Identification of a major radiometabolite of [11C]PBB3
Keywords: سیتوکروم پی۴۵۰; [11C]PBB3; tau probe; PET; radiometabolite; sulfotransferase; cytochrome P450;
مقالات ISI سیتوکروم پی۴۵۰ (ترجمه نشده)
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Metabolism of palmatine by human hepatocytes and recombinant cytochromes P450
Keywords: سیتوکروم پی۴۵۰; Palmatine; Mass spectrometry; Metabolism; Cytochrome P450; CYP2D6;
Interaction of rocuronium with human liver cytochromes P450
Keywords: سیتوکروم پی۴۵۰; Rocuronium; Cytochrome P450; Drug interactions
The double mutation of cytochrome P450's and fatty acid desaturases affect lipid regulation and longevity in C. elegans
Keywords: سیتوکروم پی۴۵۰; C. elegans; Nematode; Cytochrome P450; Fatty acid desaturase; Life-span
In Vitro Metabolism and Stability of the Actinide Chelating Agent 3,4,3-LI(1,2-HOPO)
Keywords: سیتوکروم پی۴۵۰; Chelation therapy; stability; microsomes; ADME; protein binding; cytochrome P450; intestinal absorption;
Cloning, expression and purification of isoflavone-2â²-hydroxylase from Astragalus membranaceus Bge. Var. mongolicus (Bge.) Hsiao
Keywords: سیتوکروم پی۴۵۰; Cytochrome P450; Isoflavone-2â²-hydroxylase; Expression vector; LC-ESI-MS/MS; CO difference spectrum;
A single nucleotide change in a core promoter is involved in the progressive overexpression of the duplicated CYP9M10 haplotype lineage in Culex quinquefasciatus
Keywords: سیتوکروم پی۴۵۰; Insecticide resistance; Core promoter; TATA-box; Regulatory mutation; Cytochrome P450;
Genome-wide association study of plasma levels of polychlorinated biphenyls disclose an association with the CYP2B6 gene in a population-based sample
Keywords: سیتوکروم پی۴۵۰; Genome-wide association studies; Polychlorinated biphenyls; Cytochrome P450; Single nucleotide polymorphisms; Metabolism; Pollutants;
Levels of PBDEs in plasma of juvenile starlings (Sturnus vulgaris) from British Columbia, Canada and assessment of PBDE metabolism by avian liver microsomes
Keywords: سیتوکروم پی۴۵۰; BDE-47; 2,2â²,4,4â²-Tetrabromodiphenyl ether; BDE-99; 2,2â²,4,4â²,5-Pentabromodiphenyl ether; CYP; Cytochrome P450; CMP; Environment Canada Chemical Management Plan; GC-ECNI/MS; Gas chromatography-electron capture negative ionization mass spectromet
Distribution and excretion of 2,2â²,3,4â²,5,5â²,6-heptachlorobiphenyl (CB187) and its metabolites in rats and guinea pigs
Keywords: سیتوکروم پی۴۵۰; PCB; polychlorinated biphenyls; OH; hydroxy; GC; gas chromatography; ECD; electron capture detector; MS; mass spectrometry; PB; phenobarbital; MC; 3-methylcholanthrene; IP; intraperitoneally; heptaCB; heptachlorobiphenyl; hexaCB; hexachlorobiphenyl; penta
Improved assays for xenosensor activation based on reverse transfection
Keywords: سیتوکروم پی۴۵۰; AhR; human aryl hydrocarbon receptor; BNF; β-naphthoflavone; CAR; human constitutive androstane receptor; CV; coefficient of variation; CYP; cytochrome P450; DMEM; Dulbecco's modified Eagle medium; FBS; fetal bovine serum; FDA; Food and Drug Administra
Association of serum aryl hydrocarbon receptor activity and RBC omega-3 polyunsaturated fatty acids with flow-mediated dilation in healthy, young Hispanic cigarette smokers
Keywords: سیتوکروم پی۴۵۰; AHR; aryl hydrocarbon receptor; ALA; α-linolenic acid; CALUX; chemically activated luciferase expression; CYP; cytochrome P450; DHA; docosahexanoic acid; EPA; eicosapentanoic acid; FMD; flow-mediated dilation; HDL; high density lipoprotein cholesterol; L
Ontogenic expression of human carboxylesterase-2 and cytochrome P450 3A4 in liver and duodenum: Postnatal surge and organ-dependent regulation
Keywords: سیتوکروم پی۴۵۰; CES2; carboxylesterase-2; CYP3A4; cytochrome P450 3A4; GAPDH; glyceradehyde-3-phosphate dehydrogenase; GI; gastrointestinal; PBS; phosphate buffered saline; PPARα; peroxisome proliferator-activated receptor-α; RT-qPCR; reverse transcription-quantitative
Hepato-protective effects of six schisandra lignans on acetaminophen-induced liver injury are partially associated with the inhibition of CYP-mediated bioactivation
Keywords: سیتوکروم پی۴۵۰; ALT; alanine aminotransferase; APAP; acetaminophen; AST; aspartate aminotransferase; CYP; cytochrome P450; GSH; glutathione; NAPQI; N-acetyl-p-benzoquinone imine; SinA; Schisandrin A; SinB; Schisandrin B; SinC; Schisandrin C; SolA; Schisandrol A; SolB; Sc
Effects of extremely low frequency electromagnetic field (ELF-EMF) on catalase, cytochrome P450 and nitric oxide synthase in erythro-leukemic cells
Keywords: سیتوکروم پی۴۵۰; K562; Catalase; Cytochrome P450; INOS;
Functional role of the conserved i-helix residue I346 in CYP5A1-Nanodiscs
Keywords: سیتوکروم پی۴۵۰; Eicosanoids; Cytochrome P450; Thromboxane synthase; Protein engineering; CYP5A1; Nanodiscs;
Expression and membrane-targeting of an active plant cytochrome P450 in the chloroplast of the green alga Chlamydomonas reinhardtii
Keywords: سیتوکروم پی۴۵۰; Chlamydomonas; Chloroplast transformation; Cytochrome P450; Diterpenoids; Thylakoid membrane;
Identification and functional analysis of a cytochrome P450 gene CYP9AQ2 involved in deltamethrin detoxification from Locusta migratoria
Keywords: سیتوکروم پی۴۵۰; Cytochrome P450; Locusta migratoria; Insecticide; Deltamethrin; RNA interference;
Expression profile analysis of silkworm P450 family genes after phoxim induction
Keywords: سیتوکروم پی۴۵۰; Bombyx mori; Phoxim; Cytochrome P450;
Identification of new substrates for the CYP106A1-mediated 11-oxidation and investigation of the reaction mechanism
Keywords: سیتوکروم پی۴۵۰; CYP106A1; 11β-Hydroxysteroid; 11-Oxidation; Kinetic solvent isotope effect; Cytochrome P450; Ferric peroxoanion;
Relative contribution of P450c17 towards the acute cortisol response: Lessons from sheep and goats
Keywords: سیتوکروم پی۴۵۰; Cortisol; Stress; HPA axis; CYP17; Cytochrome P450
Pharmacocinétique des médicaments en insuffisance rénale : nouveautés
Keywords: سیتوکروم پی۴۵۰; Cytochrome P450; Élimination des médicaments; Insuffisance rénale; Métabolisme de phase II; Pharmacocinétique; Transporteurs ABCABC transporters; Cytochrome P450; Drug disposition; Kidney disease; Pharmacokinetics; Phase II metabolism
Resistance selection and molecular mechanisms of cypermethrin resistance in red hairy caterpillar (Amsacta albistriga walker)
Keywords: سیتوکروم پی۴۵۰; Cytochrome P450; Metabolic enzymes; Gene expression; Pyrethriod resistant; Electrophoresis
Dietary accumulation of tetrabromobisphenol A and its effects on the scallop Chlamys farreri
Keywords: سیتوکروم پی۴۵۰; Tetrabromobisphenol A; Dietary accumulation; Cytochrome P450; Detoxification; Chlamys farreri;
Azinphos-methyl and chlorpyrifos, alone or in a binary mixture, produce oxidative stress and lipid peroxidation in the freshwater gastropod Planorbarius corneus
Keywords: سیتوکروم پی۴۵۰; AChE; acetylcholinesterase; AZM; azinphos-methyl; BHT; butylated hydroxytoluene; CAT; catalase; CDNB; 1-chloro-2,4-dinitrobenzene; CES; carboxylesterases; CPF; chlorpyrifos; CYP; cytochrome P450; GR; glutathione reductase; G6PDH; glucose 6-phosphate dehyd
Bioinformatic analysis of miRNAs targeting the key nuclear receptors regulating CYP3A4 gene expression: The challenge of the CYP3A4 “missing heritability” enigma
Keywords: سیتوکروم پی۴۵۰; miRNA; Gene regulation; CYP3A4; Cytochrome P450; Metabolism
In vitro metabolism of BDE-47, BDE-99, and α-, β-, γ-HBCD isomers by chicken liver microsomes
Keywords: سیتوکروم پی۴۵۰; Polybrominated diphenyl ethers; Hexabromocyclododecane; Biotransformation; Cytochrome P450; Chicken liver microsomes;
Effect of phytochemical intervention on dibenzo[a,l]pyrene-induced DNA adduct formation
Keywords: سیتوکروم پی۴۵۰; Cytochrome P450; Dibenzo[a,l]pyrene; DNA adducts; Polycyclic aromatic hydrocarbons; 32P-postlabeling
Diastereoisomer-specific effects of hexabromocyclododecanes on hepatic aryl hydrocarbon receptors and cytochrome P450s in zebrafish (Danio rerio)
Keywords: سیتوکروم پی۴۵۰; Hexabromocyclododecane; Diastereoisomer; Aryl hydrocarbon receptor; Cytochrome P450;
Stage-dependent ethoxyresorufin-O-deethylase (EROD) in vivo activity in medaka (Oryzias latipes) embryos
Keywords: سیتوکروم پی۴۵۰; Cytochrome P450; Fish embryo toxicity; Gallbladder; Morphometry; Quantitative fluorescence; Risk assessment;
Research ArticlePharmacokinetics and safety of co-administered paritaprevir plus ritonavir, ombitasvir, and dasabuvir in hepatic impairment
Keywords: سیتوکروم پی۴۵۰; HCV; hepatitis C virus; Cmax; maximal plasma concentration; AUC; area under the plasma concentration-time curve; DAA; direct-acting antiviral agent; NS; nonstructural; CYP; cytochrome P450; Paritaprevir/r; paritaprevir administered with ritonavir; SVR12;
Research ArticleMetformin ameliorates acetaminophen hepatotoxicity via Gadd45β-dependent regulation of JNK signaling in mice
Keywords: سیتوکروم پی۴۵۰; APAP; acetaminophen; ALT; alanine aminotransferase; AST; aspartate aminotransferase; CAR; constitutive androstane receptor; CYP450; cytochrome P450; GSH; glutathione; Gadd45β; growth arrest and DNA damage-inducible 45 beta; JNK; c-Jun-N-terminal kinase;
Analysis of pooled phase III trials of adjunctive perampanel for epilepsy: Impact of mechanism of action and pharmacokinetics on clinical outcomes
Keywords: سیتوکروم پی۴۵۰; AE; adverse event; AED; antiepileptic drug; AMPA; α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic acid; CYP; cytochrome P450; EIAED; enzyme-inducing antiepileptic drug; SCB; sodium channel blocker; TEAE; treatment-emergent adverse event; Perampanel; Par
Consequences of Mrp2 deficiency for diclofenac toxicity in the rat intestine ex vivo
Keywords: سیتوکروم پی۴۵۰; ACN; acetonitrile; AMV-RT; avian myeloblastosis virus reverse transcriptase; BSA; bovine serum albumin; Ct; comparative threshold cycle; CYP; cytochrome P450; DAG; diclofenac acyl-glucuronide; DCF; diclofenac; DMSO; dimethylsulfoxide; DTNB; 5,5â²-dithiob
Functional characterization of 12 allelic variants of CYP2C8 by assessment of paclitaxel 6α-hydroxylation and amodiaquine N-deethylation
Keywords: سیتوکروم پی۴۵۰; Cytochrome P450; CYP2C8; Genetic polymorphisms; Paclitaxel; Amodiaquine
Inhibitory effects of cytochrome P450 enzymes CYP1A2, CYP2A6, CYP2E1 and CYP3A4 by extracts and alkaloids of Gelsemium elegans roots
Keywords: سیتوکروم پی۴۵۰; Gelsemium elegans; Cytochrome P450; Alkaloids; Drug-herb interactions; Enzyme inhibition;
Constitutive expression of the AHR signaling pathway in a bovine mammary epithelial cell line and modulation by dioxin-like PCB and other AHR ligands
Keywords: سیتوکروم پی۴۵۰; AHR; aryl hydrocarbon receptor; AHR; RAHR-repressor; ARNT; AHR-nuclear translocator; B[a]P; benzo[a]pyrene; β-NAF; β-naphthoflavone; CYP; cytochrome P450; cDNA; complimentary DNA; DL; dioxin-like; GST; glutathione S-transferase; NQO1; quinone oxidoreduc
Vinclozolin modulates hepatic cytochrome P450 isoforms during pregnancy
Keywords: سیتوکروم پی۴۵۰; Vinclozolin; Cytochrome P450; Endocrine disruption; Pregnancy; Testosterone; Estradiol;
Effects of aflatoxin B1, fumonisin B1 and their mixture on the aryl hydrocarbon receptor and cytochrome P450 1A induction
Keywords: سیتوکروم پی۴۵۰; AFB1; aflatoxin B1; Ahr; aryl hydrocarbon receptor; AFBO; AFB1-exo-8,9-epoxide; βNF; β-naphthoflavone; Cyp; cytochrome P450; DRE; dioxin responsive elements; EROD; 7-ethoxyresorufin-O-deethylase; FB1; fumonisin B1; ERK; extracellular signal-regulated ki
In vivo prediction of CYP-mediated metabolic interaction potential of formononetin and biochanin A using in vitro human and rat CYP450 inhibition data
Keywords: سیتوکروم پی۴۵۰; BCA, Biochanin A; CYP, Cytochrome P450; FMN, Formononetin; Cmax, Maximum systemic concentration; SD, Sprague DawleyIsoflavones; liver microsomes; Cytochrome P450; Herb–drug interaction; Enzyme inhibition
The cytochrome P450 family in the parasitic nematode Haemonchus contortus
Keywords: سیتوکروم پی۴۵۰; Parasite; Nematode; Metabolism; Cytochrome P450; Gene expression; Resistance;
Functional importance of a peripheral pocket in mammalian cytochrome P450 2B enzymes
Keywords: سیتوکروم پی۴۵۰; Cytochrome P450; Structure-function relationship; Site-directed mutagenesis; Monooxygenase coupling; CYP; cytochrome P450; ITC; isothermal titration calorimetry; H/D; hydrogen deuterium; DXMS; H/D exchange coupled to mass spectrometry; SNP; single nucle
Evaluation of 6β-Hydroxycortisol and 6β-Hydroxycortisone as Biomarkers for Cytochrome P450 3A Activity: Insight into Their Predictive Value for Estimating Oral Immunosuppressant Metabolism
Keywords: سیتوکروم پی۴۵۰; cytochrome P450; phenotype; drug metabolizing enzymes; pharmacokinetics; biopharmaceutics classification system;
A novel cytochrome P450 CYP6AB14 gene in Spodoptera litura (Lepidoptera: Noctuidae) and its potential role in plant allelochemical detoxification
Keywords: سیتوکروم پی۴۵۰; Spodoptera litura; Cytochrome P450; Plant allelochemical; RNA interference; CYP6AB14
Modulating effect of synthetic statins against damage induced by doxorubicin in somatic cells of Drosophila melanogaster
Keywords: سیتوکروم پی۴۵۰; Atorvastatin; Rosuvastatin; Modulatory effect; Smart; Drosophila melanogaster; BH; balancer heterozygote descendants; CYP; cytochrome P450; CYP2C9; cytochrome P450 2C9; CYP 2C19; cytochrome P450 2C19; DXR; doxorubicin; eNOS; endothelial nitric oxide synth
Expression of hepatic cytochrome P450s and UDP-glucuronosyltransferases in PXR and CAR double humanized mice treated with rifampicin
Keywords: سیتوکروم پی۴۵۰; Nuclear receptor; Humanized mice; Rifampicin; Cytochrome P450; UDP-glucuronosyltransferase;
The Influence of Single-Dose and Short-Term Administration of Quercetin on the Pharmacokinetics of Midazolam in Humans
Keywords: سیتوکروم پی۴۵۰; drug interactions; pharmacokinetics; flavonoids; metabolism; quercetin; cytochrome P450; midazolam; gastrointestinal; bioavailability
Transcriptomic analysis of untreated and drug-treated differentiated HepaRG cells over a 2-week period
Keywords: سیتوکروم پی۴۵۰; CYP; cytochrome P450; DMSO; dimethyl sulfoxide; FBS; fetal bovine serum; LFC; log2 fold change; PPAR; peroxisome proliferator-activated receptor; HepaRG cells; Transcriptomics; PPAR agonists; Repeated treatments; Time-dependent changes; Gene profiling;
Rat precision-cut intestinal slices to study P-gp activity and the potency of its inhibitors ex vivo
Keywords: سیتوکروم پی۴۵۰; P-gp; P-glycoprotein; PCIS; Precision-Cut Intestinal Slices; R123; Rhodamine 123; DDI(s); drug-drug interaction(s); IC50; half maximal inhibitory concentration; ABC; ATP-binding cassette; CYP; cytochrome P450; CP100356; 4-(3,4-dihydro-6,7-dimethoxy-2(1H
Genetic Polymorphisms of ALOX5AP and CYP3A5 Increase Susceptibility to Ischemic Stroke and Are Associated with Atherothrombotic Events in Stroke Patients
Keywords: سیتوکروم پی۴۵۰; Stroke; GMDR; genetics; variants; 5-lipoxygenase activating protein; cytochrome P450;