Drug Interactions-A Review
Keywords: سیتوکروم پی۴۵۰; cytochrome P450; P-glycoprotein; monoamine oxidase inhibitors; drug interactions;
مقالات ISI سیتوکروم پی۴۵۰ (ترجمه نشده)
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Multiple P450 substrates in a single run: rapid and comprehensive in vitro interaction assay
Keywords: سیتوکروم پی۴۵۰; Cytochrome P450; CYP; In vitro cocktail; Inhibition; LC/MS; Human liver microsomes;
Pre-cholesterol precursors in gametogenesis
Keywords: سیتوکروم پی۴۵۰; Cytochrome P450; Lanosterol 14α-demethylase; Meiosis activating sterol; Gametogenesis; Post-transcriptional modifications; Poly (A);
Induction of hepatic drug-metabolising enzymes and tamoxifen metabolite profile in relation to administration route during low-dose treatment in nude rats
Keywords: سیتوکروم پی۴۵۰; Tamoxifen; Cytochrome P450; CYP; Enzyme induction; Pharmacokinetics;
Evaluation of α-cyano ethers as fluorescent substrates for assay of cytochrome P450 enzyme activity
Keywords: سیتوکروم پی۴۵۰; Cytochrome P450; Fluorescent substrate; Liver microsomes; α-Cyanohydrin ether;
Regulatory network of lipid-sensing nuclear receptors: roles for CAR, PXR, LXR, and FXR
Keywords: سیتوکروم پی۴۵۰; Nuclear receptors; Drug-induction; Lipids; Bile acids; Cholesterol; CAR; PXR; LXR; FXR; Cytochrome P450;
Interactions of mammalian cytochrome P450, NADPH-cytochrome P450 reductase, and cytochrome b5 enzymes
Keywords: سیتوکروم پی۴۵۰; Cytochrome P450; NADPH-cytochrome P450 reductase; Cytochrome b5;
The N-terminal membrane anchor domain of the membrane-bound prostacyclin synthase involved in the substrate presentation of the coupling reaction with cyclooxygenase
Keywords: سیتوکروم پی۴۵۰; Prostacyclin synthase; Prostaglandin; Prostaglandin I2 synthase; Cytochrome P450; Prostanoid synthase; Cyclooxygenase;
CYP35: Xenobiotically induced gene expression in the nematode Caenorhabditis elegans
Keywords: سیتوکروم پی۴۵۰; Caenorhabditis elegans; Cytochrome P450; CYP35; Organic xenobiotics; Gene expression; Reproduction assay; RNAi;
Complementary Stimulation of Hepatobiliary Transport and Detoxification Systems by Rifampicin and Ursodeoxycholic Acid in Humans
Keywords: سیتوکروم پی۴۵۰; 4β-OH-C; 4β-hydroxy cholesterol; BAAT; bile acid amino transferase; BSEP; bile salt export pump; C4; 7α-hydroxy-4-cholesten-3-one; CA; cholic acid; CYP; cytochrome P450; DCA; deoxycholic acid; HCA; hyocholic acid; LCA; lithocholic acid; CDCA; chenodeox
Characterization of a cetacean aromatase (CYP19) and the phylogeny and functional conservation of vertebrate aromatase
Keywords: سیتوکروم پی۴۵۰; Cytochrome P450; CYP19; Aromatase; P450arom; Heterologous expression; Phylogeny; Vertebrata; Mammalia; Pisces; Cetacean;
Identification of cytochrome P450 and glutathione-S-transferase genes preferentially expressed in chemosensory organs of the swallowtail butterfly, Papilio xuthus L.
Keywords: سیتوکروم پی۴۵۰; Papilio xuthus L.; Cytochrome P450; Glutathione-S-transferase; Chemoreception; Tarsal chemosensillum;
Metabolism of osaterone acetate in dogs and humans
Keywords: سیتوکروم پی۴۵۰; Drug metabolism; Species differences; Osaterone acetate; 11β-Hydroxylation; 11β-HSD; Cytochrome P450;
Modulation of cytochrome P450 enzymes by organosulfur compounds from garlic
Keywords: سیتوکروم پی۴۵۰; AMS, allyl methyl sulfide; AOM, azoxymethane; CRC, colorectal cancer; CYP, cytochrome P450; DADS, diallyl disulfide; DAS, diallyl sulfide; DASO, diallyl sulfone; DASO2, diallyl sulfoxide; DPDS, dipropyl disulfide; DPS, dipropyl sulfide; GAPDH, glyceraldeh
Cytochrome P450-mediated metabolism of estrogens and its regulation in human
Keywords: سیتوکروم پی۴۵۰; Cytochrome P450; Estrogen; Metabolism; Regulation; Carcinogenesis;
Increased mortality associated with TCDD exposure in mice infected with influenza A virus is not due to severity of lung injury or alterations in Clara cell protein content
Keywords: سیتوکروم پی۴۵۰; Ah receptor; Dioxin; Clara cells; Clara cell secretory protein (CCSP); Pulmonary damage; Cytochrome P450;
Organophosphorothionate pesticides inhibit the bioactivation of imipramine by human hepatic cytochrome P450s
Keywords: سیتوکروم پی۴۵۰; Organophosphorothionate pesticides; Imipramine; Cytochrome P450; Metabolism; Inhibition; Human liver;
Modelling enzyme reaction mechanisms, specificity and catalysis
Keywords: سیتوکروم پی۴۵۰; Pharmaceutical Science; Drug Discovery; Bioinformatics; Chemical Biology; QM/MM; molecular dynamics; transition state; drug metabolism; polymorphism; Cytochrome P450; pharmacogenomics;
Beyond vitamin E supplementation: An alternative strategy to improve vitamin E status
Keywords: سیتوکروم پی۴۵۰; Blood plasma; Carboxyethyl hydroxychromanols; Humans; Liver; Metabolites; Rats; Tocopherols; Vitamin E status; BHT; butylated hydroxytoluene; CEHC; carboxyethyl hydroxychromanol; CYP; cytochrome P450; T; tocopherol; α-TTP; α-tocopherol transfer protein;
Involvement of SULT1A3 in elevated sulfation of 4-hydroxypropranolol in Hep G2 cells pretreated with β-naphthoflavone
Keywords: سیتوکروم پی۴۵۰; BNF; β-naphthoflavone; CYP; cytochrome P450; 4-OH-BTL; 4-hydroxybunitrolol; DHEA; dehydroepiandrosterone; 4-OH-PL; 4-hydroxypropranolol; IPTG; isopropyl-β-d-thiogalactopyranoside; NDP; N-desisopropyl propranolol; PL; propranolol; PVDF; polyvinylidene di
Quantitative PCR assay for cytochromes P450 2B and 3A induction in rat precision-cut liver slices: Correlation study with induction in vivo
Keywords: سیتوکروم پی۴۵۰; AhR; aryl hydrocarbon receptor; CAR; constitutive androstane receptor; CYP; cytochrome P450; HPBCD; hydroxypropyl-β-cyclodextrin; MGB; minor groove binding; NCEs; new chemical entities; PAHs; polycyclic aromatic hydrocarbons; PB; phenobarbital; PCN; preg
Determination of phase I metabolic enzyme activities in liver microsomes of Mrp2 deficient TRâ and EHBR rats
Keywords: سیتوکروم پی۴۵۰; Phase I metabolizing enzyme; Cytochrome P450; Mrp2 deficient; TRâ rats; EHBR rats;
Characterization of a polyclonal antiserum against the monoterpene monooxygenase, geraniol 10-hydroxylase from Catharanthus roseus
Keywords: سیتوکروم پی۴۵۰; Catharanthus roseus; Cytochrome P450; Geraniol 10-hydroxylase; Hairy roots; Monooxygenase; P450 reductase; (NBT); 4-nitroblue-tetrazolium chloride; (BCIP); 5-bromo-4-chloro-3-indolyl-phosphate; (ARP); Avocado related P450 protein; (P450); Cytochrome; (CPR
Expression of Nuclear Receptor and Target Genes in Liver and Intestine of Neonatal Calves Fed Colostrum and Vitamin A
Keywords: سیتوکروم پی۴۵۰; nuclear receptor; retinoic acid; cytochrome P450; neonatal calves; CAR; constitutive androstane receptor; CO; colostrum-fed group; CYP; cytochrome p450; FA; formula plus vitamin A-fed group; FO; formula-fed group; LRAT; lecithin: retinol acyltransferase;
A role for βFTZ-F1 in regulating ecdysteroid titers during post-embryonic development in Drosophila melanogaster
Keywords: سیتوکروم پی۴۵۰; Ecdysteroid; Cytochrome P450; Drosophila; Ring gland; ftz-f1;
Acetaminophen decreases intracellular glutathione levels and modulates cytokine production in human alveolar macrophages and type II pneumocytes in vitro
Keywords: سیتوکروم پی۴۵۰; APAP; acetaminophen; CYP; cytochrome P450; DDTC; diethyldithiocarbamic acid; DMEM; Dulbecco's modified Eagle's medium; DNase; deoxyribonuclease; FBS; fetal bovine serum; GSH; reduced glutathione; PGHS; prostaglandin H synthetase; IL-6; interleukin 6; IL-8
A retinoic acid binding cytochrome P450: CYP120A1 from Synechocystis sp. PCC 6803
Keywords: سیتوکروم پی۴۵۰; Cytochrome P450; Synechocystis sp. PCC6803; Homology modeling; In silico docking; Retinoic acid;
Regulation of Bcl-2 and Bcl-xL anti-apoptotic protein expression by nuclear receptor PXR in primary cultures of human and rat hepatocytes
Keywords: سیتوکروم پی۴۵۰; AS; antisense oligonucleotides; CELL; non-treated control-cells; CLO; clotrimazole; CYP; cytochrome P450; DEX; dexamethasone; FBS; foetal bovine serum; GST; glutathione S-transferase; MDR1; multidrug resistance-1; MP; metyrapone; MRP; multidrug resistance
Cyclopropylamine inactivation of cytochromes P450: Role of metabolic intermediate complexes
Keywords: سیتوکروم پی۴۵۰; Cytochrome P450; Flavin-containing monooxygenase; Metabolic intermediate complex; Mechanism-based inactivation; Suicide substrate;
Dimemorfan N-demethylation by mouse liver microsomal cytochrome P450 enzymes
Keywords: سیتوکروم پی۴۵۰; Dimemorfan; Cytochrome P450; Liver; Mice;
Properties and regional expression of a CYP3A-like protein in channel catfish intestine
Keywords: سیتوکروم پی۴۵۰; Cytochrome P450; CYP3A; Testosterone 6β-hydroxylase; AHH; (â)-Benzo(a)pyrene-7,8-dihydrodiol; CYP inhibitors;
Functional characterization of medaka CYP3A38 and CYP3A40: Kinetics and catalysis by expression in a recombinant baculovirus system
Keywords: سیتوکروم پی۴۵۰; Medaka; CYP3A; Baculovirus; Cytochrome P450; Kinetics; Testosterone; BFC; Metabolism;
Gene-inducing program of human dendritic cells in response to BCG cell-wall skeleton (CWS), which reflects adjuvancy required for tumor immunotherapy
Keywords: سیتوکروم پی۴۵۰; ADA; adenosine deaminase; ANOVA; analysis of variance; AP-1; activating protein-1; BCG-CWS; bacillus Calmette-Guérin cell-wall skeleton; BIGM103; BCG-induced gene in monocyte, clone 103; CCL; chemokine (C-C motif) ligand; CD; cluster of differentiation;
Hepatoprotective mechanisms of Yan-gan-wan
Keywords: سیتوکروم پی۴۵۰; YGW; Yan-gan-wan; CYP; cytochrome P450; LPS; lipopolysaccharide; TNFα; tumor necrosis factor α; RT-PCR; reverse transcription-polymerase chain reaction; RNA; ribonucleic acid; cDNA; complimentary deoxyribonucleic acid; CCl4; carbon tetrachloride; ALT; a
Cytochrome P450 expression and activities in human tongue cells and their modulation by green tea extract
Keywords: سیتوکروم پی۴۵۰; Cytochrome P450; Tongue; Oral; Green tea; RT-PCR;
BmiGI: A database of cDNAs expressed in Boophilus microplus, the tropical/southern cattle tick
Keywords: سیتوکروم پی۴۵۰; Boophilus microplus; Acaricide resistance; Acetylcholinesterase; Expressed sequence tags; Glutathione S-transferase; Cytochrome P450;
Lack of evidence for metabolism of p-phenylenediamine by human hepatic cytochrome P450 enzymes
Keywords: سیتوکروم پی۴۵۰; Cytochrome P450; Arylamine; p-Phenylenediamine; 2-Aminofluorene; Metabolic oxidation; N-acetylation;
Hartree-Fock and density functional theory calculations for the reaction mechanism of nitric oxide reductase cytochrome P450nor from Fusarium oxysporum
Keywords: سیتوکروم پی۴۵۰; Nitric oxide reductase; Cytochrome P450; Quantum chemical calculation; Reaction mechanism;
Transport of the investigational anti-cancer drug 5,6-dimethylxanthenone-4-acetic acid and its acyl glucuronide by human intestinal Caco-2 cells
Keywords: سیتوکروم پی۴۵۰; ACSRC; Auckland Cancer Society Research Centre; AP; apical; BL; basolateral; CYP; cytochrome P450; DMSO; dimethyl sulphoxide; DMXAA; 5,6-dimethylxanthenone-4-acetic acid; DMXAA-G; DMXAA acyl glucuronide; HBSS; Hanks' balanced salt solution; HEPES; N-[2-
Characterization of heme environment and mechanism of peroxide bond cleavage in human prostacyclin synthase
Keywords: سیتوکروم پی۴۵۰; PGIS; prostacyclin synthase; PGI2; prostacyclin or prostaglandin I2; Ni-NTA; Nickel nitrilotriacetate agarose; MCD; magnetic circular dichroism; EPR; electron paramagnetic resonance; MDA; malondialdehyde; 10-OOH-18:2; 10-hydroperoxyocatdeca-8,12-dienoic a
Expression patterns of mouse and human CYP orthologs (families 1-4) during development and in different adult tissues
Keywords: سیتوکروم پی۴۵۰; Cytochrome P450; CYP orthologs; CYP tissue distribution;
Presence of splice variant forms of cytochrome P4502D1 in rat brain but not in liver
Keywords: سیتوکروم پی۴۵۰; Disorders of nervous system; Neuropsychiatric disorders; Brain; Drug metabolism; Cytochrome P450; CYP2D; Monooxygenase;
Characterization of human liver cytochrome P450 enzymes involved in the metabolism of a new H+/K+-ATPase inhibitor KR-60436
Keywords: سیتوکروم پی۴۵۰; KR-60436; Cytochrome P450; Human liver microsomes; Oxidation;
Induction of phase-1 metabolizing enzymes by oltipraz, flavone and indole-3-carbinol enhance the formation and transport of benzo[a]pyrene sulfate conjugates in intestinal Caco-2 cells
Keywords: سیتوکروم پی۴۵۰; ABC; ATP-binding cassette; AhR; aryl hydrocarbon receptor; BP; benzo[a]pyrene; 3-OH-BP; 3-hydroxybenzo[a]pyrene; INF; indeno[1,2,3-cd]fluoranthene; 3-MC; 3-methylcholanthrene; β-NF; β-naphthoflavone; CYP; cytochrome P450; DMSO; dimethylsulfoxide; GST; g
Histomorphological changes and cytochrome P450 isoforms expression and activities in precision-cut liver slices from neonatal rats
Keywords: سیتوکروم پی۴۵۰; BNF; β-naphthoflavone; BSA; bovine serum albumin; CYP; cytochrome P450; DEX; dexamethasone; DMSO; dimethylsulfoxide; ECOD; ethoxycoumarin O-deethylation; EROD; ethoxyresorufin O-deethylation; HE; hematoxylin and eosin; PAS; periodic acid-Schiff; PB; phen
CYP1A1 and CYP1B1 genotypes, haplotypes, and TCDD-induced gene expression in subjects from Seveso, Italy
Keywords: سیتوکروم پی۴۵۰; EROD; ethoxyresorufin-O-deethylase; TCDD; 2,3,7,8-tetrachlorodibenzo-p-dioxin; CYP; cytochrome P450; LD; linkage disequilibrium; AhR; aryl hydrocarbon receptor; SNP; single nucleotide polymorphisms; ppt; parts per trillion; RT-PCR; reverse transcription p
Activation of the aryl hydrocarbon receptor by berberine in HepG2 and H4IIE cells: Biphasic effect on CYP1A1
Keywords: سیتوکروم پی۴۵۰; AhR; aryl hydrocarbon receptor; AhR-GFP; chimera aryl hydrocarbon receptor-green fluorescent protein; ARNT; AhR nuclear translocator; CAR; constitutive androstane receptor; CDK; cyclin-dependent kinase; COX-2; prostaglandin H synthase; DRE; dioxin-respons
Significant differences in the disposition of cyclic prodrugs of opioid peptides in rats and guinea pigs following IV administration
Keywords: سیتوکروم پی۴۵۰; opioid peptide; prodrugs; chirality; blood-brain barrier; membrane permeability; biliary excretion; cytochrome P450; efflux pumps; species differences;
The Metabolic Profile of Azimilide in Man: In Vivo and in Vitro Evaluations
Keywords: سیتوکروم پی۴۵۰; mass balance; metabolism; cytochrome P450; drug metabolizing enzymes; flavin monooxygenases; monoamine oxidase; xanthine oxidase;
Anti–diabetic activity of the semi–purified fractions of Averrhoa bilimbi in high fat diet fed–streptozotocin–induced diabetic rats
Keywords: سیتوکروم پی۴۵۰; Averrhoa bilimbi; Sprague–Dawley rats; High fat diet; Streptozotocin; Hepatic glycogen; Thiobarbituric acid reactive substances; Cytochrome P450