Imaging-guided delivery of RNAi for anticancer treatment
Keywords: siRNA; Molecular imaging; Cancer; Nanocarrier; siRNA; RNA interference; Gene delivery; Theranostics
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Aire knockdown in medullary thymic epithelial cells affects Aire protein, deregulates cell adhesion genes and decreases thymocyte interaction
Keywords: siRNA; Thymus; mTEC; Thymocyte; mTEC-thymocyte adhesion; Aire gene; siRNA;
Intracellular and extracellular microRNA: An update on localization and biological role
Keywords: siRNA; miRNA; microRNA; siRNA; small interfering RNA; pRNA; promoter-associated RNA; PTGS; post-transcriptional gene silencing; RNAi; RNA interference; AGO; argonaute proteins; RISC; RNA-induced silencing complexes; miRISC; miRNA-induced silencing complexes; RNP
Application of bifurcation theory and siRNA-based control signal to restore the proper response of cancer cells to DNA damage
Keywords: siRNA; SiRNA; Transduction pathway; Bifurcation theory;
An albumin-mediated cholesterol design-based strategy for tuning siRNA pharmacokinetics and gene silencing
Keywords: siRNA; Albumin; Drug delivery; siRNA; Biodistribution; Half-life extension; Factor VII;
Reduction of p53 by Knockdown of the UGT1 Locus in Colon Epithelial Cells Causes an Increase in Tumorigenesis
Keywords: siRNA; Apoptosis; Colon Cancer; ER Stress; UGT1A; AOM; azoxymethane; CRC; colorectal cancer; DSS; dextran sodium sulfate; ER; endoplasmic reticulum; IEC; intestinal epithelial cells; IL; interleukin; MTT; 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium brom
A cellular high-throughput screening approach for therapeutic trans-cleaving ribozymes and RNAi against arbitrary mRNA disease targets
Keywords: siRNA; High throughput screening; Gene therapy; Hammerhead ribozyme; RNAi; siRNA; shRNA; DNAzyme; RNA drug discovery; Hereditary retinal degenerations; Autosomal dominant retinitis pigmentosa; anova; analysis of variance; bp; base pair; CV; coefficient of variat
Conjugates of small targeting molecules to non-viral vectors for the mediation of siRNA
Keywords: siRNA; Gene delivery; Non-viral vector; Ligand-targeted therapeutics; Transfection efficiency; siRNA
Novel RNA-binding activity of NQO1 promotes SERPINA1 mRNA translation
Keywords: siRNA; ARE; antioxidant response elements; A1AT; α-1-antitrypsin; COPD; chronic obstructive pulmonary disease; CR; coding region; FL; firefly luciferase; GRB; growth factor receptor-bound protein; IP; immunoprecipitation; Keap1; Kelch-like ECH-associated protei
Nanosystems based on siRNA silencing HuR expression counteract diabetic retinopathy in rat
Keywords: siRNA; Diabetic retinopathy; VEGF; HuR/ELAV; siRNA; Solid lipid nanoparticles; Liposomes;
Long non-coding RNA: A newly deciphered “code” in prostate cancer
Keywords: siRNA; Androgen receptor; LNCaP; Biomarker; PCa; prostate cancer; ncRNA; non-coding RNAs; lncRNA; long ncRNA; miRNA; microRNA; snRNA; small nuclear RNA; siRNA; small interfering RNA; tRNA; transfer RNA; rRNA; ribosomal RNA; PCA3; PCa antigen 3; PIN; prostatic in
microRNAs target SRSF7 splicing factor to modulate the expression of osteopontin splice variants in renal cancer cells
Keywords: siRNA; qPCR; quantitative real-time PCR; SR proteins; serine/arginine-rich proteins; miRNA; microRNA; siRNA; small interfering RNA; SDS-PAGE; sodium dodecyl sulfate-polyacrylamide gel electrophoresis; SRSF7; Osteopontin; SPP1; Alternative splicing; microRNA; Ren
Repression of harmful meiotic recombination in centromeric regions
Keywords: siRNA; DSB; DNA double-strand break; MI; first meiotic division; MII; second meiotic division; PSSC; precocious separation of sister chromatids; H3 K9me; histone H3 methylated on lysine 9; siRNA; small interfering RNA; IH; interhomolog; IS; intersister; MRN; Mre
NOX4-derived reactive oxygen species limit fibrosis and inhibit proliferation of vascular smooth muscle cells in diabetic atherosclerosis
Keywords: siRNA; Apoe; Apolipoprotein e; CTGF; Connective tissue growth factor; CNN; Calponin; DN; Dominant negative; ECM; Extracellular matrix; FBS; Foetal bovine serum; HG; High glucose; LCA; Left common carotid artery; mRNA; Messenger ribonucleic acid; MASM; Mouse Aort
Two-Step Forward Genetic Screen in Mice Identifies Ral GTPase-Activating Proteins as Suppressors of Hepatocellular Carcinoma
Keywords: siRNA; Sleeping Beauty; Liver Cancer; RalGAPs; Kinase Inhibitor; CCG; candidate cancer genes; CIS; common transposon insertion site; gCIS; gene-centric common transposon insertion site-calling method; GTPase; guanosine triphosphatase; HBsAg; hepatitis B surfac
Protective effects of organic acid component from Taraxacum mongolicum Hand.-Mazz. against LPS-induced inflammation: Regulating the TLR4/IKK/NF-κB signal pathway
Keywords: siRNA; TMHM,; Taraxacum mongolicum Hand.-Mazz; OAC; organic acid component; LPS; lipopolysaccharide; IKK; inhibitor of nuclear factor kappa-B kinase; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; NHBE; Normal Human Bronchial Epithelial; IF; Immunofluorescence
Desmoglein 3-Dependent Signaling Regulates Keratinocyte Migration and Wound Healing
Keywords: siRNA; Dsc3; desmocollin 3; Dsg3; desmoglein 3; ERK; extracellular signal-regulated kinase; GFP; green fluorescent protein; MEK; murine epidermal keratinocytes; p38MAPK; p38 mitogen-activated protein kinase; PKC; protein kinase C; PV; pemphigus vulgaris; PV-IgG;
PLGA-based nanoparticles: A new paradigm in biomedical applications
Keywords: siRNA; Biodegradable; Poly(lactic-co-glycolic acid); Nanoparticles; Targeting; Sustained release; DCC; N,N-Dicyclohexylcarbodiimide; DDS; Drug delivery system; DNA; Deoxyribose nucleic acid; EDC; 1-ethyl-3-(3-dimethylaminopropyl carbodiimide); EGFR; Epidermal gr
Short interfering RNA induced generation and translation of stable 5â² mRNA cleavage intermediates
Keywords: siRNA; siRNA; shRNA; RNAi; mRNA cleavage; mRNA decay;
Smyd3 open & closed lock mechanism for substrate recruitment: The hinge motion of C-terminal domain inferred from μ-second molecular dynamics simulations
Keywords: siRNA; SET; Suppressor of variegation, Enhancer of Zeste, Trithorax; MYND; Myeloid-Nervy-DEAF1; siRNA; small interfering RNA; VEGFR1; vascular endothelial growth factor receptor-1; MD; molecular dynamics; HKMT; histone lysine methyltranferase; RMSD; root-mean sq
Netrin-1 Protects Hepatocytes Against Cell Death Through Sustained Translation During the Unfolded Protein Response
Keywords: siRNA; Netrin; UPR; Hepatocyte; Translation; ATF6; activated transcription factor 6; CMV; cytomegalovirus; DAPK; death-associated protein kinase; DMS; dimethyl sulfate; DR; dependence receptor; DTT; dithiothreitol; eIF2α; Eukaryotic translation initiation facto
AP1S3 Mutations Cause Skin Autoinflammation by Disrupting Keratinocyte Autophagy and Up-Regulating IL-36 Production
Keywords: siRNA; 3-MA; 3-methyladenine; AID; autoinflammatory disorder; CRISPR; clustered regularly-interspaced short palindromic repeats; Cas9; CRISPR-associated endonuclease 9; GFP; green fluorescent protein; MALP-2; macrophage-activating lipopeptide 2; siRNA; small int
Ferritin-mediated siRNA delivery and gene silencing in human tumor and primary cells
Keywords: siRNA; siRNA; Ferritin; Primary cells; Gene silencing; Drug delivery;
Analysis of the miRNA expression profile in an Aedes albopictus cell line in response to bluetongue virus infection
Keywords: siRNA; BTV; bluetongue virus; CHIKV; Chikungunya virus; CPE; cytopathic effect; DENV; dengue fever virus; dsRNA; double-stranded RNA; DMEM; Dulbecco's modified Eagle's medium; FBS; fetal bovine serum; GO; gene ontology; KEGG; Kyoto Encyclopedia of Genes Genomes;
Akt phosphorylates myc-associated zinc finger protein (MAZ), releases P-MAZ from the p53 promoter, and activates p53 transcription
Keywords: siRNA; p53; Arf; Mdm2; Akt; MAZ; Phosphorylation; ChIP; chromatin immunoprecipitation; Dox; doxycycline; EMSA; electrophoretic mobility shift assay; IB; immunoblotting; IP; immunoprecipitation; Myr-Akt; myristoylatedAkt; siRNA; small interference RNA; WB; Wester
A Bifunctional Approach of Immunostimulation and uPAR Inhibition Shows Potent Antitumor Activity in Melanoma
Keywords: siRNA; B-RAFi; B-RAF inhibition; ctrl; control; CXCL10; C-X-C motif chemokine 10; DR; acquired double resistance to B-RAFi and MEKi; MEKi; mitogen-activated protein kinase/extracellular signal-regulated kinase inhibition; OH; unmodified siRNA (hydroxy terminus);
Potent effects of dioscin against gastric cancer in vitro and in vivo
Keywords: siRNA; Apoptosis; Cell migration; Dioscin; Gastric cancers; Proteomics; iTRAQ; isobaric tags for relative and absolute quantitation; MTT; 3-(4, 5-dimethylthiazol-2-yl) -2,5-diphenyl tetrazolium bromide; AO; acridine orange; EB; ethidium bromide; DAPI; 4,6-diamid
Development of Cell-Penetrating Asymmetric Interfering RNA Targeting Connective Tissue Growth Factor
Keywords: siRNA; asiCTGF; asymmetric small interfering RNA targeting connective tissue growth factor; asiRNA; asymmetric small interfering RNA; cp-asiRNA; cell-penetrating asymmetric small interfering RNA; cp-asiCTGF; cell-penetrating asymmetric small interfering RNA; CTG
TSLP Down-Regulates S100A7 and Ã-Defensin 2 Via the JAK2/STAT3-Dependent Mechanism
Keywords: siRNA; AD; atopic dermatitis; AMP; antimicrobial peptide; hBD2; human β-defensin 2; HSEM; human skin equivalent model; NHEKs; normal human epidermal keratinocytes; RT-PCR; reverse transcriptase-PCR; S100A7 (psoriasin); S100 calcium-binding protein A7; siRNA; sm
Characterization of TNF-α- and IL-17A-Mediated Synergistic Induction of DEFB4 Gene Expression in Human Keratinocytes through IκBζ
Keywords: siRNA; AP-1; activator protein-1; C/EBP-β; CCAAT-enhancer-binding protein-β; ERK; extracellular signal-regulated kinase; hBD2; human β-defensin 2; JNK; c-Jun N-terminal kinase; MAPK; mitogen-activated protein kinase; mRNA; messenger RNA; OCT1; octamer transcr
Reactive Oxygen Species Dictate the Apoptotic Response of Melanoma Cells to TH588
Keywords: siRNA; 8-oxo-dGTP; 8-oxo-deoxy-guanine; MTH1; MutT homolog 1; ROS; reactive oxygen species; shRNA; small hairpin RNA; siRNA; small interfering RNA;
Antiadipogenic and proosteogenic effects of luteolin, a major dietary flavone, are mediated by the induction of DnaJ (Hsp40) Homolog, Subfamily B, Member 1
Keywords: siRNA; Pparγ; peroxisome proliferator activated receptor γ; aP2; adipocyte protein 2; siRNA; small interfering RNA; MSC; mesenchymal stem cells; DMI; Dexamethasone, IBMX, and Insulin; Dnajb1; DnaJ (Hsp40) Homolog, Subfamily B, Member 1; LCA; licochalcone A; TN
MicroRNA-455-3p modulates cartilage development and degeneration through modification of histone H3 acetylation
Keywords: siRNA; miR; microRNA; HDAC; histone deacetylase; OA; osteoarthritis; COL2A1; collagen 2; SOX9; SRY (sex-determining region Y)-box 9; RUNX2; Runt-related transcription factor 2; HAT; histone acetyltransferase; TSA; trichostatin A; Mmp13; matrix metalloproteinase
Aptamers as smart ligands for nano-carriers targeting
Keywords: siRNA; Aptamer; Targeting; Nano-carriers; Cancer therapy; Affinity ligand; 225Ac; Actinium isotope 225; Bcl-xl; B-cell lymphoma-extra large transmembrane protein; CD; Cluster of differentiation; CNTs; Carbon nanotubes; CTLA 4; cytotoxic T-lymphocyte-associated p
Delivery of siRNA targeting tumor metabolism using non-covalent PEGylated chitosan nanoparticles: Identification of an optimal combination of ligand structure, linker and grafting method
Keywords: siRNA; SiRNA; Chitosan; RGD peptidomimetic; Tumor metabolism; Lactate; Glutamine;
Xeroderma Pigmentosum Group A Promotes Autophagy to Facilitate Cisplatin Resistance in Melanoma Cells through the Activation of PARP1
Keywords: siRNA; DPQ; 3,4-dihydro-5-[4-(1-piperidinyl) butoxy]-1(2H)-isoquinolinone; HMGB1; high-mobility group protein B1; LC3; light chain 3 protein; MC; normal human melanocytes; mTOR; mechanistic target of rapamycin; NER; nucleotide excision repair; PAR; poly(adenosin
Liver X Receptor Regulates Triglyceride Absorption Through Intestinal Down-regulation of Scavenger Receptor Class B, Type 1
Keywords: siRNA; Hypertriglyceridemia; Lipid-Sensing; Fat Absorption; Triglyceride-Rich Lipoproteins; apoB; apolipoprotein B; BBM; brush-border membrane; CM; chylomicron; DMSO; dimethyl sulfoxide; LXR; liver X receptor; mRNA; messenger RNA; PDZK1; PDZ-containing kidney pr
Variation in Hsp70-1A Expression Contributes to Skin Color Diversity
Keywords: siRNA; AA; African American; ER; endoplasmic reticulum; Hsp; heat shock protein; LC3-II; microtubule-associated protein light chain 3 (LC3)-phosphatidylethanolamine conjugate; NHEM; normal human epidermal melanocyte; siRNA; small interfering RNA; TYR; tyrosinase
Deletion of sirtuin 6 accelerates endothelial dysfunction and atherosclerosis in apolipoprotein E-deficient mice
Keywords: siRNA; ApoEâ/â; apolipoprotein E-deficient; GAPDH; glyceraldehyde-3-phosphate dehydrogenase; HCD; high-cholesterol diet; HDL; high-density lipoprotein; HUVEC; human umbilical vein endothelial cells; ICAM-1; intracellular adhesion molecule-1; LDL; low-densi
Guidelines for the optimal design of miRNA-based shRNAs
Keywords: siRNA; RNAi; shRNA; siRNA; miRNA; Gene therapy; RNA structure;
Intranasal brain delivery of cationic nanoemulsion-encapsulated TNFα siRNA in prevention of experimental neuroinflammation
Keywords: siRNA; LPS; lipopolysaccharide; TNFα; tumor necrosis factor-alpha; siRNA; small interfering ribonucleic acids; CNS; central nervous system; SNTF; TNFα silencing siRNA in aqueous solution; SNE; TNFα silencing siRNA-encapsulated in cationic nanoemulsion.; Neuro
FHL3 differentially regulates the expression of MyHC isoforms through interactions with MyoD and pCREB
Keywords: siRNA; MyHC; myosin heavy chain; FHL; four and half LIM domain protein; CRE; cyclic AMP-responsive element; CREB; cAMP-response-element-binding protein; PKA; cAMP-activited protein kinase A; MyoG; myogenin; MyoD; myogenic differentiation 1; SDS; Sodium Dodecyl S
Ginsenoside Rg3 induces FUT4-mediated apoptosis in H. pylori CagA-treated gastric cancer cells by regulating SP1 and HSF1 expressions
Keywords: siRNA; H. pylori; Helicobacter pylori; CagA; cytotoxin associated antigen A; DAPI; 4-6-diamidino-2-phenylindole; ELISA; enzyme-linked immunosorbent assay; FACS; fluorescence activated cell sorting; FUTs; fucosyltransferases; FUT4; fucosyltransferase IV; HSF1; he
Spleen Tyrosine Kinase Mediates EGFR Signaling to Regulate Keratinocyte Terminal Differentiation
Keywords: siRNA; ITAM; immunoreceptor tyrosine-based activation motif; NHEK; normal human epidermal keratinocytes; PMA; phorbol 12-myristate 13-acetate; siRNA; small interfering RNA; Syk; spleen tyrosine kinase; TGase; transglutaminase;
Ezetimibe, an NPC1L1 inhibitor, is a potent Nrf2 activator that protects mice from diet-induced nonalcoholic steatohepatitis
Keywords: siRNA; NAFLD; nonalcoholic fatty liver disease; NASH; nonalcoholic steatohepatitis; Nrf2; nuclear factor erythroid 2-related factor 2; Keap1; Kelch-like ECH associated protein 1; TUNEL; terminal deoxynucleotidyl transferase dUTP nick end labeling; MTT; 3-(4,5-di
Modified siRNA effectively silence inducible immunoproteasome subunits in NSO cells
Keywords: siRNA; siRNA; Immunoproteasome; Chemical modifications; NSO cells;
miRNA alterations are important mechanism in maize adaptations to low-phosphate environments
Keywords: siRNA; SP; sufficient phosphate; LP; low phosphate; miRNAs; microRNAs; sRNAs; small RNAs; siRNA; small interfering RNAs; ARFs; auxin response factors; SPL; squamosa promoter-binding-like protein; miRNAs; Low-phosphate stress; Maize; Auxin; Root architecture modi
An overview of chemical inhibitors of the Nrf2-ARE signaling pathway and their potential applications in cancer therapy
Keywords: siRNA; AA; Ascorbic acid; AEM1; ARE expression modulator 1; AEG1; Astrocyte elevated gene-1; Akt; Protein kinase B; AMPK; AMP-activated protein kinase; APL; Acute promyelocytic leukemia; ARE; Antioxidant response element; ATO; Arsenic trioxide; Bach; BTB and CNC
RISC assembly: Coordination between small RNAs and Argonaute proteins
Keywords: siRNA; RNA silencing; Small RNAs; RISC; Argonaute; Chaperone; siRNA; miRNA; piRNA;
Tumor acidity-sensitive linkage-bridged block copolymer for therapeutic siRNA delivery
Keywords: siRNA; PEG detachment; Tumor pH-responsive; siRNA; Cancer nanotechnology;