دانلود مقالات ISI درباره پیش دارو + ترجمه فارسی

Synthesis and evaluation of N-acylamino acids derivatives of triazenes. Activation by tyrosinase in human melanoma cell lines

Keywords: پیش دارو; Prodrugs; Triazenes; Tyrosinase; Melanoma cells;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and in vitro cytostatic activity of 1,2- and 1,3-diacylglycerophosphates of clofarabine

Keywords: پیش دارو; Clofarabine; Prodrugs; Phosphoramidite approach; 1,2-, 1,3-Diacylglycerophospholipids; Antitumor activity;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Microwave synthesis and in vitro stability of diclofenac-β-cyclodextrin conjugate for colon delivery

Keywords: پیش دارو; Large intestine; Colonic targeting; Microbiota; Fermentation; Prodrugs; Oligosaccharides

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2013 سفارش ترجمه

Amphiphilic polycarbonate conjugates of doxorubicin with pH-sensitive hydrazone linker for controlled release

Keywords: پیش دارو; Polycarbonates; Doxorubicin; Prodrugs; pH-sensitive; Controlled release

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2013 سفارش ترجمه

Transdermal Iontophoretic Delivery of Propofol: A General Anaesthetic in the Form of its Phosphate Salt

Keywords: پیش دارو; Iontophoresis; propofol phosphate; permeation enhancers; prodrugs; pharmacokinetics; NMR spectroscopy;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2013 سفارش ترجمه

Mutual prodrugs containing bio-cleavable and drug releasable disulfide linkers

Keywords: پیش دارو; Prodrugs; Controlled release; Synthesis; Preclinical pharmacokinetics; Stability; Mutual prodrugs; Drug releasable disulfide linkers; Self-immolative bio-cleavable linkers; Sulfhydryl-assisted cleavage; Thiol-assisted cleavage

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Functional characterization and molecular expression of large neutral amino acid transporter (LAT1) in human prostate cancer cells

Keywords: پیش دارو; Tyrosine; LAT1; Cellular uptake mechanism; Prostate cancer; Prodrugs; Drug delivery

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Ozonated oils as functional dermatological matrices: Effects on the wound healing process using SKH1 mice

Keywords: پیش دارو; Wound healing; 1,2,4-Trioxolane moiety; Prodrugs; Vegetable matrices

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

Pharmacokinetics of Vicagrel, a Promising Analog of Clopidogrel, in Rats and Beagle Dogs

Keywords: پیش دارو; vicagrel; clopidogrel; prodrugs; 2-oxo-clopidogrel; drug resistance; active metabolite; pharmacokinetics; polymorphism; drug metabolizing enzymes;

دانلود رایگان متن کامل مقاله ISI 9 صفحه سال انتشار : 2013 سفارش ترجمه

9-[2-(R)-(Phosphonomethoxy)propyl]-2,6-diaminopurine (R)-PMPDAP and its prodrugs: Optimized preparation, including identification of by-products formed, and antiviral evaluation in vitro

Keywords: پیش دارو; PMPDAP; Prodrugs; (Phosphonomethoxy)propyl; Purine; Acyclic nucleoside phosphonates; Antivirals; HIV

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Compartmental Absorption Modeling and Site of Absorption Studies to Determine Feasibility of an Extended-Release Formulation of an HIV-1 Attachment Inhibitor Phosphate Ester Prodrug

Keywords: پیش دارو; dissolution; colonic drug delivery; site-specific absorption; in silico modeling; prodrugs;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Exploiting endobiotic metabolic pathways to target xenobiotic antioxidants to mitochondria

Keywords: پیش دارو; Mitochondria; Antioxidants; Drug targeting; β-oxidation; Prodrugs

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2013 سفارش ترجمه

Prodrugs incorporated into nanotechnology-based drug delivery systems for possible improvement in bioavailability of ocular drugs delivery

Keywords: پیش دارو; Ocular/ophthalmic drug delivery; Prodrugs; Nanocarriers; Penetration; Precorneal retention; Bioavailability

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2013 سفارش ترجمه

Prodrugs: A challenge for the drug development

Keywords: پیش دارو; prodrugs; drugs’ metabolism; blood-brain barrier; ADEPT; GDEPT

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2013 سفارش ترجمه

Synthesis and antiprotozoal activities of benzyl phenyl ether diamidine derivatives

Keywords: پیش دارو; Diamidines; Prodrugs; Benzyl phenyl ether derivatives; Antiprotozoal; Antitrypanosomal; Antiplasmodial; AntileishmanialATMS, artemisinin; BPE, benzyl phenyl ether; CQ, chloroquine; FMD, furamidine; HAT, human African trypanosomiasis; IC50, 50% inhibition

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2013 سفارش ترجمه

Extracellular and intracellular esterase processing of SCFA-hexosamine analogs: Implications for metabolic glycoengineering and drug delivery

Keywords: پیش دارو; FBS; fetal bovine serum; hCE1; human carboxylesterase 1; GalNAc; N-acetyl-d-galactosamine; GlcNAc; N-acetyl-d-glucosamine; ManNAc; N-acetyl-d-mannosamine; SCFA; short chain fatty acids; ManNAc analogs; Metabolic oligosaccharide engineering; Esterase; Prod

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2012 سفارش ترجمه

Comparative canine Pharmacokinetics–Pharmacodynamics of Fospropofol Disodium Injection, Propofol Eemulsion, and Cyclodextrin-Enabled Propofol Solution Following Bolus Parenteral Administration

Keywords: پیش دارو; propofol; pain on injection; cyclodextrin; fospropofol; pharmacodynamics; pharmacokinetics; prodrugs; mathematical model

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Conformational and configurational study of 2-phenyl-4-aryl-1,3,2-dioxaphosphonates derived from xylofuranose derivatives. The anomeric effect in the spontaneous isomerization of cyclic phosphonates

Keywords: پیش دارو; Conformation; Configuration; Anomeric effect; Prodrugs; Phosphonates;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2012 سفارش ترجمه

Liposomes as carriers for colchicine-derived prodrugs: Vascular disrupting nanomedicines with tailorable drug release kinetics

Keywords: پیش دارو; Liposomes; Colchicine; Colchicinoids; Cancer; Prodrugs; Vascular disrupting agents

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Drug Delivery Trends in Clinical Trials and Translational Medicine: Growth in Biologic Molecule Development and Impact on Rheumatoid Arthritis, Crohn's Disease, and Colitis

Keywords: پیش دارو; pharmacokinetics; proteins; biotechnology; macromolecular drug delivery; targeted drug delivery; physicochemical properties; drug interaction; pharmacodynamics; formulation; prodrugs;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

A carbamate-based approach to primaquine prodrugs: Antimalarial activity, chemical stability and enzymatic activation

Keywords: پیش دارو; Malaria; Primaquine; Prodrugs; Carbamates; Chemical stability; Metabolic activation;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

In Vitro and In Vivo Evaluation of a Sulfenamide Prodrug of Basic Metformin

Keywords: پیش دارو; bioavailability; Caco-2 cells; in vitro/in vivo correlations (IVIVC); log P; oral absorption; permeability; prodrugs;

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2012 سفارش ترجمه

Synthesis and antiviral evaluation of bis(POM) prodrugs of (E)-[4′-phosphono-but-2′-en-1′-yl]purine nucleosides

Keywords: پیش دارو; Acyclic nucleoside phosphonate; Prodrugs; Mitsunobu reaction; Antiviral evaluation; VZV; varicella zoster virus; VV; vaccinia virus; HSV; herpes simplex virus; VSV; vesicular stomatitis virus; DNA; deoxyribonucleic acid; RNA; ribonucleic acid; CC50; compo

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Synthesis and biological evaluation of ester prodrugs of benzafibrate as orally active hypolipidemic agents

Keywords: پیش دارو; Benzafibrate; Prodrugs; Hypolipidemic activity; Physicochemical properties; HPLC; high performance liquid chromatography; GC; gas chromatograph; API; active pharmaceutical ingredient; DMAc; dimethylacetamide; Ar; aryl; PPAR-α; peroxisome proliferator-act

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Route of administration determines the anxiolytic activity of the flavonols kaempferol, quercetin and myricetin - are they prodrugs?

Keywords: پیش دارو; Flavonoids; Prodrugs; Intestinal microflora; Gut sterilization; p-Hydroxyphenylacetic acid; DOPAC;

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Hemodynamic Profile in Rabbits of Fospropofol Disodium Injection Relative to Propofol Emulsion Following Rapid Bolus Injection

Keywords: پیش دارو; fospropofol; dose-response; pharmacodynamics; pharmacokinetics; prodrugs; propofol; solubility; tachycardia

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Determination of the Permeability Characteristics of Two Sulfenamide Prodrugs of Linezolid Across Caco-2 Cells

Keywords: پیش دارو; sulfenamides; prodrugs; permeability; Caco-2 cells; bioconversion; stability; MDCK cells

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Synthesis and antiviral activities of hexadecyloxypropyl prodrugs of acyclic nucleoside phosphonates containing guanine or hypoxanthine and a (S)-HPMP or PEE acyclic moiety

Keywords: پیش دارو; Antivirals; Prodrugs; Acyclic nucleoside phosphonate; Phosphonate ester; In vitro evaluation

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2012 سفارش ترجمه

Preparation and biological evaluation of tumor-specific Ara-C liposomal preparations containing RGDV motif

Keywords: پیش دارو; drug delivery systems; drug targeting; liposomes; prodrugs; 1-β-d-arabinofuranosylcytosine (Ara-C); RGD; antitumor;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Physicochemical Characterization of a Prodrug of a Radionuclide Decorporation Agent for Oral Delivery

Keywords: پیش دارو; absorption potential; DTPA; decorporation; oral drug delivery; physicochemical properties; preformulation; prodrugs;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Species Difference of Esterase Expression and Hydrolase Activity in Plasma

Keywords: پیش دارو; metabolism; prodrugs; drug metabolizing enzymes; albumin; enzymology;

دانلود رایگان متن کامل مقاله ISI 10 صفحه سال انتشار : 2012 سفارش ترجمه

Effect of Intestinal First-Pass Hydrolysis on the Oral Bioavailability of an Ester Prodrug of Fexofenadine

Keywords: پیش دارو; absorption; intestinal absorption; bioavailability; intestinal metabolism; pharmacokinetics; prodrugs; oral drug delivery; metabolic clearance; first-pass metabolism; intestinal secretion/transport

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

New retinoid derivatives as back-ups of Adarotene

Keywords: پیش دارو; Adarotene derivatives; Atypical retinoids; Prodrugs;

دانلود رایگان متن کامل مقاله ISI 11 صفحه سال انتشار : 2012 سفارش ترجمه

Redox activation of metal-based prodrugs as a strategy for drug delivery

Keywords: پیش دارو; Prodrugs; Pt anticancer drugs; Ru anticancer drugs; Activation by reduction; Medicinal inorganic chemistry; Nanocarriers

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

N-Succinylaspart-1-yl Celecoxib is a Potential Colon-Specific Prodrug of Celecoxib with Improved Therapeutic Properties

Keywords: پیش دارو; site-specific delivery; colonic drug delivery; prodrugs; oral drug delivery; controlled release/delivery; chemoprevention; celecoxib; familial adenomatous polyposis; cardiovascular toxicity;

دانلود رایگان متن کامل مقاله ISI 12 صفحه سال انتشار : 2012 سفارش ترجمه

Intestinal permeability of lamivudine (3TC) and two novel 3TC prodrugs. Experimental and theoretical analyses

Keywords: پیش دارو; Lamivudine; Intestinal absorption; Prodrugs; P-glycoprotein; Molecular modeling

دانلود رایگان متن کامل مقاله ISI 14 صفحه سال انتشار : 2012 سفارش ترجمه

Transporter-Targeted Lipid Prodrugs of Cyclic Cidofovir: A Potential Approach for the Treatment of Cytomegalovirus Retinitis

Keywords: پیش دارو; transporters; bioavailability; drug transport; HIV/AIDS; lipids; MDCK cells; membrane transport; ophthalmic drug delivery; prodrugs; targeted drug delivery

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Stereoselective Evasion of P-glycoprotein, Cytochrome P450 3A, and Hydrolases by Peptide Prodrug Modification of Saquinavir

Keywords: پیش دارو; prodrugs; structure–activity relationship (SAR); P-glycoprotein; peptide transporters; metabolism; CYP enzymes; stability

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Biomolecular Chemistry of Isopropyl Fibrates

Keywords: پیش دارو; fibrates; polymorph; puckered; surface area; packing energy; drug-like properties; biophysical models; prodrugs; crystal engineering;

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Finding the optimal balance: Challenges of improving conventional cancer chemotherapy using suitable combinations with nano-sized drug delivery systems

Keywords: پیش دارو; Drug delivery; Prodrugs; Drug carrier; Cancer chemotherapy; Combination therapy; Albumin

دانلود رایگان متن کامل مقاله ISI 15 صفحه سال انتشار : 2012 سفارش ترجمه

Clinical impact of serum proteins on drug delivery

Keywords: پیش دارو; Human serum albumin; Transferrin; Drug delivery; Serum proteins; Prodrugs; Drug carrier

دانلود رایگان متن کامل مقاله ISI 17 صفحه سال انتشار : 2012 سفارش ترجمه

Vitamin E TPGS as a molecular biomaterial for drug delivery

Keywords: پیش دارو; Cancer nanotechnology; Biodegradable polymers; Liposomes; Micelles; Nanoparticles; Prodrugs

دانلود رایگان متن کامل مقاله ISI 18 صفحه سال انتشار : 2012 سفارش ترجمه

Impact of albumin on drug delivery — New applications on the horizon

Keywords: پیش دارو; Human serum albumin; Drug carrier; Drug delivery; Prodrugs; Peptides; Antibodies

دانلود رایگان متن کامل مقاله ISI 25 صفحه سال انتشار : 2012 سفارش ترجمه

Reversion of Sulfenamide Prodrugs in the Presence of Free Thiol-Containing Proteins

Keywords: پیش دارو; prodrugs; sulfenamides; bioreversion; thiols; HSA; proteins; stability; metabolism;

دانلود رایگان متن کامل مقاله ISI 5 صفحه سال انتشار : 2011 سفارش ترجمه

Synthesis of phosphates and phosphates-acetates hybrids of green tea polyphenol (−)-epigallocatechine-3-gallate (EGCG) and its G ring deoxy analogs as potential anticancer prodrugs

Keywords: پیش دارو; Green tea polyphenols; Prodrugs; Anticancer; Phosphates; Acetates;

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

Putting bioactivation reactions to work: Targeting antioxidants to mitochondria

Keywords: پیش دارو; DCTH, 5,6-dichloro-4-thia-5-hexenoate; DCVC, S-(1,2-dichlorovinyl)-l-cysteine; MCAD, medium-chain acyl-CoA dehydrogenaseMitochondria; β-Oxidation; Drug targeting; Prodrugs; Antioxidants; Bioactivaton

دانلود رایگان متن کامل مقاله ISI 6 صفحه سال انتشار : 2011 سفارش ترجمه

A series of mononuclear Co(III) complexes using tridentate N,O-donor ligands: Chemical properties and cytotoxicity activity

Keywords: پیش دارو; Cobalt complexes; Hypoxia; Melanoma; Prodrugs; B16F10

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Selective bone targeting 5-fluorouracil prodrugs: Synthesis and preliminary biological evaluation

Keywords: پیش دارو; Bone targeting; 5-Fluorouracil; Asp oligopeptides; Drug release; Prodrugs

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

A novel and efficient one-pot synthesis of symmetrical diamide (bis-amidate) prodrugs of acyclic nucleoside phosphonates and evaluation of their biological activities

Keywords: پیش دارو; Prodrugs; Phosphonodiamides; Bis-amidates; Acyclic nucleoside phosphonates; GS-9219

دانلود رایگان متن کامل مقاله ISI 7 صفحه سال انتشار : 2011 سفارش ترجمه

Poly(D,L-lactide-co-glycolide)/hydroxyapatite core–shell nanosphere. Part 2: Simultaneous release of a drug and a prodrug (clindamycin and clindamycin phosphate)

Keywords: پیش دارو; Controlled release; PLGA/HAp core–shells; Prodrugs; Simultaneous release; Prolonged release

دانلود رایگان متن کامل مقاله ISI 8 صفحه سال انتشار : 2011 سفارش ترجمه