Biological significance of 18F-FDG uptake on PET in patients with non-small-cell lung cancer
Keywords: ژن PTEN; 18F-FDG PET; NSCLC; GLUT1; Hypoxia; mTOR; PTEN;
مقالات ISI ژن PTEN (ترجمه نشده)
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Research ArticleHelium preconditioning protects mouse liver against ischemia and reperfusion injury through the PI3K/Akt pathway
Keywords: ژن PTEN; ALT; alanine aminotransferase; I/R; ischemia reperfusion; HPC; helium preconditioning; HEX; helium exposure; NPC; neon preconditioning; NEX; neon exposure; bpv (HOpic); dipotassium bisperoxo (5-hydroxypyridine-2-carboxyl) oxovanadate (V); PTEN; phosphatas
The role of PI3K/AKT/mTOR pathway in the modulation of autophagy and the clearance of protein aggregates in neurodegeneration
Keywords: ژن PTEN; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid; AMPAR; α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors; ATP; adenosine triphosphate; Aβ; amyloid β peptide; AD; Alzheimer's disease; APP; amyloid precursor protein; AMP; adenos
SIPL1-facilitated PTEN ubiquitination contributes to its association with PTEN
Keywords: ژن PTEN; SIPL1/sharpin; PTEN; Ubiquitination; Protein-protein interaction;
Quinovic acid glycosides purified fraction from Uncaria tomentosa induces cell death by apoptosis in the T24 human bladder cancer cell line
Keywords: ژن PTEN; ATCC; American Type Culture Collection; DMSO; dimethyl sulfoxide; ERK; extracellular signal-regulated kinase; FBS; fetal bovine serum; MTT; 3-[4,5-dimethylthiazol-2-yl]-2,5-diphenyl-tetrazolium bromide; NF-κB; nuclear factor kappa B; PTEN; phosphatase an
Vav1 increases Bcl-2 expression by selective activation of Rac2-Akt in leukemia T cells
Keywords: ژن PTEN; GEF; guanine nucleotide exchange factor; T-CVID; T cell type common variable immunodeficiency; B-CLL; B-cell chronic lymphocytic leukemia; shRNA; short-hairpin RNA; SDS-PAGE; SDS-polyacrylamide gel electrophoresis; GST; Glutathione S-transferase; PAK1; p2
MiR-21 overexpression is associated with acquired resistance of EGFR-TKI in non-small cell lung cancer
Keywords: ژن PTEN; Non-small cell lung cancer; miR-21; EGFR-TKI; Acquired resistance; PTEN; PDCD4; PI3K/Akt;
Docosahexaenoic acid reverses angiotensin II-induced RECK suppression and cardiac fibroblast migration
Keywords: ژن PTEN; Fibrosis; RECK; MicroRNA; Ï â 3 lipids; PTEN; SPRY1;
miR-21 alleviated apoptosis of cortical neurons through promoting PTEN-Akt signaling pathway in vitro after experimental traumatic brain injury
Keywords: ژن PTEN; TBI; Neuron; miR-21; Apoptosis; PTEN; Akt
MiRNA in melanoma-derived exosomes
Keywords: ژن PTEN; Biomarker; Exosome; Melanoma; MicroRNA; MiRNA; AGO-2; argonaute protein 2; BMDCs; bone marrow-derived cells; BMP4; bone morphogenetic protein 4; CCND1; cyclin D1; CDK4; cyclin-dependent kinase; DGCR8; DiGeorge critical region gene 8; EMT; epithelial to me
Prediction for response duration to epidermal growth factor receptor-tyrosine kinase inhibitors in EGFR mutated never smoker lung adenocarcinoma
Keywords: ژن PTEN; EGFR; PI3KCA; PTEN; AKT1, 2; STK11 mutations; Response to EGFR TKIs; Lung adenocarcinoma
cJun promotes CNS axon growth
Keywords: ژن PTEN; JUN; Jun oncogene; GAP43; growth associated protein 43; ITGA7; integrin alpha 7; PN; postnatal day; SOCS3; suppressor of cytokine signaling 3; KLFs; Krüppel-like transcription factors; PTEN; phosphatase and tensin homologue; DRG; dorsal root ganglion; CG
PTEN inhibits the invasion and metastasis of gastric cancer via downregulation of FAK expression
Keywords: ژن PTEN; PTEN; phosphatase and tensin homolog; FAK; focal adhesion kinase; AKT; protein kinase B; NF-κB; nuclear factor B or NF-kappaB; ChIP; chromatin immunoprecipitation; EMSA; electrophoretic mobility shift assay; DAPI; 4â²,6-diamidino-2-phenylindole; Focal a
The multiple layers of non-genetic regulation of PTEN tumour suppressor activity
Keywords: ژن PTEN; PTEN; Tumour suppressor; PI3K-Akt/PKB pathway; Non-genetic inactivation; Epigenetic, transcriptional, post-transcriptional and post-translational regulation; Cancer; Leukaemia;
High RNA-binding motif protein 3 expression is an independent prognostic marker in operated prostate cancer and tightly linked to ERG activation and PTEN deletions
Keywords: ژن PTEN; RBM3; ERG; PTEN; Prostate cancer; TMA;
EGR1-dependent PTEN upregulation by 2-benzoyloxycinnamaldehyde attenuates cell invasion and EMT in colon cancer
Keywords: ژن PTEN; Colon cancer; Epithelial–mesenchymal transition (EMT); Metastasis; 2′-Benzoyloxycinnamaldehyde; Early growth response protein-1 (EGR1); PTEN
Journal of Hepatology Update: Hepatitis CFacts and fictions of HCV and comorbidities: Steatosis, diabetes mellitus, and cardiovascular diseases
Keywords: ژن PTEN; HCV; hepatitis C virus; HIV; human immunodeficiency virus; LDL; low density lipoprotein; HCC; hepatocellular carcinoma; PTEN; phosphatase and tensin homologue deleted on chromosome 10; NAFLD; non-alcoholic fatty liver disease; NASH; non-alcoholic steatohe
PRAS40 plays a pivotal role in protecting against stroke by linking the Akt and mTOR pathways
Keywords: ژن PTEN; Focal cerebral ischemia; Akt; Stroke; mTOR; PRAS40; PTEN;
CKD712, a synthetic isoquinoline alkaloid, enhances the anti-cancer effects of paclitaxel in MDA-MB-231 cells through regulation of PTEN
Keywords: ژن PTEN; PTEN; NF-κB; Apoptosis; Invasion; Breast cancer; Paclitaxel
Nuclear trafficking of Pten after brain injury leads to neuron survival not death
Keywords: ژن PTEN; Ndfip1; Neuroprotection; Nedd4; Pten; Traumatic brain injury; Ubiquitination
Altered miRNA expression is associated with neuronal fate in G93A-SOD1 ependymal stem progenitor cells
Keywords: ژن PTEN; ALS; amyotrophic lateral sclerosis; Ccnd2; cyclin D2; Dlx2; distal-less homeobox 2; epSPCs; ependymal stem/progenitor cells; FALS; familial ALS; GAD 67; glutamic acid decarboxylase 67; GFAP; glial fibrillary acidic protein; Hes1; hairy and enhancer of spl
Optimal protocol for PTEN immunostaining; role of analytical and preanalytical variables in PTEN staining in normal and neoplastic endometrial, breast, and prostatic tissues
Keywords: ژن PTEN; PTEN; Immunohistochemistry; Preanalytical variables; Protocol;
Insight into the structural mechanism for PKBα allosteric inhibition by molecular dynamics simulations and free energy calculations
Keywords: ژن PTEN; PKB/Akt; protein kinase B; MD; molecular dynamics; PI3K; phosphatidylinostiol-3-kinase; PDK1; 3â²-phosphoinositide-dependent kinase-1; PTEN; phosphatase and tensin homolog; MM/PBSA; molecular mechanics/Poisson Boltzmann surface area; MM/GBSA; molecular m
Involvement of the AMPK-PTEN pathway in insulin resistance induced by high glucose in cultured rat podocytes
Keywords: ژن PTEN; Podocytes; Hyperglycemia; AMPK; PTEN; Metformin;
Phytoestrogens as alternative hormone replacement therapy in menopause: What is real, what is unknown
Keywords: ژن PTEN; Akt; protein kinase B; AMPK; 5â² AMP-activated protein kinase; BBB; blood-brain barrier; COX2; cyclooxygenase 2; E2; estradiol; EGTA; ethylene glycol tetraacetic acid; ER; estrogen receptor; ERE; Estrogen-responsive elements; ERK; Extracellular signal-re
The links between AKT and two intracellular proteolytic cascades: Ubiquitination and autophagy
Keywords: ژن PTEN; BRCA1; breast cancer susceptibility gene 1; BRCT; Brca1 C-terminal; CHIP; chaperone-associated ubiquitin ligase; CYLD; cylindromatosis; DAPK; death-associated protein kinase; DUB; deubiquitinating enzyme); EGF; epidermal growth factor; FADD; fas-associate
Insulin-sensitizing and insulin-mimetic activities of Sarcopoterium spinosum extract
Keywords: ژن PTEN; AMPK; AMP-activated protein kinase; BAD; Bcl 2-antagonist of cell death; 2-DG; 2-deoxy-d-glucose; FoxO; forkhead transcription factor; GSK3β; glycogen synthase kinase 3β; IBMX; isobutylmethylxanthine; IKK; inhibitor of nuclear factor kappa-B kinase; IR;
Cellular prostatic acid phosphatase, a PTEN-functional homologue in prostate epithelia, functions as a prostate-specific tumor suppressor
Keywords: ژن PTEN; AcP; acid phosphatase; AI; androgen-independent; AS; androgen-sensitive; cPAcP; cellular prostatic acid phosphatase; CR PCa; castration-resistant prostate cancer; DSP; dual specificity phosphatase; EGFR; epidermal growth factor receptor; HER-2/ErbB-2/neu;
The role of COX-2 in mediating the effect of PTEN on BMP9 induced osteogenic differentiation in mouse embryonic fibroblasts
Keywords: ژن PTEN; BMP9; PTEN; Osteogenic differentiation; MEFs; PI3K/Akt; COX-2;
Activation of PI3K/Akt signaling in rostral ventrolateral medulla impairs brain stem cardiovascular regulation that underpins circulatory depression during mevinphos intoxication
Keywords: ژن PTEN; aCSF; artificial cerebrospinal fluid; Akt; serine/threonine protein kinase; EMSA; electrophoretic mobility shift assay; HR; heart rate; LF; low-frequency; 3-MA; 3-methyladenine; NF-κB; nuclear factor-κB; NO; nitric oxide; NOS; nitric oxide synthase; NRS
PTEN/PIK3CA genes are frequently mutated in spontaneous and medroxyprogesterone acetate-accelerated 7,12-dimethylbenz(a)anthracene-induced mammary tumours of tree shrews
Keywords: ژن PTEN; Breast cancer; Tree shrew; Animal model; PTEN; PIK3CA; Gene mutation;
New insights into Notch1 regulation of the PI3K-AKT-mTOR1 signaling axis: Targeted therapy of γ-secretase inhibitor resistant T-cell acute lymphoblastic leukemia
Keywords: ژن PTEN; ADAM; a disintegrin and metalloprotease; AICAR; 5-aminoimidazole-4-carboxamide ribonucleotide; AKT; protein kinase B (PKB); ALL; acute lymphoblastic leukemia; AML; acute myeloid leukemia; AMPK; adenosine monophosphate (AMP) activated protein kinase; ANK;
Biomarkers for virus-induced hepatocellular carcinoma (HCC)
Keywords: ژن PTEN; AFP; α-fetoprotein; HCC; hepatocellular carcinoma; HBV/HCV; Hepatitis B virus/C virus; DCP; des-gamma-carboxy prothrombin; GP73; Golgi protein; GPC3; Glypican-3; CD10; Cluster of differentiation 10; CD36; Cluster of differentiation 36; SAGE; serial analy
Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism
Keywords: ژن PTEN; Synaptic plasticity; Developmental disorders; Mental retardation; Fragile X; Fmrp; TSC; PTEN; Neuroligin; Homer; SHANK; SAPAP3;
The H+-ATP synthase: A gate to ROS-mediated cell death or cell survival
Keywords: ژن PTEN; AIF; apoptosis inducing factor; Akt; v-Akt murine thymoma viral oncogene; AP-1; activator protein 1; ARE; antioxidant responsive element; ASK1; apoptosis signal-regulated kinase 1; ATM; ataxia telangiectasia mutated; Duox; Dual oxidase enzymes; DUSP3; dua
PTEN expression and function in adult cancer stem cells and prospects for therapeutic targeting
Keywords: ژن PTEN; PTEN; Cancer stem cells; PI3K; MAPK; Crosstalk; Feedback loops; Combination therapy
The neurodegenerative effects of selenium are inhibited by FOXO and PINK1/PTEN regulation of insulin/insulin-like growth factor signaling in Caenorhabditis elegans
Keywords: ژن PTEN; Selenium; Neurodegeneration; Insulin/insulin-like signaling; PTEN; PINK1; Amyotrophic lateral sclerosis;
Nrf2, the master redox switch: The Achilles' heel of ovarian cancer?
Keywords: ژن PTEN; ARE; antioxidant response element; ATF; artificial transcription factor; BER; base excision repair; β-TrCP; beta-transducin repeat-containing protein; CNL; copy number loss; dsDNA; double strand DNA; EOC; epithelial ovarian cancer; EEE; engineered epigen
mTOR signaling in tumorigenesis
Keywords: ژن PTEN; mTOR; the mechanistic target of rapamycin or the mammalian target of rapamycin; PIKK; phosphoinositide 3-kinase related protein kinase; ATM; ataxia-telangiectasia mutated; ATR; ataxia-telangiectasia and rad3-related; DNAPK; DNA-dependent protein kinase; R
S100A4 negatively regulates β-catenin by inducing the Egr-1-PTEN-Akt-GSK3β degradation pathway
Keywords: ژن PTEN; EMT; epithelial-to-mesenchymal transition; GSK; glycogen synthase kinase; MMP; matrix metalloproteinase; PTEN; phosphatase and tensin homolog; S100A4; β-Catenin; Egr-1; Akt; Breast cancer;
Molecular targets for cancer therapy in the PI3K/AKT/mTOR pathway
Keywords: ژن PTEN; PI3K pathway; Targeted therapy; Predictive biomarkers; 4EBP1; 4E-binding protein 1; AKT; protein kinase-B; AMPK; AMP-activated protein kinase; COSMIC; Catalogue of Somatic Mutations in Cancer; eIF4E; eukaryotic initiation factor 4E; ERK; extracellular-sig
DNA methylation: New therapeutic implications for hepatic fibrosis
Keywords: ژن PTEN; HSCs; hepatic stellate cells; ECMs; extracellular matrices; α-SMA; α-smooth muscle actin; TGF-β; transforming growth factor-β; PDGF; platelet-derived growth factor; DNMTs; DNA methyltransferases; DNMT1; DNA methyltransferase 1; 5-Aza-dC; 5-Aza-2â²-de
Insulin-dependent apolipoprotein B degradation is mediated by autophagy and involves class I and class III phosphatidylinositide 3-kinases
Keywords: ژن PTEN; ERAD; endoplasmic reticulum-associated degradation; PI3K; phosphatidylinositide 3-kinase; PIP3; phosphatidylinositide (3,4,5) triphosphate; PI3P; phosphatidylinositide 3 monophosphate; PTEN; phosphatase and tensin homologue; PERPP; post-ER presecretory pr
C-Myc negatively controls the tumor suppressor PTEN by upregulating miR-26a in glioblastoma multiforme cells
Keywords: ژن PTEN; PTEN; phosphatase and tensin homolog located on chromosome 10; GBM; glioblastoma multiforme; miRNA; microRNA; 3â²-UTR; 3â²-untranslated region; BCL; B-cell lymphoma; AML; acute myeloid leukemia; CCK-8; Cell Counting Kit-8; C-Myc; MiR-26a; PTEN; Prolifer
Reactivation of AKT signaling following treatment of cancer cells with PI3K inhibitors attenuates their antitumor effects
Keywords: ژن PTEN; PI3K; phosphatidylinositol-3-kinase; PTEN; phosphatase and tensin homolog; PI3K inhibitors; AKT; Cancer; Resistance; Signaling;
INPP4B-mediated tumor resistance is associated with modulation of glucose metabolism via hexokinase 2 regulation in laryngeal cancer cells
Keywords: ژن PTEN; ERK-1/2; extracellular signal-regulated protein kinase-1/2; FDG; fluorodeoxyglucose; HIF-1α; hypoxia-inducible factor-1α; HK2; hexokinase 2; INPP4B; inositol polyphosphate 4-phosphatase Type II; PI3K; phosphoinositide 3-kinases; PTEN; phosphatase and te
Determinants of the tumor suppressor INPP4B protein and lipid phosphatase activities
Keywords: ژن PTEN; PI3K; by phosphatidyl 3-kinase; PI4K; phosphatidyl 4-kinase; PI5K; phosphatidyl 5-kinase; INPP4B; inositol polyphosphate 4-phosphatase type II; PTP; protein tyrosine phosphatase; pNPP; para-nitrophenyl phosphate; DifMUP; 6,8-difluoro-4-methylumbelliferyl
Rapamycin preserves the follicle pool reserve and prolongs the ovarian lifespan of female rats via modulating mTOR activation and sirtuin expression
Keywords: ژن PTEN; P70S6K; ribosomal protein S6 kinase; mTOR; the mammalian target of rapamycin; SIRT; silent information regulator; Tsc; tuberous sclerosis complex; mTORC1; the mammalian target of rapamycin complex 1; POF; premature ovarian failure; PTEN; phosphatase and t
miR-21 confers cisplatin resistance in gastric cancer cells by regulating PTEN
Keywords: ژن PTEN; miRNAs; microRNAs; miR-21; microRNA-21; DDP; cisplatin; PTEN; phosphatase and tension homolog deleted on chromosome 10; MTT; the thiazolyl blue tetrazolium blue; PI; propidium iodide; 3â²UTR; 3â²untranslated region; NC; negative control; IC50; the 50% i
Dehydration mediated microRNA response in the African clawed frog Xenopus laevis
Keywords: ژن PTEN; AMPK; Adenosine monophosphate-activated protein kinase; ERK; Extracellular signal-regulated kinases; HIF-1α; Hypoxia inducible factor-1α; JNK; C-Jun N-terminal kinases; KEGG; Kyoto encyclopedia of Genes and Genomes; MAPK; Mitogen activated protein kinas