Linear ubiquitination in NF-κB signaling and inflammation: What we do understand and what we do not
Keywords: یوبیکویتین; Immunity; NF-κB; Signaling; TNF; Ubiquitin;
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Featured ArticleAn analysis of global research funding for the frontotemporal dementias: 1998-2008
Keywords: یوبیکویتین; Frontotemporal dementia; Research funding; Landscape analysis; Tau; Tangle; Pick's disease; Ubiquitin; TDP-43; Corticobasal degeneration;
Rapid identification of protein-protein interfaces for the construction of a complex model based on multiple unassigned signals by using time-sharing NMR measurements
Keywords: یوبیکویتین; CAPRI; Critical Assessment of PRedicted Interactions; HSQC; heteronuclear single quantum correlation; RDC; residual dipolar coupling; TEV; tobacco etch virus; TROSY; transverse relaxation-optimized spectroscopy; Ub; ubiquitin; YUH; yeast ubiquitin hydrola
Nitric Oxide Increases Lysine 48-Linked Ubiquitination Following Arterial Injury1
Keywords: یوبیکویتین; neointimal hyperplasia; nitric oxide; ubiquitin; lysine 48-linked ubiquitin; proteasome
Protein import machineries of peroxisomes
Keywords: یوبیکویتین; AAA; ATPase associated with various cellular activities; PTS; peroxisomal targeting signal; RING; really interesting new gene; Ub; ubiquitin; Peroxisome biogenesis; Protein targeting; PEX; Peroxin;
TRIM29 negatively regulates p53 via inhibition of Tip60
Keywords: یوبیکویتین; TRIM29; p53; Tip60; Ubiquitin; Ataxia-telangiectasia;
Changing the ubiquitin landscape during viral manipulation of the DNA damage response
Keywords: یوبیکویتین; Ubiquitin; Ubiquitin ligase; DNA damage; DNA repair; Virus infection;
Regulation of TNF-induced NF-κB activation by different cytoplasmic ubiquitination events
Keywords: یوبیکویتین; TNF; NF-κB; Ubiquitin; A20; Immunity
Protein homeostasis and aging: The importance of exquisite quality control
Keywords: یوبیکویتین; Autophagy; Chaperones; Proteases; Proteasome; Proteolysis; Ubiquitin
Helicobacter pylori affects the cellular deubiquitinase USP7 and ubiquitin-regulated components TRAF6 and the tumour suppressor p53
Keywords: یوبیکویتین; Helicobacter pylori; Ubiquitin; Deubiquitinating enzyme; USP7; TRAF6; Oncogene p53; Infection and cancer
Ubiquitin-proteasome pathway and cellular responses to oxidative stress
Keywords: یوبیکویتین; Ubiquitin; Proteasome; Oxidative stress; Protein quality control; Free radicals;
Intracellular colocalization of HAP1/STBs with steroid hormone receptors and its enhancement by a proteasome inhibitor
Keywords: یوبیکویتین; Huntington's disease; Polyglutamine; Steroid; Ubiquitin; MG132; Time-lapse analysis;
Accumulation and distribution of α-synuclein and ubiquitin in the CNS of Gaucher disease mouse models
Keywords: یوبیکویتین; Glucocerebrosidase (GCase); Lysosomal storage diseases; Parkinsonism; α-synuclein; Ubiquitin
Gene expression in the hippocampus: Regionally specific effects of aging and caloric restriction
Keywords: یوبیکویتین; Aging; Diet; Hippocampus; Transcription; Proteosome; Ubiquitin
Prolyl hydroxylation- and glycosylation-dependent functions of Skp1 in O2-regulated development of Dictyostelium
Keywords: یوبیکویتین; GlcNAc; N-acetyl-d-glucosamine; HIF; hypoxia inducible factor; Hyp; 4-hydroxyproline; PHD; prolyl hydroxylase domain protein; RFP; red fluorescent protein; rP4H1; recombinant His6P4H1 isolated from E. coli; rGnt1; recombinant His6Gnt1 isolated from E. col
A Proteasome Assembly Defect in rpn3 Mutants Is Associated with Rpn11 Instability and Increased Sensitivity to Stress
Keywords: یوبیکویتین; multiUb, multiubiquitinated; GST, glutathione S-transferase; GFP, green fluorescent protein; CP, catalytic particle; HA, hemagglutinin; WT, wild typeproteasome; Rpn3; ubiquitin; proteolysis; Rad23
Alzheimer's disease as homeostatic responses to age-related myelin breakdown
Keywords: یوبیکویتین; Aging; Oligodendrocyte; Peroxisome; BACE; Neuregulin; Apolipoprotein; Prevention; Ubiquitin; α-Synuclein; TDP-43; FTLD
Condensed E. coli cultures for highly efficient production of proteins containing unnatural amino acids
Keywords: یوبیکویتین; Unnatural amino acid; tRNA; Ubiquitin; Aminoacyl-tRNA synthetaseUAA, unnatural amino acid; Ub, ubiquitin; sfGFP, superfolder green fluorescent protein
Ubiquitination of LHY by SINAT5 regulates flowering time and is inhibited by DET1
Keywords: یوبیکویتین; E1; ubiquitin-activating enzyme; E2; ubiquitin-conjugating enzyme; E3; ubiquitin ligase; HECT; E6-associated protein carboxyl terminus; SINA; seven in absentia; SINAT5; an Arabidopsis homologue of the SINA; Siah1; a human homologue of the SINA; NAC1; NOAP
PerspectiveAlzheimer's disease, a multifactorial disorder seeking multitherapies
Keywords: یوبیکویتین; Alzheimer disease subgroups; Cerebrospinal fluid; CSF biomarkers; Aβ1-42; Tau; Ubiquitin; Alzheimer disease therapeutics; Neurofibrillary degeneration; β-amyloid;
An immunohistochemical study of ubiquitin in the skin of sporadic amyotrophic lateral sclerosis
Keywords: یوبیکویتین; Amyotrophic lateral sclerosis; Ubiquitin; Skin; Immunohistochemistry; Epidermis
Up-regulation of ferritin ubiquitination in skeletal muscle of transgenic rats bearing the G93A hmSOD1 gene mutation
Keywords: یوبیکویتین; Iron; Ubiquitin; Oxidative stress;
Delineating role of ubiquitination on nuclear factor-kappa B pathway by a computational modeling approach
Keywords: یوبیکویتین; Ubiquitin; NF-κB; Cell signaling; Post-translational modification; Computational modeling;
Physiological significance of selective degradation of p62 by autophagy
Keywords: یوبیکویتین; Autophagy; Ubiquitin; p62; Neighbor of BRCA1 gene 1; TRAF6; Caspase-8; Keap1Atg, autophagy-related; DISC, death-inducing signaling complex; LC3, microtubule-associated protein 1 light chain 3; LIR, LC3-interacting region; LRS, LC3 recognition sequence; Nb
c-Cbl mediated ubiquitylation and regulation of cell surface exposure of CD5
Keywords: یوبیکویتین; CD5; c-Cbl; Ubiquitin; Thymus; Receptor downregulation
The COP9 signalosome and its role in plant development
Keywords: یوبیکویتین; Arabidopsis; Auxin response; Cell cycle; COP9 signalosome; CSN5; DNA damage; E3 ubiquitin ligases; NEDD8; Ubiquitin
PI3K inhibition causes the accumulation of ubiquitinated presenilin 1 without affecting the proteasome activity
Keywords: یوبیکویتین; Alzheimer’s disease; γ-Secretase complex; Presenilin 1; Phosphatidylinositol-3 kinase; Proteasome; Ubiquitin
The E3 ubiquitin ligase WWP1 regulates ÎNp63-dependent transcription through Lys63 linkages
Keywords: یوبیکویتین; Ubiquitin; HECT; Ubiquitin ligase; p63; Transcription; Cell death; Skin; Epidermis;
Protein stability at negative pressure
Keywords: یوبیکویتین; Pressure denaturation; Thermal denaturation; Ubiquitin; Protein folding; NMR spectroscopy;
Biochemical and cellular effects of inhibiting Nedd8 conjugation
Keywords: یوبیکویتین; Nedd8; Ubc12; Cullin RING E3 ligases; Ubiquitin; RhoA; Neddylation; Actin cytoskeleton; Protein degradation
Decreased replication of human respiratory syncytial virus treated with the proteasome inhibitor MG-132
Keywords: یوبیکویتین; HRSV; Ubiquitin; Budding; Proteasome; eIF2α; Translation inhibition
Effect of the overexpression of mutant ubiquitin (K48R) on the cellular response induced by 4-hydroxy-2,3-trans-nonenal, an end-product of lipid peroxidation
Keywords: یوبیکویتین; Ubiquitin; Proteasome; Oxidative/nitrative damage; 4-Hydroxy-2,3-trans-nonenal;
Human SUMO fusion systems enhance protein expression and solubility
Keywords: یوبیکویتین; Fusion protein; SUMO1; SUMO2; Ubiquitin; Soluble expression; Protein purification;
Functional availability of γ-herpesvirus K-cyclin is regulated by cellular CDK6 and p16INK4a
Keywords: یوبیکویتین; KSHV; Cyclin; Ubiquitin; ProteasomeKSHV, Kaposi’s sarcoma-associated herpesvirus; HHV-8, human herpes virus-8; EBV, Epstein-Barr virus; HHV-4, human herpes virus-4
CTLA-4 (CD152) inhibits T cell function by activating the ubiquitin ligase Itch
Keywords: یوبیکویتین; CFSE; 5,6-carboxyfluorescein diacetate succinimidyl ester; CTLA-4; cytotoxic T lymphocyte antigen-4; PKC-Î; protein kinase C Î; PLC-γ1; phospholipase C-γ1; SHP-2; SH2-domain containing protein tyrosine phosphatase 2; Costimulation; Signal transduction
Increased neuronal Rab5 immunoreactive endosomes do not colocalize with TDP-43 in motor neuron disease
Keywords: یوبیکویتین; Cathepsin; Endosome; Lysosome; Motor neuron disease; Rab5; TDP-43; Ubiquitin
Regulation of gap junction intercellular communication by the ubiquitin system
Keywords: یوبیکویتین; Gap junction; Connexin; Ubiquitin; ERAD; Endocytosis
MafB protein stability is regulated by the JNK and ubiquitin–proteasome pathways
Keywords: یوبیکویتین; JNK; MafB; Phosphorylation; Proteasome; Stability; Ubiquitin
Temporal and spatial regulatory functions of the V(D)J recombinase
Keywords: یوبیکویتین; Recombination; Lymphocyte development; Epigenetic control; Histone methylation; Plant homeodomain; Cell cycle; DNA repair; Protein degradation; Ubiquitin
Post-translational modification of CASK leads to its proteasome-dependent degradation
Keywords: یوبیکویتین; CASK; MAGUK; Ubiquitin; Proteasome; Phosphorylation;
The contribution of plasmid design and release to in vivo gene expression following delivery from cationic polymer modified scaffolds
Keywords: یوبیکویتین; Sustained gene delivery; Cationic polymers; Ubiquitin; Tissue engineering; Layered scaffolds; Polydopamine
Selective vulnerability of neurons to acute toxicity after proteasome inhibitor treatment: Implications for oxidative stress and insolubility of newly synthesized proteins
Keywords: یوبیکویتین; Neuron; Proteasome; Ubiquitin; Oxidative stress; Astrocyte; Free radicals;
Increased protein hydrophobicity in response to aging and Alzheimer disease
Keywords: یوبیکویتین; Alzheimer disease; Aging; Oxidative stress; Neuron; Proteasome; Ubiquitin; Free radicals
Neurons but not glial cells overexpress ubiquitin in the rat brain following focused ultrasound-induced opening of the blood–brain barrier
Keywords: یوبیکویتین; blood–brain barrier; BBB; ultrasound; ubiquitin; apoptosis; chaperonesBBB, blood–brain barrier; ER, endoplasmic reticulum; GFAP, glial fibrillary acidic protein; Hsp70, heat-shock protein 70
Tissue-specific variation of Ube3a protein expression in rodents and in a mouse model of Angelman syndrome
Keywords: یوبیکویتین; Angelman syndrome; Ubiquitin; Ubiquitin ligase; E6-AP; Ube3a; Genetic imprinting; Synapse; Epilepsy; Thalamocortical; Interneurons;
TRIM9, a novel brain-specific E3 ubiquitin ligase, is repressed in the brain of Parkinson's disease and dementia with Lewy bodies
Keywords: یوبیکویتین; α-Synuclein; Dementia with Lewy bodies; Parkinson's disease; Tripartite motif protein 9 (TRIM9); Ubiquitin
Rational design based synthetic polyepitope DNA vaccine for eliciting HIV-specific CD8+ T cell responses
Keywords: یوبیکویتین; HIV-1; CD8+ T cell epitopes; Poly-CD8+ T cell epitope immunogen; DNA vaccine; Ubiquitin; Proteasome-mediated processing; CD8+ T cell responses; Immunogenicity
UBQLN1 interacts with SPEM1 and participates in spermiogenesis
Keywords: یوبیکویتین; Spermatogenesis; Ubiquitination; Ubiquitin; Sperm; Infertility; Manchette; Protein turnover
Celastrol can inhibit proteasome activity and upregulate the expression of heat shock protein genes, hsp30 and hsp70, in Xenopus laevis A6 cells
Keywords: یوبیکویتین; Heat shock protein; Xenopus; Ubiquitin; Proteasome; Confocal microscopy; KNK437
Ageing enhances α-synuclein, ubiquitin and endoplasmic reticular stress protein expression in the nigral neurons of Asian Indians
Keywords: یوبیکویتین; PD; Parkinson's disease; ER; endoplasmic reticulum; GRP78; glucose-regulated protein of 78Â kDa molecular weight; TH; tyrosine hydroxylase; SNpc; substantia nigra pars compacta; 28GW; 28 gestational weeks; BSA; bovine serum albumin; FITC; fluorescein isot