Tracheostomy in Palliative Care
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; Tracheostomy; Palliation; Respiratory failure; Ventilator; ALS; End of life; Aspiration;
مقالات ISI بیماری اسکلروز جانبی آمیوتروفیک (ترجمه نشده)
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Role of APE1 in differentiated neuroblastoma SH-SY5Y cells in response to oxidative stress: Use of APE1 small molecule inhibitors to delineate APE1 functions
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; APE1; human apurinic (apyrimidinic) endonuclease/redox effector factor; WT-APE1; wild type APE1; C65-APE1; repair competent/redox deficient APE1; 177/226-APE1; repair deficient/redox competent APE1; MX; methoxyamine; BQP; 3-[5-(2,3-dimethoxy-6-methyl-1,4-
Enzymatically inactive adenylate kinase 4 interacts with mitochondrial ADP/ATP translocase
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; AK; adenylate kinase; AK4; adenylate kinase 4; NMPK; nucleoside monophosphate kinase; ANT; mitochondrial ADP/ATP translocase; VDAC; voltage dependent anion channel; MPTP; mitochondrial permeability transition pore; shRNA; short hairpin RNA; DAPI; 4â²,6-d
Boosting T-cell immunity as a therapeutic approach for neurodegenerative conditions: The role of innate immunity
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; macrophages; microglia; neurodegeneration; protective autoimmunity; T cells; therapeutic vaccination; ALS; amyotrophic lateral sclerosis; BDNF; brain-derived neurotrophic factor; CNS; central nervous system; GA; glatiramer acetate; MS; multiple sclerosis;
A soluble activin type IIB receptor improves function in a mouse model of amyotrophic lateral sclerosis
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; Myostatin; Activin receptor; SOD1; ALS; Treatment; Muscle
An in vitro screening cascade to identify neuroprotective antioxidants in ALS
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; 5-LOX; 5-lipoxygenase; AAPH; 2,2â²-azobis(2-methylpropionamidine) dihydrochloride; ALS; amyotrophic lateral sclerosis; ARE; antioxidant response element; BBB; blood-brain barrier; CAPE; caffeic acid phenethyl ester; CNS; central nervous system; DCF; di
Increased persistent sodium current determines cortical hyperexcitability in a genetic model of amyotrophic lateral sclerosis
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; Ionic channels; Persistent sodium current; Riluzole; ALS; Patch-clamp
Metabolomics tools for identifying biomarkers for neuropsychiatric diseases
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; MDD; Major Depressive Disorder; CSF; Cerebrospinal fluid; PCA; Principal components analysis; NMR; 1H Nuclear magnetic resonance spectroscopy; LC; Liquid chromatography; GC; Gas chromatography; MS; Mass spectrometry; LC-MS; Liquid chromatography togethe
Metabotropic Glutamate Receptors as Targets for Multipotential Treatment of Neurological Disorders
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; Astrocytes; inflammation; metabotropic glutamate receptors; microglia; neuron; neuroprotection; 4CPG; (S)-4-carboxyphenylglycine; 6-OHDA; 6-hydroxydopamine; Aβ; β-amyloid; AIDA; 1-aminoindan-1, 5-dicarboxylic acid; ALS; amyotrophic lateral sclerosis; AM
CD44 is expressed in non-myelinating Schwann cells of the adult rat, and may play a role in neurodegeneration-induced glial plasticity at the neuromuscular junction
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; CD44; Neuromuscular junction; NMJ; Amyotrophic lateral sclerosis; ALS; Schwann cell; ErbB; Denervation; Reinnervation; Axonal sprouting; Confocal microscopy; Stimulated emission depletion; STED; Fluorescence resonance energy-transfer; FRET;
Axonal ligation induces transient redistribution of TDP-43 in brainstem motor neurons
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; amyotrophic lateral sclerosis (ALS); TAR DNA binding protein 43 (TDP-43); hypoglossal nerve; importin; choline acetyltransferase (ChAT); axonal flow; ALS; amyotrophic lateral sclerosis; ChAT; choline acetyltransferase; DAB; diaminobenzidine; LCM; laser ca
A90V TDP-43 variant results in the aberrant localization of TDP-43 in vitro
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; TDP-43; FTLD-U; ALS; TARDBP mutations; A90V
Low Ca2+ buffering in hypoglossal motoneurons of mutant SOD1 (G93A) mice
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; ALS; Calcium; Buffer; Mitochondria; SOD1; Motoneuron
A prospective multicentre study on sural nerve action potentials in ALS
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; ALS; Sensory nerve action potentials; Neurophysiological examination; Multicentre study
VCP disease associated with myopathy, Paget disease of bone and frontotemporal dementia: Review of a unique disorder
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; Inclusion body; Vacuolar myopathy; ALS; FSH; Alzheimer; TDP-43; Ubiquitin; AAA protein;
ALSFRS-R score and its ratio: A useful predictor for ALS-progression
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; ALS; Predictors; Survival; Disease progression
An epidemiologic investigation of amyotrophic lateral sclerosis in Jefferson County, Missouri, 1998–2002
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; ALS; Prevalence; Capture–recapture; Spatial analysis
Combined lithium and valproate treatment delays disease onset, reduces neurological deficits and prolongs survival in an amyotrophic lateral sclerosis mouse model
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; lithium; valproic acid; GSK-3β; ALS; G93A mice; behavioral deficitsALS, amyotrophic lateral sclerosis; Bcl-2, beta cell lymphoma-2; GSK-3, glycogen synthase kinase-3; HDAC, histone deacetylase; PBS, phosphate-buffered saline; SOD1, superoxide dismutase-1;
Neuron-specific overexpression of the co-chaperone Bcl-2-associated athanogene-1 in superoxide dismutase 1G93A–transgenic mice
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; motoneuron disease; neurodegeneration; ALS; protein folding; aggregopathy; neuroprotectionALS, amyotrophic lateral sclerosis; BAG1, Bcl-2-associated athanogene-1; Bcl-2, B-cell lymphoma 2; Hsp70, heat-shock protein 70; mtSOD1, mutant superoxide dismutase
ALS2/alsin deficiency in neurons leads to mild defects in macropinocytosis and axonal growth
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; ALS2; Alsin; Rab5; Endosome; Motor neuron disease; Macropinocytosis; ALS; Macropinosome; Axon
Outcome and attitudes toward home tracheostomy ventilation of consecutive patients: A 10-year experience
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; ALS, amyotrophic lateral sclerosis; COPD, chronic obstructive pulmonary disease; NIV, non-invasive ventilation; TIPPV, tracheostomy-intermittent positive-pressure ventilationTracheostomy mechanical ventilation; Respiratory failure; Survival; ALS; COPD; Ca
Presymptomatic biochemical changes in hindlimb muscle of G93A human Cu/Zn superoxide dismutase 1 transgenic mouse model of amyotrophic lateral sclerosis
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; Amyotrophic lateral sclerosis; ALS; Cyclin-dependent kinase 5; cdk5; G93A hSOD1; Transgenic mice; Muscle; MyoD; Cyclin D1; Presymptomatic
Detection of resistance to acetohydroxyacid synthase inhibitors in Amaranthus sp. using DNA polymorphisms
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; Restriction fragment length polymorphism; PCR amplification of specific alleles; Herbicide resistance; Acetolactate synthase; ALS; AHAS
An analysis of the entire SOD1 gene in sporadic ALS
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; Amyotrophic lateral sclerosis; ALS; Superoxide dismutase 1; SOD1; Non-coding; Promoter; Introns; Splice sites; Somatic mutation;
GABAA and strychnine-sensitive glycine receptors modulate N-methyl-d-aspartate-evoked acetylcholine release from rat spinal motoneurons: A possible role in neuroprotection
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; primary cultures; ALS; radiolabeled neurotransmitter; calcium channels; NMDA receptor subunit; ACh; acetylcholine; ACM; astrocyte-conditioned medium; ALS; amyotrophic lateral sclerosis; ANOVA; analysis of variance; DMEM; Dulbecco's modified Eagle's medium
Gain of interaction of ALS-linked G93A superoxide dismutase with cytosolic malate dehydrogenase
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; SOD1; ALS; Amyotrophic Lateral Sclerosis; Malate dehydrogenase; Protein interactions; FRET; Neurons
Restricted expression of mutant SOD1 in spinal motor neurons and interneurons induces motor neuron pathology
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; Familial amyotrophic lateral sclerosis; ALS; Mutant Cu/Zn superoxide dismutase type 1 (SOD1); Motor neurons; Degeneration
Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; ASK1; apoptosis signal-regulating kinase 1; Cd; cadmium; CM-H2DCFDA; 5-(and-6)-chloromethyl-2â²,7â²-dichlorodihydrofluorescein diacetate; DAPI; 4â²,6-diamidino-2-phenylindole; DMEM; Dulbecco'
Towards an independent brain–computer interface using steady state visual evoked potentials
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; BCI; BMI; EEG; ALS; Locked in syndrome; SSVEP; Attention; Dependent; Assistive communication
Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; Non-cell autonomous; HSV-TK; GFAP; Ganciclovir; SOD1; ALS; Neuroadapted sindbis virus; Astroglia; Proliferation; Astrogliosis
Inhibition of 6-hydroxydopamine-induced oxidative damage by 4,5-dihydro-3H-2-benzazepine N-oxides
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; PD; Parkinson's disease; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; 6-OHDA; 6-hydroxydopamine; MPTP; N-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PBN; α-phenyl-N-tert-butylnitrone; ROS; reactive oxygen species; OH; hydroxyl radical; LP
Upregulation of cathepsin S in the aging and pathological nervous system of mice
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; ALS; amyotrophic lateral sclerosis; BSt; brainstem; CATB; cathepsin B; CATD; cathepsin D; CATE; cathepsin E; CATL; cathepsin L; CATS; cathepsin S; CATX; cathepsin X; Cor; cortex (cerebral); Cer; cerebellum; GFAP; glial fibrillary acidic protein; Hipp; hip
Receptor mosaics of neural and immune communication: Possible implications for basal ganglia functions
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; Ab; amyloid-beta protein; ABGA; antibasal ganglia antibody; AD; Alzheimer's disease; AGE; advanced glycation endproducts; AIDS; acquired immunodeficiency syndrome; ALS; amyotrophic lateral sclerosis; CA; cornu ammonis; CB; cannabinoid; CD; cluster designa
Intranasal delivery of insulin and a nitric oxide synthase inhibitor in an experimental model of amyotrophic lateral sclerosis
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; amyotrophic lateral sclerosis; insulin; free oxygen radicals; endplate innervation; behavior testing; electrophysiology; ALS; amyotrophic lateral sclerosis; ChAT; choline acetyltransferase; CMAP; compound motor action potential; CREB; cAMP response elemen
Variations in the coding and regulatory sequences of the angiogenin (ANG) gene are not associated to ALS (amyotrophic lateral sclerosis) in the Italian population
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; Angiogenin; ALS; Case–control study; Regulatory region; Polymorphisms; Italian population
Recombinant Human Insulin-Like Growth Factor I (rhIGF-I) and rhIGF-I/rhIGF-Binding-Protein-3: New Growth Treatment Options?
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; ALS; Acid labile subunit; GH; Growth hormone; GHD; GH deficient; GHRD; GH receptor deficient; IGFBP; IGF-binding proteins; IGF-I; Insulin-like growth factor I; rhIGF-I; Recombinant IGF-I; SDS; Standard deviation score; FDA; US Food and Drug Administration
Lack of TDP-43 abnormalities in mutant SOD1 transgenic mice shows disparity with ALS
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; TAR-DNA binding protein; TDP43; ALS; mutant SOD1 transgenic mice
Increased autophagy in transgenic mice with a G93A mutant SOD1 gene
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; Autophagy; LC3; mTOR; Spinal cord; G93A; ALS
Evidence for astrocytosis in ALS demonstrated by [11C](l)-deprenyl-D2 PET
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; Amyotrophic lateral sclerosis; ALS; Motor neuron disease; Astrocytosis; PET; MAO-B; Deprenyl
Assessing the role of immuno-proteasomes in a mouse model of familial ALS
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; ALS; Motor neuron; Spinal cord; Astrocyte; Microglia; Aggregation
The IGF-I splice variant MGF increases progenitor cells in ALS, dystrophic, and normal muscle
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; Muscle stem; Satellite cells; ALS; Muscular dystrophy; Insulin-like growth factor I; Mechano growth factor
Divergent effects of prostaglandin receptor signaling on neuronal survival
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; Prostaglandin; Receptor; Neuroprotection; Organotypic culture; Excitotoxicity; ALS; Lipopolysaccharide; Inflammation
IGF-I, IGFBP-3 and ALS generation test in Turner syndrome
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; Growth hormone; Short stature; Turner syndrome; Generation test; IGF-I; IGFBP-3; ALS
Therapeutic immunization with a glatiramer acetate derivative does not alter survival in G93A and G37R SOD1 mouse models of familial ALS
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; ALS; SOD1; TV-5010; Glatiramer acetate; Immunization; Disease progression
Expression of the exon 9–skipping form of EAAT2 in astrocytes of rats
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; glutamate transporter; EAAT; ALS; white matter; astrocyte; excitotoxicityBSA, bovine serum albumin; EAAT, excitatory amino acid transporter; GFAP, glial fibrillary acidic protein; GLAST, glutamate aspartate transporter; GLT-1, glutamate transporter 1; P,
Statistical MUNE: A comparison of two methods of setting recording windows in healthy subjects and ALS patients
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; Statistical MUNE; Recording window; ALS;
Inhibition of dynein but not kinesin induces aberrant focal accumulation of neurofilaments within axonal neurites
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; Neurofilament; Spheroid; ALS; Dynein; Kinesin; Axonal transport
Cortical activation during motor imagery is reduced in Amyotrophic Lateral Sclerosis
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; ALS; Functional imaging; MRI; Motor imagery
14-3-3 protein binds to the low molecular weight neurofilament (NFL) mRNA 3′ UTR
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; Neurofilament; RNA stability; Motor neuron disease; ALS
Matrix metalloproteinase-9 regulates TNF-α and FasL expression in neuronal, glial cells and its absence extends life in a transgenic mouse model of amyotrophic lateral sclerosis
Keywords: بیماری اسکلروز جانبی آمیوتروفیک; Mutant SOD1; ALS; MMP-9; Motor neuron disease; TNF-α; Fas ligand