Characterization of sphere-propagating cells with stem-like properties from DU145 prostate cancer cells
Keywords: ژن PTEN; Prostate cancer stem cell; PI3K; AKT; PTEN;
مقالات ISI ژن PTEN (ترجمه نشده)
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Constitutively expressed COX-2 in osteoblasts positively regulates Akt signal transduction via suppression of PTEN activity
Keywords: ژن PTEN; Cyclooxygenase-2; Cyclooxygenase-1; PTEN; Akt; Osteoblast
Tissue and serum biomarkers as prognostic variables in endometrioid-type endometrial cancer
Keywords: ژن PTEN; Endometriod endometrial carcinoma; p53; PTEN; mTOR; Microsatellite instability; β-Catenin; K-ras; Vascular endothelial growth factor; DNA aneuploidy; CA 125
Research ReportNeuroprotective effects of KR-62980, a new PPARγ agonist, against chemical ischemia-reperfusion in SK-N-SH cells
Keywords: ژن PTEN; Chemical ischemia; PPARγ; ROS; PTEN; Rosiglitazone;
Targeting PI3K Signaling as a Therapeutic Approach for Colorectal Cancer
Keywords: ژن PTEN; Colon Cancer; Neoplasm; Signal Transduction; Genetics; Tumor; CRC; colorectal cancer; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; GPCR; G-protein-coupled receptor; IRS1; insulin receptor substrate 1; MEF; murine embryonic fibro
Management of Arteriovenous Malformations
Keywords: ژن PTEN; Arteriovenous malformation; AVM; Capillary malformation; CM-AVM; Embolization; PTEN;
Animal models relevant to human prostate carcinogenesis underlining the critical implication of prostatic stem/progenitor cells
Keywords: ژن PTEN; ADT; androgen deprivation therapy; AI; androgen-independent; ALDH; aldehyde dehydrogenase; AR; androgen receptor; ARR2; two androgen-responsive regions; BM; bone marrow; CXCR4; CXC chemokine receptor 4; CK; cytokeratin; ECM; extracellular matrix; EGFR; ep
Differentiation of the ductal epithelium and smooth muscle in the prostate gland are regulated by the Notch/PTEN-dependent mechanism
Keywords: ژن PTEN; Prostate development; Notch; RBP-J; Epithelium; Smooth muscle; Vimentin; PTEN; p63
Identification of MET and SRC Activation in Melanoma Cell Lines Showing Primary Resistance to PLX4032
Keywords: ژن PTEN; AK; adenylate kinase; AKT; v-akt murine thymoma viral oncogene homolog; ANOVA; analysis of variance; BCRP; breast cancer resistance protein; BRAF; v-raf murine sarcoma viral oncogene homolog B1; CCND1; cyclin D1; CRAF; v-raf-1 murine leukemia viral oncoge
Targeted Therapy for Melanoma: A Primer
Keywords: ژن PTEN; Targeted therapy; BRAF; NRAS; c-KIT; PTEN; GNαQ;
Selected Topics in the Molecular Pathology of Endometrial Carcinoma
Keywords: ژن PTEN; Endometrial cancer; Estrogen; PTEN; Microsatellite instability; Epithelial-to-mesenchymal transition
Persistent Inflammation Leads to Proliferative Neoplasia and Loss of Smooth Muscle Cells in a Prostate Tumor Model
Keywords: ژن PTEN; AR; androgen receptor; IKK2; IκB kinase 2; PTEN; phosphatase and tensin homolog; SMA; smooth muscle actin;
Bone Morphogenetic Protein 4 Induces Differentiation of Colorectal Cancer Stem Cells and Increases Their Response to Chemotherapy in Mice
Keywords: ژن PTEN; Neoplasia; Colon Cancer; Drug Resistance; Tumor Resistance to Chemotherapy; AKT/PKB; AKT/protein kinase B; ALDH; aldehyde dehydrogenase; APC; adenomatous polyposis coli; BMP; bone morphogenetic protein; BMPR; bone morphogenetic protein receptor; CR; color
Protein-intrinsic and signaling network-based sources of resistance to EGFR- and ErbB family-targeted therapies in head and neck cancer
Keywords: ژن PTEN; PLC-γ; PI3K; PTEN; SHC; GRB2; RAS; STAT; IGFR; c-MET
Energy metabolism in adult neural stem cell fate
Keywords: ژن PTEN; ACC; adenylate cyclase complex; AICAR; aminoimidazole carboxamide ribonucleotide; AMPK; AMP-activated protein kinase; Aspm; abnormal spindle-like microcephaly-associated; BDNF; brain-derived neurotrophic factor; bFGF; basic fibroblast growth factor; bHLH;
CD151 Amplifies Signaling by Integrin α6β1 to PI3K and Induces the Epithelial-Mesenchymal Transition in HCC Cells
Keywords: ژن PTEN; Liver Cancer; Tumor Progression; Metastasis; Tumor Invasion; α-SMA; α-smooth muscle actin; Akt; protein kinase B; EMT; epithelial-mesenchymal transition; ERK; extracellular regulated protein kinase; GSK-3; glycogen synthase kinase 3; Ln-5; Laminin 5; MA
Genetic alterations in malignant melanoma
Keywords: ژن PTEN; BRAF; CDKN2A; melanoma; mutations; PTEN; RAS
PTEN-loss and nuclear atypia of EIN in endometrial biopsies can predict the existence of a concurrent endometrial carcinoma
Keywords: ژن PTEN; PTEN; Atypia; EIN
Accumulation of tumor-suppressor PTEN in Alzheimer neurofibrillary tangles
Keywords: ژن PTEN; PTEN; Phosphatase; PI3K; Tau; Neurofibrillary tangles; Alzheimer's disease
PTEN mutations and relationship to EGFR, ERBB2, KRAS, and TP53 mutations in non-small cell lung cancers
Keywords: ژن PTEN; PTEN; EGFR; KRAS; TP53; Non-small cell lung cancer
Juvenile Polyps: Recurrence in Patients With Multiple and Solitary Polyps
Keywords: ژن PTEN; Juvenile Polyp; Juvenile Polyposis Syndrome; Neoplasia; Dysplasia; Hamartomas; Hereditary Hemorrhagic Telangiectasia; Pediatric; Gastrointestinal Bleeding; BMPR1A; bone morphogenetic protein receptor 1A; JPS; juvenile polyposis syndrome; PTEN; phosphatase
Loss of PTEN/MMAC1 activity is a rare and late event in the pathogenesis of nephroblastomas
Keywords: ژن PTEN; PTEN; Nephroblastoma; Nephrogenic rest
TSPYL5 is involved in cell growth and the resistance to radiation in A549 cells via the regulation of p21WAF1/Cip1 and PTEN/AKT pathway
Keywords: ژن PTEN; TSPYL5; γ-Radiation; PTEN; AKT
PTEN/mTOR and axon regeneration
Keywords: ژن PTEN; Pten; mTOR; axon; regeneration; PNS; CNS;
Addiction to protein kinase CK2: A common denominator of diverse cancer cells?
Keywords: ژن PTEN; ALCL; anaplastic large cell lymphoma; ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; CML; chronic myeloid leukemia; MDR; multi-drug resistance; MM; multiple myeloma; NF-kB; nuclear factor-kB; PDK1; 3â²-phosphoinositide-dependent kinase-1
FSH-stimulated PTEN activity accounts for the lack of FSH mitogenic effect in prepubertal rat Sertoli cells
Keywords: ژن PTEN; FSH; PTEN; Cell differentiation (rat testis); Sertoli cells
Suppression of Akt1 phosphorylation by adenoviral transfer of the PTEN gene inhibits hypoxia-induced proliferation of rat pulmonary arterial smooth muscle cells
Keywords: ژن PTEN; Hypoxia; Pulmonary artery; Smooth muscle; Proliferation; PTEN; Akt
MicroRNA-21 (miR-21) represses tumor suppressor PTEN and promotes growth and invasion in non-small cell lung cancer (NSCLC)
Keywords: ژن PTEN; NSCLC, non-small cell lung cancer; PTEN, phosphatase and tensin homologue; miR-21, microRNA-21; miRNAs, microRNAs; qRT-PCR, quantitative reverse transcription polymerase chain reaction; TNM, tumor node metastasis; FBS, fetal bovine serumNSCLC; PTEN; Micro
Deciphering the Role of PI3K/Akt/mTOR Pathway in Breast Cancer Biology and Pathogenesis
Keywords: ژن PTEN; HER2; Mammalian target of rapamycin; Phosphatidylinositol 3-kinase; PTEN
Overexpressed miR-494 down-regulates PTEN gene expression in cells transformed by anti-benzo(a)pyrene-trans-7,8-dihydrodiol-9,10-epoxide
Keywords: ژن PTEN; Anti-BPDE; Cell transformation; MicroRNA; MiR-494; PTEN
Rapamycin inhibits cell proliferation in type I and type II endometrial carcinomas: A search for biomarkers of sensitivity to treatment
Keywords: ژن PTEN; Rapamycin; PTEN; Akt; hTERT; Endometrial carcinoma; mTOR pathway
Cowden syndrome
Keywords: ژن PTEN; Cowden syndrome; Cowden disease; PTEN
The role of the PTEN gene in malignant gliomas
Keywords: ژن PTEN; PTEN; AKT; gliomaPTEN; AKT; glejak
Clinical-Alimentary TractFrequent Gastrointestinal Polyps and Colorectal Adenocarcinomas in a Prospective Series of PTEN Mutation Carriers
Keywords: ژن PTEN; Colorectal Cancer; Cowden Syndrome; Hamartomatous Polyposis; PTEN; CS; Cowden syndrome; GI; gastrointestinal; HPS; hyperplastic polyposis syndrome; ICC; International Cowden Consortium; PTEN; phosphatase and tensin homolog; SIR; standardized incidence rat
Predictive and Prognostic Biomarkers for Targeted Therapy in Metastatic Colorectal Cancer
Keywords: ژن PTEN; Bevacizumab; BRAF; EGFR; IGF-1R; NRAS; PIK3CA; PIP3; PTEN; KRAS; VEGF
Deregulated signalling networks in human brain tumours
Keywords: ژن PTEN; GBM; glioblastoma multiforme; RTK; receptor tyrosine kinase; EGF(R); epidermal growth factor (receptor); PDGF(R); platelet-derived growth factor (receptor); VEGF(R); vascular endothelial growth factor (receptor); ERBB2; v-erb-b2 erythroblastic leukemia vi
Human umbilical cord blood mesenchymal stem cell-derived extracellular matrix prohibits metastatic cancer cell MDA-MB-231 proliferation
Keywords: ژن PTEN; Extracellular matrix; Mesenchymal stem cells; Human umbilical cord blood; Breast cancer; PTEN
Loss of function of PTEN alters the relationship between glucose concentration and cell proliferation, increases glycolysis, and sensitizes cells to 2-deoxyglucose
Keywords: ژن PTEN; Glucose; 2-Deoxyglucose; Glioma; PTEN; Glycolysis
Complicated biallelic inactivation of Pten in radiation-induced mouse thymic lymphomas
Keywords: ژن PTEN; Pten; Thymic lymphoma; Epigenetic silencing; Mutation; Deletion; Radiation
Folic acid consumption reduces resistin level and restores blunted acetylcholine-induced aortic relaxation in obese/diabetic mice
Keywords: ژن PTEN; Folic acid; Relaxation; Acetylcholine; PTEN; eNOS; +db/+db mice
Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in HeLa cells
Keywords: ژن PTEN; Deoxypodophyllotoxin; G2/M arrest; Apoptosis; p53; PTEN
Prognostic value of microsatellite instability (MSI) and PTEN expression in women with endometrial cancer: Results from studies of the NCIC Clinical Trials Group (NCIC CTG)
Keywords: ژن PTEN; Endometrial cancer; MSI; PTEN; Prognostic factor;
Modulation in Activation and Expression of Phosphatase and Tensin Homolog on Chromosome Ten, Akt1, and 3-Phosphoinositide-Dependent Kinase 1: Further Evidence Demonstrating Altered Phosphoinositide 3-Kinase Signaling in Postmortem Brain of Suicide Subject
Keywords: ژن PTEN; Akt; depression; hippocampus; PDK1; prefrontal cortex; PTEN; suicide
The PI3K-Akt-mTOR pathway in initiation and progression of thyroid tumors
Keywords: ژن PTEN; PTEN; Akt; Cowden's syndrome; PIK3CA; Invasion; Anaplastic thyroid cancer; Follicular thyroid cancer
Development of cetuximab-resistant human nasopharyngeal carcinoma cell lines and mechanisms of drug resistance
Keywords: ژن PTEN; Cetuximab; Drug resistance; Nasopharyngeal carcinoma; Ras; IGF-1R; PTEN
Transcriptional regulation of the insulin signaling pathway genes by starvation and 20-hydroxyecdysone in the Bombyx fat body
Keywords: ژن PTEN; InR; IRS; PI3K; PTEN; PDK; Akt; Transcriptional regulation; Starvation; 20-Hydroxyecdysone; Fat body; Bombyx mori
Histologic-Type Specific Role of Cell Cycle Regulators in Non-Small Cell Lung Carcinoma
Keywords: ژن PTEN; cell cycle; non-small cell lung carcinoma; prognosis; p27; Cks1; Skp2; PTEN
Le syndrome de Cowden ou syndrome des hamartomes multiples en endocrinologie clinique
Keywords: ژن PTEN; Cowden syndrome; PTEN; Thyroid cancer; Hamartomatous tumor; PTEN hamartoma tumor syndromes; Hereditary cancerSyndrome de Cowden; PTEN; Cancers thyroïdiens; Hamartomes; Syndromes tumoraux hamartomateux liés àPTEN; Syndrome héréditaire de prédisposition tum
Acquired resistance to cetuximab is mediated by increased PTEN instability and leads cross-resistance to gefitinib in HCC827 NSCLC cells
Keywords: ژن PTEN; Cetuximab; Gefitinib; Acquired resistance; PTEN; Akt
Biomarkers and Patient Selection for PI3K/Akt/mTOR Targeted Therapies: Current Status and Future Directions
Keywords: ژن PTEN; HER2; PI3KCA; PTEN; TSC1; TSC2