Keywords: توده سیاه; Parkinson's disease; Transcranial sonography; Substantia nigra; Disease severity; Chinese
مقالات ISI توده سیاه (ترجمه نشده)
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Keywords: توده سیاه; Stress; Dopamine; Neurodegeneration; Microglia; Oxidative stress; Substantia nigra; Parkinson’s disease
18F-FP-CIT dopamine transporter PET findings in cirrhotic patients with parkinsonism
Keywords: توده سیاه; Parkinson's disease; Liver cirrhosis; Substantia nigra; Striatum; Manganism;
Photobiomodulation reduces gliosis in the basal ganglia of aged mice
Keywords: توده سیاه; Caudate-putamen complex; Substantia nigra; Interneurons; Astrocytes; Microglia;
Tau Deficiency Down-Regulated Transcription Factor Orthodenticle Homeobox 2 Expression in the Dopaminergic Neurons in Ventral Tegmental Area and Caused No Obvious Motor Deficits in Mice
Keywords: توده سیاه; mDANs; midbrain dopaminergic (DA) neurons; OTX2; Orthodenticle homeobox 2; PD; Parkinson's disease; Lmx1b; LIM homeobox transcription factors 1-beta; Pitx3; pituitary homeobox 3; Girk2; G protein-gated inwardly rectifying K+ channel; DAT; dopamine trans
Selegiline increases on time without exacerbation of dyskinesia in 6-hydroxydopamine-lesioned rats displaying l-Dopa-induced wearing-off and abnormal involuntary movements
Keywords: توده سیاه; 6-OHDA; 6-hydroxydopamine; AIMs; abnormal involuntary movements; ALO; axial, forelimb and orolingual; ANOVA; analysis of variance; Arc; activity-regulated cytoskeleton-associated protein; CDS; continuous dopaminergic stimulation; COMT; catechol-O-methyltr
Neurotensin speeds inhibition of dopamine neurons through temporal modulation of GABAA and GABAB receptor-mediated synaptic input
Keywords: توده سیاه; Dopamine; GABA; Neurotensin; Readily releasable pool; Neuropeptide; Substantia nigra; Mouse;
6-Hydroxydopamine induces autophagic flux dysfunction by impairing transcription factor EB activation and lysosomal function in dopaminergic neurons and SH-SY5Y cells
Keywords: توده سیاه; PD; Parkinson's disease; iPSC; induced pluripotent stem cells; 6-OHDA; 6-hydroxydopamine; DAT; dopamine transporter; ROS; reactive oxygen species; TUNEL; terminal deoxynucelotidyl transferase-mediated deoxyuridine triphosphate nick end labeling; CCK-8;
Determination of Imaging Biomarkers to Decipher Disease Trajectories and Differential Diagnosis of Neurodegenerative Diseases (DIsease TreND)
Keywords: توده سیاه; AN; anterior nucleus of thalamus; BD18; Brodmann area 18; BD19; Brodmann area 19; BD23; Brodmann area 23; BD27; Brodmann area 27; BD29; Brodmann area 29; BD30; Brodmann area 30; BD33; Brodmann area 33; CB; caudate body; CL; cerebellar lingual; CoV; culmen
Specific visualization of neuromelanin-iron complex and ferric iron in the human post-mortem substantia nigra using MR relaxometry at 7T
Keywords: توده سیاه; Substantia nigra; Neuromelanin; MR relaxometry; Parkinson's disease;
Activation of the Nrf2 signaling pathway and neuroprotection of nigral dopaminergic neurons by a novel synthetic compound KMS99220
Keywords: توده سیاه; Parkinson's disease; Substantia nigra; Oxidative stress; Protein aggregation; Neuroprotection;
The neuroanatomic complexity of the CRF and DA systems and their interface: What we still don't know
Keywords: توده سیاه; Primate; Rat; Mouse; VTA; Substantia nigra; Retrorubral field; Stress; Extended amygdala;
Substantia nigra fractional anisotropy changes confirm the PD at-risk status of patients with idiopathic smell loss
Keywords: توده سیاه; Idiopathic smell loss; Substantia nigra; Fractional anisotropy; Parkinson's disease;
Histamine H3 Receptors Decrease Dopamine Release in the Ventral Striatum by Reducing the Activity of Striatal Cholinergic Interneurons
Keywords: توده سیاه; aCSF; artificial cerebral spinal fluid; ChAT; choline acetyltransferase; CPM; counts per minute; Ct; cycle number; DTT; dithiothreitol; FACS; fluorescence activated cell sorting; FBS; fetal bovine serum; FSCV; fast-scan cyclic voltammetry; GAPDH; glyceral
Elevated nuclear phosphatase and tensin homolog (PTEN) and altered insulin signaling in substantia nigral region of patients with Parkinson's disease
Keywords: توده سیاه; Parkinson's disease; PTEN nuclear translocation; Insulin signaling; Substantia nigra; Postmortem brain;
Prion-like propagation of α-synuclein in the gut-brain axis
Keywords: توده سیاه; CNS; central nervous system; DA; dopamine; DMV; dorsal motor nucleus of the vagus; ENS; enteric nervous system; GI; gastrointestinal; IL-1; interleukin-1; LBs; Lewy bodies; LPS; lipopolysaccharide; LAG3; lymphocyte-activation gene 3; MPTP; 1-Methyl-4-phen
Analysis of macroautophagy related proteins in G2019S LRRK2 Parkinson's disease brains with Lewy body pathology
Keywords: توده سیاه; AMPK; 5â²AMP-activated protein kinase; LRRK2; Leucine rich repeat kinase; LAMP1; Lysosomal associated membrane protein 1; iPD; idiopathic PD; mTOR; mammalian target of rapamycin; LC3; microtubule-associated protein1A/1B light chain 3; PD; Parkinson's d
AMPA-induced extracellular Zn2+ influx into nigral dopaminergic neurons causes movement disorder in rats
Keywords: توده سیاه; Zinc; Dopaminergic neuron; Substantia nigra; AMPA receptor; Movement disorder; Parkinson's syndrome;
Parkinson's disease related signal change in the nigrosomes 1-5 and the substantia nigra using T2* weighted 7T MRI
Keywords: توده سیاه; Nigrosome; MRI; Parkinson's disease; Substantia Nigra; T2*;
Resveratrol and pinostilbene confer neuroprotection against aging-related deficits through an ERK1/2-dependent mechanism
Keywords: توده سیاه; Resveratrol; Pinostilbene; Striatum; Substantia nigra; Aging; ERK1/2; SH-SY5Y;
MR findings in the substantia nigra on phase difference enhanced imaging in neurodegenerative parkinsonism
Keywords: توده سیاه; Parkinson's disease; Progressive supranuclear palsy; Multiple system atrophy; Phase difference enhanced imaging; Substantia nigra;
Phosphorylated α-Synuclein Accumulations and Lewy Body-like Pathology Distributed in Parkinson's Disease-Related Brain Areas of Aged Rhesus Monkeys Treated with MPTP
Keywords: توده سیاه; CN III; oculomotor nucleus; I.M.; intramuscular injection; LBs; Lewy bodies; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; NHP; non-human primate; OC; occipital cortex; PD; Parkinson's disease; PFC; prefrontal cortex; P-Ser 129 α-syn; phosphoryla
Anatomic & metabolic brain markers of the m.3243A>G mutation: A multi-parametric 7T MRI study
Keywords: توده سیاه; 15-WLT; 15-Words Learning Task; ADL; Activities daily life; ASL; Arterial spin labeling; CBF; Cerebral blood flow; cGM; Cortical gray matter; CSF; Cerebral spinal fluid; CN; Caudate nucleus; CNR; Contrast-to-noise ratio; DN; Dentate nucleus; EPI; Echo pla
Paraquat and MPTP induce alteration in the expression profile of long noncoding RNAs in the substantia nigra of mice: Role of the transcription factor Nrf2
Keywords: توده سیاه; Anti-DIG; antibody against digoxigenin; APES; 3-aminopropyl-triethoxysilane; ARE; antioxidant response element; BSA; bovine serum albumin; CNC; coding-non-coding; Cy3; cyanine dye 3; DA; dopamine; DAPI; 4,6-diamidino-2-phenylindole; DEPC; Diethyl pyrocarb
Resveratrol protects neuronal-like cells expressing mutant Huntingtin from dopamine toxicity by rescuing ATG4-mediated autophagosome formation
Keywords: توده سیاه; Huntington; Parkinson; Dopaminergic neurons; Autophagy; Anti-oxidant; Neurodegeneration; CD; Cathepsin D; DA; dopamine; E2; 17-β-Estradiol; HD; Huntington Disease; Htt; Huntingtin; LIR; LC3-interacting region; PE; PhosphatydilEthanolamin; RV; Resveratrol
Intrastriatal Chromospheres' Transplant Reduces Nociception in Hemiparkinsonian Rats
Keywords: توده سیاه; ANOVA; analysis of variance; AP; anterior-posterior; AUC; against time curves; PD; Parkinson's disease; SNc; substantia nigra; 6-OHDA; 6-hydroxydopamine; TH; tyrosine-hydroxylase; chromospheres; dopamine; Parkinson's disease; cell transplant;
Genetic disruption of the nuclear receptor Nur77 (Nr4a1) in rat reduces dopamine cell loss and l-Dopa-induced dyskinesia in experimental Parkinson's disease
Keywords: توده سیاه; NGFI-B; Nuclear receptor; Transcription factor; Dopamine denervation; Mutant transgenic rat; Knockout mice; Substantia nigra; Striatum;
Triptolide up-regulates metabotropic glutamate receptor 5 to inhibit microglia activation in the lipopolysaccharide-induced model of Parkinson's disease
Keywords: توده سیاه; mGlu; Metabotropic glutamate receptor; PD; Parkinson's disease; T10; Triptolide; LPS; lipopolysaccharide; NO; nitric oxide; iNOS; inducible nitric oxide synthase; TNF; tumor necrosis factor; IL; interleukin; SN; substantia nigra; COX; cyclooxygenase; JN
Substance P and neurotensin in the limbic system: Their roles in reinforcement and memory consolidation
Keywords: توده سیاه; ACh; acetylcholine; BLA; basolateral amygdala; BNST; bed nucleus of stria terminalis; CeA; central nucleus of amygdala; CPU; caudate-putamen; CPP; conditioned place preference; DA; dopamine; dPAG; dorsal part of the periaqueductal gray matter; EPM; elevat
Absence of regulator of G-protein signaling 4 does not protect against dopamine neuron dysfunction and injury in the mouse 6-hydroxydopamine lesion model of Parkinson's disease
Keywords: توده سیاه; RGS4; Parkinson's disease; 6-OHDA; Mouse model; Histopathology; Behavior; Neuroprotection; Target validation; Substantia nigra;
Biomonitorization of iron accumulation in the substantia nigra from Lewy body disease patients
Keywords: توده سیاه; AAS; atomic absorption spectroscopy; AD; AlzheimeÅs disease; LBs; Lewy bodies; LBD; Lewy body disease; PD; ParkinsoÅs disease; SN; substantia nigra; Brain; Iron; AAS; ParkinsoÅs disease; Lewy body disease;
Bilateral upregulation of α-synuclein expression in the mouse substantia nigra by intracranial rotenone treatment
Keywords: توده سیاه; α-synuclein; Tyrosine hydroxylase; Striatum; Substantia nigra; Rotenone; Mouse;
Axonal damage and loss of connectivity in nigrostriatal and mesolimbic dopamine pathways in early Parkinson's disease
Keywords: توده سیاه; SN; substantia nigra; VTA; ventral tegmental area; DPU; dorsal putamen; DCA; dorsal caudate; VST; ventral striatum; SUVr; standardized uptake value ratio; AI; asymmetry index; cAS; clinical asymmetry; Parkinson's disease; Positron emission tomography; Dop
Dopamine D3 receptor-modulated neuroprotective effects of lisuride
Keywords: توده سیاه; 6-hydroxydopamine; Dopamine; D3 receptor; Lisuride; Substantia nigra; 6-OHDA; 6-hydroxydopamine; DAergic; dopaminergic; E; embryonic day; l-DOPA; levodopa; PD; Parkinson's disease; SN; substantia nigra; TEM; transmission electron microscopy; TH; tyrosine
Circadian neurons in the lateral habenula: Clocking motivated behaviors
Keywords: توده سیاه; 5-HT; 5-hydroxytryptamine/serotonin; βCaMKII; βeta calmodulin-dependent protein kinase type II; DA; dopamine; DBS; deep brain stimulation; FR; fasciculus retroflexus; GABA; gamma-aminobutyric acid; GLT-1; glutamate transporter 1; GLUT; glutamate; ipRGC'
An investigation of gene expression in single cells derived from Nestin-expressing cells in the adult mouse midbrain in vivo
Keywords: توده سیاه; Substantia nigra; Parkinson's disease; Dopamine; Adult neurogenesis;
RevisiónEl modelo de 6-hidroxidopamina y la fisiopatologÃa parkinsoniana: nuevos hallazgos en un viejo modeloThe 6-hydroxydopamine model and parkinsonian pathophysiology: Novel findings in an older model
Keywords: توده سیاه; Apoptosis; VÃa nigroestriatal; Neurodegeneración; Substantia nigra; Neuroinflamación; Estrés oxidativo; Apoptosis; Nigrostriatal pathway; Neurodegeneration; Substantia nigra; Neuroinflammation; Oxidative stress;
Research articleNeuroprotective effects of lentivirus-mediated cystathionine-beta-synthase overexpression against 6-OHDA-induced parkinson's disease rats
Keywords: توده سیاه; PD; parkinson's disease; DA; dopaminergic; SN; substantia nigra; H2S; hydrogen sulfide; CBS; cystathionine-beta-synthas; 6-OHDA; 6-Hydroxydopamine; SOD; superoxide dismutase; GSH-Px; glutathione peroxidase; MDA; mlonic dialdehyde; α-SYN; α-synuclein; AO
Parkin deficiency accelerates consequences of mitochondrial DNA deletions and Parkinsonism
Keywords: توده سیاه; PD; Parkinson's disease; mtDNA; mitochondrial DNA; SN; substantia nigra; DA; dopaminergic; TH; tyrosine hydroxylase; HPLC; high performance liquid chromatography; Q-PCR; quantitative polymerase chain reaction; SNC; substantia nigra compacta layer; OCR; ox
Reconsidering the role of glial cells in chronic stress-induced dopaminergic neurons loss within the substantia nigra? Friend or foe?
Keywords: توده سیاه; α-Synuclein; Astrocytes; Chronic stress; Microglia; Neurodegeneration; Oxidative stress; Substantia nigra;
Subcellular expression of aquaporin-4 in substantia nigra of normal and MPTP-treated mice
Keywords: توده سیاه; AQP4; aquaporin-4; DA; dopaminergic; GFAP; glial fibrillary acidic protein; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PD; Parkinson's disease; SN; substantia nigra; SNpc; substantia nigra pars compacta; TH; tyrosine hydroxylase; aquaporin-4; a
Daily consumption of methylene blue reduces attentional deficits and dopamine reduction in a 6-OHDA model of Parkinson's disease
Keywords: توده سیاه; LID; l-dopa-induced dyskinesia; MB; methylene blue; NHS; normal horse serum; PB; phosphate buffer; PBS; phosphate-buffered saline; PD; Parkinson's disease; PFA; paraformaldehyde; SNc; substantia nigra; TH; tyrosine hydroxylase; VTA; ventral tegmental ar
Depressive-like neurochemical and behavioral markers of Parkinson's disease after 6-OHDA administered unilaterally to the rat medial forebrain bundle
Keywords: توده سیاه; APO; apomorphine; DA; dopamine; HIP; hippocampus; 5-HT; serotonin; LC; locus coeruleus; MFB; medial forebrain bundle; NA; noradrenaline; 6-OHDA; 6-hydroxydopamine; PD; Parkinson's disease; PFC; prefrontal cortex; SN; substantia nigra; STR; striatum; Asy
Atypical dopamine transporter inhibitors R-modafinil and JHW 007 differentially affect D2 autoreceptor neurotransmission and the firing rate of midbrain dopamine neurons
Keywords: توده سیاه; Dopamine neuron; Dopamine transporter; Cocaine; D2 autoreceptor; Mouse; Substantia nigra; Ventral tegmental area; Neurotransmission; Firing; DAT; dopamine transporter; DA; dopamine; SNc; substantia nigra pars compacta; VTA; ventral tegmental area; IPSC; i
Chemical exploration of 4-(4-fluorobenzyl)piperidine fragment for the development of new tyrosinase inhibitors
Keywords: توده سیاه; Synthesis; Tyrosinase inhibitors; SARs; Kinetic mechanism; Docking studies; Crystallography; l-DOPA; o-Diphenol 3,4-dihydroxyphenylalanine; SN; Substantia nigra;
Reduced noradrenergic innervation of ventral midbrain dopaminergic cell groups and the subthalamic nucleus in MPTP-treated parkinsonian monkeys
Keywords: توده سیاه; Locus coeruleus; Substantia nigra; Ventral tegmental area; Norepinephrine; Noradrenaline; Parkinson's disease; Ultrastructure; Dopamine beta hydroxylase;
Ultraschall des Mittelhirns
Keywords: توده سیاه; Transkranielle Sonographie; Hirnsonographie; Substantia nigra; Parkinson-Syndrom; Tiefe Hirnstimulation; Transcranial sonography; brain sonography; substantia nigra; Parkinson's disease; deep brain stimulation;
The significance of rotational behavior and sensitivity of striatal dopamine receptors in hemiparkinsonian rats: A comparative study of lactacystin and 6-OHDA
Keywords: توده سیاه; DA; dopamine; DOPAC; dihydroxyphenylacetic acid; HVA; homovanilic acid; MPP+; 1-methyl-4-phenylpyridinium ion; MPTP; 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PD; Parkinson's disease; SN; substantia nigra; SNc; substantia nigra pars compacta; SNr; s
Intrastriatal injection of ionomycin profoundly changes motor response to l-DOPA and its underlying molecular mechanisms
Keywords: توده سیاه; AIMs; abnormal involuntary movement scale; ANOVA; analysis of variance; CPU; striatum; CREB; cAMP response element-binding protein; DARPP32; dopamine- and c-AMP-regulated phosphoprotein of 32Â kDa; DREAM; calcium-binding protein downstream regulatory elem
Early and progressive microstructural brain changes in mice overexpressing human α-Synuclein detected by diffusion kurtosis imaging
Keywords: توده سیاه; MRI; Diffusion kurtosis imaging; Substantia nigra; Striatum; Thalamus; TNWT-61; Parkinson's disease; Transgenic mice; Animal model;