Nitric Oxide-Related Drug Targets in Headache
Keywords: توسعه دارویی; Cerebral circulation; drug development; experimental headache; headache; nitroglycerin; pain;
مقالات ISI توسعه دارویی (ترجمه نشده)
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Cdc7 kinase - A new target for drug development
Keywords: توسعه دارویی; Cdc7 kinase; Drug development; Cell cycle; Target;
Preclinical evaluation of anti-HIV microbicide products: New models and biomarkers
Keywords: توسعه دارویی; Microbicide; Antiviral; Drug development; Non-clinical studies; HIV prevention; Pre-exposure prophylaxis
Regulatory aspects of oncology drug safety evaluation: Past practice, current issues, and the challenge of new drugs
Keywords: توسعه دارویی; Cancer; Preclinical; Drug development; Regulation; Lehman
Featured ArticleDeveloping a national strategy to prevent dementia: Leon Thal Symposium 2009
Keywords: توسعه دارویی; Alzheimer's disease; Dementia; Mild cognitive impairment; Prevention; Biomarkers; Diagnosis; Screening; Clinical trials; MCI; Asymptomatic; Risk factors; Registry; Longitudinal studies; Database; PAD2020; Leon Thal Symposium; Treatment; Drug development;
An elastic network model to identify characteristic stress response genes
Keywords: توسعه دارویی; Gene expression; Microarray data; Toxicology prediction; Stress response; Pharmacology; Drug development
Evaluation of policies to support drug development in New Zealand
Keywords: توسعه دارویی; Health policy; Drug development; Pharmaceutical industry
Future Directions in Castrate-Resistant Prostate Cancer Therapy
Keywords: توسعه دارویی; Clinical trials; CRPC; Drug development; Targeted therapy
Phospholipase A2s: Developing drug targets for atherosclerosis
Keywords: توسعه دارویی; Atherosclerosis; Drug development; Phospholipase; Varespladib; Darapladib; Secreted; Lipoprotein-associated
Molecular Approaches to Improving General Anesthetics
Keywords: توسعه دارویی; General anesthesia; Drug development; Drug discovery; Mechanism; Trends; Etomidate; Xenon;
Antihypertensive drug development: current challenges and future opportunities
Keywords: توسعه دارویی; Hypertensive; drug development
Novel phage peptides attenuate beta amyloid-42 catalysed hydrogen peroxide production and associated neurotoxicity
Keywords: توسعه دارویی; Phage display; Peptides; Beta amyloid; Neutralization; Drug development
Clinical development of drugs for epilepsy: A review of approaches in the United States and Europe
Keywords: توسعه دارویی; Epilepsy; Seizure; Antiepileptic drug; Anti-seizure drug; Drug development; FDA; EMEA; Regulation; Drug registration
Novel targeted therapeutics for metastatic castration-resistant prostate cancer
Keywords: توسعه دارویی; Metastatic castration-resistant prostate cancer; Targeted therapies; Immune therapies; Molecular targets; Clinical trials; Drug development
Working with OpusXpress: Methods for high volume oocyte experiments
Keywords: توسعه دارویی; Oocytes; High throughput; Ion channels; Heterologous expression; Drug development;
Specific chemotherapy of Chagas disease: Relevance, current limitations and new approaches
Keywords: توسعه دارویی; Chagas disease; Pathogenesis; Drug development; Posaconazole; Ravuconazole
ReviewInduced pluripotent stem cells: A new era for hepatology
Keywords: توسعه دارویی; Induced pluripotent stem (iPS) cells; Hepatology; Transplantation; Gene therapy; Bio-artificial livers; Drug development;
Neuropharmacology of Sleep and Wakefulness
Keywords: توسعه دارویی; Neurotransmitters; Receptors; Translational research; Drug development;
Assessing cognitive function in clinical trials of schizophrenia
Keywords: توسعه دارویی; Cognition; Neuropsychology; Schizophrenia; Clinical trials; CANTAB; Translational research; MATRICS; CNTRICS; Drug development
The relevance of preclinical research models for the development of antimigraine drugs: Focus on 5-HT1B/1D and CGRP receptors
Keywords: توسعه دارویی; 5-HT1B/1D receptor agonists; CGRP receptor antagonists; Drug development; Meningeal artery; Migraine; Preclinical migraine modelsBBB, blood–brain barrier; BP, blood pressure; BRL 15572, 3-[4-(4-chlorophenyl)piperazin-1-yl]-1,1-diphenyl-2-propanol hydrochl
Progress report on new antiepileptic drugs: A summary of the Tenth Eilat Conference (EILAT X)
Keywords: توسعه دارویی; Antiepileptic drugs; Drug development; Epilepsy; Pharmacology; Clinical trials; Conference
Preparative enzymatic synthesis of trypanothione and trypanothione analogues
Keywords: توسعه دارویی; Trypanothione; Trypanothione synthetase; Trypanothione reductase; Crithidia fasciculata; Glutathionylspermidine; Drug development;
Clinical benefit in oncology trials: Is this a patient-centred or tumour-centred end-point?
Keywords: توسعه دارویی; Clinical trials; Randomised controlled trials; Drug development; Patient outcomes assessment
Application of toxicogenomic tools in the drug research and development process
Keywords: توسعه دارویی; Gene expression; In vitro; In vivo; Toxicity; Drug development; Toxicogenomics
TRAIL as a target in anti-cancer therapy
Keywords: توسعه دارویی; TRAIL; Chemosensitivity; Apoptosis; Drug development
Neuroimaging as a Tool for Pain Diagnosis and Analgesic Development
Keywords: توسعه دارویی; Neuroimaging; pain; analgesia; drug development;
Design of clinical trials for therapeutic cancer vaccines development
Keywords: توسعه دارویی; Cancer vaccine; Whole cell cancer vaccine; Drug development; Clinical trial; Proof-of-principle trial; Efficacy trial; End point
Phase 0 clinical trials: Recommendations from the task force on methodology for the development of innovative cancer therapies
Keywords: توسعه دارویی; Clinical trials; Phase 0; Drug development; Oncology; MDICT
Antimalarial and antitrypanosomal activity of a series of amide and sulfonamide derivatives of a 2,5-diaminobenzophenone
Keywords: توسعه دارویی; Malaria; Sleeping sickness; Plasmodium falciparum; Trypanosoma brucei; Multidrug resistance transporter; Drug development
Developing new molecular imaging probes for PET
Keywords: توسعه دارویی; Positron emission tomography; PET; Molecular imaging; Radiopharmaceutical; Fluorine-18; Carbon-11; Iodine-124; Gallium-68; Copper-64; Drug development
Positron Emission Tomography (PET) and breast cancer in clinical practice
Keywords: توسعه دارویی; Position Emission Tomography (PET); Breast cancer; MRI; Prognosis; Drug development; Response assessment; Residual disease
Bioanalyse en chimie médicinale : de la mise au point d'analyses à la conception évolutive de médicaments
Keywords: توسعه دارویی; Conception des substances actives; Identification des substances actives; Instruments analytiques; Puce; Criblage haut débit; Drug design; Drug development; Instrumental analytics; Chip; High throughput screening;
Tartrate-resistant acid phosphatase (TRACP 5b): A biomarker of bone resorption rate in support of drug development: Modification, validation and application of the BoneTRAP® kit assay
Keywords: توسعه دارویی; TRACP 5b; Bone resorption biomarker; Immunoassay; Method validation; Drug development;
Testing additivity of anticancer agents in pre-clinical studies: A PK/PD modelling approach
Keywords: توسعه دارویی; PK/PD model; Anticancer activity of combination regimens; Tumour growth inhibition model; Xenograft mice; Drug development; Mathematical model; Quantification of combined drug effect; Drug additivity; Drug interaction; Combination studies;
Principles of laboratory assessment of drug abuse liability and implications for clinical development
Keywords: توسعه دارویی; Abuse liability; Clinical trial; Drug abuse; Drug development; Drug discrimination; Self-administration
The development of stroke therapeutics: Promising mechanisms and translational challenges
Keywords: توسعه دارویی; Ischemia; Neuroprotection; Regeneration; Inflammation; Neuroimaging; Translational medicine; Drug development
Method validation of protein biomarkers in support of drug development or clinical diagnosis/prognosis
Keywords: توسعه دارویی; Method validation; Protein biomarkers; Drug development; Clinical diagnosis/prognosis; Ligand binding assay; Mass spectrometric method
Selection of cytotoxicity markers for the screening of new chemical entities in a pharmaceutical context: A preliminary study using a multiplexing approach
Keywords: توسعه دارویی; Cytotoxicity; HepG2 cells; LC50; Multiplexing; Screening; Pharmaceutical compounds; Drug development
The β3-adrenoceptor as a therapeutic target: Current perspectives
Keywords: توسعه دارویی; β3-Adrenoceptors; Therapeutic target; Drug development
From parasite genomes to one healthy world: Are we having fun yet?
Keywords: توسعه دارویی; Parasite; Genome; Drug resistance; Phylogenomics; Host genetics; Drug development
The role of CGRP in the pathophysiology of migraine and efficacy of CGRP receptor antagonists as acute antimigraine drugs
Keywords: توسعه دارویی; Antimigraine drug; CGRP; CGRP receptor antagonists; Drug development; Headache; Migraine; Olcegepant; TelcagepantAM, adrenomedullin; AMY, amylin; BIBN4096BS, (1-piperidinecarboxamide,N-[2-[[5-amino-1-[[4-(4-pyridinyl)-1-piperazinyl]carbonyl]pentyl]amino]-
Animal Models of Sepsis
Keywords: توسعه دارویی; Sepsis; Septic shock; Animal models; Severe sepsis; Drug development;
Progress report on new antiepileptic drugs: A summary of the Ninth Eilat Conference (EILAT IX)
Keywords: توسعه دارویی; Antiepileptic drugs; Drug development; Epilepsy; Pharmacology; Clinical trials; Conference
Loading doses for costly cancer biologicals: A cause for concern or tilting at windmills?
Keywords: توسعه دارویی; Pharmacokinetics; Health economics; Cost-effectiveness; Drug development;
Malaria drug and vaccine trials in Africa: obstacles and opportunities
Keywords: توسعه دارویی; Malaria; Trials; Public–private partnerships; Drug development; Vaccine development; Capacity building; Africa
Integrating systems approaches into pharmaceutical sciences
Keywords: توسعه دارویی; Modelling and simulation; Systems biology; Drug development
FDA perspective on antivirals against biothreats: Communicate early and often
Keywords: توسعه دارویی; Food and Drug Administration (FDA); Highly pathogenic viruses; Antiviral products; Drug development; Clinical trials; Animal Rule; Biothreats; Drugs; Therapeutic biologics
Approaches to the identification of new nonhormonal targets for male contraception
Keywords: توسعه دارویی; Male contraception; Genomics; Proteomics; Microarray; Drug development; Target identification and validation
Évaluation de l’efficacité d’un médicament : de la découverte à la mise sur le marché
Keywords: توسعه دارویی; Drug development; therapeutic evaluation; methodology; new drug authorizationÉvaluation thérapeutique; médicaments; méthodologie; mise sur le marché
Discovery and development of antiviral drugs for biodefense: Experience of a small biotechnology company
Keywords: توسعه دارویی; Antiviral; Drug development; Smallpox; Hemorrhagic fever virus; Category A; Biothreat agents