Phase II study of everolimus in refractory testicular germ cell tumors
Keywords: ژن PTEN; Testicular germ cell tumors; Refractory; Everolimus; mTOR inhibition; PTEN;
مقالات ISI ژن PTEN (ترجمه نشده)
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Enhanced miR-9 promotes laryngocarcinoma cell survival via down-regulating PTEN
Keywords: ژن PTEN; Laryngocarcinoma; PTEN; MiR-9;
Correlations of PTEN genetic polymorphisms with the risk of depression and depressive symptoms in a Chinese population
Keywords: ژن PTEN; SNPs; single nucleotide polymorphisms; PCR-RFLP; polymerase chain reaction-restriction fragment length polymorphism; HAMD; Hamilton Depression; OR; odds ratio; RR; relative risk; WHO; World Health Organization; PTEN; Genetic polymorphisms; Depression; Dep
miR-543 is up-regulated in gefitinib-resistant non-small cell lung cancer and promotes cell proliferation and invasion via phosphatase and tensin homolog
Keywords: ژن PTEN; miR-543; PTEN; NSCLC; Gefitinib;
MiR-454 promotes the progression of human non-small cell lung cancer and directly targets PTEN
Keywords: ژن PTEN; MiR-454; Non-small cell lung cancer; PTEN; Prognosis; Proliferation; Apoptosis
Biological and clinical significance of loss of heterozygosity at the INPP4B gene locus in Japanese breast cancer
Keywords: ژن PTEN; INPP4B; PTEN; Loss of heterozygosity; Breast cancer; Triple-negative breast cancerLOH, loss of heterozygosity; ROH, retention of heterozygosity; INPP4B, Inositol polyphosphate 4-phosphatase type II; PI3K, phosphoinositide 3-kinase; PTEN, phosphatase and t
Odontogenic ameloblast-associated protein (ODAM) inhibits human colorectal cancer growth by promoting PTEN elevation and inactivating PI3K/AKT signaling
Keywords: ژن PTEN; ODAM; PTEN; PI3K/AKT; Colorectal cancer;
Remote ischemic postconditioning protects against renal ischemia/reperfusion injury by activation of T-LAK-cell-originated protein kinase (TOPK)/PTEN/Akt signaling pathway mediated anti-oxidation and anti-inflammation
Keywords: ژن PTEN; Remote ischemic postconditioning; TOPK; PTEN; Akt; NF-κB; Nrf2;
MicroRNA-19a/b mediates grape seed procyanidin extract-induced anti-neoplastic effects against lung cancer
Keywords: ژن PTEN; MiRNA; IGF-2R; PTEN; AKT; Grape seed procyanidin B1 bioavailability
MicroRNAs: New regulators of IL-22
Keywords: ژن PTEN; IL-22; interleukin-22; Th22; T helper 22 cell; Th1; T helper 1 cell; Th17; T helper 17 cell; NK22; natural killer 22; NKT; natural killer T cell; ILCs; innate lymphoid cells; RORγt; retinoid orphan receptor γt; STAT3; signal transducer and activator of
High concentrations of H2O2 trigger hypertrophic cascade and phosphatase and tensin homologue (PTEN) glutathionylation in H9c2 cardiomyocytes
Keywords: ژن PTEN; Cardiomyocytes; Hypertrophy; Hydrogen peroxide; Pten
First application of the Automated QUantitative Analysis (AQUA) technique to quantify PTEN protein expression in ovarian cancer: A correlative study of NCIC CTG OV.16
Keywords: ژن PTEN; OC, epithelial ovarian cancer; PTEN, phosphatase and tensin homolog; AQUA, Automated QUantitative Analysis; RD, residual disease; OS, overall survival; PFS, progression free survival; RR, response rate; HR, hazard ratioBRCA1; PTEN; Ovarian carcinoma; AQUA
Alterations of mTOR and PTEN protein expression in schistosomal squamous cell carcinoma and urothelial carcinoma
Keywords: ژن PTEN; MTOR; PTEN; Urothelial carcinoma; Squamous cell carcinoma
GFRα2 prompts cell growth and chemoresistance through down-regulating tumor suppressor gene PTEN via Mir-17-5p in pancreatic cancer
Keywords: ژن PTEN; GFRα2; PTEN; Mir-17-5p; Chemoresistance; Pancreatic cancer;
Differential effects of inhibitors of the PI3K/mTOR pathway on the expansion and functionality of regulatory T cells
Keywords: ژن PTEN; iTregs; in vitro-induced Tregs; LAP; Latency Associated Peptide; PD-1; programmed death-1; pNET; pancreatic neuroendocrine tumor; PTEN; phosphatase and tensin homolog deleted on chromosome 10; pTregs; peripherally derived Tregs; Tconv; conventional T cell
PTEN Loss as Determined by Clinical-grade Immunohistochemistry Assay Is Associated with Worse Recurrence-free Survival in Prostate Cancer
Keywords: ژن PTEN; Biomarker; ERG; Immunohistochemistry; PTEN; Prostatic carcinoma; Radical prostatectomy;
MAGI-2 in prostate cancer: an immunohistochemical study
Keywords: ژن PTEN; MAGI-2; PTEN; Prostate cancer; Immunohistochemistry; Image analysis;
ERG and PTEN status of isolated high-grade PIN occurring in cystoprostatectomy specimens without invasive prostatic adenocarcinoma
Keywords: ژن PTEN; Prostatic carcinoma; Prostatic intraepithelial neoplasia (PIN); PTEN; ERG; Immunohistochemistry; Radical cystoprostatectomy;
PTEN mRNA detection by chromogenic, RNA in situ technologies: a reliable alternative to PTEN immunohistochemistry
Keywords: ژن PTEN; PTEN; Immunohistochemistry; RNA; Chromogenic ISH; Heterogeneity
Inherited PTEN mutations and the prediction of phenotype
Keywords: ژن PTEN; PTEN; Phosphatase; Tumour suppressor; Mutation; Cancer; Autism spectrum disorder;
Small RNA profiling reveals deregulated phosphatase and tensin homolog (PTEN)/phosphoinositide 3-kinase (PI3K)/Akt pathway in bronchial smooth muscle cells from asthmatic patients
Keywords: ژن PTEN; Small noncoding RNA; asthma; smooth muscle cells; phosphatase and tensin homolog/phosphoinositide 3-kinase/Akt pathway; BSM; Bronchial smooth muscle; FC; Fold change; IPA; Ingenuity Pathway Analysis; miRNA; MicroRNA; piRNA; PIWI-interacting RNA; PTEN; Pho
Liver cancer cells are sensitive to Lanatoside C induced cell death independent of their PTEN status
Keywords: ژن PTEN; Lanatoside C; Oxidative stress; ERK; Akt; PTEN; Hepatocellular carcinoma; HCC; hepatocellular carcinoma; DCFH-DA; dichlorofluorescin diacetate; DMEM; Dulbecco's modification of Eagle's medium; EMT; epithelial mesenchymal transition; JNK; c-Jun N-terminal
SPINK1 expression in relation to PTEN and ERG in matched primary and lymph node metastatic prostate cancer: Implications for biomarker development
Keywords: ژن PTEN; Prostate cancer; Biomarkers; SPINK1; ERG; PTEN; lymph node metastasis; High-risk primary localized prostate cancer;
Oral intake of genetically engineered high-carotenoid corn ameliorates hepatomegaly and hepatic steatosis in PTEN haploinsufficient mice
Keywords: ژن PTEN; Non-alcoholic fatty liver disease (NAFLD); Genetically engineered high-carotenoid corn; PTEN; Retinoic acid;
Nuclear PTEN interferes with binding of Ku70 at double-strand breaks through post-translational poly(ADP-ribosyl)ation
Keywords: ژن PTEN; PTEN; Double-strand breaks; Non-homologous end-joining; Homologous recombination; Ku70; Poly(ADP-ribosyl)ation;
Hydrogen sulfide prevents Abeta-induced neuronal apoptosis by attenuating mitochondrial translocation of PTEN
Keywords: ژن PTEN; AD, Alzheimer’s disease; H(2)S, hydrogen sulfide; Aβ, Abeta; NaHS, sodium hydrosulfide; PTEN, phosphatase and tensin homologs deleted on chromosome 10hydrogen sulfide; apoptosis; PTEN; PI3K; Alzheimer’s disease
The clinical correlation of phosphatase and tensin homolog on chromosome 10, phosphorylation of AKT to an activated state, and odontogenic ameloblast–associated protein in gastrointestinal stromal tumors
Keywords: ژن PTEN; ODAM; PTEN; pAKT; GIST; Gastrointestinal tumors
Regulation of the ErbB network by the MIG6 feedback loop in physiology, tumor suppression and responses to oncogene-targeted therapeutics
Keywords: ژن PTEN; RTK; receptor tyrosine kinase; EGF; epidermal growh factor; EGFR; epidermal growth factor receptor; LRIG1; leucin-rich repeats and immunoglobulin-like domains1; MIG; 6mitogen inducible gene 6; RALT; receptor associated late transducer; ERRFI1; ErbB recept
PTEN alterations of the stromal cells characterise an aggressive subpopulation of pancreatic cancer with enhanced metastatic potential
Keywords: ژن PTEN; Stromal cells; Tumour microenvironment; Pancreatic cancer; PTEN; MicroRNA-21;
Cancer development, chemoresistance, epithelial to mesenchymal transition and stem cells: A snapshot of IL-6 mediated involvement
Keywords: ژن PTEN; Cytokine; IL-6; Cancer stem cell; Chemoresistance and EMT; MAPK; mitogen-activated protein kinases; STAT3; signal transducer and activator of transcription 3; gp130; glycoprotein 130; C/EBP; CCAAT/enhancer-binding protein; JAK; Janus kinase; PI3K; phospho
Kindlin-1 Regulates Keratinocyte Electrotaxis
Keywords: ژن PTEN; EF; electric field; KS; Kindler syndrome; KS_MT; kindlin-1-mCherryW612A point mutation; KS_WT; Kindler syndrome cells infected with wild-type kindlin-1-mCherry; NHK; normal human keratinocyte; PH; pleckstrin homology; PI(3)K; phosphoinositide 3-kinase
PKC-alpha modulation by miR-483-3p in platinum-resistant ovarian carcinoma cells
Keywords: ژن PTEN; API5; apoptosis inhibitor 5; ARF1; ADP ribosylation factor 3; BCA; bicinchoninic acid; BBC3/PUMA; BCL2 binding component 3; BIRC5; baculoviral IAP (inhibitor of apoptosis) repeat containing 5; CDC25A; cell division cycle 25A; CDK4; cyclin-dependent kinase
The role of connexin43-Src interaction in astrocytomas: A molecular puzzle
Keywords: ژن PTEN; Cx43; connexin43; Cx43CT; C-terminal domain of connexin43; GLUT-3; glucose transporter-3; GSC; glioma stem cells; HIF; hypoxia-inducible factor; HK2; type II hexokinase; IDP; intrinsically disordered protein; IDR; intrinsically disordered region; MAPK; mi
Potential of aqueous extract of saffron (Crocus sativus L.) in blocking the oxidative stress by modulation of signal transduction in human vascular endothelial cells
Keywords: ژن PTEN; Inflammation; Oxidative stress; micro-RNA; AKT1; PTEN; Saffron; Crocin (PubChem CID: 5281233); 2,2-Azobis (2-amidinopropane) dihydrochloride (AAPH) (PubChem CID: 84924); Tert-butylhydroperoxide (TBHP) (PubChem CID: 8033); 2,2-Diphenyl-1-(2,4,6-trinitrophe
Co-targeting hexokinase 2-mediated Warburg effect and ULK1-dependent autophagy suppresses tumor growth of PTEN- and TP53-deficiency-driven castration-resistant prostate cancer
Keywords: ژن PTEN; Warburg effect; Autophagy; PTEN; TP53; Hexokinase 2; AMPK; ULK-1; MCL-1; 2-Deoxy-glucose; Chloroquine; Androgen receptor; Castration-resistant prostate cancer; Genetically-engineered mouse model
Original ArticleEnhanced growth inhibition of prostate cancer in vitro and in vivo by a recombinant adenovirus-mediated dual-aptamer modified drug delivery system
Keywords: ژن PTEN; Dual aptamer; Recombinant adenovirus; Doxorubicin; Targeted drug delivery system; Antitumor activity and toxicity; ADDP-Ad5; A10-3.2(DOX)/DUP-1-PEG-Ad5; PTEN; phosphatase and tensin homolog; DOX; doxorubicin; PEG; polyethylene glycol; PSMA; prostate-speci
Intracellular Ca2+ signaling and Ca2+ microdomains in the control of cell survival, apoptosis and autophagy
Keywords: ژن PTEN; Apoptosis; Autophagy; Endoplasmic reticulum; IP3 receptor; Lysosomes; Mitochondria; AMBRA1; autophagy/Beclin 1 regulator 1; AMPK; AMP-activated kinase; ATF4; activating transcription factor-4; Atg; autophagy-related; BIRD-2; Bcl-2/IP3R disruptor-2; CREB;
Effects of the multikinase inhibitors Sorafenib and Regorafenib in PTEN deficient neoplasias
Keywords: ژن PTEN; PTEN; Carcinoma; Multikinase inhibitor; Sorafenib; Regorafenib;
Regulation of connexins by the ubiquitin system: Implications for intercellular communication and cancer
Keywords: ژن PTEN; AMSH; associated molecule with the SH3 domain of STAM (signal transducing adaptor molecule); ATP; adenosine triphosphate; cAMP; cyclic adenosine monophosphate; CIP75; Cx43-interacting protein of 75 kD; CIP85; Cx43-interacting protein of 85 kDa; Cx; connex
FGFR and PTEN signaling interact during lens development to regulate cell survival
Keywords: ژن PTEN; Lens; FGF Receptor; PTEN; Differentiation; Survival
Molecular cloning and characterization of PTEN in the orange-spotted grouper (Epinephelus coioides)
Keywords: ژن PTEN; Epinephelus coioides; PTEN; Gene expression; Vibrio alginolyticus;
PTEN Loss in E-Cadherin-Deficient Mouse Mammary Epithelial Cells Rescues Apoptosis and Results in Development of Classical Invasive Lobular Carcinoma
Keywords: ژن PTEN; breast cancer; classical invasive lobular carcinoma; genetically engineered mouse model; Cre-lox; E-cadherin; PTEN; metastasis; tumor microenvironment; BEZ235
LncRNA FER1L4 suppresses cancer cell proliferation and cycle by regulating PTEN expression in endometrial carcinoma
Keywords: ژن PTEN; Endometrial carcinoma; Cell proliferation; Cell cycle; FER1L4; PTEN;
PTEN is required to maintain luminal epithelial homeostasis and integrity in the adult mammary gland
Keywords: ژن PTEN; Epithelial; Homeostasis; Mammary; PTEN;
Long non-coding RNA TUG1 acts as a miR-26a sponge in human glioma cells
Keywords: ژن PTEN; Glioma; TUG1; miR-26a sponge; PTEN;
Up-regulation of genes involved in the insulin signalling pathway (IGF1, PTEN and IGFBP1) in the endometrium may link polycystic ovarian syndrome and endometrial cancer
Keywords: ژن PTEN; Endometrial cancer; IGF1; IGFBP1; PCOS; PTEN;
IL-1β/NF-kb signaling promotes colorectal cancer cell growth through miR-181a/PTEN axis
Keywords: ژن PTEN; IL-1β; NF-κB; miR-181a; PTEN; Colorectal caner;
Nuclear factor-κB-dependent microRNA-130a upregulation promotes cervical cancer cell growth by targeting phosphatase and tensin homolog
Keywords: ژن PTEN; NF-κB; Cervical cancer; miR-130a; PTEN; AKT; Tumorigenesis;
Polymerase delta-interacting protein 2 regulates collagen accumulation via activation of the Akt/mTOR pathway in vascular smooth muscle cells
Keywords: ژن PTEN; Akt; protein kinase B; Atg; autophagy-related gene; ECM; extracellular matrix; 4E-BP1; eukaryotic initiation factor 4E binding protein 1; eIF4E; eukaryotic translation initiation factor 4E; Hsc70; heat shock cognate protein 70; LC3B; microtubule-associate
MiR-200a acts as an oncogene in colorectal carcinoma by targeting PTEN
Keywords: ژن PTEN; Colorectal cancer; miR-200a; PTEN; In situ hybridization; Immunohistochemistry;