Challenging transcription by DNA-binding antitumor drugs
Keywords: توسعه دارویی; Cancer therapy; DNA-protein interactions; Drug development; Transcription; Transcription factors;
Characterization and validation of Entamoeba histolytica pantothenate kinase as a novel anti-amebic drug target
Keywords: توسعه دارویی; Entamoeba histolytica; Amebiasis; Coenzyme A; Pantothenate kinase; Gene silencing; Drug development;
In vivo MR in the drug pipeline
Keywords: توسعه دارویی; Drug development; Magnetic resonance; Imaging; Biomarkers; Antivascular therapy;
Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis
Keywords: توسعه دارویی; atherosclerosis; drug development; immunology; inflammation; nanotechnology; Apoe; apolipoprotein E; BMDM; bone marrow-derived macrophage; CVD; cardiovascular disease; DC; dendritic cell; NF-κB; nuclear factor kappa-light-chain-enhancer of activated B ce
Ethnopharmacology and toxicology of Pakistani medicinal plants used to treat gynecological complaints and sexually transmitted infections
Keywords: توسعه دارویی; Women health; Reproductive problems; Pharmacology; Toxicity; Drug development;
Discovery and development of next generation sGC stimulators with diverse multidimensional pharmacology and broad therapeutic potential
Keywords: توسعه دارویی; Nitric oxide; Guanylyl cyclase; Stimulator; Praliciguat; Olinciguat; IWP-051; Drug development; Multidimensional pharmacology; Fibrosis; Inflammation; Metabolism; Vascular function; Neuronal function; Smooth muscle function;
Synthesis and evaluation of 4-cycloheptylphenols as selective Estrogen receptor-β agonists (SERBAs)
Keywords: توسعه دارویی; SERBA; Estrogen receptor agonist; Drug development; Cancer;
Therapeutic targeting of PP2A
Keywords: توسعه دارویی; Protein phosphatase 2A; PP2A; SET; CIP2A; PME-1; LCMT-1; FTY720; OP449; Bortezomib; Erlotinib; Celastrol; ABL-127; SMAPs; Phenothiazines; LB-100; Protein phosphatases; Drug development; Cancer; Cell signaling; Tumor suppressors;
Metabolic/inflammatory/vascular comorbidity in psychiatric disorders; soluble epoxide hydrolase (sEH) as a possible new target
Keywords: توسعه دارویی; Omega-3 fatty acids; Soluble epoxide hydrolase; Lipidomics; Depression; Drug development; ER stress; NLRP3; Inflammasome; Metabolism; Mitochondrial dysfunction; Dementia; Neuroprogression; Neurodegeneration; Obesity; Diabetes; Heart disease; Stroke;
The contribution of DNA microarray technology to gene expression profiling in Leishmania spp.: A retrospective view
Keywords: توسعه دارویی; DNA microarrays; Leishmania; Differential gene expression; Transcriptome; Post-transcriptional regulation; Differentiation; Drug development; Vaccines;
JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice
Keywords: توسعه دارویی; Tumor Microenvironment; Drug Development; Targeted Therapy; Pancreas; AE; anion exchanger; CA; carbonic anhydrase; GPCR; G protein-coupled receptor; GPX; glutathione peroxidase; GSH; glutathione; HCQ; hydroxychloroquine; HMGB1; high mobility group box 1;
In vitro and in vivo experimental models employed in the discovery and development of antiepileptic drugs for pharmacoresistant epilepsy
Keywords: توسعه دارویی; CNS; central nervous system; COX; cyclooxygenase; EEG; electroencephalography; ED50; median effective dose; MAM; methylazoxymethanol; MES; maximal electroshock; MRP; multidrug resistance-associated protein; PTZ; pentylenetetrazole; scPTZ; subcutaneous pen
Original ResearchClinical outcomes and prognostic factors of patients with advanced mesothelioma treated in a phase I clinical trials unit
Keywords: توسعه دارویی; Mesothelioma; Phase 1; Drug development; PI3K; Targeted therapies;
Synthesis and evaluation of analogues of the tuberculosis drug bedaquiline containing heterocyclic B-ring units
Keywords: توسعه دارویی; Bedaquiline; Bedaquiline analogues; Tuberculosis; Drug development; IELUSPZMPMQMCV-IXCJQBJRSA-N; RWCFTLBNENZRDY-XTEPFMGCSA-N; MSXQUXXBKKFYJJ-RPLLCQBOSA-N; WVFOCKMBPLYIFE-RPLLCQBOSA-N; YTFZAFCCTKVTFB-LBNVMWSVSA-N; BQMBVYCTLLIOSP-LEAFIULHSA-N; PPOLZVZOUVMCC
Progress and promise of antisense oligonucleotide therapeutics for central nervous system diseases
Keywords: توسعه دارویی; Antisense oligonucleotides; Drug development; CNS diseases;
Enzastaurin: A lesson in drug development
Keywords: توسعه دارویی; Enzastaurin; Protein kinase C; Drug development;
African Genetic Diversity: Implications for Cytochrome P450-mediated Drug Metabolism and Drug Development
Keywords: توسعه دارویی; Pharmacogenetics; CYP450; Genetic diversity; Drug metabolism; Africa; Drug development;
Recent advances in clinical development of leukotriene B4 pathway drugs
Keywords: توسعه دارویی; Leukotriene; LTB4; BLT1; LTA4 hydrolase; Drug development; Clinical study;
Original ResearchSafety, tolerability and antitumour activity of LY2780301 (p70S6K/AKT inhibitor) in combination with gemcitabine in molecularly selected patients with advanced or metastatic cancer: a phase IB dose escalation study
Keywords: توسعه دارویی; LY2780301; Gemcitabine; PI3K/AKT/mTOR pathway; Dual p70S6K/AKT inhibition; PTEN; Molecular alterations; Phase I; Molecular screening; Drug development;
In vitro screening of the open source Pathogen Box identifies novel compounds with profound activities against Neospora caninum
Keywords: توسعه دارویی; MMV Pathogen Box; Neospora caninum; Drug development; Mitochondrion; Transmission electron microscopy; Neosporosis mouse model; Real time PCR; Cerebral infection;
Prediction of inter-individual variability on the pharmacokinetics of CYP2C8 substrates in human
Keywords: توسعه دارویی; CYP2C8; Inter-individual variability; Monte carlo simulation; Human pharmacokinetics; Drug development;
2017 ACC/AAP/AHA Health Policy Statement on Opportunities and Challenges in Pediatric Drug Development: Learning From Sildenafil
Keywords: توسعه دارویی; Health Policy Statement; drug development; pediatric clinical trials; sildenafil; U.S. Food and Drug Administration;
Ensayos clÃnicos precoces en oncologÃa pediátrica en España: una perspectiva nacional
Keywords: توسعه دارویی; OncologÃa y hematologÃa pediátrica; Ensayos clÃnicos precoces; Desarrollo de nuevos fármacos; Medicina personalizada; Paediatric haematology and oncology; Early phase clinical trials; Drug development; Personalised medicine;
Position PaperSocietal challenges of precision medicine: Bringing order to chaos
Keywords: توسعه دارویی; Biomarkers; Drug development; Precision oncology; Preanalytical and analytical validation; Assay validation; Regulatory sciences;
Quality by design (QbD) approach of pharmacogenomics in drug designing and formulation development for optimization of drug delivery systems
Keywords: توسعه دارویی; Pharmacogenomics; Genetic polymorphism; Genetic markers; Drug development; Drug designing; Drug targets; Bioinformatics; Dosage form evaluation and quality by design;
Novel β-carboline-quinazolinone hybrids disrupt Leishmania donovani redox homeostasis and show promising antileishmanial activity
Keywords: توسعه دارویی; Leishmania donovani; Trypanothione reductase; β-Carboline-quinazolinone hybrid; Atomic Force Microscopy; In-silico docking; Drug development;
Pharmaceutical salt of BM635 with improved bioavailability
Keywords: توسعه دارویی; Tuberculosis; BM635; MmpL3; Pharmaceutical salts; Drug development;
The computational analysis and modelling of substitution effects on hydrolysis of formanilides in acidic aqueous solutions
Keywords: توسعه دارویی; Substituent effect; Amide moiety; Hydrolysis; Drug development;
Preclinical safety evaluation of IQG-607 in rats: Acute and repeated dose toxicity studies
Keywords: توسعه دارویی; Tuberculosis; IQG-607; Drug development; Preclinical toxicology; Rodents;
Toxicological profile of IQG-607 after single and repeated oral administration in minipigs: An essential step towards phase I clinical trial
Keywords: توسعه دارویی; Tuberculosis; IQG-607; Drug development; Preclinical toxicology; Minipig;
Auranofin inactivates Trichomonas vaginalis thioredoxin reductase and is effective against trichomonads in vitro and in vivo
Keywords: توسعه دارویی; Protozoa; Parasite; Antimicrobial therapy; Drug development; Gold compounds; Auranofin;
Antitumor and immunomodulatory activities of thiosemicarbazones and 1,3-Thiazoles in Jurkat and HT-29 cells
Keywords: توسعه دارویی; Drug development; Cancer; Immune system; 1,3-thiazoles; Thiosemicarbazones; Cell death
Nanomedicines for kidney diseases
Keywords: توسعه دارویی; diagnostics; drug development; imaging; nanoparticles; theranostics; therapeutics;
Cardiac troponin I elevation and overall survival among cancer patients receiving investigational compounds during phase I trials
Keywords: توسعه دارویی; Troponin; Cardio oncology; Cardiotoxicity; Phase I trial; Drug development;
Micrococcin P1 - A bactericidal thiopeptide active against Mycobacterium tuberculosis
Keywords: توسعه دارویی; Tuberculosis; Drug development; Translation; Thiopeptides;