Loading and pre-loading processes generate a distinct siRNA population in Tetrahymena
Keywords: siRNA; siRNA; Argonaute; Dicer; Tetrahymena;
مقالات ISI siRNA (ترجمه نشده)
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GRK-6 mediates FSH action synergistically enhanced by estrogen and the oocyte in rat granulosa cells
Keywords: siRNA; DES; diethylstilbestrol; FSHR; follicle-stimulating hormone receptor; GRK; G protein-coupled receptor kinase; IBMX; 3-isobutyl-1-methylxanthine; P450arom; P450 aromatase; siRNA; small interfering RNA; StAR; steroidogenic acute regulatory protein; Estrogen
Molecular cloning and characterization of a novel isoform of the non-canonical poly(A) polymerase PAPD7
Keywords: siRNA; ncPAP; noncanonical poly(A) polymerase; NES; nuclear export signal; NLS; nuclear localization signal; NTD; nucleotidyl transferase domain; CUT; cryptic unstable transcripts; siRNA; small interfering RNA; LMB; leptomycin B; Polyadenylation; PAPD5; PAPD7; N
CEACAM1 inhibits cell-matrix adhesion and promotes cell migration through regulating the expression of N-cadherin
Keywords: siRNA; CEA; carcinoembryonic antigen; CEACAM1; carcinoembryonic antigen related cell adhesion molecule 1; EMT; epithelial-mesenchymal transition; ITIMs; immunoreceptor tyrosine-based inhibitory motifs; siRNA; small interfering RNA; TBST; tris buffered saline w
Knockdown of legumain inhibits cleavage of annexin A2 in the mouse kidney
Keywords: siRNA; Z; benzyloxycarbonyl; MCA; methylcumarinamide; siRNA-lipoplex; siRNA-cationic liposome complex; NEM; N-ethyl maleimide; 2-ME; 2-mercaptoetanol; PBS; phosphate buffered saline; Legumain; Annexin A2; Cationic liposome; siRNA; Invivo; Mouse kidney;
B56α subunit of protein phosphatase 2A mediates retinoic acid-induced decreases in phosphorylation of endothelial nitric oxide synthase at serine 1179 and nitric oxide production in bovine aortic endothelial cells
Keywords: siRNA; eNOS; endothelial nitric oxide synthase; EC; endothelial cell(s); NO; nitric oxide; AMPK; AMP-activated protein kinase; CaMKII; calmodulin-dependent kinase II; PKA; protein kinase A; atRA; all-trans retinoic acid; PP; protein phosphatase; PP2A Cα; cataly
Involvement of Ran in the regulation of phagocytosis against virus infection in S2 cells
Keywords: siRNA; Ran; Ras related nuclear protein; Rab; Ras gene from rat brain; Rho; Ras homology; Arf; ADP-ribosylation factor; S2; Schneider line 2; PCR; polymerase chain reaction; DCV; Drosophila C virus; PMSF; phenylmethylsulfonyl fluoride; FITC; fluorescein isothioc
Delivery of siRNA to the brain using a combination of nose-to-brain delivery and cell-penetrating peptide-modified nano-micelles
Keywords: siRNA; Tat analog; Nose-to-brain; siRNA; Central nerve system; Nano-sized micelles;
Cell-penetrating cationic siRNA and lipophilic derivatives efficient at nanomolar concentrations in the presence of serum and albumin
Keywords: siRNA; ACN; acetonitrile; DMT; dimethoxytrityl; EMAM; ethanolic methylamine/aqueous methylamine; MALDI-TOF; matrix assisted laser desorption/ionization - time of flight; MOPS; 3-(N-morpholino)propanesulfonic acid; ON; oligonucleotide; PAGE; polyacrylamide gel
Trefoil factor 3 peptide regulates migration via a Twist-dependent pathway in gastric cell
Keywords: siRNA; TFF3; trefoil factor 3; ITF; intestinal trefoil factor; ZO-1; zonula occludens protein 1; CK-8; cytokeratin 8; siRNA; small interfering RNA; HRP; Horseradish peroxidase; Twist; Trefoil factor 3; Migration; Gastric cancer;
Knockdown of TIGAR by RNA interference induces apoptosis and autophagy in HepG2 hepatocellular carcinoma cells
Keywords: siRNA; siRNA; small interference RNA; RNAi; RNA interference; HCC; hepatocellular carcinoma; ROS; reactive oxygen species; TIGAR; TP53-induced glycolysis and apoptosis regulator; siTIGAR; siRNA for TIGAR; TIGAR; Apoptosis; Autophagy; Hepatocellular carcinoma; RN
Role of hypoxia inducible factor-1α in remote limb ischemic preconditioning
Keywords: siRNA; RIPC; remote ischemic preconditioning; I/R; ischemia/reperfusion; HIF-1α; hypoxia inducible factor-1α; HIF1a; gene encoding the HIF-1α protein; MI; myocardial infarction; Cd; cadmium; IS; infarct size; IPC; local ischemic preconditioning; PCR; polymera
HDL drug carriers for targeted therapy
Keywords: siRNA; HDL; high-density lipoprotein; SR-BI; scavenger receptor class B type I; eNOS; endothelial nitric oxide synthase; miRNAs; microRNAs; S1PRs; sphingosine 1-phosphate receptors; S1P; sphingosine 1-phosphate; PGI2; prostaglandin I2; COX-2; cyclooxygenase-2; F
Evaluation of UGT protein interactions in human hepatocytes: Effect of siRNA down regulation of UGT1A9 and UGT2B7 on propofol glucuronidation in human hepatocytes
Keywords: siRNA; UDP-Glucuronosyltransferase; siRNA; Protein interactions; Hepatocytes;
Downregulation of the small GTPase Ras-related nuclear protein accelerates cellular ageing
Keywords: siRNA; HDF; human diploid fibroblast; HGPS; Hutchinson-Gilford progeria syndrome; MEF; mouse embryonic fibroblast; MnSOD; manganese superoxide dismutase; Ran; Ras-related nuclear protein; ROS; reactive oxygen species; SA-β-gal; senescence-associated β-galact
NEDD4 is overexpressed in colorectal cancer and promotes colonic cell growth independently of the PI3K/PTEN/AKT pathway
Keywords: siRNA; AKT; v-akt murine thymoma viral oncogene; CRC; colorectal cancer; FDR; false discovery rate; HECT; homologous to E6AP C terminus; KEGG; Kyoto Encyclopedia of Genes and Genomes; mut; mutated; NCBI; National Center for Biotechnology Information; PBS; phosph
Activation of TRPV4 channel in pancreatic INS-1E beta cells enhances glucose-stimulated insulin secretion via calcium-dependent mechanisms
Keywords: siRNA; 4α-PDD; the phorbol ester 4α-phorbol 12,13-didecanoate; cAMP; cyclic adenosine monophosphate; hIAPP; human islet amyloid polypeptide; KRHB; Krebs-Ringer-HEPES buffer; PKC; protein kinase C; siRNA; small interfering RNA; nt siRNA; non-targeting siRNA;
Hepatitis B virus X protein protects hepatoma and hepatic cells from complement-dependent cytotoxicity by up-regulation of CD46
Keywords: siRNA; HBx; hepatitis B virus X protein; HCC; hepatocellular carcinoma; mCRPs; membrane-bound complement regulatory proteins; CDC; complement-dependent cytotoxicity; COX-2; cyclooxygenase-2; PGE2; prostaglandin E2; CREB; cAMP response element-binding protein; RN
ECHS1 acts as a novel HBsAg-binding protein enhancing apoptosis through the mitochondrial pathway in HepG2 cells
Keywords: siRNA; HBV; hepatitis B virus; HCC; hepatocellular carcinoma; HBsAg; hepatitis B surface antigen; HBs; S region of HBsAg; CH; chronic hepatitis; ECHS1; mitochondrial short chain enoyl-CoA hydratase; MMP; mitochondrial membrane potential; AIP; arylhydrocarbon rec
HER2 regulates Brk/PTK6 stability via upregulating calpastatin, an inhibitor of calpain
Keywords: siRNA; ALLN; N-acetyl-leucyl-leucyl-norleucinal; Brk; breast tumor kinase; CHX; cycloheximide; DMEM; Dulbecco's modified Eagle's medium; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; Erk; extracellular signal-regulated kinase; FAK;
Modulation of turkey myogenic satellite cell differentiation through the shedding of glypican-1
Keywords: siRNA; CON; control; DMEM; Dulbecco's Modified Eagle Medium; ECM; extracellular matrix; FGF2; fibroblast growth factor 2; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; GAG; glycosaminoglycan; GPI; glycosylphosphatidylinositol; sol-GPC1; glypican-1 without GPI
Demonstration of dose dependent cytotoxic activity in SW480 colon cancer cells by 177Lu-labeled siRNA targeting IGF-1R
Keywords: siRNA; IGF-1R; siRNA; 177Lu; Colon cancer; Cellular uptake; Apoptosis;
Chemically modified siRNAs and miRNAs bearing urea/thiourea-bridged aromatic compounds at their 3â²-end for RNAi therapy
Keywords: siRNA; RNAi; siRNA; miRNA; Urea/thiourea; Aromatic compound;
In vivo biodistribution of siRNA and cisplatin administered using CD44-targeted hyaluronic acid nanoparticles
Keywords: siRNA; Hyaluronic acid; siRNA; Cisplatin; Nanoparticles; Tumor targeting; Multidrug resistance;
Macrophage specific delivery of TNF-α siRNA complexed with β-1,3-glucan inhibits LPS-induced cytokine production in a murine acute hepatitis model
Keywords: siRNA; Schizophyllan; siRNA; Dectin-1; Macrophage; Hepatitis;
Polypeptide cationic micelles mediated co-delivery of docetaxel and siRNA for synergistic tumor therapy
Keywords: siRNA; Polypeptide micelle; DTX; siRNA; Co-delivery; Synergistic tumor therapy;
Amphiphilic polyallylamine based polymeric micelles for siRNA delivery to the gastrointestinal tract: In vitro investigations
Keywords: siRNA; Amphiphilic poly(allylamine); siRNA; Polymeric micelles; Nano-sized; Gastrointestinal disease; Non-viral delivery; Ch2.5; cholesteryl modified poly(allylamine); GI; gastrointestinal; MTT; 3-(4,5dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; NP; na
Identification of proteins that mediate the pro-viral functions of the interferon stimulated gene 15 in hepatitis C virus replication
Keywords: siRNA; Acadm; acyl-coenzyme A dehydrogenase medium chain; HCV; hepatitis C virus; Herc5; HECT and RLD domain containing E3 ubiquitin protein ligase 5; HnrnpA3; heterogeneous nuclear ribonucleoprotein A3; HnrnpK; heterogeneous nuclear ribonucleoprotein K; Hmgcs1;
Jaceosidin, isolated from dietary mugwort (Artemisia princeps), induces G2/M cell cycle arrest by inactivating cdc25C-cdc2 via ATM-Chk1/2 activation
Keywords: siRNA; ATM; atazia-telagiectasia mutated; Caspase; cystein aspartyl-specific protease; Cdc 2; cell division cycle 2; Cdk; cyclin-dependent kinase; CDKI; cyclin-dependent kinase inhibitor; ERK; extracellular signal-regulated kinase; MAPK; mitogen activated protei
Suppressive effects of Indigofera suffruticosa Mill extracts on lipopolysaccharide-induced inflammatory responses in murine RAW 264.7 macrophages
Keywords: siRNA; ARE; antioxidant response element; CO; carbon monoxide; DMSO; dimethyl sulfoxide; EE-IDS; ethanol extracts of Indigofera suffruticosa Mill; EMSA; electrophoretic mobility shift assay; ERK1/2; extracellular signal-regulated kinase 1/2; FE; formononetin equ
Production of Cyr61 protein is modulated by extracellular acidification and PI3K/Akt signaling in prostate carcinoma PC-3 cells
Keywords: siRNA; NAC; N-acetylcysteine; ECM; extracellular matrix; PI3K; phosphoinositide 3-kinase; SDS; sodium dodecyl sulfate; HRP; horseradish peroxidase; ECL; enhanced chemiluminescence; siRNA; small interfering RNA; PBS; phosphate buffered saline; Akt; serine/threoni
The effect of regions flanking target site on siRNA potency
Keywords: siRNA; siRNA; Support vector machine; Regression analysis; Flanking sequence;
Research ArticleActivated human hepatic stellate cells induce myeloid derived suppressor cells from peripheral blood monocytes in a CD44-dependent fashion
Keywords: siRNA; HSC; hepatic stellate cell; IFN; interferon; MDSC; myeloid derived suppressor cell; PGE2; prostaglandin E2; SCF; stem cell factor; siRNA; small interfering RNA; shRNA; small hairpin RNA; VEGF; vascular endothelial growth factor; Hepatic stellate cell; Mye
TRPC3 regulates release of brain-derived neurotrophic factor from human airway smooth muscle
Keywords: siRNA; ASM; airway smooth muscle; BAL; bronchial alveolar lavage; BAPTA; 1,2-bis(o-aminophenoxy)ethane-N,N,Nâ²,Nâ²-tetraacetic acid; BDNF; brain-derived neurotrophic factor; NT; neurotrophins; ELISA; enzyme linked immunosorbent assay; GFP; green fluorescent pr
Genomic era analyses of RNA secondary structure and RNA-binding proteins reveal their significance to post-transcriptional regulation in plants
Keywords: siRNA; dsRNase; double-stranded RNase; ssRNase; single-stranded RNase; miRNA; microRNA; PIP-seq; protein interaction profile sequencing; siRNA; small interfering RNA; PARS; parallel analysis of RNA structure; RNA secondary structure; RNA-binding proteins; Post-t
Erythropoietin improves insulin resistance via the regulation of its receptor-mediated signaling pathways in 3T3L1 adipocytes
Keywords: siRNA; 3T3L1 adipocytes; Insulin resistance (IR); Recombinant human erythropoietin (rHuEPO); Erythropoietin receptor (EPOR); siRNA;
Use of experimental design methodology for the development of new magnetic siRNA nanovectors (MSN)
Keywords: siRNA; MSN; magnetic siRNA nanovectors; SPIONs; superparamagnetic iron oxide nanoparticles; MDT; magnetic drug targeting; MRI; magnetic resonance imaging; MPS; mononuclear phagocyte system; OFAT; one factor at a time; DOE; design of experiment; MR; mass ratio (i
Oncostatin M promotes mesenchymal stem cell-stimulated tumor growth through a paracrine mechanism involving periostin and TGFBI
Keywords: siRNA; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; hASCs; human adipose tissue-derived MSCs; MSCs; mesenchymal stem cells; OSM; oncostatin M; OSM CM; conditioned medium from OSM-treated hASCs; PBS; phosphate-buffered saline; SDF-1; stromal cell-derived fact
Glyceollin improves endoplasmic reticulum stress-induced insulin resistance through CaMKK-AMPK pathway in L6 myotubes
Keywords: siRNA; CaMKK; Ca2+/calmodulin-dependent protein kinase kinase; AMPK; AMP-activated protein kinase; ACC; acetyl-CoA carboxylase; ER; endoplasmic reticulum; PERK; double stranded RNA-activated protein kinase-like ER-associated kinase; IRE-1; inositol requiring ER-
Intracellular processing of immunostimulatory CpG-siRNA: Toll-like receptor 9 facilitates siRNA dicing and endosomal escape
Keywords: siRNA; siRNA; TLR9; CpG; Dicer; Cytoplasmic release; Endosomal escape;
Molecular characterization of the first commercial transgenic common bean immune to the Bean golden mosaic virus
Keywords: siRNA; BGMV; Bean golden mosaic virus; RNAi; interfering RNA; GM; genetically modified; TAIL-PCR; thermal asymmetric interlaced PCR; siRNA; small interfering RNA; PTGS; post-transcriptional gene silencing; NUPTs; nuclear-plastid sequences; Begomovirus; Dry bean;
New generation of efficient peptide-based vectors, NickFects, for the delivery of nucleic acids
Keywords: siRNA; CPP; cell-penetrating peptide; CR; charge ratio; DLS; dynamic light scattering; DIEA; diisopropylethylamine; EGFP; enhanced green fluorescent protein; HBTU; O-benzotriazole-N,N,Nâ²,Nâ²-tetramethyl-uronium-hexafluoro-phosphate; HOBT; hydroxybenzotriazole
Motoneuron BDNF/TrkB signaling enhances functional recovery after cervical spinal cord injury
Keywords: siRNA; Neurotrophin; Neuroplasticity; Spinal hemisection; Diaphragm muscle; Phrenic motoneuron; Respiratory; Respiration; CREB; siRNA; TrkB-Fc;
Involvement of connexin43 in the EGF/EGFR signalling during self-renewal and differentiation of neural progenitor cells
Keywords: siRNA; bFGF; basic fibroblast growth factor; Cx(s); connexin(s); EdU; 5-ethynyl-2â²-deoxyuridine; EGF; epidermal growth factor; EGFR; epidermal growth factor receptor; FRAP; fluorescence recovery after photobleaching; GJ(s); gap junction(s); GJIC; gap junctiona
Cytokine regulation by MAPK activated kinase 2 in keratinocytes exposed to sulfur mustard
Keywords: siRNA; SM; sulfur mustard; NHEK; normal human epidermal keratinocytes; MAPK; mitogen activated protein kinase; siRNA; small interfering RNA; MK2/MAPKAPK2; MAPK activated kinase 2; MK3/MAPKAPK3; MAPK activated kinase 3; MK5/MAPKAPK5; MAPK activated kinase 5; TNF-
Synthesis and evaluation of degradable polyurea block copolymers as siRNA delivery agents
Keywords: siRNA; siRNA; Delivery; Polyurea; Polylysine; Reducible;
Functionalized liposomes loaded with siRNAs targeting ion channels in effector memory T cells as a potential therapy for autoimmunity
Keywords: siRNA; Autoimmunity; T cell; Kv1.3 ion channel; Lipid nanoparticles; siRNA;
Dexamethasone-conjugated polyethylenimine/MIF siRNA complex regulation of particulate matter-induced airway inflammation
Keywords: siRNA; PM (particulate matter); Airway inflammation; DEXA-PEI; MIF; siRNA; Gene delivery;
Enhanced hepatic delivery of siRNA and microRNA using oleic acid based lipid nanoparticle formulations
Keywords: siRNA; Cationic lipid nanoparticles; Helper lipids; siRNA; microRNA; Hepatic delivery;
Aldo-keto reductases mediate constitutive and inducible protection against aldehyde toxicity in human neuroblastoma SH-SY5Y cells
Keywords: siRNA; AKR; aldo-keto reductases; CSF; cerebrospinal fluid; 4-HNE; 4-hydroxynonenal; RNAi; RNA interference; siRNA; small inhibitory RNA; t-BHQ; tert-butylhydroquinone; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide; D3T; 3H-1,2-dithiole-3-t