Ubiquitination-proteasome system: A new player in the pathogenesis of psoriasis and clinical implications
Keywords: پروتئازوم; Ubiquitination; Proteasome; Psoriasis; Treatment;
مقالات ISI پروتئازوم (ترجمه نشده)
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Nrf1 is paved as a new strategic avenue to prevent and treat cancer, neurodegenerative and other diseases
Keywords: پروتئازوم; Nrf1; Drug; Cancer; Neurodegenerative; Proteasome; Chemoprevention; Therapy;
K48-linked polyubiquitination of dengue virus NS1 protein inhibits its interaction with the viral partner NS4B
Keywords: پروتئازوم; Dengue virus; NS1; NS4B; Ubiquitination; K48-linked polyubiquitin; Deubiquitinase; Proteasome;
Pharmacophore-based virtual screening for identifying β5 subunit inhibitor of 20S proteasome
Keywords: پروتئازوم; MM-PBSA; Molecular docking; Molecular dynamics simulation; Pharmacophore model; Proteasome; Virtual screening;
Progress curve analysis of the kinetics of slow-binding anticancer drug inhibitors of the 20S proteasome
Keywords: پروتئازوم; Bortezomib; Proteasome; Carfilzomib; Slow-binding; Ixazomib; Inhibitor; EDTA; ethylenediaminetetraacetic acid; HEPES; 4-(2-hydroxyethyl)piperazine-1-ethanesulfonic acid; Suc-LLVY-AMC; N-succinyl-Leu-Leu-Val-Tyr-7-amino-4-methylcoumarin; λEx and λEm; exc
Mutant Muscle LIM Protein C58G causes cardiomyopathy through protein depletion
Keywords: پروتئازوم; Hypertrophic cardiomyopathy; MLP C58G mutation; Mouse knock-in model; In vivo phenotyping; RNAseq transcriptome analysis; Protein depletion; Proteasome; Sarcomere;
AGE-albumin enhances ABCA1 degradation by ubiquitin-proteasome and lysosomal pathways in macrophages
Keywords: پروتئازوم; Advanced glycation end products; ABCA1; Atherosclerosis; Macrophages; Proteasome; Lysosome;
The deubiquitinase inhibitor b-AP15 induces strong proteotoxic stress and mitochondrial damage
Keywords: پروتئازوم; Proteasome; Deubiquitinase; VCP/p97 ATPase; Bis-benzylidine piperidones; Mitochondria;
Targeting ubiquitin-proteasome pathway by natural, in particular polyphenols, anticancer agents: Lessons learned from clinical trials
Keywords: پروتئازوم; Ubiquitin; Proteasome; Anti-cancer agents; Polyphenols; Ubiquitin-proteasome pathway; Oncoproteins; Enzymatic modulator; Cancer;
Co-inhibition of BET and proteasome enhances ER stress and Bim-dependent apoptosis with augmented cancer therapeutic efficacy
Keywords: پروتئازوم; BET; Proteasome; Apoptosis; Bim; Cancer;
Role of p53 circuitry in tumorigenesis: A brief review
Keywords: پروتئازوم; p53; miRNA; Mdm2; Pirh2; COP1; Ubiquitin; Proteasome; Modulators; Pharmacophore;
Mechanisms controlling the multistage post-translational processing of endogenous Nrf1α/TCF11 proteins to yield distinct isoforms within the coupled positive and negative feedback circuits
Keywords: پروتئازوم; Nrf1; DDI-1/2; p97; Proteoform; Proteasome; Post-Translational Modification; Proteolysis; ER Stress; Hrd1; BTZ; bortezomib; CNC; cap 'n' collar; CHX; cycloheximide; DDI-1; DNA-damage inducible protein homolog 1; Epox; expoxomicin; ER; endoplasmic reticulu
Development of a peptide-based inducer of protein degradation targeting NOTCH1
Keywords: پروتئازوم; Transcriptional factor; NOTCH1; Protein knockdown; Ubiquitin; Proteasome;
Identification of UBact, a ubiquitin-like protein, along with other homologous components of a conjugation system and the proteasome in different gram-negative bacteria
Keywords: پروتئازوم; UBact; Ubiquitin; Pup; Proteasome; Bacteria; Dop; Deamidase of Pup; Mpa; mycobacterial proteasome ATPase; PafA; Proteasome accessory factor A; PPS; Pup-proteasome system; PrcA; proteasome subunit α; PrcB; proteasome subunit β; Pup; prokaryotic ubiquitin
Molecular mechanisms of UVB-induced senescence of dermal fibroblasts and its relevance for photoaging of the human skin
Keywords: پروتئازوم; UVB; Skin aging; Fibroblasts; Photoaging; Autophagy; Proteasome;
Molecular chaperones of the Hsp70 family assist in the assembly of 20S proteasomes
Keywords: پروتئازوم; Proteasome; Protein assembly; Molecular chaperone; Yeast; Heat shock protein; Hsp70; CP; core particle; RP; regulatory particle; UPS; ubiquitin-proteasome system; MCN; molecular chaperone network; ICAR; immobilized-cobalt affinity resin;
Assembly of proteasome subunits into non-canonical complexes in vivo
Keywords: پروتئازوم; Proteasome; Assembly; Yeast; Protein complex; Native PAGE; CP; core particle; HMWC; high molecular weight complex; RP; regulatory particle; ICAR; immobilized-cobalt affinity resin;
Disulfiram is a slow-binding partial noncompetitive inhibitor of 20S proteasome activity
Keywords: پروتئازوم; Disulfiram; Proteasome; Diethyldithiocarbamate; Slow-binding; Noncompetitive;
Crucial role of ATP-bound Sse1 in Upf1-dependent degradation of the truncated product
Keywords: پروتئازوم; Nonsense-mediated decay; Hsp70/Sse1 complex; Ubiquitination; Proteasome;
RPS27a enhances EBV-encoded LMP1-mediated proliferation and invasion by stabilizing of LMP1
Keywords: پروتئازوم; EBV; LMP1; RPS27a; Proteasome; Ubiquitination;
Cleavage of the Interleukin-11 receptor induces processing of its C-terminal fragments by the gamma-secretase and the proteasome
Keywords: پروتئازوم; Interleukin-11; Interleukin-11 receptor; Proteolysis; Proteasome; Gamma-secretase;
A comparative analysis between proteasome and immunoproteasome inhibition in cellular and humoral alloimmunity
Keywords: پروتئازوم; Proteasome; Immunoproteasome; Cellular alloimmunity; Humoral alloimmunity; Transplantation;
Immature human DCs efficiently translocate endocytosed antigens into the cytosol for proteasomal processing
Keywords: پروتئازوم; Ag; antigen; Apaf-1; apoptotic protease-activating factor 1; APC; antigen presenting cell; CD; cluster of differentiation; DC; dendritic cell; GM-CSF; granulocyte-macrophage colony-stimulating factor; HLA; human leukocyte antigen; iDC; immature dendritic
Redox regulation of proteasome function
Keywords: پروتئازوم; Abcd1; ATP binding cassette subfamily D member 1; AD; Alzheimer's disease; ALD; adrenoleukodystrophy; ALS; amyotrophic lateral sclerosis; AP-1; activator protein-1; APP; amyloid precursor protein; CNS; central nervous system; DDI; DNA-damage inducible 1;
Lead discovery and chemical biology approaches targeting the ubiquitin proteasome system
Keywords: پروتئازوم; Proteasome; Protein degradation; Molecular glue; Drug discovery; High-throughput; Ubiquitin;
Potential peptidic proteasome inhibitors by incorporation of an electrophilic trap based on amino acid derived α-substituted sulfonyl fluorides
Keywords: پروتئازوم; Drug design; Peptido sulfonyl fluoride; Proteasome; Sulfonyl fluoride warhead; α-Substituted sulfonyl fluoride;
Roles for the VCP co-factors Npl4 and Ufd1 in neuronal function in Drosophila melanogaster
Keywords: پروتئازوم; Proteasome; TDP-43 accumulation; Neurodegeneration; Drosophila; ALS; amyotrophic lateral sclerosis; IBMPDF; inclusion body myopathy with Paget's disease of the bone and frontotemporal dementia; NMJ; neuromuscular junction; Npl4; nuclear protein localizati
A dual role for the RhoGEF Ephexin5 in regulation of dendritic spine outgrowth
Keywords: پروتئازوم; Dendritic spine; Ephexin5; Activity-dependent; Hippocampus; Structural plasticity; Proteasome;
Proteasome inhibitors to alleviate aberrant IKBKAP mRNA splicing and low IKAP/hELP1 synthesis in familial dysautonomia
Keywords: پروتئازوم; Familial dysautonomia; Proteasome; Carfilzomib; IKBKAP; mRNA splicing; MicroRNA;
Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
Keywords: پروتئازوم; α-SYN; alpha synuclein; β-TrCP; β-transducin repeat containing E3 ubiquitin protein ligase; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AMPK; AMP-activated protein kinase; ARE; antioxidant response element; ASK1; apo
Bortezomib induces neuropathic pain through protein kinase C-mediated activation of presynaptic NMDA receptors in the spinal cord
Keywords: پروتئازوم; Synaptic plasticity; NMDA receptor; Synaptic transmission; Proteasome; Neuropathic pain; Spinal cord; NMDA; N-methyl-d-aspartate; NMDAR; NMDA receptor; EPSCs; excitatory postsynaptic currents; mEPSCs; miniature excitatory postsynaptic currents; PKC; prote
Signaling Pathways Relevant to Nerve Growth Factor-induced Upregulation of Transient Receptor Potential M8 Expression
Keywords: پروتئازوم; 4-OHT; 4-hydroxytamoxifen; ANOVA; analysis of variance; DAG; diacylglycerol; DMSO; dimethyl sulfoxide; DRG; dorsal root ganglion; EmGFP; Emerald green fluorescent protein; HEPES; 4-(2-hydroxyethyl)-1-piperazineethanesulfonic acid; IP3; inositol 1,4,5-tris
A misannotated locus positively influencing Arabidopsis seed germination is deconvoluted using multiple methods, including surrogate splicing
Keywords: پروتئازوم; (bps); base pairs; (FBPs); F-BOX PROTEINS; (nts); nucleotides; (RT-PCR); reverse transcription-polymerase chain reaction; (WT); wild type; Activation tagging; F-Box; Germination; Proteasome; Seed; Surrogate splicing;
ReviewWhat have we learned on aging from omics studies?
Keywords: پروتئازوم; Aging; Genomics; Proteomics; Transcriptomics; Killifish; Nothobranchius furzeri; Pathways; Protein complex; Stoichiometry; Data integration; Proteostasis; Ribosome; Proteasome; Lysosome; RNAseq; Mitochondria;
The two Dictyostelium discoideum autophagy 8 proteins have distinct autophagic functions
Keywords: پروتئازوم; Dictyostelium discoideum; Autophagy; ATG8/LC3/GABARAP; Ubiquitin; Proteasome;
Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting
Keywords: پروتئازوم; Ubiquitin; Proteasome; Protein degradation; Lysosome; ODC; ornitihine decarboxylase; G6PD; glucose-6-phosphate dehydrogenase; PEPCK; phosphoenol-pyruvate carboxykinase; TAT; tyrosine aminotransferase; APF-1; ATP-dependent Proteolysis Factor 1 (ubiquitin);
Synthesis and antiproteasomal activity of novel O-benzyl salicylamide-based inhibitors built from leucine and phenylalanine
Keywords: پروتئازوم; Proteasome; Inhibitor; Apoptosis; Ubiquitin; Salicylamide;
Genetic interferonopathies: An overview
Keywords: پروتئازوم; Interferonopathies; Aicardi-Goutières syndrome; Proteasome; CANDLE; SAVI;
E6AP inhibits G-CSFR turnover and functions by promoting its ubiquitin-dependent proteasome degradation
Keywords: پروتئازوم; Ubiquitin ligase; Ubiquitination; Proteasome; Cell differentiation; G-CSFR;
4-Hydroxynonenal (HNE) modified proteins in metabolic diseases
Keywords: پروتئازوم; AcLDL; Acetylated low density lipoprotein; AD; Alzheimer's disease; ADH; Alcohol dehydrogenase; ADP; Adenine dinucleotide; ADPRT; ADP ribosyl-transferase; ALDH; Aldehyde dehydrogenase; Arg; Arginine; ATPase; ATP synthase; CYP2E1; P450 cytochrome 2E1; Cys;
Identification of 4-arylidene curcumin analogues as novel proteasome inhibitors for potential anticancer agents targeting 19S regulatory particle associated deubiquitinase
Keywords: پروتئازوم; 26S; proteasome; RP; regulatory particle; CP; proteolytic core particle; DUBs,; deubiquitinating enzymes; Ub-AMC; ubiquitin 7-amido-4-methylcoumarin; TNFα; tumor necrosis factor α; ER; endoplasmic reticulum; NF-κB; nuclear factor κB; IκB; inhibitor o
How to control an intracellular proteolytic system: Coordinated regulatory switches in the mycobacterial Pup-proteasome system
Keywords: پروتئازوم; Dop; PafA; Proteasome; Proteolysis; Pup;
Regulated proteolysis as an element of ER stress and autophagy: Implications for intestinal inflammation
Keywords: پروتئازوم; Autophagy; Inflammatory bowel disease; Er stress; Cell death; Proteolysis; Proteasome; Necroptosis;
Drosophila Argonaute2 turnover is regulated by the ubiquitin proteasome pathway
Keywords: پروتئازوم; Argonaute; RNAi; Protein stability; Ubiquitin; Proteasome;
Proteasomes in corneal epithelial cells and cultured autologous oral mucosal epithelial cell sheet (CAOMECS) graft used for the ocular surface regeneration
Keywords: پروتئازوم; Corneal epithelial cells (CEC); Cultured autologous oral mucosal epithelial cell sheets (CAOMECS); Limbal stem cell deficiency; Proteasome;
Sexual dimorphism in oxidant-induced adaptive homeostasis in multiple wild-type D. melanogaster strains
Keywords: پروتئازوم; Proteasome; Proteostasis; Adaptive homeostasis; Oxidative stress; Hydrogen peroxide; Redox cycling;
Terminal functionalized thiourea-containing dipeptides as multidrug-resistance reversers that target 20S proteasome and cell proliferation
Keywords: پروتئازوم; Pseudopeptides; Thioureas; Proteasome; Anti-tumor; Multidrug resistance;
Postnatal Proteasome Inhibition Promotes Amyloid-β Aggregation in Hippocampus and Impairs Spatial Learning in Adult Mice
Keywords: پروتئازوم; APP-CTFβ; amyloid precursor protein C-terminal fragments; EDTA; ethylenediaminetetraacetic acid; EGTA; (ethylene glycol-bis(β-aminoethyl ether)-N,N,Nâ²,Nâ²-tetraacetic acid; LTP; long-term potentiation; MVBs; multivesicular bodies; MWM; Morris water m
Hinokitiol copper complex inhibits proteasomal deubiquitination and induces paraptosis-like cell death in human cancer cells
Keywords: پروتئازوم; Hinokitiol; Copper; Proteasome; Deubiquitinase; Paraptosis; Cancer;
Effect of ionizing radiation exposure on Trypanosoma cruzi ubiquitin-proteasome system
Keywords: پروتئازوم; Trypanosoma cruzi; Proteasome; Ionizing radiation;