CpG-ODNs induces up-regulated expression of chemokine CCL9 in mouse macrophages and microglia
Keywords: بتا آمیلوئید; Microglia; Macrophage; CCL9; CCR1; Amyloid beta; CpG-ODNs; TLR9
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Real-time observation of model membrane dynamics induced by Alzheimer's amyloid beta
Keywords: بتا آمیلوئید; Amyloid beta; Alzheimer's; Aggregation species; Membrane transformation; Membrane fluctuation;
Activation of phospholipase A2 by 1-palmitoyl-2-(9'-oxo-nonanoyl)-sn-glycero-3-phosphocholine in vitro
Keywords: بتا آمیلوئید; Aβ; amyloid beta; C28-OPHPM; 1-octosanyl-2-(pyren-1-yl)hexanoyl-sn-glycero-3-phosphatidylmonomethyl ester; CMC; critical micelle concentration; CD; circular dichroism; DPPC; 1,2-dipalmitoyl-sn-glycero-3-phosphocholine; EDTA; ethylenediaminetetraacetic ac
Amelioration of the Alzheimer's Disease Phenotype by Absence of 12/15-Lipoxygenase
Keywords: بتا آمیلوئید; Alzheimer's disease; amyloid beta; lipoxygenase; transgenic animal models
Preclinical Alzheimer disease: Brain oxidative stress, Aβ peptide and proteomics
Keywords: بتا آمیلوئید; Preclinical Alzheimer; Oxidative stress; Amyloid beta; Proteomics; Brain; Inferior parietal lobule (IPL)
Stabilization of transcription factor Nrf2 by tBHQ prevents oxidative stress-induced amyloid β formation in NT2N neurons
Keywords: بتا آمیلوئید; Alzheimer's disease; Amyloid beta; Nrf2; NT2N neurons; tBHQAD, Alzheimer's disease; AREs, Antioxidant response elements; Nrf2, Nuclear factor-erythroid 2 related factor 2; Keap1, Kelch-like ECH-associated protein 1; tBHQ, tert-Butylhydroquinone; γ-GCS, γ-
Role of amyloid beta in lipid homeostasis
Keywords: بتا آمیلوئید; Alzheimer's disease; Lipids; Amyloid beta; Sphingolipid; Secretase; Ganglioside; Cholesterol; Raft; Sphingomyelinase; SMase; 3-Hydroxy-3-methylglutaryl CoA; HMGCR
l-theanine protects the APP (Swedish mutation) transgenic SH-SY5Y cell against glutamate-induced excitotoxicity via inhibition of the NMDA receptor pathway
Keywords: بتا آمیلوئید; Alzheimer's disease; amyloid beta; l-theanine; calcium; nitric oxide; neuroprotectionAβ, amyloid beta; AD, Alzheimer's disease; DAF-FM DA, 3-amino,4-aminomethyl-2′,7′-difluorescein, diacetate; DMSO, dimethyl sulfoxide; EGTA, (−)-epigallocatechingallate; i
Multiple neurotrophic effects of VEGF on cultured neurons
Keywords: بتا آمیلوئید; PEDF; Amyloid beta; Apoptosis; Survival; p38 MAP kinase; Bcl-2; Caspase 3
Plasminogen and plasmin in Alzheimer's disease
Keywords: بتا آمیلوئید; Plasminogen; Plasmin; Alzheimer's disease; Amyloid beta
Linear and conformation specific antibodies in aged beagles after prolonged vaccination with aggregated Abeta
Keywords: بتا آمیلوئید; Alzheimer's disease; Immunotherapy; Amyloid beta; Large animal model; Aged beagles; Conformational antibodies;
Aggregation and cytotoxic properties towards cultured cerebrovascular cells of Dutch-mutated Aβ40 (DAβ1-40) are modulated by sulfate moieties of heparin
Keywords: بتا آمیلوئید; Alzheimer's disease; Amyloid beta; Heparan sulfate proteoglycans; Glycosaminoglycans; Cerebrovascular cells
Alginate protects NT2 neurons against H2O2-induced neurotoxicity
Keywords: بتا آمیلوئید; Alginate; Alzheimer’s disease; Amyloid beta; Nrf2; NT2 neurons
Mitochondria: The calcium connection
Keywords: بتا آمیلوئید; Aβ; amyloid beta; ÎΨm; inner mitochondrial membrane potential; APP; amyloid precursor protein; BRET; bioluminescence resonance energy transfer; [Ca2+]c; cytosolic Ca2+ concentration; [Ca2+]ER; endoplasmic reticulum Ca2+ concentration; [Ca2+]m; mitochon
Amyloid precursor protein mediates monocyte adhesion in AD tissue and apoE−/− mice
Keywords: بتا آمیلوئید; Alzheimer’s disease; Amyloid beta; Cardiovascular; Endothelial; Vascular; Adhesion
Peripheral T cells derived from Alzheimer's disease patients overexpress CXCR2 contributing to its transendothelial migration, which is microglial TNF-α-dependent
Keywords: بتا آمیلوئید; Alzheimer's disease; Amyloid beta; T cell; CXCR2; IL-8; TNF-α; Microglia; Blood–brain barrier; Brain endothelial cells
Surface plasmon resonance biosensors for detection of Alzheimer disease biomarker
Keywords: بتا آمیلوئید; Alzheimer disease; 17β-HSD10; Amyloid beta; SPR sensor
Bridging the gap: From protein misfolding to protein misfolding diseases
Keywords: بتا آمیلوئید; SDS-PAGE; sodium dodecyl sulfate-polyacrylamide gel electrophoresis; AD; Alzheimer's Disease; Aβ; Amyloid Beta; APP; Amyloid Precursor Protein; AFM; Atomic Force Microscopy; TCCD; Two Colour Coincidence Detection; QCM; Quartz Crystal Microbalance;
Pregnenolone protects the PC-12 cell line against amyloid beta peptide toxicity but its sulfate ester does not
Keywords: بتا آمیلوئید; Pregnenolone; Pregnenolone sulfate; Amyloid beta; Neurotoxicity; Alzheimer’s disease; Neurosteroid
Enrichment and analysis of Alzheimer's Aβ1-42 peptide in human plasma and whole blood
Keywords: بتا آمیلوئید; Amyloid beta; Solid-phase extraction; HPLC; ELISA;
A capillary electrophoresis method for evaluation of Aβ proteolysis in vitro
Keywords: بتا آمیلوئید; Alzheimer’s disease; Amyloid beta; Insulin-degrading enzyme; Capillary electrophoresis
Oligomeric aggregates of amyloid β peptide 1–42 activate ERK/MAPK in SH-SY5Y cells via the α7 nicotinic receptor
Keywords: بتا آمیلوئید; Amyloid beta; SH-SY5Y cells; ERK/MAPK; α7 nicotinic receptor; Atomic force microscopy; Oligomeric amyloid; Fibrillar amyloid
Amyloid beta, mitochondrial structural and functional dynamics in Alzheimer's disease
Keywords: بتا آمیلوئید; Amyloid precursor protein; Amyloid beta; Mitochondria; Alzheimer's disease
Perspectives in designing anti aggregation agents as Alzheimer disease drugs
Keywords: بتا آمیلوئید; Anti aggregation agents; Amyloid beta; Alzheimer disease; Self assemblage tendency
Protection against β-amyloid induced abnormal synaptic function and cell death by Ginkgolide J
Keywords: بتا آمیلوئید; Gingko biloba; Long-term potentiation; Amyloid beta; Cell death
Alzheimer's-associated Aβ oligomers show altered structure, immunoreactivity and synaptotoxicity with low doses of oleocanthal
Keywords: بتا آمیلوئید; AD, Alzheimer's disease; ADDLs, Aβ-derived diffusible ligands; oAβs, oligomeric Aβ; OC, oleocanthal; Aβ-OC, ADDLs formed in the presence of OC; ADDL+OC, preformed ADDLs treated with OCAlzheimer's disease; Amyloid beta; Oligomer; Olive oil; Synapse
Amyloid β induces cellular relocalization and production of agrin and glypican-1
Keywords: بتا آمیلوئید; Alzheimer's disease; Amyloid beta; Heparan sulfate proteoglycan; Agrin; Glypican-1; Human brain pericyte
Acute and chronic effects of intravitreally injected β-amyloid on the neurotransmitter system in the retina
Keywords: بتا آمیلوئید; Alzheimer's disease; Neurotransmitter systems; Amyloid beta; Choline acetyltransferase (ChAT); Gamma-aminobutyric acid (GABA) and 5-tryptamine hydroxylase systems (5 TryptH);
Structural optimization of a CXCR2-directed antagonist that indirectly inhibits γ-secretase and reduces Aβ
Keywords: بتا آمیلوئید; Alzheimer’s disease; Secretase; CXCR2; Amyloid beta
Plasma biomarkers for mild cognitive impairment and Alzheimer's disease
Keywords: بتا آمیلوئید; Mild cognitive impairment; Alzheimer's disease; Proteomics; Amyloid beta; Plasma; Biomarker
Aβ peptide conformation determines uptake and interleukin-1α expression by primary microglial cells
Keywords: بتا آمیلوئید; Microglia; Phagocytosis; IL-1α; Amyloid beta; Oligomer; Alzheimer's disease
A highly insoluble state of Aβ similar to that of Alzheimer's disease brain is found in Arctic APP transgenic mice
Keywords: بتا آمیلوئید; Immunotherapy; Solubility; ABeta-peptide; Alzheimer's disease; Amyloid beta; Transgenic
Featured ArticleDefining and labeling disease-modifying treatments for Alzheimer's disease
Keywords: بتا آمیلوئید; Alzheimer's disease; Treatment; Disease-modification; Neuroprotection; Amyloid beta; Tau; Biomarker; Primary prevention; Clinical trial;
Gene expression profile of the PDAPP mouse model for Alzheimer's disease with and without Apolipoprotein E
Keywords: بتا آمیلوئید; Alzheimer's disease; Amyloid beta; Apolipoprotein E; Transgenic mice; Microarray analysis; Gene expression profiling
Detection of Alzheimer’s amyloid beta aggregation by capturing molecular trails of individual assemblies
Keywords: بتا آمیلوئید; Alzheimer’s disease (AD); Amyloid beta; Aggregation; Oligomerisation; Molecular trails; Hydrodynamic radius (RH); Brownian motion; Fluorescence microscopy
Beta-site amyloid precursor protein-cleaving enzyme-1 (BACE1)-mediated changes of endogenous amyloid beta in wild-type and transgenic mice in vivo
Keywords: بتا آمیلوئید; Abeta; amyloid beta; AD; Alzheimer's disease; APP; amyloid precursor protein; BACE1; beta-site amyloid precursor protein-cleaving enzyme-1; Alzheimer's disease; Amyloid beta; Beta-site amyloid precursor protein (APP)-cleaving enzyme-1 (BACE1); Non-transge
Amyloid beta toxicity dependent upon endothelial cell state
Keywords: بتا آمیلوئید; Amyloid beta; Endothelium repair; Alzheimer's; Cerebral amyloid angiopathy
Diagnostic utility of APOE, soluble CD40, CD40L, and Aβ1–40 levels in plasma in Alzheimer’s disease
Keywords: بتا آمیلوئید; CD40; Alzheimer; ApoE; Amyloid beta; Diagnostic
α-Synuclein enhances secretion and toxicity of amyloid beta peptides in PC12 cells
Keywords: بتا آمیلوئید; α-Synuclein; Amyloid beta; PC12 cells; Nitric oxide; Programmed cell death
Phosphatidylinositol-3-kinase activation blocks amyloid beta-induced neurotoxicity
Keywords: بتا آمیلوئید; Amyloid beta; Phosphatidylinositol-3-kinase; Neurotoxicity; Alzheimer's dementia
Amyloid-beta-induced neurotoxicity is reduced by inhibition of glycogen synthase kinase-3
Keywords: بتا آمیلوئید; Amyloid beta; Glycogen synthase kinase-3; Neurotoxicity; Alzheimer's dementia
PPARγ Agonists as Therapeutics for the Treatment of Alzheimer's Disease
Keywords: بتا آمیلوئید; Peroxisome proliferator-activated receptor gamma; thiazolidinedione; Alzheimer's disease; amyloid beta; inflammation; apolipoprotein E;
Alzheimer's disease protein Aβ1–42 does not disrupt isolated synaptic vesicles
Keywords: بتا آمیلوئید; Amyloid beta; Synaptic vesicle; Alzheimer's disease; Total internal reflection fluorescence; Integrity; Leakage
Multitracer PET imaging of amyloid plaques and neurofibrillary tangles in Alzheimer's disease
Keywords: بتا آمیلوئید; Alzheimer; Amyloid beta; Tau; Neuropathology; Pet; Imaging
Hypometabolism and Altered Cerebrospinal Fluid Markers in Normal Apolipoprotein E E4 Carriers with Subjective Memory Complaints
Keywords: بتا آمیلوئید; Alzheimer’s disease; amyloid beta; ApoE; CSF; FDG-PET; isoprostane; normal aging; subjective memory complaints; tau
Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model
Keywords: بتا آمیلوئید; Alzheimer's disease; Transgenic mice; Amyloid beta; Beta-secretase; Neprilysin; Gender difference; Oligomer; Tau; Hyperphosphorylation
Aβ inhibits the proteasome and enhances amyloid and tau accumulation
Keywords: بتا آمیلوئید; Proteasome; Alzheimer's disease; Amyloid beta; Tau; Transgenic; Oliogmers; Immunotherapy
The normal equilibrium between CSF and plasma amyloid beta levels is disrupted in Alzheimer's disease
Keywords: بتا آمیلوئید; Alzheimer's disease; Mild cognitive impairment (MCI); Cerebrospinal fluid; Case control studies; Amyloid beta; APOE
Anti-amyloidogenic activity of S-allyl-l-cysteine and its activity to destabilize Alzheimer's β-amyloid fibrils in vitro
Keywords: بتا آمیلوئید; Amyloid beta; Aggregation; S-Allyl-l-cysteine
Acute inhibition of calcineurin restores associative learning and memory in Tg2576 APP transgenic mice
Keywords: بتا آمیلوئید; Amyloid beta; Calcineurin; Tg2576 mice; Fear conditioning; Behavior; FK506; SY5Y cells