Cdk5 regulates Rap1 activity
Keywords: هدایت سیگنال; Signal transduction; Cyclin-dependent kinase 5; Rap1; C3G; Neurones;
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Structural studies of cerebral cavernous malformations 2 (CCM2) reveal a folded helical domain at its C-terminus
Keywords: هدایت سیگنال; Protein-protein interaction; Signal transduction; Cerebral cavernous malformation; X-ray crystallography; Harmonin-homology domain;
Tyrosine phosphorylation of the orphan receptor ESDN/DCBLD2 serves as a scaffold for the signaling adaptor CrkL
Keywords: هدایت سیگنال; ESDN; endothelial and smooth muscle cell-derived neuropilin-like protein; DCBLD2; discoidin CUB and LCCL domain containing 2; CUB; complement C1r/C1s Uegf Bmp1; CrkL; CrkCT10 regulator of kinase Crk-Like; SFK; Src family tyrosine kinase; Cas; Crk-associat
Cutl1: A potential target for cancer therapy
Keywords: هدایت سیگنال; CDP; CCAAT displacement protein; HCC; human hepatocellular carcinoma; LETFs; liver-enriched transcription factors; HNF; hepatocyte nuclear factor; Shh; Sonic hedgehog; C/EBPα; CCAAT/enhancer-binding protein; MMTV; mouse mammary tumor virus; PCAF; p300/CR
Atg5 regulates formation of MyD88 condensed structures and MyD88-dependent signal transduction
Keywords: هدایت سیگنال; Autophagy; Condensed structures; MyD88; Signal transduction; Toll-like receptors (TLRs);
Direct inhibition of cell surface ephrin-B2 by recombinant ephrin-B2/FC
Keywords: هدایت سیگنال; Endocytosis; Ephrin-B2; Neural stem cell; Neurogenesis; Signal transduction;
The effect of CD137-CD137 ligand interaction on phospholipase C signaling pathway in human endothelial cells
Keywords: هدایت سیگنال; CD137; CD137 ligand; Phospholipase C; Endothelial; Cells; Signal transduction;
Mesenchymal stem cells from osteoporotic patients feature impaired signal transduction but sustained osteoinduction in response to BMP-2 stimulation
Keywords: هدایت سیگنال; Mesenchymal stem cells; Osteoporosis; BMP-2; Signal transduction; Osteogenic differentiation;
WKYMVm-induced cross-talk between FPR2 and HGF receptor in human prostate epithelial cell line PNT1A
Keywords: هدایت سیگنال; FPR2; c-Met; NADPH oxidase; Transactivation; Signal transduction;
Relevance of signaling molecules for apoptosis induction on influenza A virus replication
Keywords: هدایت سیگنال; Akt; v-akt murine thymoma viral oncogene homolog 1; Apaf-1; apoptotic protease activating factor 1; Bax; Bcl-2-associated x protein; Bcl-2; B-cell lymphoma 2; BH; Bcl-2 homology; Caspases; cysteine-aspartic acid protease; DAP3; death-associated protein
ADAM17 silencing by adenovirus encoding miRNA-embedded siRNA revealed essential signal transduction by angiotensin II in vascular smooth muscle cells
Keywords: هدایت سیگنال; ADAM17; Epidermal growth factor receptor; Angiotensin II type 1 receptor; Signal transduction; Vascular biology;
Nitric oxide signaling in ghrelin-induced LH release from goldfish pituitary cells
Keywords: هدایت سیگنال; Goldfish ghrelin; Nitric oxide synthase isoform-selective inhibitors; Signal transduction; Primary goldfish pituitary cell culture; Maturational gonadotropin GTH-II;
Activation of ERK signaling in rostral ventromedial medulla is dependent on afferent input from dorsal column pathway and contributes to acetic acid-induced visceral nociception
Keywords: هدایت سیگنال; Visceral pain; Signal transduction; Dorsal column; Rostral ventromedial medulla;
Modification of p115RhoGEF Ser330 regulates its RhoGEF activity
Keywords: هدایت سیگنال; ATRA; All-trans retinoic acid; DH; Dbl homology; DMEM; Dulbecco's modified Eagle's medium; FBS; Fetal bovine serum; GAP; GTPase activating protein; HPLC-MS/MS; High pressure/tandem mass spectrometry; LARG; Leukemia-associated RhoGEF; LC/MS/MS; Liquid ch
Vaspin attenuates high glucose-induced vascular smooth muscle cells proliferation and chemokinesis by inhibiting the MAPK, PI3K/Akt, and NF-κB signaling pathways
Keywords: هدایت سیگنال; Adipokine; Proliferation; Signal transduction; Reactive oxygen species; Vascular smooth muscle cell; BSA; bovine serum albumin; DMEM; Dulbecco's modified Eagle's media; EdU; 5-ethynyl-2â²-deoxyuridine; H2DCFDA; 2â², 7â²-diclorofluorescein diacetate; IR
Effects of β3-adrenoceptor on scavenger receptor class B type 1 and its signal transduction pathway in apolipoprotein E knockout mice
Keywords: هدایت سیگنال; β3 adrenoceptors; Lipids; SR-B1; Signal transduction;
The activation and regulation of IL-17 receptor mediated signaling
Keywords: هدایت سیگنال; Interleukin-17; Act1; Inflammation; Signal transduction;
The hormone-dependent function of Hsp90 in the crosstalk between 20-hydroxyecdysone and juvenile hormone signaling pathways in insects is determined by differential phosphorylation and protein interactions
Keywords: هدایت سیگنال; 20-hydroxyecdysone (20E); Juvenile hormone (JH); Signal transduction; Heat shock protein 90; Phosphorylation;
CYT-1 isoform of ErbB4 is an independent prognostic factor in serous ovarian cancer and selectively promotes ovarian cancer cell growth in vitro
Keywords: هدایت سیگنال; Ovarian cancer; Signal transduction; Growth factors; ErbB4; HER4;
Aloe vera downregulates LPS-induced inflammatory cytokine production and expression of NLRP3 inflammasome in human macrophages
Keywords: هدایت سیگنال; ATP; adenosine-5â²-triphosphate; ASC; apoptosis-associated speck-like protein containing a caspase recruitment domain; ELISA; enzyme-linked immunosorbent assay; ERK; extracellular-signal-regulated kinase; GM-CSF; granulocyte-macrophage colony stimulating
The activation and differential signalling of the growth hormone receptor induced by pGH or anti-idiotypic monoclonal antibodies in primary rat hepatocytes
Keywords: هدایت سیگنال; pGH; porcine growth hormone; mAb; monoclonal antibody; PRL; prolactin; GHR; growth hormone receptor; CLSM; confocal laser scanning microscope; FITC; fluorescein isothiocyanate; Ab2; anti-idiotypic antibody; PBS; phosphate-buffered saline; TMB; tetramethyl
Differential modulation of ghrelin-induced GH and LH release by PACAP and dopamine in goldfish pituitary cells
Keywords: هدایت سیگنال; Goldfish ghrelin; Fura-2/AM calcium imaging; Signal transduction; Primary goldfish pituitary cell culture; Maturational gonadotropin GTH-II;
Original ResearchFull Report: Basic and Translational-PancreasA High-Fat Diet Activates Oncogenic Kras and COX2 to Induce Development of Pancreatic Ductal Adenocarcinoma in Mice
Keywords: هدایت سیگنال; Pancreatic Cancer; Signal Transduction; Oncogene; Prostaglandin; α-SMA; α-smooth muscle actin; BAC; bacterial-artificial-chromosome; BW; body weight; CD; control diet; COX; cyclooxygenase; Ela; elastase; ERK; extracellular signal-regulated kinase; GTP;
Deletion of the β2-adrenergic receptor prevents the development of cardiomyopathy in mice
Keywords: هدایت سیگنال; Adrenergic receptors; Cardiomyopathy; Excitation-contraction coupling; Signal transduction;
Inhibition of UVB-induced skin phototoxicity by a grape seed extract as modulator of nitrosative stress, ERK/NF-kB signaling pathway and apoptosis, in SKH-1 mice
Keywords: هدایت سیگنال; AP-1; activator protein 1; Apaf; apoptotic protease activating factor-1; ABTS; 2â²-azino-bis(3-ethylbenzothiazoline-6-sulfonate; Bcl-2; B-cell lymphoma 2; Bax; Bcl-2-associated X protein; CPDs; cyclobutane pyrimidine dimers; DAB; diaminobenzidine tetrahy
Requirement for protein kinase A in the phosphorylation of the TGFβ receptor-interacting protein km23-1 as a component of TGFβ downstream effects
Keywords: هدایت سیگنال; TGFβ; km23-1; Protein kinase A; Phosphorylation; Signal transduction;
A structural perspective of the MAVS-regulatory mechanism on the mitochondrial outer membrane using bioluminescence resonance energy transfer
Keywords: هدایت سیگنال; BiFC; bimolecular fluorescence complementation; BRET; bioluminescence resonance energy transfer; CARD; caspase activation and recruitment domain; HCV; hepatitis C virus; HEK; human embryonic kidney; HR1; 4,3 hydrophobic heptad repeat region 1; IFN-β; int
Cellular mechanisms of the cytotoxic effects of the zearalenone metabolites α-zearalenol and β-zearalenol on RAW264.7 macrophages
Keywords: هدایت سیگنال; α-Zearalenol; β-Zearalenol; Mitochondrial stress; Reactive oxygen species; Signal transduction; Antioxidants;
Receptor for advanced glycation end-products (RAGE) activates divergent signaling pathways to augment neurite outgrowth of adult sensory neurons
Keywords: هدایت سیگنال; Neurotrophic factor; Axon regeneration; NF-kappaB; Human glycated albumin; Lentiviral shRNA; JAK/STAT; Signal transduction;
Oncogenic Ras suppresses Cdk1 in a complex manner during the incubation of activated Xenopus egg extracts
Keywords: هدایت سیگنال; Signal transduction; Oncogenic Ras; Cdk1; Cell cycle arrest; Xenopus egg extracts;
Dynamic regulation of innate immunity by ubiquitin and ubiquitin-like proteins
Keywords: هدایت سیگنال; Ubiquitin; SUMO; ISG15; Signal transduction; Innate immunity;
Role of adult neurogenesis in hippocampus-dependent memory, contextual fear extinction and remote contextual memory: New insights from ERK5 MAP kinase
Keywords: هدایت سیگنال; Adult neurogenesis; Learning and memory; Signal transduction; MAPK;
Original ResearchFull Report: Basic and Translational-PancreasHippo Signaling Regulates Differentiation and Maintenance in the Exocrine Pancreas
Keywords: هدایت سیگنال; Mouse Model; Signal Transduction; Hpo; Wts; AP; acute appendicitis; BrdU; bromodeoxyuridine; CK19; cytokeratin 19; CPA1; carboxypeptidase A1; DKO; double knockout; GFP; green fluorescent protein; TUNEL; terminal deoxynucleotidyl transferase-mediated deo
Morphine withdrawal produces ERK-dependent and ERK-independent epigenetic marks in neurons of the nucleus accumbens and lateral septum
Keywords: هدایت سیگنال; Opioids; Epigenetics; ERK; MeCP2; Signal transduction; Molecular & cellular neurobiology; Neuroanatomy; ARC; activity-regulated cytoskeleton-associated protein; ERK; extracellular signal-regulated kinase; DS; dorsal striatum; IEG; immediate early genes; L
βarrestin2 interacts with TβRII to regulate Smad-dependent and Smad-independent signal transduction
Keywords: هدایت سیگنال; Transforming growth factor beta receptor; Signal transduction; Receptor trafficking; Membrane rafts; Beta arrestin; Endocytosis;
IL-17 family cytokines mediated signaling in the pathogenesis of inflammatory diseases
Keywords: هدایت سیگنال; IL-17 family cytokines; Signal transduction; Inflammation;
Aldosterone signaling through transient receptor potential melastatin 7 cation channel (TRPM7) and its α-kinase domain
Keywords: هدایت سیگنال; TRPM7; Aldosterone; Signal transduction; Mg2Â +;
Discrete signal transduction pathway utilization by a neuropeptide (PACAP) and a cytokine (TNF-alpha) first messenger in chromaffin cells, inferred from coupled transcriptome-promoter analysis of regulated gene cohorts
Keywords: هدایت سیگنال; Affymetrix; Agilent; Chromaffin cell; Cyclic AMP; ERK; Gene induction; Microarray; NF-kB; PACAP; PAC1; Signal transduction; TNF-alpha; Transcriptional regulation; TNFR2;
Age-related changes in the response of intestinal cells to 1α,25(OH)2-vitamin D3
Keywords: هدایت سیگنال; Intestine; Aging; Signal transduction; Vitamin D3;
BMP10 as a potent inducer of trophoblast differentiation in human embryonic and induced pluripotent stem cells
Keywords: هدایت سیگنال; Embryonic stem cells; Induced pluripotent stem cells; Bone morphogenetic proteins (BMPs); BMP4, BMP5, BMP6, BMP7, BMP10, BMP13; Signal transduction; Trophoblast differentiation;
Intracellular targets for a phosphotyrosine peptidomimetic include the mitotic kinesin, MCAK
Keywords: هدایت سیگنال; Signal transduction; SH2 domain; Drug delivery; Peptidomimetic; Kinesin; MCAK;
Protein tyrosine kinase regulation by ubiquitination: Critical roles of Cbl-family ubiquitin ligases
Keywords: هدایت سیگنال; Cbl; E3 ubiquitin ligase; Tyrosine kinase binding domain; Ubiquitination; Signal transduction; Animal model;
Original ResearchFull Report: Basic and Translational-Alimentary TractHuman Umbilical Cord Blood Mesenchymal Stem Cells Reduce Colitis in Mice by Activating NOD2 Signaling to COX2
Keywords: هدایت سیگنال; Mouse Model; IBD; Immune Regulation; Signal Transduction; CFSE; 5,6-carboxy fluorescein succinimidyl ester; CM; culture media; COX-2; cyclooxygenase-2; DSS; dextran sulfate sodium; Foxp3; forkhead box p3; hMNC; human mononuclear cell; hUCB-MSCs; human umb
Loss of SMAD4 From Colorectal Cancer Cells Promotes CCL15 Expression to Recruit CCR1+ Myeloid Cells and Facilitate Liver Metastasis
Keywords: هدایت سیگنال; Colon Cancer; Carcinoma; Signal Transduction; Chemokine; BMDC; bone marrow-derived cell; BMP; bone morphogenetic proteins; CRC; colorectal cancer; DFS; disease-free survival; mCCL9; mouse CCL9; MMP; matrix metalloproteinase; mRNA; messenger RNA; SBE; Smad
Ground state structure of D75N mutant of sensory rhodopsin II in complex with its cognate transducer
Keywords: هدایت سیگنال; Membrane protein; Signal transduction; Retinal protein; X-ray crystallography; Protein crystallization
Herkinorin dilates cerebral vessels via kappa opioid receptor and cyclic adenosine monophosphate (cAMP) in a piglet model
Keywords: هدایت سیگنال; Herkinorin; Opioid receptors; Signal transduction; Cerebrovasodilation
Intraluminal crawling versus interstitial neutrophil migration during inflammation
Keywords: هدایت سیگنال; Inflammation; Neutrophil; Integrins; Migration; Signal transduction
Comparative aspects of kisspeptin gene regulation
Keywords: هدایت سیگنال; Kiss1; Kiss2; GnRH; Transcription; Receptor; Signal transduction
Vascular fibrosis in atherosclerosis
Keywords: هدایت سیگنال; Atherosclerosis; Fibrosis; Pathogenesis; Signal transduction; Risk factors
Sensitivity and mechanisms of taxol-resistant prostate adenocarcinoma cells to Vernonia amygdalina extract
Keywords: هدایت سیگنال; Vernonia amygdalina; PC-3 cells; Chemotherapy; Signal transduction; Proto-oncogenes; P-glycoprotein activity