Bax Inhibitor-1-mediated Ca2+ leak is decreased by cytosolic acidosis
Keywords: شبکه آندوپلاسمی ; Bax Inhibitor-1; Ca2+ signaling; Endoplasmic reticulum; Acidification;
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A short C-terminal tail prevents mis-targeting of hydrophobic mitochondrial membrane proteins to the ER
Keywords: شبکه آندوپلاسمی ; Endoplasmic reticulum; Mitochondria; Signal sequence; Co-translational translocation; Succinate dehydrogenase;
Inhibition of ADP-ribosylation suppresses aberrant accumulation of lipidated apolipoprotein B in the endoplasmic reticulum
Keywords: شبکه آندوپلاسمی ; ADP; adenosine diphosphate; ALLN; N-acetyl-l-leucyl-l-leucyl-l-norleucinal; ApoB; apolipoprotein B-100; Arf1; ADP-ribosylation factor 1; BFA; brefeldin A; DAPI; 4,6-diamidino-2-phenylindole; DHA; docosahexaenoic acid; ER; endoplasmic reticulum; GDP; guani
Congenital disorder of glycosylation due to DPM1 mutations presenting with dystroglycanopathy-type congenital muscular dystrophy
Keywords: شبکه آندوپلاسمی ; CDG; congenital disorder of glycosylation; DPM; dolichol-P-mannose synthase; DLO; dolichol-linked oligosaccharides; ER; endoplasmic reticulum; CK; creatine kinase; MRI; magnetic resonance imaging; EEG; electroencephalogram; CGH; comparative genomic hybrid
An asparagine at position 417 of tissue-nonspecific alkaline phosphatase is essential for its structure and function as revealed by analysis of the N417S mutation associated with severe hypophosphatasia
Keywords: شبکه آندوپلاسمی ; ALP; alkaline phosphatase; asparagine (417); asparagine at position 417 of TNSALP; ER; endoplasmic reticulum; Endo H; endo-β-N-acetylglucosaminidase H; GPI; glycosylphosphatidylinositol; HPP; hypophosphatasia; PI-PLC; phosphatidylinositol-specific phosph
Modulatory roles of NHERF1 and NHERF2 in cell surface expression of the glutamate transporter GLAST
Keywords: شبکه آندوپلاسمی ; PDZ; PSD-95/Drosophila discs-large protein/zonula occludens protein; NHERF; Na+/H+ exchanger regulatory factor; ER; endoplasmic reticulum; ERGIC; ER-Golgi intermediated compartment; EGFP; enhanced green fluorescent protein; COPII; coatomer protein compl
Lipids â A key for hepatitis C virus entry and a potential target for antiviral strategies
Keywords: شبکه آندوپلاسمی ; Hepatitis C virus; Lipids; Lipo-viro-particles; Viral entry; Membrane fusion; Antiviral; eLVP; empty Lipo-Viro-Particle; ER; endoplasmic reticulum; HCV; hepatitis C virus; HCVcc; cell culture-produced HCV; HCVpp; HCV pseudoparticles; HDL, LDL and VLDL; hi
TRAP assists membrane protein topogenesis at the mammalian ER membrane
Keywords: شبکه آندوپلاسمی ; Sec61 complex; Translocon associated proteins; Endoplasmic reticulum; Membrane protein topogenesis; RNA interference;
Involvement of SIRT1-AMPK signaling in the protective action of indole-3-carbinol against hepatic steatosis in mice fed a high-fat diet
Keywords: شبکه آندوپلاسمی ; I3C; indole-3-carbinol; HFD; high-fat diet; ND; normal diet; SREBP-1c; sterol regulatory element-binding protein-1c; FAS; fatty acid synthase; LPL; lipoprotein lipase; SIRT1; silent mating type information regulation 2 homolog 1; AMPK; AMP-activated prote
Anti-influenza A virus activity of uridine derivatives of 2-deoxy sugars
Keywords: شبکه آندوپلاسمی ; CC50; concentration of the compound required to reduce cell viability by 50%; CPE; cytopathic effect; CSFV; classical swine fever virus; Ct; cycle threshold; ER; endoplasmic reticulum; HA; hemagglutinin; IC50; concentration of the compound required to red
Novel imino sugar α-glucosidase inhibitors as antiviral compounds
Keywords: شبکه آندوپلاسمی ; Imino sugars; Neoglycoconjugates; Bovine viral diarrhea virus; Endoplasmic reticulum; Glucosidases;
Involvement of ASK1-p38 pathway in the pathogenesis of diabetes triggered by pancreatic à cell exhaustion
Keywords: شبکه آندوپلاسمی ; Ins2; Insulin 2 protein; ER; endoplasmic reticulum; ASK1; apoptosis signal-regulating kinase 1; UPR; unfolded protein response; PERK; protein kinase RNA-like ER kinase; ATF6; activating transcription factor 6; IRE1; inositol-requiring enzyme 1; ERAD; ER-a
Singularities of calcium signaling in effector T-lymphocytes
Keywords: شبکه آندوپلاسمی ; [Ca]i; intracellular calcium concentration; Cav; voltage dependent calcium (channels); Cav1AS; Cav1 specific antisense oligodeoxynucleotides; ER; endoplasmic reticulum; IL; interleukin; IP3; 1,4,5 triphosphate; OVA; ovalbumin; TCR; T-cell receptor; Th; T
Natural mutations lead to enhanced proteasomal degradation of human Ncb5or, a novel flavoheme reductase
Keywords: شبکه آندوپلاسمی ; Missense mutation; Proteasome; Desaturase; Endoplasmic reticulum; Diabetes; Ncb5or; NADH cytochrome b5 oxidoreductase; ER; endoplasmic reticulum; FFA; free fatty acid;
Chibby drives β catenin cytoplasmic accumulation leading to activation of the unfolded protein response in BCR-ABL1 + cells
Keywords: شبکه آندوپلاسمی ; CML; chronic myeloid leukemia; TK; tyrosine kinase; LSC; leukemic stem cell; APC; Adenomatous polyposis coli; GSK3; glycogen synthase kinase 3; CBY; Chibby; TCF; T cell factor; LEF; lymphoid enhancer factor; ER; endoplasmic reticulum; UPR; unfolded protei
Homer1 knockdown protects dopamine neurons through regulating calcium homeostasis in an in vitro model of Parkinson's disease
Keywords: شبکه آندوپلاسمی ; Parkinson's disease; Homer; Calcium channel; Endoplasmic reticulum;
Conjugated linoleic acid-induced apoptosis in mouse mammary tumor cells is mediated by both G protein coupled receptor-dependent activation of the AMP-activated protein kinase pathway and by oxidative stress
Keywords: شبکه آندوپلاسمی ; AMPK; AMP-activated protein kinase; 2-APB or APB; 2-aminoethyl diphenylborinate; BAPTA-AM; 1,2-bis(o-aminophenoxy)-ethane-N,N,-N',N'-tetraacetic acid tetraacetoxy-methyl ester; CaMKKα; calcium/calmodulin-dependent protein kinase kinase α; CLA; conjugate
Selective control of SNARE recycling by Golgi retention
Keywords: شبکه آندوپلاسمی ; Golgi; SNARE; Recycling; Retention; Endoplasmic reticulum; ER; Lipid raft; Membrane fusion; Vesicle; Dynamic equilibrium; i-SNARE; Homotypic fusion; Golgi tether; Entropy;
Optical manipulation of Saccharomyces cerevisiae cells reveals that green light protection against UV irradiation is favored by low Ca2+ and requires intact UPR pathway
Keywords: شبکه آندوپلاسمی ; BAPTA; 1,2-bis(o-aminophenoxy)-ethane-N,N,Nâ²,Nâ²-tetraacetic acid; DTT; dithiothreitol; EGTA; ethylene glycol-bis(2-aminoethylether)-N,N,Nâ²,Nâ²-tetraacetic acid; ER; endoplasmic reticulum; GL; green light; BL; blue light; MU; Miller units; ONPG; o-n
Proteomic-based identification of multiple pathways underlying n-butylidenephthalide-induced apoptosis in LNCaP human prostate cancer cells
Keywords: شبکه آندوپلاسمی ; 2DE; two-dimensional gel electrophoresis; ABC; ammonium bicarbonate; ACN; acetonitrile; BAD; BCL2 antagonist of cell death; BCL2; B-cell lymphoma 2; BP; n-butylidenephthalide; CCND1; cyclin D1; CDC25A; cell division cycle 25 homolog A; CDK; cyclin depende
BIG1, a brefeldin A-inhibited guanine nucleotide-exchange protein regulates neurite development via PI3K-AKT and ERK signaling pathways
Keywords: شبکه آندوپلاسمی ; AKT; protein kinase B; Arf; ADP-ribosylation factor; BFA; brefeldin A; BIG1; BFA-inhibited guanine nucleotide-exchange protein 1; DIV; days in vitro; ECL; Dulbecco's modification of Eagle's medium; ER; enhanced chemiluminescence; EDTA; ethylenediamine
New mutation in the myocilin gene segregates with juvenile-onset open-angle glaucoma in a Brazilian family
Keywords: شبکه آندوپلاسمی ; ER; endoplasmic reticulum; IOP; intraocular pressure; JOAG; juvenile-onset open-angle glaucoma; LE; left eye; MYOC; myocilin gene; POAG; primary open-angle glaucoma; RE; right eye; RMSD; root-mean-square deviation; SHI; Surface Hydrophobicity Index; I
Identification of calcium-transporting ATPases of Entamoeba histolytica and cellular localization of the putative SERCA
Keywords: شبکه آندوپلاسمی ; Entamoeba histolytica; Calcium-ATPases; Organellar ATPases; Calcium homeostasis; Endoplasmic reticulum;
Research reportDietary supplementation with Salvia sahendica attenuates memory deficits, modulates CREB and its down-stream molecules and decreases apoptosis in amyloid beta-injected rats
Keywords: شبکه آندوپلاسمی ; Aβ; amyloid beta; AD; Alzheimer's disease; ANOVA; analysis of variance; CREB; Ca2+/cAMP-response element binding protein; DAB; diaminobenzidine; ECL; electrochemiluminescence; ER; endoplasmic reticulum; MWM; Morris water maze; PGC-1α; peroxisome prolife
Research ArticleTIP47 plays a crucial role in the life cycle of hepatitis C virus
Keywords: شبکه آندوپلاسمی ; HCV; hepatitis C virus; LD; lipid droplet; TIP47; tail interacting protein of 47Â kD; NS5A; non-structural protein 5A; RC; replicon complex; ER; endoplasmic reticulum; MPR; mannose-6-phosphate receptor; PEI; polyethyleneimine; HPLC; high performance liqui
Research ArticleCHOP is a critical regulator of acetaminophen-induced hepatotoxicity
Keywords: شبکه آندوپلاسمی ; DILI; drug induced liver injury; APAP; acetaminophen (N-acetyl-p-aminophenol); NAPQI; N-acetylbenzoquinoneimine; GSH; glutathione; ER; endoplasmic reticulum; UPR; unfolded protein response; ALI; acute liver injury; ROS; reactive oxygen species; ALT; alani
Glucotoxic conditions induce endoplasmic reticulum stress to cause caspase 3 mediated lamin B degradation in pancreatic β-cells: Protection by nifedipine
Keywords: شبکه آندوپلاسمی ; CHOP; C/EBP homologous protein; ER; endoplasmic reticulum; FTase; farnesyl transferase; FTI; farnesyl transferase inhibitor; Nif; nifedipine; PBA; 4-phenylbutyric acid; Tg; thapsigargin; Caspase 3; Glucotoxicity; Nuclear lamin B; Pancreatic islet β-cell;
FRET-based sensor analysis reveals caveolae are spatially distinct Ca2+ stores in endothelial cells
Keywords: شبکه آندوپلاسمی ; LOX-1; lectin-like oxidized low-density lipoprotein receptor 1; ER; endoplasmic reticulum; IP3; inositol 1,4,5-trisphosphate; FRET; Cameleon; Ca2+ regulation; Endothelial cells; Vascular endothelial function;
Long-term liraglutide treatment is associated with increased insulin content and secretion in β-cells, and a loss of α-cells in ZDF rats
Keywords: شبکه آندوپلاسمی ; ANOVA; analysis of variance; BSA; bovine serum albumin; EM; electron microscope; ER; endoplasmic reticulum; GLP-1; glucagon-like peptide-1; HbA1c; glycated hemoglobin; HRP; horseradish peroxidase; IACUCI; nstitutional Animal Care and Use Committee; IF; im
The effect of inorganic arsenic on endothelium-dependent relaxation: Role of NADPH oxidase and hydrogen peroxide
Keywords: شبکه آندوپلاسمی ; ACh; acetylcholine; CPA; cyclopiazonic acid; DHE; dihydroethidium; ER; endoplasmic reticulum; KCa; calcium-activated K+ channels; NO; nitric oxide; H2O2; hydrogen peroxide; L-NAME; NG-nitro-L-arginine methyl ester; O2â¢â; superoxide anion; PE; phenylep
Lead-induced ER calcium release and inhibitory effects of methionine choline in cultured rat hippocampal neurons
Keywords: شبکه آندوپلاسمی ; [Ca2+]i; intracellular free calcium ion concentration; [Ca2+]ER; endoplasmic reticulum free calcium ion concentration; ER; endoplasmic reticulum; LMWH; low molecular weight heparin; DIV; days in vitro; IP3; inositol-1,4,5-triphosphate; IP3R; IP3 receptors
The α2δ subunits of voltage-gated calcium channels
Keywords: شبکه آندوپلاسمی ; DHP; dihydropyridine; DRG; dorsal root ganglion; ER; endoplasmic reticulum; HVA; high-voltage activated; LVA; low voltage-activated; MIDAS; metal ion dependent adhesion site; VWA; von Willebrand factor-A; Calcium channel; Auxiliary subunit; Electrophysiol
Targeting CD133 in an in vivo ovarian cancer model reduces ovarian cancer progression
Keywords: شبکه آندوپلاسمی ; dCD133KDEL; deimmunized pseudomonas exotoxin fused to anti-CD133 scFv with a KDEL terminus; aa; amino acid; Ab; antibody; CD19; cluster of differentiation 19; CD45; cluster of differentiation 45; ER; endoplasmic reticulum; FITC; fluorescein isothiocyanate
Role of cysteine-protease CGHC motifs of ER-60, a protein disulfide isomerase, in hepatic apolipoprotein B100 degradation
Keywords: شبکه آندوپلاسمی ; ApoB Degradation; ER-60; Cysteine protease; Protein disulfide isomerase; Endoplasmic reticulum;
Src kinases are important regulators of mitochondrial functions
Keywords: شبکه آندوپلاسمی ; OXPHOS; oxidative phosphorylation; ETS; electron transport system; PKA; cAMP-dependent protein kinase; ROS; reactive oxygen species; Y; tyrosine; MEF; mouse embryonic fibroblasts; ER; endoplasmic reticulum; PKCδ; protein kinase C δ; RBM; rat brain mitoc
Glyceollin improves endoplasmic reticulum stress-induced insulin resistance through CaMKK-AMPK pathway in L6 myotubes
Keywords: شبکه آندوپلاسمی ; CaMKK; Ca2+/calmodulin-dependent protein kinase kinase; AMPK; AMP-activated protein kinase; ACC; acetyl-CoA carboxylase; ER; endoplasmic reticulum; PERK; double stranded RNA-activated protein kinase-like ER-associated kinase; IRE-1; inositol requiring ER-
Primary pathways of intracellular Ca2Â + mobilization by nanosecond pulsed electric field
Keywords: شبکه آندوپلاسمی ; 2-APB; 2-aminoethoxydiphenyl borate; CICR; Ca2Â +-induced Ca2Â +-release; [Ca2Â +]i; intracellular concentration of free Ca2Â + ions; [Ca2Â +]o; extracellular concentration of free Ca2Â + ions; DMSO; dimethylsolfoxide; EGTA; ethylene glycol tetraacetic ac
Changes in vimentin, lamin A/C and mitofilin induce aberrant cell organization in fibroblasts from Fanconi anemia complementation group A (FA-A) patients
Keywords: شبکه آندوپلاسمی ; Fanconi anemia; Oxidative stress; Cell structure; 2D-PAGE; two dimensional polyacrylamide gel electrophoresis; AML; acute myeloid leukemia; BM; bone marrow; DSBs; double strand breaks; ER; endoplasmic reticulum; GRP94; glucose response protein 94; HSC; hu
Neuroprotective changes of thalamic degeneration-related gene expression by acupuncture in an MPTP mouse model of parkinsonism: Microarray analysis
Keywords: شبکه آندوپلاسمی ; MPTP; 1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine; PD; Parkinson's disease; DA; Dopamine; 6-OHDA; 6-Hydroxydopamine; TBS; Tris-buffered saline; TH; tyrosine hydroxylase; SDS-PAGE; sodium dodecyl sulfate-polyacrylamide gel electrophoresis; PVDF; polyvinyl
Polycystin-2 mutations lead to impaired calcium cycling in the heart and predispose to dilated cardiomyopathy
Keywords: شبکه آندوپلاسمی ; ADPKD; autosomal dominant polycystic kidney disease; APD; action potential duration; AV; atrioventricular; bpm; beats per minute; dpf; days post fertilization; CICR; calcium-induced calcium release; ER; endoplasmic reticulum; hpf; hours post fertilization
Functional characterization of the plant ubiquitin regulatory X (UBX) domain-containing protein AtPUX7 in Arabidopsis thaliana
Keywords: شبکه آندوپلاسمی ; AAA-ATPase; ATPase associated with diverse cellular activities; ER; endoplasmic reticulum; ERAD; endoplasmic reticulum-associated protein degradation; IME; intron-mediated enhancement; PUX; plant ubiquitin regulatory X domain-containing protein; Ub; ubiqu
Research ArticleER stress in human hepatic cells treated with Efavirenz: Mitochondria again
Keywords: شبکه آندوپلاسمی ; ER; endoplasmic reticulum; UPR; unfolded protein response; PI; protease inhibitor; HIV1; human immunodeficiency virus 1; HCV; hepatitis C virus; EFV; efavirenz; cART; combined antiretroviral therapy; ÎΨm; mitochondrial membrane potential; ROS; reactive
D. melanogaster, mitochondria and neurodegeneration: small model organism, big discoveries
Keywords: شبکه آندوپلاسمی ; AD; Alzeheimer's disease; ADOA; Autosomal dominant optic atrophy; AP; Amyloid plaque; APP; Amyloid precursor protein; Aβ; Amino acids amyloid β-peptides; CaMKIIa; Calcium/calmodulin dependent protein kinase II alpha; CMTIIa; Charcot-Marie-Tooth type
The hyperglycemia stimulated myocardial endoplasmic reticulum (ER) stress contributes to diabetic cardiomyopathy in the transgenic non-obese type 2 diabetic rats: A differential role of unfolded protein response (UPR) signaling proteins
Keywords: شبکه آندوپلاسمی ; AMPK; 5â² adenosine monophosphate-activated protein kinase; ATF6; activated transcription factor 6; BW; body weight; CHOP/GADD153; CCAAT/-enhancer-binding protein homologous protein; CPT1; carnitine palmitoyl transferase 1; ER; endoplasmic reticulum; GLU
Neuroprotective effects of Total Saikosaponins of Bupleurum yinchowense on corticosterone-induced apoptosis in PC12 cells
Keywords: شبکه آندوپلاسمی ; Total Saikosaponins; Corticosterone; Neuroprotection; Mitochondria; Endoplasmic reticulum; PC12 cells;
Glycogen synthase kinase 3 regulates expression of nuclear factor-erythroid-2 related transcription factor-1 (Nrf1) and inhibits pro-survival function of Nrf1
Keywords: شبکه آندوپلاسمی ; ARE; antioxidant response element; CNC-BZIP; Cap 'n' Collar-type basic leucine zipper; CPD; Cdc4 phosphodegron domain; ER; endoplasmic reticulum; GSK3; glycogen synthase kinase 3; Nrf1; nuclear factor E2-related factor-1; SCF; Skp1-Cul1-F-box; UPS
Involvement of endoplasmic reticulum and autophagy in microcystin-LR toxicity in Vero-E6 and HepG2 cell lines
Keywords: شبکه آندوپلاسمی ; Microcystin-LR; Vero-E6 cells; HepG2 cells; Autophagy; Lysosomes; Endoplasmic reticulum;
Cylindrospermopsin induced transcriptional responses in human hepatoma HepG2 cells
Keywords: شبکه آندوپلاسمی ; AP-1; activator protein; BER; base excision repair; CDK; cyclin-dependant kinase; CDKI; cyclin-dependant kinase inhibitor; CYN; cylindrospermopsin; CYP450; cytochrome P450; DSB; DNA double-strand break; ER; endoplasmic reticulum; GST; glutathione S-transf
Painful nerve injury decreases sarco-endoplasmic reticulum Ca2+-ATPase activity in axotomized sensory neurons
Keywords: شبکه آندوپلاسمی ; ANOVA; analysis of variance; [Ca2+]c; cytoplasmic Ca2+ concentration; [Ca2+]L; endoplasmic reticulum lumen Ca2+ concentration; CICR; Ca2+-induced Ca2+ release; DMSO; dimethyl sulfoxide; DRG; dorsal root ganglion; ER; endoplasmic reticulum; HEPES; 4-(2-hyd
Endoplasmic reticulum-localized hepatic lipase decreases triacylglycerol storage and VLDL secretion
Keywords: شبکه آندوپلاسمی ; apoB; apolipoprotein B; ATGL; adipose triglyceride lipase; CE; cholesteryl ester; DG; diacylglycerol; ER; endoplasmic reticulum; E600; diethyl-p-nitrophenylphosphate; FA; fatty acid; HL; hepatic lipase; HL-R; ER-retained hepatic lipase; McA; McArdle-RH777