The rise, the fall and the renaissance of vitamin E
Keywords: هدایت سیگنال; Vitamin E; Tocopherols; Non-antioxidant functions; Polyphenols; Signal transduction; Gene expression;
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Apigenin inhibits the inducible expression of programmed death ligand 1 by human and mouse mammary carcinoma cells
Keywords: هدایت سیگنال; Breast cancer; Flavonoid; Immune evasion; PD-L1; Signal transduction;
AMPK is critical for mitochondrial function during reperfusion after myocardial ischemia
Keywords: هدایت سیگنال; AA; antimycin A; AMPK; AMP-activated protein kinase; CG5N; calcium green 5Â N; CRC; calcium retention capacity; FCCP; carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone; Gapdh; glyceraldehyde 3-phosphate dehydrogenase; IR; ischemia-reperfusion; JNK; c
The hepatocyte growth factor isoform NK2 activates motogenesis and survival but not proliferation due to lack of Akt activation
Keywords: هدایت سیگنال; Pulmonary; Tissue repair; HGF isoforms; Signal transduction; Fibrosis;
The N-terminus of the yeast G protein-coupled receptor Ste2p plays critical roles in surface expression, signaling, and negative regulation
Keywords: هدایت سیگنال; G protein-coupled receptor (GPCR); Ste2p; Yeast; Signal transduction; Saccharomyces cerevisiae;
Research PaperColitis-induced bladder afferent neuronal activation is regulated by BDNF through PLCγ pathway
Keywords: هدایت سیگنال; Colon; Bladder; Cross-sensitization; BDNF; Signal transduction;
The Brassinosteroid-Activated BRI1 Receptor Kinase Is Switched off by Dephosphorylation Mediated by Cytoplasm-Localized PP2A B′ Subunits
Keywords: هدایت سیگنال; Brassinosteroid; signal transduction; receptor inactivation; BRI1 dephophorylation; PP2A
Combination of galectin inhibitor GCS-100 and BH3 mimetics eliminates both p53 wild type and p53 null AML cells
Keywords: هدایت سیگنال; LGALS3; Galectin 3; LGALS1; Galectin 1; AML; Acute myeloid leukemia; qRT-PCR; Real-time PCR; AKT; Protein kinase B; ERK; Extracellular receptor kinase; BCL2; B cell lymphoma 2; BCL-XL; B cell lymphoma 2 Like 1; MCL-1; Myeloid cell leukemia 1; Ph +;  Phi
Signaling pathways involved in HSP32 induction by hyperbaric oxygen in rat spinal neurons
Keywords: هدایت سیگنال; Hyperbaric oxygen; Heat shock protein 32; Signal transduction; Negative regulation; Reactive oxygen species;
Differential regulation of the phosphorylation of Trimethyl-lysine27 histone H3 at serine 28 in distinct populations of striatal projection neurons
Keywords: هدایت سیگنال; Dopamine receptor; Histone modifications; Protein phosphorylation; Signal transduction; Polycomb; Drug action; Striatum; Amphetamine; Haloperidol; Mouse;
The G protein estrogen receptor (GPER) is regulated by endothelin-1 mediated signaling in cancer cells
Keywords: هدایت سیگنال; ET-1; endothelin-1; ETAR; endothelin receptor A; ETBR; endothelin receptor B; PI3K; phosphatidylinositol 3-kinase; ERK; extracellular signal-regulated kinase; CTGF; connective tissue growth factor; Egr-1; early related gene; HIF-1; hypoxia inducible facto
Induction of Gnrh mRNA expression by the ω-3 polyunsaturated fatty acid docosahexaenoic acid and the saturated fatty acid palmitate in a GnRH-synthesizing neuronal cell model, mHypoA-GnRH/GFP
Keywords: هدایت سیگنال; GnRH; Free fatty acids; Cell biology; Signal transduction; Gene expression; Neuroendocrine
Conformational features of the Staphylococcus aureus AgrA-promoter interactions rationalize quorum-sensing triggered gene expression
Keywords: هدایت سیگنال; Transcription activation; Quorum sensing; Signal Transduction; Two-component system
The small GTPase Rap1 is a modulator of Hedgehog signaling
Keywords: هدایت سیگنال; Hedgehog; Signal transduction; Morphogenesis; GTPase; Rap1;
JNK and p38 mitogen-activated protein kinase pathways contribute to porcine epidemic diarrhea virus infection
Keywords: هدایت سیگنال; PEDV; p38 MAPK; JNK1/2; Signal transduction; Viral replication
Original ResearchFull Report: Basic and Translational-Alimentary TractActivity of SHIP, Which Prevents Expression of Interleukin 1β, Is Reduced in Patients With Crohn's Disease
Keywords: هدایت سیگنال; PI3Kp110α; Signal Transduction; Inflammatory; Phosphatidylinositol; ATP; adenosine triphosphate; BMM; bone marrowâderived macrophage; CD; Crohn's disease; clod-lip; clodronate-containing liposomes; DSS; dextran sulfate sodium; ELISA; enzyme-linked im
Ageing is associated with reduction of mechanically-induced activation of Smad2/3P signaling in articular cartilage
Keywords: هدایت سیگنال; Cartilage; Ageing; TGF-beta; Smad2/3P signaling; Mechanosensitivity; Signal transduction;
Antifibrotic Actions of Serelaxin – New Roles for an Old Player
Keywords: هدایت سیگنال; collagen; fibrosis; relaxin; serelaxin; signal transduction; TGF-β1
Proteolytic Cleavage Governs Interleukin-11 Trans-signaling
Keywords: هدایت سیگنال; interleukin-11; ADAM10; ADAM17; proteolysis; signal transduction
Wnt and BMP signaling crosstalk in regulating dental stem cells: Implications in dental tissue engineering
Keywords: هدایت سیگنال; BMP signaling; Dental stem cells; Oral stem cells; Regenerative dentistry; Signal transduction; Tissue engineering; Wnt signaling;
Withaferin A induces heme oxygenase (HO-1) expression in endothelial cells via activation of the Keap1/Nrf2 pathway
Keywords: هدایت سیگنال; Antioxidant; Endothelial cell; Molecular pharmacology; Phytochemical; Signal transduction; Transcription regulation
The implication of SUMO in intrinsic and innate immunity
Keywords: هدایت سیگنال; SUMO; TRIM proteins; Innate immunity; Signal transduction; Restriction factors;
Biochemical characterization of the tomato phosphatidylinositol-specific phospholipase C (PI-PLC) family and its role in plant immunity
Keywords: هدایت سیگنال; At; Arabidopsis thaliana; DAG; diacylglycerol; ETI; effector-triggered immunity; HR; hypersensitive response; InsP3; inositol 1,4,5-triphosphate; PA; phosphatidic acid; PAMPs; pathogen-associated molecular patterns; PI; phosphatidylinositol; PI-PLC; phosp
Transcriptome analysis of the molting gland (Y-organ) from the blackback land crab, Gecarcinus lateralis
Keywords: هدایت سیگنال; Blast2GO; Crustacea; Decapoda; Ecdysteroid; Gecarcinus; Molting; mTOR; Transforming growth factor beta; Transcriptome; Y-organ; Signal transduction; Molt-inhibiting hormone
Generalized travelling wave solutions for hyperbolic chemotaxis PDEs
Keywords: هدایت سیگنال; Lie symmetries; Group-invariant solutions; Velocity-jump process; Signal transduction
Feedback regulation of G protein-coupled receptor signaling by GRKs and arrestins
Keywords: هدایت سیگنال; GPCR; G protein; Arrestin; GRK; Signal transduction; Biased signaling;
Inhibitors of Arg-Gly-Asp-Binding Integrins Reduce Development of Pancreatic Fibrosis in Mice
Keywords: هدایت سیگنال; Signal Transduction; Pancreas; Inflammation; PeptidomimeticCol1a1, collagen type I α1; CP, chronic pancreatitis; CTGF, connective tissue growth factor; CWHM, Center for World Health and Medicine; DMEM, Dulbecco's modified Eagle medium; DMSO, dimethyl sulf
Mixed - Lineage Protein kinases (MLKs) in inflammation, metabolism, and other disease states
Keywords: هدایت سیگنال; Signal transduction; Kinase; Inflammation; Metabolism; Insulin resistance; Disease; Mixed-lineage kinase;
The role of class I, II and III PI 3-kinases in platelet production and activation and their implication in thrombosis
Keywords: هدایت سیگنال; PI 3-kinase isoforms; Platelets; Thrombosis; Signal transduction;
Expression of Activated Ras in Gastric Chief Cells of Mice Leads to the Full Spectrum of Metaplastic Lineage Transitions
Keywords: هدایت سیگنال; Carcinogenesis; MAP Kinase; Differentiation; Signal Transduction; AB; Alcian blue; DAB; 3,3â²-diaminobenzidine tetra hydrochloride; DMSO; dimethyl sulfoxide; ERK; extracellular signal-regulated kinase; GFP; green fluorescent protein; GSII; Griffonia s
Detention of copper by sulfur nanoparticles inhibits the proliferation of A375 malignant melanoma and MCF-7 breast cancer cells
Keywords: هدایت سیگنال; Sulfur nanoparticles; Copper; Cancer chemotherapy; Signal transduction; Combination therapy;
Beyond autophagy: New roles for ULK1 in immune signaling and interferon responses
Keywords: هدایت سیگنال; ULK1; Interferon; Signal transduction; Immune signaling; Innate immunity;
Characterization, expression, and functional study of IRAK-1 from grouper, Epinephelus coioides
Keywords: هدایت سیگنال; Epinephelus coioides; IRAK-1; Signal transduction; Cryptocaryon irritans;
Epithelial Transforming Growth Factor-β Signaling Does Not Contribute to Liver Fibrosis but Protects Mice From Cholangiocarcinoma
Keywords: هدایت سیگنال; TGFβ; Signal Transduction; Mouse Model; Liver Cancer; α-SMA; α-smooth muscle actin; BDL; bile duct ligation; DDC; 3,5-diethoxycarbonyl-1,4-dihydro-collidin; DEN; diethylnitrosamine; HCC; hepatocellular carcinoma; HSC; hepatic stellate cell; mRNA; messe
mTOR inactivation in myocardium from infant mice rapidly leads to dilated cardiomyopathy due to translation defects and p53/JNK-mediated apoptosis
Keywords: هدایت سیگنال; mTOR; Heart postnatal development; Signal transduction; Translation; Cardiomyocyte apoptosis; Myocardial metabolism;
The unique role of STAT2 in constitutive and IFN-induced transcription and antiviral responses
Keywords: هدایت سیگنال; STAT2 transcription factor; ISGF3; STAT2/IRF9; Cytokines/interferon; Signal transduction; Host-pathogen interactions; Alternative interferon response pathway;
Pancreatic Premalignant Lesions Secrete Tissue Inhibitor of Metalloproteinases-1, Which Activates Hepatic Stellate Cells Via CD63 Signaling to Create a Premetastatic Niche in the Liver
Keywords: هدایت سیگنال; Tissue Inhibitor of Metalloproteinases; Tumor Progression; Signal Transduction; Microenvironment; CP; chronic pancreatitis; HSC; hepatic stellate cell; PanIN; pancreatic intra-epithelial neoplasia; PDAC; pancreatic ductal adenocarcinoma; PDGF-B; platelet-
Inhibition of Tumor Growth and Metastasis in Pancreatic Cancer Models by Interference With CD44v6 Signaling
Keywords: هدایت سیگنال; Tumor Development; Signal Transduction; Pancreas; Oncogene; EWQ; glutamic acid-tryptophane-glutamine; FCS; fetal calf serum; GWQ; glycine-tryptophane-glutamine; HGF; hepatocyte growth factor; KPC; LSL-KrasG12D/+, LSL-Trp53R172H/+, Pdx1-Cre; PDAC; pancreat
OVOL2, an Inhibitor of WNT Signaling, Reduces Invasive Activities of Human and Mouse Cancer Cells and Is Down-regulated in Human Colorectal Tumors
Keywords: هدایت سیگنال; Mouse Model; Colon Cancer; Signal Transduction; Tumor Suppression; co-IP; co-immunoprecipitation; CRC; colorectal cancer; EMT; epithelial-to-mesenchymal transition; HDAC; histone deacetylase; IB; immunoblotting; mRNA; messenger RNA; TBE; T-cell factor 4 b
Impairment and reorganization of the phosphoinositide-specific phospholipase C enzymes in suicide brains
Keywords: هدایت سیگنال; Suicide; Signal transduction; Human brain; Phospholipase C;
Apelin-13 upregulates Egr-1 expression in rat vascular smooth muscle cells through the PI3K/Akt and PKC signaling pathways
Keywords: هدایت سیگنال; Signal transduction; G protein; MAPK; PKC; PI3K/Akt; Egr-1;
Identification of the tethered peptide agonist of the adhesion G protein-coupled receptor GPR64/ADGRG2
Keywords: هدایت سیگنال; GPR64; GPCR; G protein; Molecular pharmacology; Signal transduction; Peptide agonist; 7TM; seven-transmembrane spanning domain; CTF; C-terminal fragment; ECD; extracellular domain; eV; empty vector; DMEM; dulbecco minimum essential medium; ELISA; enzyme-l
The regulator of G-protein signaling 18 regulates platelet aggregation, hemostasis and thrombosis
Keywords: هدایت سیگنال; Platelets; Signal transduction; Regulators of G-protein signaling; Regulator of G-protein signaling 18; Hemostasis; Thrombosis;
Ginsenoside Rd and ischemic stroke; a short review of literatures
Keywords: هدایت سیگنال; ginsenoside Rd; Panax ginseng; signal transduction
SHIP1 and the negative control of mast cell/basophil activation by supra-optimal antigen concentrations
Keywords: هدایت سیگنال; Mast cell; Basophil; Lipid phosphatase; Signal transduction; Allergy;
The role of the IL-33/IL-1RL1 axis in mast cell and basophil activation in allergic disorders
Keywords: هدایت سیگنال; BMMCs; bone marrow-derived murine mast cell; ECM; extracellular matrix; eQTLs; expression quantitative trait loci; ERK; extracellular signal-regulated kinases; GATA1; globin transcription factor 1; GATA2; globin transcription factor 2; GI tract; Gastroint
Signal transduction and downregulation of C-MET in HGF stimulated low and highly metastatic human osteosarcoma cells
Keywords: هدایت سیگنال; Osteosarcoma; C-MET; Signal transduction; TPR-MET;
ROZA-XL, an improved FRET based biosensor with an increased dynamic range for visualizing Zeta Associated Protein 70 kD (ZAP-70) tyrosine kinase activity in live T cells
Keywords: هدایت سیگنال; Zeta Associated Protein-70 kD (ZAP-70); Syk family kinase; T-cell receptor; Signal transduction; Fluorescence resonance energy transfer (FRET); Biosensor; ZAP-70; Zeta Associated Protein 70 kD; SH2; Src homology 2; LAT; Linker for Activation of T cells; P
Map kinase and PKC signaling pathways modulate NGF-mediated apoE transcription
Keywords: هدایت سیگنال; ANOVA; analysis of variance; AD; Alzheimer's disease; AP-1; activator protein 1; APP; amyloid precursor protein; apoE; apolipoprotein E; BIS-1; bisindolylmaleimide 1; ChaT; choline acetyltransferase; L-NAME; NÏ-nitro-L-arginine methylester; LRP1; low d
Physiological roles of peroxido-vanadium complexes: Leitmotif as their signal transduction pathway
Keywords: هدایت سیگنال; Peroxidovanadium compounds; Diabetes; Signal transduction; Reactive oxygen species (ROS)