Development of a peptide-based inducer of protein degradation targeting NOTCH1
Keywords: یوبیکویتین; Transcriptional factor; NOTCH1; Protein knockdown; Ubiquitin; Proteasome;
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Identification of UBact, a ubiquitin-like protein, along with other homologous components of a conjugation system and the proteasome in different gram-negative bacteria
Keywords: یوبیکویتین; UBact; Ubiquitin; Pup; Proteasome; Bacteria; Dop; Deamidase of Pup; Mpa; mycobacterial proteasome ATPase; PafA; Proteasome accessory factor A; PPS; Pup-proteasome system; PrcA; proteasome subunit α; PrcB; proteasome subunit β; Pup; prokaryotic ubiquitin
A20 inhibits both the degradation and limited processing of the NF-κB p105 precursor: A novel additional layer to its regulator role
Keywords: یوبیکویتین; A20; NF-κB; p105; Processing; Ubiquitin; KPC1;
The role of SUMOylation in ageing and senescent decline
Keywords: یوبیکویتین; Ageing; Autophagy; PML body; Reactive oxygen species; Senescence; SUMO; Ubiquitin;
CACUL1/CAC1 attenuates p53 activity through PML post-translational modification
Keywords: یوبیکویتین; CACUL1; PML; SUMO; Ubiquitin; p53;
Regulation of REST levels overcomes dysregulation of neural stem cell differentiation caused by disruption of polyubiquitin gene Ubb
Keywords: یوبیکویتین; Polyubiquitin gene; Ubiquitin; Neuronal development; Neurogenesis; Repressor element-1 silencing transcription factor (REST); Apoptosis; REST; repressor element-1 silencing transcription factor; Ub; ubiquitin; NSC; neural stem/progenitor cell; KD; knockdo
Effects of first exogenous nutrients on the mRNA levels of atrogin-1/MAFbx and GLUT1 in the skeletal muscles of newly hatched chicks
Keywords: یوبیکویتین; GLUT; glucose transporter; MAFbx; muscle atrophy F-box; Ub; ubiquitin; MeHis; 3-methylhistidine; Atrogin-1/MAFbx; AKT; Glucose transporter; Neonatal chicks; Skeletal muscle;
E6AP/UBE3A catalyzes encephalomyocarditis virus 3C protease polyubiquitylation and promotes its concentration reduction in virus-infected cells
Keywords: یوبیکویتین; 3C protease; ARIH1; E6AP/UBE3A; Encephalomyocarditis virus; UbcH7/UBE2L3; Ubiquitylation; 3Cpro; 3C protease; EMCV; encephalomyocarditis virus; HRV; human rhinovirus; HECT; homologous to E6AP carboxyl terminus; RBR; ring between ring; RING; really interes
Working your SOCS off: The role of ASB10 and protein degradation pathways in glaucoma
Keywords: یوبیکویتین; ASB10; Glaucoma; Protein degradation; SOCS proteins; Autophagy; Ubiquitin; Retinal ganglion cells;
Lead discovery and chemical biology approaches targeting the ubiquitin proteasome system
Keywords: یوبیکویتین; Proteasome; Protein degradation; Molecular glue; Drug discovery; High-throughput; Ubiquitin;
ReviewParkin and PINK1 functions in oxidative stress and neurodegeneration
Keywords: یوبیکویتین; PINK1; Parkin; Ubiquitin; Neurodegeneration; Oxidative stress; Mitophagy;
Nitric oxide-regulated proteolysis of human CYP2B6 via the ubiquitin-proteasome system
Keywords: یوبیکویتین; AAF; L-alanyl-N-[(1S)â3-chloro-2-oxo-1-(phenylmethyl)propyl]-L-alaninamide, mono trifluoro-acetate; ALLN; N-acetyl-L-leucyl-N-[(1S)â1-formylpentyl]-L-leucinamide; Cal III; N-[(1S)â1-[[(1-formyl-2-phenylethyl)amino]carbonyl]â2-methylpropyl]-carbami
Modulation of proteostasis by transcription factor NRF2 and impact in neurodegenerative diseases
Keywords: یوبیکویتین; α-SYN; alpha synuclein; β-TrCP; β-transducin repeat containing E3 ubiquitin protein ligase; Aβ; amyloid beta; AD; Alzheimer's disease; ALS; amyotrophic lateral sclerosis; AMPK; AMP-activated protein kinase; ARE; antioxidant response element; ASK1; apo
Immune defects caused by mutations in the ubiquitin system
Keywords: یوبیکویتین; Ubiquitin; nuclear factor κB; immunodeficiency; CVID; Common variable immunodeficiency; DUB; Deubiquitinating enzyme; EDA-ID; Ectodermal dysplasia with immunodeficiency; HECT; Homologous to EGAP C-terminus; HOIL-1; Heme-oxidase iron responsive element bi
The two Dictyostelium discoideum autophagy 8 proteins have distinct autophagic functions
Keywords: یوبیکویتین; Dictyostelium discoideum; Autophagy; ATG8/LC3/GABARAP; Ubiquitin; Proteasome;
A Highly Diverse and Functional Naïve Ubiquitin Variant Library for Generation of Intracellular Affinity Reagents
Keywords: یوبیکویتین; Ubv; ubiquitin variant; Ub; ubiquitin; wt; wild-type; EGFR; epidermal growth factor receptor; EGF; epidermal growth factor; Her3; human epidermal growth factor receptor 3; NRG; neuregulin; Grb2; growth factor receptor-bound protein 2; GST; glutathione S-t
Effect of alternative oil sources at different dietary inclusion levels on food intake and appetite regulation via enteroendocrine and central factors in juvenile Solea senegalensis (Kaup, 1858)
Keywords: یوبیکویتین; FO; fish oil; VO; vegetable oil; FM; fish meal; PUFA; polyunsaturated fatty acid; LC-PUFA; long-chain polyunsaturated fatty acid; MUFA; monounsaturated fatty acids; SFA; saturated fatty acids; DHA; docosahexaenoic acid; EPA; eicosapentaenoic acid; FA; fat
Systemic insulin sensitivity is regulated by GPS2 inhibition of AKT ubiquitination and activation in adipose tissue
Keywords: یوبیکویتین; Adipose tissue; Obesity; Insulin; AKT; Ubiquitin; GPS2;
DNA damage response and autophagy in the degeneration of retinal pigment epithelial cells-Implications for age-related macular degeneration (AMD)
Keywords: یوبیکویتین; 9-1-1 complex; complex of Rad9 Rad1 and Hus1 proteins; A2E; N-retinylidene-N-retinylethanol-amine; AtRal; all-trans retinal; AMD; age-related macular degeneration; AMPK; AMP-activated protein kinase; Atg; autophagy-related gene; ATM; ataxia-telangiectasia
A Residue Specific Insight into the Arkadia E3 Ubiquitin Ligase Activity and Conformational Plasticity
Keywords: یوبیکویتین; TGF-β; transforming growth factor beta; R-Smads; receptor Smads; Ub; ubiquitin; RING; really interesting new gene; HSQC; heteronuclear single quantum coherence; APSY; automated projection spectroscopy; NOE; nuclear Overhauser effect; WT; wild-type; CSP;
Intracellular protein degradation: From a vague idea thru the lysosome and the ubiquitin-proteasome system and onto human diseases and drug targeting
Keywords: یوبیکویتین; Ubiquitin; Proteasome; Protein degradation; Lysosome; ODC; ornitihine decarboxylase; G6PD; glucose-6-phosphate dehydrogenase; PEPCK; phosphoenol-pyruvate carboxykinase; TAT; tyrosine aminotransferase; APF-1; ATP-dependent Proteolysis Factor 1 (ubiquitin);
Plant E3 ligases ubiquitinate Escherichia coli Ï32in vitro
Keywords: یوبیکویتین; E3 ligase; ubiquitin; Ï32; Escherichia coli; IPTG; isopropyl-β-d-thiogalactoside; CBB; coomassie Brilliant Blue; Co-IP; Co-Immunoprecipitation; UBL; ubiquitin-like protein; HSR; heat shock response;
Synthesis and antiproteasomal activity of novel O-benzyl salicylamide-based inhibitors built from leucine and phenylalanine
Keywords: یوبیکویتین; Proteasome; Inhibitor; Apoptosis; Ubiquitin; Salicylamide;
Molecular dynamics simulations reveal a new role for a conserved active site asparagine in a ubiquitin-conjugating enzyme
Keywords: یوبیکویتین; Ubiquitin; E2; Ubc13; Ubiquitination; Molecular dynamics;
The Itch ubiquitin ligase is required for KSHV RTA induced vFLIP degradation
Keywords: یوبیکویتین; Kaposi's sarcoma; KSHV; HHV-8; Herpesvirus; vFLIP; RTA; Ubiquitin; Itch; AIP4; NF-κB;
Drosophila Argonaute2 turnover is regulated by the ubiquitin proteasome pathway
Keywords: یوبیکویتین; Argonaute; RNAi; Protein stability; Ubiquitin; Proteasome;
KLHL7 promotes TUT1 ubiquitination associated with nucleolar integrity: Implications for retinitis pigmentosa
Keywords: یوبیکویتین; KLHL7; TUT1; Nucleolus; Ubiquitin; Retinitis pigmentosa;
Ubiquitin phosphorylated at Ser57 hyper-activates parkin
Keywords: یوبیکویتین; E3 ligase; Genetic code expansion; Parkinson's disease; Post-translational modification; Refolding; SepRS; tRNASep; Ubiquitin;
ReviewThe roles of ubiquitin modifying enzymes in neoplastic disease
Keywords: یوبیکویتین; Ubiquitin; E3 ligases; Deubiquitinating enzymes; Cancer; Dub inhibitors;
Detailed two-dimensional gel proteomic mapping of the feces of the house dust mite Dermatophagoides pteronyssinus and comparison with D. farinae: Reduced trypsin protease content in D. pteronyssinus and different isoforms
Keywords: یوبیکویتین; Digestion; Chitinase; Cysteine protease; NPC2; Ubiquitin;
Life and death in the trash heap: The ubiquitin proteasome pathway and UCHL1 in brain aging, neurodegenerative disease and cerebral Ischemia
Keywords: یوبیکویتین; Ubiquitin; Ubiquitin proteasome pathway (UPP); Neurodegenerative disease; Ubiquitin carboxy-terminal hydrolase L1(UCHL1); Cerebral ischemia; Aging;
Decreased linear ubiquitination of NEMO and FADD on apoptosis with caspase-mediated cleavage of HOIP
Keywords: یوبیکویتین; NF-κB; Apoptosis; Ubiquitin; Deubiquitinase; Caspase; CHX; cycloheximide; E3; ubiquitin ligase; FADD; Fas-associated death domain protein; IKK; IκB kinase; LUBAC; linear ubiquitin chain assembly complex; NEMO; NF-κB-essential modulator; NF-κB; nuclear
ErbB3 interacts with Hrs and is sorted to lysosomes for degradation
Keywords: یوبیکویتین; CHC; clathrin heavy chain; CHX; cycloheximide; DN; dominant negative; EEA1; early endosome antigen 1; ERAD; ER-associated degradation; ESCRT; endosomal sorting complex required for transport; Hrg; heregulin; ILVs; intra luminal vesicles; LAMP1; lysosome-a
Methylglyoxal-induced AMPK activation leads to autophagic degradation of thioredoxin 1 and glyoxalase 2 in HT22 nerve cells
Keywords: یوبیکویتین; ACC; acetyl co-enzyme A carboxylase; AGE; advanced glycation end products; AMPK; 5â² AMP-activated protein kinase; ATG; autophagy related; BAF; bafilomycin; CQ; chloroquine; DMEM; high-glucose Dulbecco's modified Eagle medium; Glo; glyoxalase; GSH; gluta
The E3 ubiquitin ligase MID1/TRIM18 promotes atypical ubiquitination of the BRCA2-associated factor 35, BRAF35
Keywords: یوبیکویتین; BHC; BRAF-histone deacetylase; BRAF35/HMG20b; BRCA2-associated factor 35; CC; coiled-coil; coREST/RCOR1; REST corepressor 1; E1; UBE1, ubiquitin activating enzyme; E2; UBE2 ubiquitin conjugating enzyme; E3; ubiquitin ligase enzyme; FN3; fibronectin type I
Happily (n)ever after: Aging in the context of oxidative stress, proteostasis loss and cellular senescence
Keywords: یوبیکویتین; AD; Alzheimer's Disease;; AGEs; advanced glycation endproducts; ALP; autophagy-lysosome pathway; ARF; alternate reading frame; ATGs; autophagy-related proteins; BAG3; Bcl2-associated athanogene 3; Bcl-2; B-cell lymphoma 2; BrdU; 5-bromodeoxyuridine;; CMA;
The double faced role of copper in Aβ homeostasis: A survey on the interrelationship between metal dyshomeostasis, UPS functioning and autophagy in neurodegeneration
Keywords: یوبیکویتین; Copper; Metal ions; Alzheimer's disease; Neurodegenerative diseases; Insulin-degrading enzyme (IDE); Proteasome; Ubiquitin; Autophagy; Proteostasis; Metallostasis; Ubiquitin proteasome system (UPS); Aging; 4-Hydroxy-2-nonenal (HNE); 4-Hydroxy-2-hexanal
Sub-cellular localization specific SUMOylation in the heart
Keywords: یوبیکویتین; AMPK; adenosine monophosphate-activated protein kinase; CAMKK; calcium-calmodulin-activated protein kinase kinase; CHIP; carboxyl terminus of HSP70-interacting protein; CVD; cardiovascular disease; cTnI; cardiac troponin I; d-flow; disturbed flow; DeSI; d
A thiirane linker for isopeptide mimetics by peptide ligation
Keywords: یوبیکویتین; CPE ligation; Histone; Post-translational modification; Thiirane; Ubiquitin;
Detection of O-propargyl-puromycin with SUMO and ubiquitin by click chemistry at PML-nuclear bodies during abortive proteasome activities
Keywords: یوبیکویتین; Protein homeostasis; Puromycin; Click chemistry; Small ubiquitin-related modifier (SUMO); Ubiquitin; Promyelocytic leukemia nuclear bodies; OP-Puro; O-propargyl-puromycin; SUMO; small ubiquitin-related modifier; PML-NBs; promyelocytic leukemia-nuclear bod
Original articleExpression of interferon-stimulated gene ISG15 and ubiquitination enzymes is upregulated in peripheral blood monocyte during early pregnancy in dairy cattle
Keywords: یوبیکویتین; Interferon-tau; Pregnancy; Ubiquitin; ISGylation cattle;
Observation of an E2 (Ubc9)-homodimer by crystallography
Keywords: یوبیکویتین; SUMO; Poly-SUMO chain; RWD; Ubiquitin; Ubc9; E1; Ubiquitin-like; Modifications
Expression and purification of the kinase domain of PINK1 in Pichia pastoris
Keywords: یوبیکویتین; Heterologous expression; PINK1; Pichia pastoris; Parkinson's disease; Ubiquitin
UbcD4, an ortholog of E2-25K/Ube2K, is essential for activation of the immune deficiency pathway in Drosophila
Keywords: یوبیکویتین; Ubiquitin-conjugating enzyme (E2); UbcD4; E2-25K/Ube2K; IMD pathway; NF-κB pathway; dipt; diptericin; IMD; immune deficiency; IR; inverted repeat; Ub; ubiquitin;
The Pol30-K196 residue plays a critical role in budding yeast DNA postreplication repair through interaction with Rad18
Keywords: یوبیکویتین; PCNA; Ubiquitin; Rad18 interaction; DNA-damage tolerance;
The dynamics of histone H2A ubiquitination in HeLa cells exposed to rapamycin, ethanol, hydroxyurea, ER stress, heat shock and DNA damage
Keywords: یوبیکویتین; DNA damage; ER stress; Heat shock; Histone H2A; Stress response; Ubiquitin; ER; endoplasmic reticulum; hH2A; histone H2A; HU; hydroxyurea; MMS; methyl methanesulfonate; Tg; thapsigargin; Tm; tunicamycin; Rap; rapamycin; Ub; ubiquitin;
The requirements of yeast Hsp70 of SSA family for the ubiquitin-dependent degradation of short-lived and abnormal proteins
Keywords: یوبیکویتین; Ubiquitin; Degradation; Chaperone; Hsp70; Co-chaperone;
Immunolocalization of Tom1 in relation to protein degradation systems in Alzheimer's disease
Keywords: یوبیکویتین; AD; Alzheimer's disease; H&E; hematoxylin and eosin; APP; amyloid precursor protein; FBS; fetal bovine serum; PBS; phosphate-buffered saline; Tom1 (target of Myb1); Tollip; Myosin IV; Ubiquitin; Autophagy; Alzheimer's disease; Dystrophic neurites; Perisom
SCAMP 3 is a novel regulator of endosomal morphology and composition
Keywords: یوبیکویتین; SCAMP; Endosome; ESCRT; Ubiquitin; EEA1; early endosome antigen-1; ESCRT; endosomal sorting complex required for transport; FBS; fetal bovine serum; BSA; bovine serum albumin;
Anionic surfactants enhance click reaction-mediated protein conjugation with ubiquitin
Keywords: یوبیکویتین; Ubiquitin; Click reaction; Surfactants; Bioorthogonal chemistry; Protein conjugation