
Handling reactive metabolite positives in drug discovery: What has retrospective structure–toxicity analyses taught us?
Keywords: گلوتاتیون; Rm, reactive metabolite; IADR, idiosyncratic adverse drug reaction; CYP, cytochrome P450; GSH, glutathione; NSAID, nonsteroidal anti-inflammatory drug; NAT 2, N-acetyltransferase 2; HLM, human liver microsomes; PK/PD, pharmacokinetic/pharmacodynamicDrug;